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Dietary supplement

Butternut Ingredients & Drug Interactions

by Hawaii Pharm

Butternut label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Butternut against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Butternut is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for constipation (laxative), digestive complaints, skin conditions.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wildcrafted Butternut extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Butternut by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Butternut by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Butternut by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a wildcrafted butternut extract. Butternut works as a stimulant laxative—it directly triggers bowel contractions to promote a bowel movement.

The liquid also includes vegetable palm glycerin, pharmaceutical-grade alcohol, and purified water as inactive ingredients to create the liquid form.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Butternut product and its label doesn't state a use — see Butternut's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The product facts we hold don't include any effectiveness ratings for butternut, so we cannot tell you whether evidence supports its use or what conditions it may help with.

The evidence, ingredient by ingredient Butternut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butternut appears to be generally well tolerated when taken by mouth, though it commonly causes diarrhea and gastrointestinal cramping or irritation. The safety data we have is limited.

The facts advise against use during pregnancy—laxative herbs may not be safe in pregnancy, and good safety data are lacking. It's also advised to avoid this product while breastfeeding, as there isn't enough safety information.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Butternut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butternut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use blood thinners like warfarin—diarrhea from butternut can increase bleeding risk. Also clear it with your pharmacist if you take diuretics (water pills), corticosteroids, stimulant laxatives, or heart medications like digoxin, as butternut may compound potassium loss with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Butternut is a stimulant laxative meant for people seeking bowel support, but it's important to know it interacts with blood thinners, diuretics, steroids, and heart medications—especially through potassium loss. If you take any prescription medications, check them against the interaction tool on this page before you start.

Talk with your doctor or pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Butternut, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 650905483462
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 237403
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Butternut by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
650905483462
IngredientAmount% DV
wildcrafted Butternut extract970 mg--

Other ingredients: Vegetable Palm Glycerin, pharmaceutical grade Alcohol, artesian Hawaiian purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hawaii Pharm Herbal Extract Highest quality since 2008

Made with Aloha!

Formulation

Contains no GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers.

Super concentrated liquid herbal extract. Dry herb/menstruum ratio: 1:3.

Manufactured in an FDA registered facility.

Non GMO Gluten free

Made in USA, Hawaii

Suggested/Recommended/Usage/Directions

Directions for use: Shake well before using. Take about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to 2-4 oz of juice or water up to 4 times per day.

Precautions

Warning: Keep out of the reach of children.

May have contraindications. We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing or taking any medications.

Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

Formula

(Juglans cinerea)

FDA Statement of Identity

Herbal Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

FDA Registered Facility Made in United States of America USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Butternut by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Butternut label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Butternut by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Wildcrafted Butternut extract

Interacts with
122 drugs
970 mg per serving

Butternut (Juglans cinerea) is a North American tree whose inner bark was traditionally used as a mild laxative and folk remedy. Modern scientific evi...

Wildcrafted Butternut extract monograph & interactions

Other (inactive) ingredients: Vegetable Palm Glycerin, Pharmaceutical grade Alcohol, Artesian Hawaiian purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Butternut by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Butternut?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

wildcrafted Butternut extract 122

Individual Drug Interactions

The ingredients in Butternut interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Butternut interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Butternut extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Butternut with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

wildcrafted Butternut extract5 drug types · 122 drugs

Corticosteroids

Butternut has stimulant laxative effects. Theoretically, concomitant use of corticosteroids with butternut can increase the risk of potassium depletion.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Butternut has stimulant laxative effects. Theoretically, potassium depletion associated with butternut might increase the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Butternut has stimulant laxative effects. Theoretically, overuse of butternut might compound diuretic-induced potassium loss. There is some concern that people receiving butternut along with potassium-depleting diuretics might be at an increased risk for hypokalemia.
Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.

Likelihood Possible Evidence D
Stimulant Laxatives

Butternut has stimulant laxative effects. Concomitant use with stimulant laxative medications might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Butternut has stimulant laxative effects. In some people butternut can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of butternut.

Likelihood Possible Evidence D
wildcrafted Butternut extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Butternut, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
City
Honolulu
State
HI
ZipCode
96815
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Butternut by Hawaii Pharm: Common Questions

Does Butternut by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Butternut has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Butternut contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data rate butternut as likely unsafe during pregnancy because laxative herbs may not be safe and data are lacking. There's also not enough safety information to use it while breastfeeding. Talk with your doctor or pharmacist for advice tailored to your situation.
What does butternut do?
Butternut is a stimulant laxative—it works by directly triggering your bowel muscles to contract and move stool. It's designed to promote a bowel movement.
Does butternut have any side effects?
Yes. It commonly causes diarrhea and gastrointestinal irritation, including cramping. The safety data on butternut are limited, so it's important to be cautious with it.
Is butternut safe to take with my blood thinner?
Not without checking first. If you take warfarin (Coumadin), butternut can increase how strongly the drug works because diarrhea from the laxative raises your bleeding risk. Talk with your doctor or pharmacist before using it.
What's in this liquid besides the butternut extract?
The inactive ingredients are vegetable palm glycerin, pharmaceutical-grade alcohol, and purified water—these make it a liquid and help preserve it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Butternut is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Butternut label
Go deeper

The Full Monographs Behind Butternut’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butternut

Interacts with 122 drugs

Butternut (Juglans cinerea) is a North American tree whose inner bark was traditionally used as a mild laxative and folk remedy. Modern scientific evidence supporting any of its uses is very...

Read the full Butternut monograph →
Sources

Sources & How We Checked

Butternut's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butternut 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Butternut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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