Interactions on record — worth a quick check against your medications. Based on 3 of 13 ingredients. Check your meds →
Dietary supplement

Ultimate Flora Probiotic Extra Care 200 Billion Ingredients & Drug Interactions

by Renew Life

Ultimate Flora Probiotic Extra Care 200 Billion label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate Flora Probiotic Extra Care 200 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultimate Flora Probiotic Extra Care 200 Billion is a dietary supplement by Renew Life with 13 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,083 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Bifidobacterium bifidum, Bifidobacterium longum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ultimate Flora Probiotic Extra Care 200 Billion by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate Flora Probiotic Extra Care 200 Billion by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ultimate Flora Probiotic Extra Care 200 Billion by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 13 active ingredients.
  • “Lactobacillus salivarius” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Bifidobacterium longum” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Extra Care 200 Billion Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This powder contains 13 active ingredients: a blend of 10 probiotic bacterial strains (several Bifidobacterium species and several Lactobacillus species), plus soluble fiber and FOS (fructooligosaccharides, a prebiotic that feeds beneficial bacteria). The label doesn't list any inactive fillers or binders — it's the active ingredients only.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive wellness and intestinal flora balance.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Celiac disease, Clostridioides difficile infection, Constipation, Diarrhea — and 4 related terms.
  • The strongest evidence on file: Black Psyllium is rated "Effective" for Constipation (Natural Medicines).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Black Psyllium is rated "Insufficient Reliable Evidence To Rate" for Diarrhea.

The data we have is limited to Bifidobacterium bifidum. It's rated possibly effective for irritable bowel syndrome (IBS) and respiratory tract infections.

For allergic rhinitis (hay fever), Alzheimer disease, and generalized anxiety disorder, the evidence isn't strong enough to rate it either way. We don't hold effectiveness data for the other nine probiotic strains in this product, so we can't comment on what they may or may not do.

The evidence, ingredient by ingredient Black Psyllium Bifidobacterium Bifidum Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bifidobacterium bifidum is generally well tolerated in healthy people. Those with weakened immune systems should be cautious, and the evidence is limited overall, so it's worth checking with your doctor or pharmacist before you start.

Bloating and gas have been reported with probiotics in general, though not specifically tied to B. bifidum itself. One case of vomiting and fever was reported in a child taking this strain alongside another probiotic, but it's unclear whether the probiotics caused it.

Sepsis from Bifidobacterium has been documented in critically ill patients, though rarely and not from B. bifidum in particular. We don't have pregnancy or breastfeeding safety data on file for any of these ingredients.

Side effects, ingredient by ingredient Black Psyllium Bifidobacterium Bifidum Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Black Psyllium, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,084 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antibiotics before you start this product. Bifidobacterium bifidum can lose effectiveness if you take it at the same time as antibiotics (Moderate interaction).

We could not check the other nine probiotic strains, soluble fiber, or FOS against your medications because we don't hold interaction data for them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have IBS or recurrent respiratory infections, this might be worth trying under your doctor's eye. If you're on antibiotics, space them out from this product — ask your pharmacist for timing.

If your immune system is weak or you're very ill, talk to your doctor first. For most other uses, the evidence just isn't there yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate Flora Probiotic Extra Care 200 Billion, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257158598
Net contents 7 Packet(s); 0.86 Ounce(s); 24.5 Gram(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 247402
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate Flora Probiotic Extra Care 200 Billion by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3.5 Gram(s)
Maximum serving Sizes:
3.5 Gram(s)
Servings per container
7
UPC/BARCODE
631257158598
IngredientAmount% DV
Calories8 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Dietary Fiber2 Gram(s)8%
Soluble Fiber2 Gram(s)--
Lactobacillus salivarius0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus plantarum0 NP--
Bifidobacterium animalis lactis0 NP--
Bifidobacterium longum0 NP--
Lactobacillus casei0 NP--
Lactobacillus rhamnosus0 NP--
Bifidobacterium infantis0 NP--
FOS2000 mg--
Lactobacillus paracasei0 NP--
Extra Care 200 Billion Blend0 NP--
Lactococcus acidophilus0 NP--
Total Bifido Probiotic Cultures0 NP--
Total Lacto Probiotic Cultures0 NP--
Total Bifido/Lacto Cultures0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Digestive wellness, naturally At Renew Life, we believe a healthy gut is a happy gut. For nearly two decades, we have pioneered superior-quality digestive care supplements to help people achieve optimal health from the inside out.

Quality, purity, and potency guaranteed through expiration.

New look, improved formula. Formerly Super Critical Recycle

Formula

Extra Care Probiotic for restoring balance Our Ultimate Flora Extra Care Probiotics provide powerful digestive support to restore your body’s good, natural flora. Ultimate Flora 200 Billion Extra Care Probiotic is a 7-day program featuring a high-potency formula with 10 specially selected strains to help restore intestinal flora balance in people who have experienced gut imbalance.

200 billion live cultures per serving 10 probiotic strains

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Good for your gut! Your gut is your engine, your digestive core. Keep it running smoothly with Ultimate Flora Probiotics. When taken regularly, Bifidobacteria and Lactobacilli help promote digestive and immune balance so you feel better, lighter, and more energized. Powerful & Effective Did you know there are 100 trillion bacteria inside your digestive tract? To keep that complex system thriving, our high-potency formulas work hard to boost the good- for-you bacteria that occur in a naturally healthy gut. Multi-Strain Benefits Maintaining good balance among all the diverse microbes in your gut is key to well-being. But stress, aging, diet, and other issues can upset this delicate equilibrium. Ultimate Flora Probiotics are made with multiple, scientifically studied strains to support digestive balance and harmony.

Promotes Digestive & Immune Health Restores Intestinal Flora Balance

Gluten Free Dairy Free Soy Free No Artificial Ingredients

Manufactured in USA in a GMP facility.

Suggested/Recommended/Usage/Directions

7-day intensive program

Directions: Mix one packet per day with cool or room temperature water, other beverage, or soft food immediately before use. Do not mix with hot beverages or food.

FDA Statement of Identity

Probiotic Supplement

Storage

Store in a dry place at 41 degrees F (5 degrees C) or below. Keep refrigerated.

Precautions

Keep out of reach of children.

Consult your physician before using this or any product if you are pregnant, nursing, or under medical supervision

Tamper Evident: Do not use if packets inside are open or torn.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate Flora Probiotic Extra Care 200 Billion by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate Flora Probiotic Extra Care 200 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate Flora Probiotic Extra Care 200 Billion by Renew Life

These are the 13 active ingredients this product is made of. Select any to open its full monograph.

Serving size3.5 Gram(s) Dosage formPowder Servings per container7 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dietary Fiber

Interacts with
2,025 drugs
2 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions
  • › Soluble Fiber

FOS

2000 mg per serving

Extra Care 200 Billion Blend

0 NP per serving
  • › Lactobacillus salivarius
  • › Bifidobacterium bifidum
  • › Lactobacillus plantarum
  • › Bifidobacterium animalis lactis
  • › Bifidobacterium longum
  • › Lactobacillus casei
  • › Lactobacillus rhamnosus
  • › Bifidobacterium infantis
  • › Lactobacillus paracasei
  • › Lactococcus acidophilus
  • › Total Bifido/Lacto Cultures

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate Flora Probiotic Extra Care 200 Billion by Renew Life Drug Interactions

Want to check YOUR meds against Ultimate Flora Probiotic Extra Care 200 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,083Drugs
205 Moderate 1,878 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Bifidobacterium bifidum 182
Bifidobacterium longum 182

Individual Drug Interactions

The ingredients in Ultimate Flora Probiotic Extra Care 200 Billion interact with 2,083 drugs. Click any drug to see the details.

3 of the 13 ingredients in Ultimate Flora Probiotic Extra Care 200 Billion interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Bifidobacterium bifidum Bifidobacterium longum

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate Flora Probiotic Extra Care 200 Billion with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultimate Flora Probiotic Extra Care 200 Billion, from the product label.

Renew Life

Name
Renew Life Formulas
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

Ultimate Flora Probiotic Extra Care 200 Billion by Renew Life: Common Questions

Does Ultimate Flora Probiotic Extra Care 200 Billion by Renew Life interact with any medications?
Yes. Based on its ingredients, Ultimate Flora Probiotic Extra Care 200 Billion has a known interaction with 2,083 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate Flora Probiotic Extra Care 200 Billion contains 13 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm on antibiotics?
Not as well if you take them together — the antibiotics may kill off the live bacteria in this product. Space them out by a few hours if you can; your pharmacist can help you figure out a good timing. Once you finish the antibiotics, you can go back to taking them together.
What's FOS, and why is it in here?
FOS stands for fructooligosaccharides — it's a prebiotic, which means it acts as food for the good bacteria in the product. It helps them grow and thrive. We don't have interaction data on file for it, but it's a common ingredient in probiotic formulas.
Can I take this if I have a weak immune system?
You should be cautious and check with your doctor first. Healthy people tolerate this strain well, but those with weakened immunity need personalized advice. Your doctor knows your full situation and can tell you if it's right for you.
Will this help my hay fever?
The evidence for Bifidobacterium bifidum against allergic rhinitis isn't strong enough to say either way. It may work, it may not — we just don't have reliable data yet. If you want to try it, talk to your doctor about what to expect.
What side effects might I get?
Bloating and gas are possible with probiotics in general, though they weren't specifically reported from this strain. One child in a study had vomiting and fever, but it's unclear if the probiotics caused it. Serious side effects like sepsis are extremely rare and weren't tied to this strain in particular.
Is it safe during pregnancy or breastfeeding?
We don't have safety data on file for any of these ingredients during pregnancy or lactation. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate Flora Probiotic Extra Care 200 Billion label
Go deeper

The Full Monographs Behind Ultimate Flora Probiotic Extra Care 200 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Ultimate Flora Probiotic Extra Care 200 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 46 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
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  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
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  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
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  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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