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Dietary supplement

Brutal 4ce Ingredients & Drug Interactions

by Blackstone Labs

Brutal 4ce label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Brutal 4ce against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Brutal 4ce is a dietary supplement by Blackstone Labs with 1 active ingredient. Its ingredients are commonly taken for muscle building, strength and athletic performance, boosting testosterone.Based on those ingredients, 8 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 4-DHEA Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Brutal 4ce by Blackstone Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Brutal 4ce by Blackstone Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Brutal 4ce by Blackstone Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “4-DHEA Blend” is a proprietary blend — the label gives one combined amount (65 mg) without saying how much of each component you get.

Brutal 4ce contains 3 active ingredients, all variants of 4-androsterone — a prohormone that your body is believed to convert into testosterone and related male hormones. The three forms (4 Androstene-3b-0l,17-one, its Undecanoate ester, and its Caprylate ester) are designed to provide different absorption or duration profiles.

The tablet also includes inactive ingredients like microcrystalline cellulose, phosphatidylcholine, cyclodextrin, phytosterol, and several others that serve as fillers, binders, and flow agents.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: lean muscle mass and athletic performance.
  • We looked for evidence on: muscle strength, athletic performance, testosterone support, body composition.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The product facts don't include effectiveness ratings for 4-androsterone, so we don't have established evidence on file about how well it works for any particular purpose. Prohormone supplements exist in a gray area where claims are often theoretical rather than backed by solid clinical data.

The evidence, ingredient by ingredient 4-androsterone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's what you need to know: prohormones like 4-androsterone can disrupt your hormone balance, strain your liver, and affect your cholesterol levels — and safety isn't well studied in humans. The theoretical concern is serious anabolic steroid-like side effects including stroke, kidney failure, and liver injury, though insufficient information is available about how often these actually occur.

Pregnancy and breastfeeding are clear no-go's. Androgenic hormones can harm a developing baby, and the hormonal effects on a nursing infant are unknown and potentially harmful — the facts advise against use in both cases.

If you're a woman of childbearing age or nursing, this product isn't appropriate.

Side effects, ingredient by ingredient 4-androsterone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — 4-androsterone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 8 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Brutal 4ce, double-check any testosterone or testosterone-replacement therapy you're using with your doctor or pharmacist — that's the documented Moderate-severity interaction. The product data doesn't show interactions with other common medication types, but we can only confirm what's been studied, so run your full medication list through the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Brutal 4ce is aimed at people interested in muscle-building and hormonal support, but it's not for everyone. If you take testosterone, any other hormones, or have liver or kidney concerns, you should talk it over with your doctor or pharmacist before starting.

Women who are pregnant, breastfeeding, or could become pregnant should not use it. Anyone considering this product should have a detailed conversation with their own healthcare provider about the risks and whether it's right for them.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Brutal 4ce, straight from the product label.

Brand Blackstone Labs
Barcode (UPC) 636823236298
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD May 24, 2018
DSLD ID 171645
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Brutal 4ce by Blackstone Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
636823236298
IngredientAmount% DV
4-DHEA Blend65 mg--
4 Androstene-3b-0l,17-one0 NP--
4 Androstene-3b-0l,17-one Undecanoate0 NP--
4 androstene-3b-0l,17-one Caprylate0 NP--

Other ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Pro anabolic precursor Increased aggression in the gym Increases lean muscle mass Not liver toxic

Destined by force

Liposomal delivery system

Suggested/Recommended/Usage/Directions

Directions As a dietary supplement, take 1 tablet twice per day. Do not exceed 2 tablets daily. Visit our website for additional information and guidance.

Storage

Store in a cool, dry place, away from light.

Precautions

Warning Keep out of reach of children. Not for use by individuals under the age of 18 years.

Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over the counter drug.

Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over the counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heart beat, dizziness, blurred vision, or other similar symptoms. This product contains steroid hormones that may cause increased facial and body hair, voice deepening. If you are at risk for prostate or breast cancer, you should not use this product. Do not use if governed by any body that prohibits hormone use.

Allergen Warning: Manufactured on shared equipment that also processes eggs, wheat, & soy (lecithin).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Brutal 4ce by Blackstone Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Brutal 4ce label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Brutal 4ce by Blackstone Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

4-DHEA Blend

Interacts with
8 drugs
65 mg per serving

4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human...

4-DHEA Blend monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-Beta-Cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Brutal 4ce by Blackstone Labs Drug Interactions

Want to check YOUR meds against Brutal 4ce?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
8Drugs
8 Moderate

Ingredients driving the most interactions

4-DHEA Blend 8

Individual Drug Interactions

The ingredients in Brutal 4ce interact with 8 drugs. Click any drug to see the details.

1 of the 1 ingredient in Brutal 4ce interact with drugs. Each result below shows which ingredient is responsible. 4-DHEA Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Brutal 4ce with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

4-DHEA Blend1 drug type · 8 drugs

Testosterone

4-Androsterone is purportedly converted to testosterone and other androgens upon ingestion. Theoretically, taking 4-androsterone with testosterone may increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.

Likelihood Possible Evidence D
4-DHEA Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Brutal 4ce, from the product label.

Blackstone Labs

See all Blackstone Labs products
Name
Blackstone Labs
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-877-454-6861
Web Address
www.BlackStoneLabs.com
Pharmacist Counseling Corner

Brutal 4ce by Blackstone Labs: Common Questions

Does Brutal 4ce by Blackstone Labs interact with any medications?
Yes. Based on its ingredients, Brutal 4ce has a known interaction with 8 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Brutal 4ce contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is 4-androsterone?
It's a prohormone — a compound your body is believed to convert into testosterone and similar male hormones. This product contains three different ester forms of it, which may affect how quickly or how long your body absorbs it.
Can I take this if I'm on testosterone replacement?
No — not without talking to your doctor first. Taking 4-androsterone alongside prescription testosterone carries a documented Moderate-risk interaction and may increase the chance of mood problems and heart, kidney, or liver strain. Check with your own doctor or pharmacist before combining them.
Can women take Brutal 4ce?
Women who are pregnant or breastfeeding should not use it — the facts advise against it because androgenic hormones can harm a developing baby and the effects on a nursing infant are unknown. Women in general should discuss it with their doctor or pharmacist, since prohormones affect hormone balance.
What are the side effects I should watch for?
There isn't much real-world data on side effects, but theoretically 4-androsterone can cause serious anabolic steroid-like problems including stroke, kidney failure, and liver injury. Prohormones can also disrupt hormones, strain the liver, and affect cholesterol. If you notice unusual mood changes, chest pain, swelling, or dark urine, stop and contact your doctor immediately.
Does Brutal 4ce actually work?
We don't have effectiveness ratings on file for this ingredient, so the evidence isn't established in our data. Claims about prohormone performance are often based on theory rather than solid clinical studies.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Brutal 4ce is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Brutal 4ce label
Go deeper

The Full Monographs Behind Brutal 4ce’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

4-androsterone

Interacts with 8 drugs

4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries...

Read the full 4-androsterone monograph →
Sources

Sources & How We Checked

Brutal 4ce's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

4-androsterone 3 references
  1. Anabolic Steroids and Other Appearance and Performance Enhancing Drugs (APEDs) — NIH National Institute on Drug Abuse Source
  2. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  3. DHEA — MedlinePlus Source

See these in context on the 4-androsterone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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