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Dietary supplement

Butternut Ingredients & Drug Interactions

by Herbal Terra

Butternut label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Butternut against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Butternut is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for constipation (laxative), digestive complaints, skin conditions.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wildcrafted Butternut (Juglans cinerea) dried inner bark liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Butternut by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Butternut by Herbal Terra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Butternut by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: wildcrafted Butternut (Juglans cinerea) dried inner bark liquid extract. Butternut works as a stimulant laxative — it triggers bowel contractions to promote a bowel movement.

The inactive ingredient is Menstruum, a liquid carrier used to prepare the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Butternut product and its label doesn't state a use — see Butternut's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

No effectiveness ratings are documented in our data for butternut. The product is marketed as a laxative, but we hold no evidence ratings on how well it works for that or any other purpose.

The evidence, ingredient by ingredient Butternut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butternut is generally well tolerated when taken by mouth, though it can cause diarrhea and gastrointestinal irritation such as cramping or digestive upset. Safety data are limited.

The product is rated Likely Unsafe in pregnancy because laxative herbs may pose risks and safety information is incomplete. It is also rated Likely Unsafe while breastfeeding due to insufficient safety data — talk with your doctor or pharmacist about personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Butternut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butternut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking butternut, check with your doctor or pharmacist if you take blood thinners (especially warfarin), water pills (diuretics), corticosteroids, the heart medication digoxin, or any other stimulant laxative. All carry Moderate-severity interaction risks centered on electrolyte loss and increased bleeding or heart medication effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Butternut is a laxative herb best reserved for occasional use by people who don't take blood thinners, diuretics, corticosteroids, or heart medications. Because it carries moderate interaction risks and limited safety data, run it past your own doctor or pharmacist before you start — especially if you're on any prescription medication or planning pregnancy.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Butternut, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 723836114566
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 234212
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Butternut by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
723836114566
IngredientAmount% DV
wildcrafted Butternut (Juglans cinerea) dried inner bark liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Origin of plant material: USA.

Manufactured in the USA in an FDA registered facility

Sugar free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Super concentrated liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Juglans cinerea

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Butternut by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Butternut label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Butternut by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Wildcrafted Butternut (Juglans cinerea) dried inner bark liquid extract

Interacts with
122 drugs
970 mg per serving

Butternut (Juglans cinerea) is a North American tree whose inner bark was traditionally used as a mild laxative and folk remedy. Modern scientific evi...

Wildcrafted Butternut (Juglans cinerea) dried inner bark liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Butternut by Herbal Terra Drug Interactions

Want to check YOUR meds against Butternut?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

wildcrafted Butternut (Juglans cinerea) dried inner bark liquid extract 122

Individual Drug Interactions

The ingredients in Butternut interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Butternut interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Butternut (Juglans cinerea) dried inner bark liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Butternut with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

wildcrafted Butternut (Juglans cinerea) dried inner bark liquid extract5 drug types · 122 drugs

Corticosteroids

Butternut has stimulant laxative effects. Theoretically, concomitant use of corticosteroids with butternut can increase the risk of potassium depletion.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Butternut has stimulant laxative effects. Theoretically, potassium depletion associated with butternut might increase the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Butternut has stimulant laxative effects. Theoretically, overuse of butternut might compound diuretic-induced potassium loss. There is some concern that people receiving butternut along with potassium-depleting diuretics might be at an increased risk for hypokalemia.
Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.

Likelihood Possible Evidence D
Stimulant Laxatives

Butternut has stimulant laxative effects. Concomitant use with stimulant laxative medications might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Butternut has stimulant laxative effects. In some people butternut can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of butternut.

Likelihood Possible Evidence D
wildcrafted Butternut (Juglans cinerea) dried inner bark liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Butternut, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Butternut by Herbal Terra: Common Questions

Does Butternut by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Butternut has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Butternut contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I use butternut if I'm pregnant or breastfeeding?
No. Butternut is rated Likely Unsafe in both pregnancy and breastfeeding because safety data are incomplete and laxative herbs carry potential risks. Talk with your doctor or pharmacist before taking it if you're pregnant, nursing, or planning pregnancy.
What side effects should I expect from butternut?
Butternut commonly causes diarrhea and digestive upset, including cramping. Most people tolerate it well when taken as directed, but these GI effects are expected because it's a laxative.
Why does it matter if I take butternut with a water pill or corticosteroid?
Butternut drains potassium through its laxative action. If you also take a potassium-depleting water pill or corticosteroid, the combined effect raises your risk of dangerously low potassium (a condition called hypokalemia). That's why the interaction is flagged as Moderate.
Is butternut safe to use long-term?
Safety data for long-term use are limited. Because stimulant laxatives can deplete electrolytes and interact with several medication classes, butternut is best used occasionally and under guidance from your doctor or pharmacist.
What is butternut extract, and how does it work?
Butternut (Juglans cinerea) dried inner bark extract is a stimulant laxative — it works by triggering muscle contractions in your bowel to promote a bowel movement. This liquid extract is made by soaking the bark in a solvent carrier.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Butternut label
Go deeper

The Full Monographs Behind Butternut’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butternut

Interacts with 122 drugs

Butternut (Juglans cinerea) is a North American tree whose inner bark was traditionally used as a mild laxative and folk remedy. Modern scientific evidence supporting any of its uses is very...

Read the full Butternut monograph →
Sources

Sources & How We Checked

Butternut's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butternut 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Butternut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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