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Dietary supplement

BroccoRaphanin Ingredients & Drug Interactions

by Progressive Professional from Progressive Laboratories

BroccoRaphanin label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BroccoRaphanin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

BroccoRaphanin is a dietary supplement by Progressive Professional from Progressive Laboratories with 2 active ingredients. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 723 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sulforaphane Glucosinolate, BroccoRaphanin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against BroccoRaphanin by Progressive Professional from Progressive Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with BroccoRaphanin by Progressive Professional from Progressive Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of BroccoRaphanin by Progressive Professional from Progressive Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

BroccoRaphanin contains 2 active ingredients: broccoli extract (standardized as BroccoRaphanin) and sulforaphane glucosinolate, a compound naturally found in broccoli and related cruciferous vegetables. These are packaged in a capsule with inactive ingredients including a cellulose-based binder, a plant-derived lubricant, and chlorophyll for color.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Prostate cancer — rated "Possibly Effective" (Sulforaphane) (Natural Medicines).
  • On file: Colorectal cancer — rated "Possibly Effective" (Broccoli) (Natural Medicines).

The evidence for BroccoRaphanin is limited to a few areas. Broccoli itself is rated possibly effective for colorectal cancer prevention, though the data for other cancers — bladder, breast, and gastric — is insufficient to rate.

Sulforaphane is rated possibly effective for prostate cancer and possibly ineffective for H. pylori infection. For other conditions like fibromyalgia, asthma, and allergies, we don't have enough reliable evidence in our data to say whether either ingredient helps.

The evidence, ingredient by ingredient Broccoli Sulforaphane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is well tolerated by most people, but concentrated supplements like this one haven't been studied as thoroughly for long-term safety — check with your doctor before starting if you're concerned. Adverse effects reported with broccoli extracts include loose stools, diarrhea, abdominal pain, and cramping, particularly at higher doses.

Sulforaphane is generally well tolerated orally, though bowel discomfort, heartburn, stomach upset, and vomiting have been reported; headache, insomnia, and irritability occurred in clinical trials. Rare cases of seizure have been reported in males with autism taking sulforaphane.

For pregnancy, the safety data advises against sulforaphane supplements — stick to broccoli in your diet instead — though regular broccoli is considered likely safe.

Side effects, ingredient by ingredient Broccoli Sulforaphane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Sulforaphane, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 724 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this supplement, double-check with your doctor or pharmacist if you take any medications metabolized by CYP1A2 enzymes (Moderate severity) — broccoli in this product can reduce their levels and effects. Also ask about drugs that depend on CYP2A6, CYP3A4, or CYP2E1, since the ingredients may affect those enzymes too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

BroccoRaphanin may be worth considering if you're interested in the research around broccoli and cancer prevention, especially colorectal cancer. But this supplement can meaningfully change how your liver processes many common medications, so it's essential to check your exact drugs with your doctor or pharmacist before you start.

If you have a history of seizures or take seizure medications, mention that when you talk it over.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BroccoRaphanin, straight from the product label.

Brand Progressive Professional from Progressive Laboratories
Barcode (UPC) 351821001661
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261463
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BroccoRaphanin by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chlorophyll Vegetable Capsule
Maximum serving Sizes:
1 Chlorophyll Vegetable Capsule
Servings per container
60
UPC/BARCODE
351821001661
IngredientAmount% DV
BroccoRaphanin300 mg--
Sulforaphane Glucosinolate30 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Vegetable Lubricant, Chlorophyll

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: One chlorophyll vegetable capsule daily, or more, as directed by a health care professional.

Precautions

Sold only for dispensing by a licensed health professional.

Not to be used by pregnant or lactating women.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of the reach of children.

Formulation

BroccoRaphanin is produced under US patents 5,725,895; 5,968,505; 5,968,567; 6,177,122; 6,242,018; 6,521,818 and other US patents. Process patents pending to C S Health. Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

Long lasting indirect antioxidant for immune system support

Seals/Symbols

GMP Good Manufacturing Practice Certified GMP Compliant 21 CFR 111

Brand IP Statement(s)

Progressive Professional from Progressive Laboratories

Formula

Broccoli extract

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat,cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BroccoRaphanin by Progressive Professional from Progressive Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BroccoRaphanin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BroccoRaphanin by Progressive Professional from Progressive Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chlorophyll Vegetable Capsule Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

BroccoRaphanin

Interacts with
187 drugs
300 mg per serving Form: Broccoli concentrate

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

BroccoRaphanin monograph & interactions

Sulforaphane Glucosinolate

Interacts with
722 drugs
30 mg per serving Form: Glucoraphanin

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effec...

Sulforaphane Glucosinolate monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Vegetable Lubricant, Chlorophyll. These complete the product’s ingredient list but are not active constituents.

Interaction report

BroccoRaphanin by Progressive Professional from Progressive Laboratories Drug Interactions

Want to check YOUR meds against BroccoRaphanin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
723Drugs
723 Moderate

Ingredients driving the most interactions

Sulforaphane Glucosinolate 722
BroccoRaphanin 187

Individual Drug Interactions

The ingredients in BroccoRaphanin interact with 723 drugs. Click any drug to see the details.

2 of the 2 ingredients in BroccoRaphanin interact with drugs. Each result below shows which ingredient is responsible. Sulforaphane Glucosinolate BroccoRaphanin

Each ingredient & the kinds of drugs it affects

For each ingredient in BroccoRaphanin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sulforaphane Glucosinolate3 drug types · 722 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP1A2 enzyme activity. However, its precursor glucoraphanin also appears to increase the expression of the CYP1A2 enzyme, which could lead to increased metabolism of CYP1A2 substrates. These effects have not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP2E1 substrates.
In vitro evidence shows that sulforaphane inhibits CYP2E1 enzymes. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, sulforaphane might increase the levels and effects of CYP3A4 substrates.
Animal and in vitro research shows that sulforaphane inhibits CYP3A4 enzyme activity and downregulates its expression. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Sulforaphane Glucosinolate full monograph & interactions

BroccoRaphanin2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
BroccoRaphanin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BroccoRaphanin, from the product label.

Progressive Professional from Progressive Laboratories

See all Progressive Professional from Progressive Laboratories products
Name
Progressive Laboratories, Inc.
City
Irving
State
Texas
ZipCode
75038
Phone Number
1-800-527-9512
Pharmacist Counseling Corner

BroccoRaphanin by Progressive Professional from Progressive Laboratories: Common Questions

Does BroccoRaphanin by Progressive Professional from Progressive Laboratories interact with any medications?
Yes. Based on its ingredients, BroccoRaphanin has a known interaction with 723 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BroccoRaphanin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is BroccoRaphanin safe to take while pregnant or breastfeeding?
Regular broccoli from your diet is considered likely safe in pregnancy. However, the safety data advises against taking concentrated sulforaphane supplements in pregnancy — talk with your doctor about sticking to food amounts instead. For breastfeeding, there isn't enough information on supplement-level doses, so use caution and prefer eating broccoli as food.
What side effects should I watch for?
The most common are digestive: loose stools, diarrhea, abdominal pain, and cramping, especially at higher doses. Sulforaphane in the product can also cause headache, insomnia, stomach upset, and heartburn. Rare cases of seizure have been reported in males with autism — if you have seizure history, mention it to your doctor before starting.
Can this supplement help with cancer prevention?
Broccoli is rated possibly effective for colorectal cancer based on available evidence. For other cancers — breast, bladder, and gastric — the evidence is insufficient to say. Sulforaphane is possibly effective for prostate cancer, but we don't have strong evidence for most other conditions in our data.
Will this supplement affect how my medications work?
Yes — broccoli and sulforaphane both influence liver enzymes that break down many common drugs, potentially reducing some medications' effectiveness or increasing others' strength. Check your specific medications with the tool on this page before starting, and discuss it with your pharmacist.
What are BroccoRaphanin and sulforaphane glucosinolate?
BroccoRaphanin is a concentrated extract from broccoli containing compounds called glucosinolates. Sulforaphane glucosinolate is another natural compound found in broccoli that converts to sulforaphane in your digestive system — both are thought to be the active parts of the plant.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BroccoRaphanin label
Go deeper

The Full Monographs Behind BroccoRaphanin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph → Herb & supplement monograph

Sulforaphane

Interacts with 722 drugs

Sulforaphane is a natural compound found in broccoli and other cruciferous vegetables that has shown promising antioxidant and anti-inflammatory effects in lab studies, but strong human evid...

Read the full Sulforaphane monograph →
Sources

Sources & How We Checked

BroccoRaphanin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Sulforaphane 16 references
  1. Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55. PubMed
  2. Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20. PubMed
  3. Cipolla BG, Mandron E, Lefort JM, et al. Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy. Cancer Prev Res (Phila). 2015;8(8):712-9. PubMed
  4. Fahey JW, Wade KL, Wehage SL, et al. Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency. Mol Nutr Food Res. 2017 Apr;61(4). PubMed
  5. Alumkal JJ, Slottke R, Schwartzman J, et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Invest New Drugs. 2015;33(2):480-9. PubMed
  6. Heber D, Li Z, Garcia-Lloret M, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014;5(1):35-41. PubMed
  7. Singh K, Connors SL, Macklin EA, et al. Sulforaphane treatment of autism spectrum disorder (ASD). Proc Natl Acad Sci U S A. 2014;111(43):15550-5. PubMed
  8. Wise RA, Holbrook JT, Criner G, et al. Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial. PLoS One. 2016;11(11):e0163716. PubMed
  9. Bent S, Lawton B, Warren T, et al. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018;9:35. PubMed
  10. Momtazmanesh S, Amirimoghaddam-Yazdi Z, Moghaddam HS, Mohammadi MR, Akhondzadeh S. Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial. Psychiatr PubMed
  11. Fimognari C, Lenzi M, Hrelia P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008;9(7):668-78. PubMed
  12. Chinnappan SM, George A, Evans M, Anthony J. Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled stud
  13. Mahéo K, Morel F, Langouët S, et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997;57(17):3649-52.
  14. Yoxall V, Kentish P, Coldham N, Kuhnert N, Sauer MJ, Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. Int J Cancer. 2005;117(3):356-62. PubMed
  15. Zimmerman AW, Singh K, Connors SL, et al. Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder. Mol Autism 2021;12(1):38.
  16. Yusin J, Wang V, Henning SM, et al. The effect of broccoli sprout extract on seasonal grass pollen-induced allergic rhinitis. Nutrients 2021;13(4):1337. PubMed

See these in context on the Sulforaphane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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