Burdock Formula Ingredients & Drug Interactions
by Herb Stop
What is this page for?
First and foremost: checking Burdock Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Burdock Formula is a dietary supplement by Herb Stop with 4 active ingredients. Its ingredients are commonly taken for skin conditions like acne and eczema, digestive support, diuretic ('detox') and blood purifier.Based on those ingredients, 2,130 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm, Turkey Rhubarb, Sheep Sorrel. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Burdock Formula by Herb Stop
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HelloPharmacist Scorecard of Burdock Formula by Herb Stop
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Herb Stop's Burdock Formula is a capsule containing four active ingredients. Burdock root, slippery elm inner bark, sheep sorrel (also called sorrel), and turkey rhubarb (a variety of rhubarb) make up the active blend.
The capsule itself is made from hydroxypropyl methylcellulose, a plant-based capsule material, with purified water as an additional ingredient.
Does it work?
Not established
The evidence on what this formula actually does is thin. Burdock has been studied for acne, aging skin, breast cancer, the common cold, and eczema — but we don't have reliable evidence it works for any of these.
Slippery elm shows the same story: insufficient evidence for cancer, constipation, cough, inflammatory bowel disease, or diarrhea. Sheep sorrel hasn't proven effective for bronchitis, breast cancer, or rhinosinusitis.
Turkey rhubarb is rated possibly effective for pancreatitis and menopausal symptoms, but the other uses listed — appendicitis, nasopharyngeal cancer, fatty liver disease, and constipation — lack reliable evidence. Overall, we don't have solid data showing this combination works for a specific health goal.
How safe is it?
Well-documented data
Burdock is likely safe as a food and for short-term use in healthy adults, though human safety data are limited. It's generally well tolerated when eaten, but rare allergic reactions — including contact dermatitis and anaphylaxis — have been reported.
A case of liver injury has been reported, though it's unclear whether burdock or other ingredients in that product were responsible. Slippery elm is generally well tolerated for short-term use, and contact dermatitis or hives can occur with exposure.
Sheep sorrel is generally safe in food amounts, but its high oxalate content can be a concern with larger doses; a rare case of kidney inflammation occurred in a child who consumed wild sorrel. Turkey rhubarb, when taken as a root for medicinal purposes, commonly causes cramping, diarrhea, nausea, or vomiting, and should not be used long-term.
Long-term or excessive use can lead to potassium loss, dehydration, and kidney damage. Pregnancy: Burdock and turkey rhubarb safety data advise against medicinal use during pregnancy.
Slippery elm and sheep sorrel don't have enough data — talk with your doctor or pharmacist for personalized advice. Breastfeeding: Burdock and turkey rhubarb are best avoided during breastfeeding; the others lack sufficient safety data.
Meds to double-check
Moderate interaction found
Check your medications against this product if you take any blood thinners or antiplatelet drugs (burdock and sheep sorrel may increase bleeding risk); any oral medications in general (slippery elm may slow absorption); fexofenadine (Allegra) or other drugs transported by OATP (sheep sorrel); drugs that can harm your kidneys or liver, water pills, heart medications like digoxin (Lanoxin), the blood thinner warfarin (Coumadin), corticosteroids, other laxatives, or cyclosporine (turkey rhubarb may affect any of these). Use the medication checker on this page to verify your specific prescriptions.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This formula combines four herbs with minimal proven effectiveness for any specific condition and several documented interactions with common medications. If you take blood thinners, water pills, heart medications, laxatives, or any oral medication regularly, check with your pharmacist before starting.
The ingredients are generally well tolerated in short-term use, but long-term safety isn't well established.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Burdock Formula, straight from the product label.
| Brand | Herb Stop |
|---|---|
| Net contents | 300 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 14, 2023 |
| DSLD ID | 297170 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Burdock Formula by Herb Stop, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 812 mg | -- |
| Burdock | 0 NP | -- |
| Slippery Elm | 0 NP | -- |
| Sheep Sorrel | 0 NP | -- |
| Turkey Rhubarb | 0 NP | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Water, Purified
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Take 2 capsules 2 to 3 times per day with water, or as directed by your qualified healthcare professional.
Precautions
Safety Guideline: Rhubarb is not recommended if you have abdominal pain or diarrhea. Discontinue use in the event of diarrhea or watery stools. Sheep Sorrel is not recommended for use by persons with a history of kidney stones.
Not to be used during pregnancy or lactation. If you have a medical condition or take pharmaceutical drugs, please consult with your doctor before use.
Keep away from children.
Use only as directed on label.
Brand IP Statement(s)
Herb Stop Health in your own hands
Formulation
98% Organic Content
Herbal capsule Promotes natural detoxification in the body Maintains healthy blood sugar levels
Vegan & Cruelty-Free
Vegan & Cruelty-Free Made in the USA.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Burdock Formula by Herb Stop label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Burdock Formula by Herb Stop
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Water, Purified. These complete the product’s ingredient list but are not active constituents.
Burdock Formula by Herb Stop Drug Interactions
HelloPharmacist Interaction Report
Herb Stop's Burdock Formula contains four active ingredients, and together they interact with a substantial number of medications.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs — both burdock and sheep sorrel may increase bleeding risk when combined with these medications, though these effects haven't been confirmed in humans yet.
Read the full breakdown — every affected drug type, severity by severity
Slippery elm may slow how your body absorbs oral medications in general, potentially reducing their effectiveness. Sheep sorrel may also interfere with certain drugs absorbed through a specific transporter (OATP) in your gut, including the allergy medication fexofenadine (Allegra).
Turkey rhubarb carries several Moderate interactions: with kidney-damaging drugs, liver-damaging drugs, water pills (diuretics), heart medications like digoxin (Lanoxin), the blood thinner warfarin (Coumadin), corticosteroids, other laxatives, and the immunosuppressant cyclosporine (Neoral, Sandimmune) — most relate to potassium loss or changes in how your body absorbs or processes these drugs.
Additionally, burdock and sheep sorrel have no known interactions beyond what's listed above. Altogether, these interactions span 2,131 individual medications.
Please check your exact prescriptions with the tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Burdock Formula?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Burdock Formula interact with 2,130 drugs. Click any drug to see the details.
4 of the 4 ingredients in Burdock Formula interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm Turkey Rhubarb Sheep Sorrel Burdock
Aluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Burdock Formula — through 4 ingredients. Tap an ingredient for the detail:
Sheep SorrelAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
Read the full Sheep Sorrel + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionSlippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionBurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionTurkey RhubarbNephrotoxic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Turkey Rhubarb + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Burdock Formula — through 4 ingredients. Tap an ingredient for the detail:
BurdockAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionTurkey RhubarbNephrotoxic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Turkey Rhubarb + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionSheep SorrelAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
Read the full Sheep Sorrel + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionSlippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aluminum, Magnesium Hydroxide (otc Drug) interactionAlvimopanEntereg
How Alvimopan interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Alvimopan interactionAmantadineGocovri, Osmolex ER, Symmetrel
How Amantadine interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amantadine interactionAmbenonium ChlorideMytelase
How Ambenonium Chloride interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Ambenonium Chloride interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Burdock Formula — through 2 ingredients. Tap an ingredient for the detail:
Turkey RhubarbHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Turkey Rhubarb + Ambrisentan interactionSlippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Ambrisentan interactionAmifampridineRuzurgi
How Amifampridine interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amifampridine interactionAmifampridine PhosphateFirdapse
How Amifampridine Phosphate interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amifampridine Phosphate interactionAmikacinAmikin, Arikayce
How Amikacin interacts with Burdock Formula — through 2 ingredients. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amikacin interactionTurkey RhubarbNephrotoxic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Turkey Rhubarb + Amikacin interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Burdock Formula — through 2 ingredients. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amiloride, Hydrochlorothiazide interactionTurkey RhubarbNephrotoxic Drugs, Diuretic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Turkey Rhubarb + Amiloride, Hydrochlorothiazide interactionAminobenzoate PotassiumPotaba
How Aminobenzoate Potassium interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aminobenzoate Potassium interactionAminocaproic Acid (oral)Amicar
How Aminocaproic Acid (oral) interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aminocaproic Acid (oral) interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aminoglutethimide interactionAminolevulinic Acid HydrochlorideAmeluz, Gleolan
How Aminolevulinic Acid Hydrochloride interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aminolevulinic Acid Hydrochloride interactionAminophyllineAminophylline
How Aminophylline interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aminophylline interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aminophylline, Amobarbital, Ephedrine interactionAminosalicylate SodiumTubasal
How Aminosalicylate Sodium interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aminosalicylate Sodium interactionAminosalicylic AcidPaser
How Aminosalicylic Acid interacts with Burdock Formula — through 2 ingredients. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Aminosalicylic Acid interactionTurkey RhubarbHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Turkey Rhubarb + Aminosalicylic Acid interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Burdock Formula — through 2 ingredients. Tap an ingredient for the detail:
Turkey RhubarbHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Turkey Rhubarb + Amiodarone interactionSlippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amiodarone interactionAmitriptylineElavil
How Amitriptyline interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Burdock Formula — through 1 ingredient. Tap an ingredient for the detail:
Slippery ElmOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Amitriptyline, Perphenazine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Burdock Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Slippery Elm
Oral Drugs
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.
Turkey Rhubarb
Corticosteroids
Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.
Cyclosporine (Neoral, Sandimmune)
Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.
Digoxin (Lanoxin)
Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.
Diuretic Drugs
Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.
Hepatotoxic Drugs
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.
Nephrotoxic Drugs
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.
Stimulant Laxatives
Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.
Sheep Sorrel
Anticoagulant/Antiplatelet Drugs
Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.
Fexofenadine (Allegra)
Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.
Burdock
Anticoagulant/Antiplatelet Drugs
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.
Brand information
Manufacturer and brand details for Burdock Formula, from the product label.
Herb Stop
See all Herb Stop products- Name
- The Herb Stop
- Street Address
- PO Box 673
- City
- Pine
- State
- AZ
- ZipCode
- 85544
- Phone Number
- 1.877.345.4372
- Web Address
- www.HerbStop.com
Burdock Formula by Herb Stop: Common Questions
Does Burdock Formula by Herb Stop interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on a blood thinner like warfarin?
Will this slow down my other medications?
What is turkey rhubarb, and why is it in here?
Is this safe to use long-term?
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The Full Monographs Behind Burdock Formula’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Burdock
Interacts with 122 drugsBurdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...
Read the full Burdock monograph → Herb & supplement monographSlippery Elm
Interacts with 2,022 drugsSlippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...
Read the full Slippery Elm monograph → Herb & supplement monographSorrel
Interacts with 169 drugsSorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...
Read the full Sorrel monograph → Herb & supplement monographRhubarb
Interacts with 658 drugsRhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...
Read the full Rhubarb monograph →Sources & How We Checked
Burdock Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 42 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Burdock 11 references
- Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
- Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
- Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
- Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
- Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
- Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
- Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
- Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
- <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
- Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
- Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
Slippery Elm 3 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed
Sorrel 8 references
- Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
- Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
- Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
- Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
- Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
- Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
- Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
- Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed
Rhubarb 20 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Kwan TH, Tong MK, Leung KT, et al. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Hong Kong Med J 2006;12:394-7.
- Fairbairn JW. The anthraquinone laxatives. Biological assay and its relation to chemical structure. Pharmacology 1976;14:48-61. PubMed
- Siegers, C. P., Hertzberg-Lottin, E., Otte, M., and Schneider, B. Anthranoid laxative abuse--a risk for colorectal cancer? Gut 1993;34(8):1099-1101. PubMed
- Fan, J. G. Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial. Hepatobiliary.Pancreat.Dis.Int 2004;3(3):375-380.
- Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. J Ethnopharmacol. 4-15-2006; PubMed
- Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Chin Med J (Engl.) 1990;103(10):788-793.
- Mitsuma, T., Yokozawa, T., Oura, H., and Terasawa, K. [Rhubarb therapy in patients with chronic renal failure (Part 2)]. Nippon Jinzo Gakkai Shi 1987;29(2):195-207.
- Wu, C. X. [A preliminary study on the effect of a single Rheum officinale in heavy doses in the treatment of acute icteric hepatitis]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(2):88-89.
- Jiao, D. H. [Clinical research on the hemostatic effect of rhubarb on peptic ulcer with acute bleeding]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(10):597-600, 579.
- Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Pharmacology 1980;20 Suppl 1:128-130.
- Zhang, JH, Yao, XD, Song, Y, and et al. [Long-term treating effects of rhubarb and captopril in delaying the progression of renal failure]. Chinese Kidney Disease Journal 1993;9(4):197-201.
- Rehman H, Begum W, Anjum F, Tabasum H, Zahid S. Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial. J Complement Integr Med. 2015 Mar;12(1):61-9.
- Yu CP, Lin HJ, Lin SP, Shia CS, Chang PH, Hou YC, Hsieh YW. Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. Xenobiotica. 2016 Aug;46(8):677-82. PubMed
- Byeon JH, Kil JH, Ahn YC, Son CG. Systematic review of published data on herb induced liver injury. J Ethnopharmacol 2019;233:190-6. PubMed
- Zhao D, Feng SX, Zhang HJ, et al. Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale. Xenobiotica. 2021;51(8):916-925. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC