Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Buddy Bear Fiber Very Cherry Flavor Ingredients & Drug Interactions

by Renew Life

Buddy Bear Fiber Very Cherry Flavor label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Buddy Bear Fiber Very Cherry Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Buddy Bear Fiber Very Cherry Flavor is a dietary supplement by Renew Life with 6 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,130 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Acacia Fiber, Stevia leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Buddy Bear Fiber Very Cherry Flavor by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Buddy Bear Fiber Very Cherry Flavor by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Buddy Bear Fiber Very Cherry Flavor by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “Proprietary Fiber Blend (Combination)” is a proprietary blend — the label gives one combined amount (1,140 mg) without saying how much of each component you get.

Buddy Bear Fiber contains 4 active ingredients: soluble fiber, acacia fiber (gum arabic), stevia leaf extract (a non-calorie sweetener), and larch fiber—all meant to support digestive health. The product also includes inactive ingredients like cane juice extract, cherry flavor, and silica, which serve as fillers and binders to hold the tablet together and give it taste.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive health and blood sugar support.
  • We looked for evidence on: Constipation, Diabetes, Hypercholesterolemia, Hyperlipidemia, Obesity, bowel regularity — and 2 related terms.
  • The strongest evidence on file: Black Psyllium is rated "Effective" for Constipation (Natural Medicines).
  • Also on file: Black Psyllium is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Obesity.
  • Also on file: Gum Arabic is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Hypercholesterolemia, Obesity.

The evidence we hold for these ingredients is limited. Acacia fiber shows insufficient reliable evidence for metabolic syndrome, kidney failure, sickle cell disease, obesity, gingivitis, and peristomal lesions.

Stevia similarly has insufficient evidence for diabetes, hypertension, and obesity. Larch fiber lacks sufficient evidence for common cold and high cholesterol.

The product is intended as a fiber supplement, but the data we have doesn't establish how well these specific ingredients work for any given condition.

The evidence, ingredient by ingredient Black Psyllium Gum Arabic Stevia Larch Arabinogalactan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Acacia fiber is generally well tolerated when used in food amounts, though supplemental doses may cause digestive upset—and a study found that 15% to 90% of subjects experienced bloating, flatulence, or mild diarrhea, which often improved within 2 weeks. Stevia appears well tolerated in typical amounts; minor side effects like headache, dizziness, nausea, or muscle pain may occur but usually resolve within the first week.

Larch fiber is generally well tolerated as a fiber source, though some people report bloating and flatulence. Long-term safety data for these supplement doses are limited.

Pregnancy and lactation safety data are not on file for any of these ingredients, so talk with your doctor or pharmacist if you're pregnant or breastfeeding before using this product.

Side effects, ingredient by ingredient Black Psyllium Gum Arabic Stevia Larch Arabinogalactan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Black Psyllium, Gum Arabic, Stevia, Larch Arabinogalactan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,131 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use lithium (mood disorder medication)—stevia may increase its levels. Also double-check amoxicillin or other antibiotics, blood pressure medications, diabetes drugs, and any immunosuppressants used after transplant or for severe immune conditions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a fiber supplement with a cherry flavor, aimed at general digestive support. If you take lithium, blood pressure drugs, diabetes drugs, or immunosuppressants, check your exact medications with the search tool below first.

If you're pregnant, breastfeeding, or have kidney disease, talk with your pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Buddy Bear Fiber Very Cherry Flavor, straight from the product label.

Brand Renew Life
Net contents 60 Chewable Bear Tablet(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2337
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Buddy Bear Fiber Very Cherry Flavor by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
IngredientAmount% DV
Total Carbohydrates2.5 g1%
Sugar1.5 g--
Calories from Fat3 {Calories}--
Total Fat0.35 g1%
Dietary Fiber1 g4%
Soluble Fiber1 g--
Total Calories13 {Calories}--
Acacia Fiber0 NP--
Stevia leaf extract0 NP--
Proprietary Fiber Blend (Combination)1140 mg--
Larch Fiber0 NP--

Other ingredients: organic Cane juice extract, Vegetable Stearine, dried Cherry, natural Cherry flavor, Fumaric Acid, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Adults and children over 2 yrs of age: Chew 2 bear tablets in the evening. This product should be consumed with 8 ounces of water or juice.

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: If you are pregnant or nursing, seek the advice of your physician before using this or any product.

Note: Do not use if child has acute cough, acute diarrhea or obstructed bowel.

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a dry place at 59-86°F (15-30°C).

General

0607

General Statements

ACACIA FIBER & LARCH FIBER HELP SUPPORT ELIMINATION AND PROMOTE HEALTHY BLOOD SUGAR LEVELS*

CHEWABLE FIBER FOR KIDS

Contains less than 2% of the recommended daily allowance for Vitamin A, C, Calcium and Iron.

DELICIOUS NATURAL VERY CHERRY FLAVOR

MADE IN USA

Quality and Purity Guaranteed

Brand IP Statement(s)

Buddy Bear(TM) Fiber contains soluble acacia fiber and larch fiber to support healthy elimination and promote healthy blood sugar levels* in a greattasting chewable bear tablet. Fiber provides numerous health benefits for growing children. Fiber supports healthy bowel movements by absorbing toxins in the digestive tract and helping to “sweep” those toxins from the body.* It also stimulates the movement of food through the intestines and lubricates the bowel to help ease elimination.* In addition, fiber helps manage your child’s hunger naturally and promotes less snacking throughout the day.* Brenda Watson recommends that children older than 2 years of age consume their age plus 5 in grams of fiber each day. Example: 8 years old + 5 = 13 grams of fiber/day

Buddy Bear(TM) Kids’ Products are formulated by Brenda Watson, C.N.C., president of ReNew Life Formulas and the founder of five natural healthcare clinics specializing in digestive care.

BUDDY BEAR(TM) PROBIOTIC A natural probiotic formula with 1 billion active cultures, including Acidophilus and Bifidus, to help support digestive and immune health.* Fructooligosaccharide (FOS) helps nourish the beneficial flora and maximize bioavailability.* BUDDY BEAR(TM) DIGEST A mild, plant-based enzyme blend formulated to assist with digestion and aid nutrient absorption.* Many children experience discomfort from incomplete digestion, and these chewable bear tablets can help.* BUDDY BEAR(TM) DHA An Omega-3 essential fatty acid (EFA) formula that provides the nourishing benefits of natural DHA from deep-sea, cold-water fish. DHA promotes healthy brain and nervous system function, as well as eye health.* BUDDY BEAR(TM) GENTLE LAX Provides gentle, natural relief from occasional constipation for children over 2 years of age.* Each chewable bear tablet blends magnesium with natural herbs to help support regular bowel movements and promote healthy elimination.*

TRY THESE OTHER BUDDY BEAR(TM) DIGESTIVE HEALTH PRODUCTS FOR KIDS!

Formulation

Contains no yeast, wheat, corn, rye, gluten, soy, salt, animal products or dairy

Seals/Symbols

RENEW LIFE(R) The Digestive Care Company

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Buddy Bear Fiber Very Cherry Flavor by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Buddy Bear Fiber Very Cherry Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Buddy Bear Fiber Very Cherry Flavor by Renew Life

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1.5 g per serving

Dietary Fiber

Interacts with
2,025 drugs
1 g per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions
  • › Soluble Fiber

Total Calories

13 {Calories} per serving

Proprietary Fiber Blend (Combination)

1140 mg per serving

Other (inactive) ingredients: Organic Cane juice extract, Vegetable Stearine, Dried Cherry, Natural Cherry flavor, Fumaric Acid, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Buddy Bear Fiber Very Cherry Flavor by Renew Life Drug Interactions

Want to check YOUR meds against Buddy Bear Fiber Very Cherry Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,130Drugs
2,094 Moderate 36 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Acacia Fiber 2,022
Stevia leaf extract 259
Larch Fiber 121

Individual Drug Interactions

The ingredients in Buddy Bear Fiber Very Cherry Flavor interact with 2,130 drugs. Click any drug to see the details.

4 of the 6 ingredients in Buddy Bear Fiber Very Cherry Flavor interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Acacia Fiber Stevia leaf extract Larch Fiber

Each ingredient & the kinds of drugs it affects

For each ingredient in Buddy Bear Fiber Very Cherry Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Acacia Fiber2 drug types · 2,022 drugs

Amoxicillin (Amoxil, Trimox)

Gum arabic can reduce the absorption of amoxicillin.
A small study in healthy volunteers shows that taking amoxicillin and gum arabic concurrently significantly reduces the absorption of amoxicillin. Separate doses of amoxicillin from gum arabic by at least 2 hours.

Likelihood Probable Evidence B
Oral Drugs

Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Gum arabic has been used as a suspending osmotic agent in drug formulations. It might improve bioavailability of water-insoluble drugs like naproxen, but reduce absorption of polar drugs like amoxicillin. To avoid changes in absorption, take gum arabic 30-60 minutes after oral medications.

Likelihood Possible Evidence B
Acacia Fiber full monograph & interactions

Stevia leaf extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia leaf extract full monograph & interactions

Larch Fiber1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D
Larch Fiber full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Buddy Bear Fiber Very Cherry Flavor, from the product label.

Renew Life

Web Address
www.renewlife.com
Pharmacist Counseling Corner

Buddy Bear Fiber Very Cherry Flavor by Renew Life: Common Questions

Does Buddy Bear Fiber Very Cherry Flavor by Renew Life interact with any medications?
Yes. Based on its ingredients, Buddy Bear Fiber Very Cherry Flavor has a known interaction with 2,130 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Buddy Bear Fiber Very Cherry Flavor contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me with constipation or digestion?
It's designed as a fiber supplement to support digestive health, but the evidence we hold doesn't establish how well these specific ingredients work for constipation or other digestive conditions. If you're managing a specific issue, ask your pharmacist or doctor whether this product is right for you.
What side effects should I expect?
The fiber ingredients may cause bloating, flatulence, mild diarrhea, nausea, or abdominal cramping—especially when you first start. These often ease within a couple of weeks. Stevia might cause headache, dizziness, or muscle soreness, which usually go away in the first week. If side effects persist or worsen, stop and talk with your pharmacist.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data on file for any of these ingredients at supplement doses during pregnancy or breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you in either situation.
Is this safe for long-term use?
Acacia and stevia are generally well tolerated, but long-term safety data for larch fiber at supplement doses are limited. If you plan to use this regularly for weeks or months, check with your doctor or pharmacist first.
What does each ingredient do in this product?
Soluble fiber, acacia fiber, and larch fiber all help bulk up stool and support healthy digestion. Stevia is a non-calorie sweetener that makes the product taste like cherry without adding sugar.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Buddy Bear Fiber Very Cherry Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Buddy Bear Fiber Very Cherry Flavor label
Go deeper

The Full Monographs Behind Buddy Bear Fiber Very Cherry Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Gum Arabic

Interacts with 2,022 drugs

Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplement for digestive health and as a prebiotic. Early s...

Read the full Gum Arabic monograph → Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Larch Arabinogalactan

Interacts with 121 drugs

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but limited, and most claims are not yet fi...

Read the full Larch Arabinogalactan monograph →
Sources

Sources & How We Checked

Buddy Bear Fiber Very Cherry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 44 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Gum Arabic 8 references
  1. Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12:147-54. PubMed
  2. Eltayeb IB, Awad AI, Elderbi MA, Shadad SA. Effect of gum arabic on the absorption of a single oral dose of amoxicillin in healthy Sudanese volunteers. J Antimicrob Chemother 2004;54:577-8. PubMed
  3. Babiker R, Merghani TH, Elmusharaf K, et al. Effects of gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized, placebo controlled, double-blind trial. Nutr J 2012;11:111. PubMed
  4. Babiker R, Elmusharaf K, Keogh MB, Banaga AS, Saeed AM. Metabolic effect of gum Arabic (Acacia senegal) in patients with type 2 diabetes mellitus (T2DM): randomized, placebo controlled double blind trial. Functional Foods in Health and Disease. 2017;7(3): DOI
  5. Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20. PubMed
  6. Ali NE, Kaddam LA, Alkarib SY, et al. Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial. Int J Nephrol. 2020;2020:7214673.
  7. Mortensen A, Aguilar F, Crebelli R, et al. Re-evaluation of acacia gum (E 414) as a food additive. EFSA J. 2017;15(4):e04741. PubMed
  8. Larson R, Nelson C, Korczak R, et al. Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects. Nutrients 2021;13(2):618. PubMed

See these in context on the Gum Arabic monograph →

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
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See these in context on the Stevia monograph →

Larch Arabinogalactan 8 references
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  5. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. PubMed
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See these in context on the Larch Arabinogalactan monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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