Buddy Bear Digest Natural Berry Flavor Ingredients & Drug Interactions
by Renew Life
What is this page for?
First and foremost: checking Buddy Bear Digest Natural Berry Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Buddy Bear Digest Natural Berry Flavor is a dietary supplement by Renew Life with 15 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 221 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are N-Acetyl D-Glucosamine, L-Glutamine, Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Buddy Bear Digest Natural Berry Flavor by Renew Life
Ask about any prescription or over-the-counter medication and we check it for interactions with Buddy Bear Digest Natural Berry Flavor by Renew Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Buddy Bear Digest Natural Berry Flavor by Renew Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Buddy Bear Digest contains 12 active ingredients, most of them digestive enzymes and amino acids. L-Glutamine and Glycine are amino acids your body uses for muscle and nerve function.
The product also includes several enzymes—Protease breaks down proteins, Lipase breaks down fats, and Lactase breaks down milk sugar (lactose). You'll also find Gamma Oryzanol, a compound from rice bran oil; N-Acetyl D-Glucosamine, a form of glucosamine that supports joint and skin health; and a proprietary amino acid blend and enzyme blend whose exact formulas are not fully disclosed on the label.
The tablet also contains inactive ingredients like organic cane juice extract, vegetable stearine, raspberry juice crystals for flavor, malic acid, vegetable stearate, and silica. We could not check the interaction data for Amylase, Cellulase, Invertase, Alpha-Galactosidase, and the Proprietary Enzyme Blend because we hold no monographs for them.
Does it work?
Strong evidence
The evidence for this product's ingredients is mixed. L-Glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting and recovery after surgery.
Lactase is effective for lactose intolerance. N-Acetyl D-Glucosamine is likely effective for osteoarthritis.
Gamma Oryzanol is possibly effective for high cholesterol (dyslipidemia). For other uses, the evidence we hold is insufficient: Glycine has possibly effective evidence only for schizophrenia; Lipase's effectiveness for digestive problems like inflammatory bowel disease or indigestion isn't well established; and Protease effectiveness ratings are not in our data.
The product is marketed as a digestive aid, but the strength of evidence supporting its use as a general digestive supplement isn't established in the facts we have.
How safe is it?
Well-documented data
Most ingredients in this product are generally well tolerated. L-Glutamine can cause bloating, nausea, diarrhea, constipation, headache, and muscle pain, particularly at higher doses.
Glycine rarely causes mild sedation, insomnia, or nausea—all of which resolve quickly when you stop it. N-Acetyl D-Glucosamine may cause bloating, constipation, diarrhea, nausea, or heartburn, and rarely allergic reactions ranging from mild (itching, hives) to severe (breathing trouble, anaphylaxis), and asthma flare-ups have been reported.
Pregnancy and breastfeeding data vary by ingredient: L-Glutamine is likely safe in pregnancy and lactation, but Lactase is likely safe in pregnancy and during breastfeeding. Glycine, Gamma Oryzanol, Protease, Lipase, and N-Acetyl D-Glucosamine lack sufficient safety data during pregnancy—the safety data advises against them unless your doctor recommends otherwise.
For breastfeeding, similar caution applies across most ingredients. People with kidney or liver disease should use L-Glutamine only under medical supervision, and those with serious digestive conditions should use Lipase only under guidance.
Meds to double-check
Major interaction found
Before you start Buddy Bear Digest, check with your doctor or pharmacist if you take warfarin or other blood thinners (major risk of increased bleeding), anticonvulsant medications, clozapine (Clozaril), diabetes medications, chemotherapy drugs like etoposide or doxorubicin, or acetaminophen regularly. These are the medication types with documented interactions in the product's ingredients.
The bottom line
Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product may help with lactose intolerance and possibly support joint health and recovery, but it's mainly marketed as a digestive aid without established evidence for that use. If you take warfarin, anticonvulsants, diabetes medications, clozapine, or chemotherapy drugs, or if you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting—the interaction risks or safety data gaps need to be sorted out for you personally.
Even if you don't take those medications, check your exact prescriptions with the tool on this page before you begin.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 7 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 25, 2015.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Buddy Bear Digest Natural Berry Flavor, straight from the product label.
| Brand | Renew Life |
|---|---|
| Net contents | 60 Chewable Bear Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Aug 25, 2015 |
| DSLD ID | 48128 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free, Children more than 1 but less than 4 |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Buddy Bear Digest Natural Berry Flavor by Renew Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1.2 Gram(s) | 1% |
| L-Glutamine | 0 NP | -- |
| Sugar | 1.1 Gram(s) | -- |
| Calories from Fat | 2 {Calories} | -- |
| Protein | 0.1 Gram(s) | 1%, 1% |
| Glycine | 0 NP | -- |
| Total Fat | 0.2 Gram(s) | 1% |
| Gamma Oryzanol | 0 NP | -- |
| Amylase | 1000 DU | -- |
| Protease | 5000 HUT | -- |
| Lipase | 32 FIP | -- |
| Lactase | 500 ALU | -- |
| Cellulase | 300 CU | -- |
| Total Calories | 7 NP | -- |
| Invertase | 100 SU | -- |
| Alpha-Galactosidase | 50 GAL | -- |
| Proprietary Amino Acid Blend | 120 mg | -- |
| N-Acetyl D-Glucosamine | 0 NP | -- |
| Proprietary Enzyme Blend | 35 mg | -- |
Other ingredients: organic Cane juice extract, Vegetable Stearine, natural Raspberry juice crystals and flavor, Malic Acid, Vegetable Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Buddy Bear(TM) Kids' Products are formulated by Brenda Watson, C.N.C., president of ReNew Life Formulas and the founder of five natural healthcare clinics specializing in digestive care.
Try the other Buddy Bear(TM) digestive health products for kids! Buddy Bear(TM) Probiotic A natural probiotic formula with 1 billion active cultures, including Acidophilus and Bifidus, to help support digestive and immune health.* Fructooligosaccharide (FOS) helps nourish the beneficial flora and maximize bioavailability.* Buddy Bear(TM) Fiber A blend of natural acacia fiber and larch fiber that supports healthy elimination and helps promote healthy blood sugar levels. Fiber also helps manage your child's hunger naturally and promote less snacking throughout the day. Buddy Bear(TM) DHA An Omega-3 essential fatty acid (EFA) formula that provides the nourishing benefits of natural DHA from deep-sea, cold-water fish. DHA promotes healthy brain and nervous system function, as well as eye health.* Buddy Bear(TM) Gental Lax Provides gentle, natural relief from occasional constipation for children over 2 years of age.* Each chewable bear tablet blends magnesium with natural herbs to help support regular bowel movements and promote healthy elimination.*
Formula
Buddy Bear(TM) digest is a natural, great-tasting, plant-based digestive enzyme formula for children that promotes digestive health and helps break down proteins, carbohydrates and fats.*
Buddy Bear(TM) digest also contains the amino acids L-glutamine and N-acetyl D-glucosmaine, along with gamma oryzanol to help maintain a healthy intestinal lining.
Chewable digestive enzyme for kids
Enhanced with L-Glutamine & NAG
Contains less that 2% of the recommended daily allowance for Vitamin A, C, Calcium and Iron.
This product contains an ingredient derived from crustacean shells (shrimp, lobster, crab).
Formulation
Contains no yeast, wheat, corn, rye, salt, soy, gluten or dairy
Precautions
Warning: If you are pregnant or nursing, seek the advice of your physician before using this or any product.
Keep out of reach of children.
This product contains an ingredient derived from crustacean shells (shrimp, lobster, crab).
Storage
Store in a dry place at 59-86(0)F (15-30(0)C).
General Statements
Quality and Purity Guaranteed
Made in USA
FDA Disclaimer Statement
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
Renew Life(R) The Digestion Care Company
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Adults and children over 2 years of age: Chew 1 bear tablet with a meal twice daily.
General
0607
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Buddy Bear Digest Natural Berry Flavor by Renew Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Buddy Bear Digest Natural Berry Flavor by Renew Life
These are the 15 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Protein
Amylase
Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsLipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsLactase
No knowninteractions
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...
Lactase monograph & interactionsCellulase
Total Calories
Invertase
Alpha-Galactosidase
Proprietary Amino Acid Blend
Proprietary Enzyme Blend
Other (inactive) ingredients: Organic Cane juice extract, Vegetable Stearine, Natural Raspberry juice crystals and flavor, Malic Acid, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Buddy Bear Digest Natural Berry Flavor by Renew Life Drug Interactions
HelloPharmacist Interaction Report
Buddy Bear Digest Natural Berry Flavor by Renew Life does interact with several medication types, most seriously with blood thinners.
N-Acetyl D-Glucosamine, an ingredient in this product, may increase the blood-thinning effects of warfarin (Coumadin) and raise your bleeding risk. Two case reports show significant increases in INR (a measure of how thin your blood is) in patients taking warfarin when they added glucosamine products.
Read the full breakdown — every affected drug type, severity by severity
L-Glutamine may theoretically work against anticonvulsant medications used to prevent seizures, though this hasn't been reported in humans yet. N-Acetyl D-Glucosamine also carries theoretical concerns with certain cancer chemotherapy drugs (topoisomerase II inhibitors like etoposide and doxorubicin) and may slightly reduce how well diabetes medications work, though the effect is considered minor.
Glycine may decrease the effectiveness of clozapine (Clozaril), an antipsychotic medication. Finally, N-Acetyl D-Glucosamine may interfere with acetaminophen (Tylenol) pain relief, particularly in people with osteoarthritis.
Additionally, we could not check Amylase, Cellulase, Invertase, Alpha-Galactosidase, and the Proprietary Enzyme Blend because we hold no interaction data for them. Altogether, these interactions span 221 individual medications.
Use the medication checker on this page to look up your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Buddy Bear Digest Natural Berry Flavor?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Buddy Bear Digest Natural Berry Flavor interact with 221 drugs. Click any drug to see the details.
3 of the 15 ingredients in Buddy Bear Digest Natural Berry Flavor interact with drugs. Each result below shows which ingredient is responsible. N-Acetyl D-Glucosamine L-Glutamine Glycine
WarfarinWarfarin
How Warfarin interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineWarfarin (coumadin) Major
Interaction Summary
Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
Read the full N-acetyl D-glucosamine + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineWarfarin (coumadin) Major
Interaction Summary
Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
Read the full N-acetyl D-glucosamine + Warfarin Sodium interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Acetazolamide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Aminophylline, Amobarbital, Ephedrine interactionAmobarbitalAmytal
How Amobarbital interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Amobarbital, Secobarbital interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Aprobarbital, Butabarbital, Phenobarbital interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Belladonna, Phenobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionButalbital, Phenobarbital, SecobarbitalTribarb
How Butalbital, Phenobarbital, Secobarbital interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Butalbital, Phenobarbital, Secobarbital interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Carbamazepine interactionCenobamateXcopri
How Cenobamate interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Cenobamate interactionClobazamFrisium, Onfi, Sympazan
How Clobazam interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Clobazam interactionClonazepamCeberclon, Klonopin, Rivotril
How Clonazepam interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Clonazepam interactionClorazepateTranxene, Tranxene SD, Tranxene T-Tab
How Clorazepate interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Clorazepate interactionClozapineClozaril, Versacloz
How Clozapine interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionDaunorubicin CitrateDaunoXome
How Daunorubicin Citrate interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Daunorubicin Citrate interactionDaunorubicin HydrochlorideCerubidine
How Daunorubicin Hydrochloride interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Daunorubicin Hydrochloride interactionDaunorubicin, CytarabineVyxeos
How Daunorubicin, Cytarabine interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Daunorubicin, Cytarabine interactionDiazepamDiastat AcuDial, Valium, Valium injection, Valtoco
How Diazepam interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Diazepam interactionDivalproex SodiumDepakote
How Divalproex Sodium interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Divalproex Sodium interactionDoxorubicinAdriamycin, Caelyx, Doxil, Myocet, Rubex
How Doxorubicin interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Doxorubicin interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Ephedrine, Phenobarbital, Theophylline interactionEpirubicinEllence
How Epirubicin interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Epirubicin interactionEthosuximideZarontin
How Ethosuximide interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Ethosuximide interactionEthotoinPaganone
How Ethotoin interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Ethotoin interactionEtoposideEtopophos, VePesid, VP16
How Etoposide interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Etoposide interactionFelbamateFelbatol
How Felbamate interacts with Buddy Bear Digest Natural Berry Flavor — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Felbamate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Buddy Bear Digest Natural Berry Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
N-Acetyl D-Glucosamine
Warfarin (Coumadin)
Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.
Topoisomerase Ii Inhibitors
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.
Acetaminophen (Tylenol, Others)
Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.
Antidiabetes Drugs
Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.
L-Glutamine
Anticonvulsants
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Buddy Bear Digest Natural Berry Flavor, from the product label.
Renew Life
- Name
- Renew Life Formulas
- City
- Clearwater
- State
- FL
- ZipCode
- 33765
- Phone Number
- 866-450-1787
- Web Address
- www.renewlife.com
Buddy Bear Digest Natural Berry Flavor by Renew Life: Common Questions
Does Buddy Bear Digest Natural Berry Flavor by Renew Life interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is L-Glutamine safe if I have liver or kidney disease?
What side effects might I notice from this product?
Can I use this product while I'm pregnant?
Is this product a proven digestive aid?
Does N-Acetyl D-Glucosamine really help osteoarthritis?
Can I take this if I have a shellfish allergy?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Buddy Bear Digest Natural Berry Flavor’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographGlutamine
Interacts with 50 drugsGlutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...
Read the full Glutamine monograph → Herb & supplement monographGlycine
Interacts with 1 drugGlycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...
Read the full Glycine monograph → Herb & supplement monographGamma-oryzanol
Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...
Read the full Gamma-oryzanol monograph → Herb & supplement monographGlucosamine
Interacts with 170 drugsGlucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...
Read the full Glucosamine monograph →Sources & How We Checked
Buddy Bear Digest Natural Berry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 79 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glutamine 11 references
- Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
- Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
- Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
- Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
- Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
- Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
- Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
- Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
- Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
- Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
- Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Glucosamine 58 references
- Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. PubMed
- Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 1994;43:1173-9. PubMed
- Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia 1995;38:518-24. PubMed
- Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes 1999;48:106-11. PubMed
- Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.
- Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9.
- Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism 1998;47:573-7.
- Almada A, Harvey P, Platt K. Effects of chronic oral glucosamine sulfate on fasting insulin resistance index (FIRI) in non-diabetic individuals. FASEB J 2000;14:A750.
- Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled trial. Lancet 2001;357:251-6.
- Does glucosamine increase serum lipid levels and blood pressure? Pharmacist's Letter/Prescriber's Letter 2001;17(11):171115.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Monauni T, Zenti MG, Cretti A, et al. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes 2000;49:926-35. PubMed
- Pouwels MJ, Jacobs JR, Span PN, et al. Short-term glucosamine infusion does not affect insulin sensitivity in humans. J Clin Endocrinol Metab 2001;86:2099-103. DOI
- Yun J, Tomida A, Nagata K, Tsuruo T. Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncol Res 1995;7:583-90.
- Pavelka K, Gatterova J, Olejarova M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113-23. PubMed
- Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
- Scroggie DA, Albright A, Harris MD. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Arch Intern Med 2003; PubMed
- Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.. PubMed
- Yu JG, Boies SM, Olefsky JM. The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. Diabetes Care 2003;26:1941-2. PubMed
- Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
- Guillaume MP, Peretz A. Possible association between glucosamine treatment and renal toxicity: comment on the letter by Danao-Camara. Arthritis Rheum 2001;44:2943-4. PubMed
- Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
- Tannis AJ, Barban J, Conquer JA. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthritis Cartilage 2004;12:506-11. PubMed
- Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
- Stumpf JL, Lin SW. Effect of glucosamine on glucose control. Ann Pharmacother 2006;40:694-8. PubMed
- Pham T, Cornea A, Blick KE, et al. Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance. Am J Med Sci 2007;333:333-9. PubMed
- Muniyappa R, Karne RJ, Hall G, et al. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects. Diabetes 2006;55:3142-50. PubMed
- Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
- Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
- Rozendaal RM, Koes BW, van Osch GJVM, et al. Effect of glucosamine sulfate on hip osteoarthritis: A randomized trial. Ann Intern Med 2008;148:268-77. PubMed
- Baron AD, Zhu JS, Zhu JH, et al. Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity. J Clin Invest 1995;96(6):2792-801. PubMed
- Nelson BA, Robinson KA, Buse MG. High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes. Diabetes 2000;49(6):981-91. PubMed
- Giordano N, Fioravanti A, Papakostas P, et al. The efficacy and tolerability of glucosamine sulfate in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Curr Ther Res Clin Exp 2009;70(3):185-196. PubMed
- Shaygannejad, V., Janghorbani, M., Savoj, M. R., and Ashtari, F. Effects of adjunct glucosamine sulfate on relapsing-remitting multiple sclerosis progression: preliminary findings of a randomized, placebo-controlled trial. Neurol Res 2010;32(9):981-985. PubMed
- Cahlin, B. J. and Dahlstrom, L. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112(6):760-766. PubMed
- Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
- Hochberg MC, Martel-Pelletier J, Monfort J, Möller I, Castillo JR, Arden N,Berenbaum F, Blanco FJ, Conaghan PG, Doménech G, Henrotin Y, Pap T, Richette P, Sawitzke A, du Souich P, Pelletier JP; on behalf of the MOVES Investigation Group. Combined chondroi
- von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
- Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
- Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
- Audimoolam VK, Bhandari S. Acute interstitial nephritis induced by glucosamine. Nephrol Dial Transplant 2006;21(7):2031. PubMed
- Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
- Wilkens, P., Scheel, I. B., Grundnes, O., Hellum, C., and Storheim, K. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial. JAMA 2010;304(1):45-52. PubMed
- Simon RR, Marks V, Leeds AR, Anderson JW. A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals. Diabetes Metab Res Rev 2011;27(1):14-27. PubMed
- Smidt D, Torpet LA, Nauntofte B, Heegaard KM, Pedersen AM. Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people. Community Dent Oral Epidemiol 2010;38(5):422-35. PubMed
- Wangroongsub Y, Tanavalee A, Wilairatana V, Ngarmukos S. Comparable clinical outcomes between glucosamine sulfate-potassium chloride and glucosamine sulfate sodium chloride in patients with mild and moderate knee osteoarthritis: a randomized, double-blind
- Chopra A, Saluja M, Tillu G, Venugopalan A, Sarmukaddam S, Raut AK, Bichile L, Narsimulu G, Handa R, Patwardhan B. A Randomized Controlled Exploratory Evaluation of Standardized Ayurvedic Formulations in Symptomatic Osteoarthritis Knees: A Government of I
- Swinburne LM. Glucosamine sulphate and osteoarthritis. Lancet 2001;357(9268):1617. PubMed
- Murphy RK, Ketzler L, Rice RD, Johnson SM, Doss MS, Jaccoma EH. Oral glucosamine supplements as a possible ocular hypertensive agent. JAMA Ophthalmol 2013;131(7):955-7. PubMed
- Kimball AB, Kaczvinsky JR, Li J, et al. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial.
- Ma H, Li X, Sun D, et al. Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank. BMJ. 2019 May 14;365:l1628. PubMed
- Hoban C, Byard R, Musgrave I. Hypersensitive adverse drug reactions to glucosamine and chondroitin preparations in Australia between 2000 and 2011. Postgrad Med J. 2019 Oct 9. pii: postgradmedj-2019-136957. PubMed
- Tenti S, Veronese N, Cheleschi S, et al. Prescription-grade crystalline glucosamine sulfate as an add-on therapy to conventional treatments in erosive osteoarthritis of the hand: results from a 6-month observational retrospective study. Aging Clin Exp Res PubMed
- Yu H, Wu J, Chen H, et al. Glucosamine use is associated with a higher risk of cardiovascular diseases in patients with osteoarthritis: results from a large study in 685,778 subjects. Nutrients 2022;14(18):3694. PubMed
- Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
- Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed
- Lehrer S, Morello T, Karrasch C, Rheinstein PH, Danias J. Effect of Glucosamine on Intraocular Pressure and Risk of Developing Glaucoma. J Glaucoma 2023. PubMed
- Rabade A, Viswanatha GL, Nandakumar K, Kishore A. Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis. Inflammopharmac PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC