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Dietary supplement

CardioSense Probiotic Ingredients & Drug Interactions

by Dr. Sinatra

CardioSense Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CardioSense Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CardioSense Probiotic is a dietary supplement by Dr. Sinatra with 3 active ingredients.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CardioSense Probiotic by Dr. Sinatra

Ask about any prescription or over-the-counter medication and we check it for interactions with CardioSense Probiotic by Dr. Sinatra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CardioSense Probiotic by Dr. Sinatra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 11 active ingredients.
  • “Tribiotic Probiotic Blend” is a proprietary blend — the label gives one combined amount (264 mg) without saying how much of each component you get.
  • “Digestive Probiotics Floradapt Intensive GI” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Bifidobacterium Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

CardioSense Probiotic contains 11 active probiotic ingredients across several proprietary blends designed to support digestive and cardiovascular health. The checked ingredients include B. longum and B. bifidum, both live Bifidobacterium species known for supporting gut function and respiratory and digestive tract health.

The product also contains several Lactobacillus plantarum strains (five variants), P. acidilactici, and B. lactis — all live probiotic organisms. The inactive ingredients are microcrystalline cellulose and hypromellose, which serve as capsule material and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive, heart, and immune health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Diarrhea, Irritable bowel syndrome (IBS), Constipation, Clostridioides difficile infection, Common cold — and 4 related terms.
  • The strongest evidence on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Respiratory tract infections (Natural Medicines).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Common cold, Constipation, Radiation-induced diarrhea, and more.

The evidence we hold is mixed and limited. B. bifidum shows possibly effective ratings for irritable bowel syndrome and respiratory tract infections.

B. longum, however, carries insufficient reliable evidence to rate it for the conditions in our database — including age-related cognitive decline, hay fever, antibiotic-associated diarrhea, anxiety, asthma, and athletic performance. For the other eight probiotic strains in this product, we have no effectiveness data on file.

If you're taking this to address a specific health goal, talk with your pharmacist about what the current evidence supports.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both B. longum and B. bifidum are generally well tolerated in healthy people, but caution is warranted if you're seriously ill or have a weakened immune system — rare cases of serious infection (bacteremia and sepsis) have been reported in critically ill patients and preterm infants on probiotics. Minor gastrointestinal side effects have been reported rarely with B. longum, including abdominal discomfort, flatulence, constipation, and one case of dry cough.

For B. bifidum, bloating and flatulence are theoretically possible with probiotics in general, though not specifically documented for this strain. Safety data for the other ingredients in this product are limited or not on file.

Because safety information for several ingredients is sparse, check with your doctor or pharmacist before use, especially if you're breastfeeding — B. bifidum has no pregnancy or lactation data on file, while B. longum is rated possibly safe during pregnancy and lactation.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bifidobacterium Bifidum, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take CardioSense Probiotic, double-check your antibiotic medications with your pharmacist. B. longum and B. bifidum can lose effectiveness when dosed at the same time as antibiotics, so you'll want to separate them by a few hours.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may be worth considering if you're looking to support digestive or cardiovascular health, but talk with your pharmacist first — especially if you take antibiotics, have a compromised immune system, or are pregnant or breastfeeding. The evidence for specific benefits is limited outside of gut health and respiratory support for B. bifidum.

Space any antibiotic doses apart from this supplement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CardioSense Probiotic, straight from the product label.

Brand Dr. Sinatra
Barcode (UPC) 810047390190
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 286041
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CardioSense Probiotic by Dr. Sinatra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
810047390190
IngredientAmount% DV
B. longum0 NP--
B. bifidum0 NP--
Tribiotic Probiotic Blend264 mg--
Digestive Probiotics Floradapt Intensive GI0 NP--
P. acidilactici KABP-0210 NP--
L. plantarum KABP-0220 NP--
L. plantarum KABP-0230 NP--
Bifidobacterium Blend0 NP--
B. lactis0 NP--
Cardio Probiotics Floradapt Cardio0 NP--
L. plantarum KABP-0110 NP--
L. plantarum KABP-0120 NP--
L. plantarum KABP-0130 NP--
Immune Probiotics Floradapt Mature0 NP--
Immune Defense0 NP--
L. plantarum KABP-320 NP--
L. plantarum KABP-310 NP--

Other ingredients: Microcrystalline Cellulose, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Almost out? Call 1-800-304-1708 or visit healthydirections.com Choose refill & save, get free shipping forever.

Formula

Dr. Sinatra's CardioSense Probiotic contains an exclusive combination of clinically validated probiotic strains to specifically support digestive, heart, and immune health.

Exclusive combination of probiotic strains that support digestive, heart, and immune health

Storage

To preserve quality and freshness, store bottle with cap tightly closed in a cool, dry place.

Precautions

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Brand IP Statement(s)

Floradapt and KABP are trademarks of Kaneka Corporation.

Dr. Sinatra America's Integrative Cardiologist

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Digestive health Heart health Immune health

3-in-1 digestion + heart + immune

Gluten free Soy free

Vegetarian

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Doctor's suggested use: Take 1 vegetarian capsule daily.

Seals/Symbols

Guaranteed potency

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CardioSense Probiotic by Dr. Sinatra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CardioSense Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CardioSense Probiotic by Dr. Sinatra

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Tribiotic Probiotic Blend

264 mg per serving
  • › Digestive Probiotics Floradapt Intensive GI
  • › Cardio Probiotics Floradapt Cardio
  • › Immune Probiotics Floradapt Mature

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

CardioSense Probiotic by Dr. Sinatra Drug Interactions

Want to check YOUR meds against CardioSense Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in CardioSense Probiotic interact with 182 drugs. Click any drug to see the details.

0 of the 3 ingredients in CardioSense Probiotic interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in CardioSense Probiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for CardioSense Probiotic, from the product label.

Dr. Sinatra

See all Dr. Sinatra products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Phone Number
1-800-304-1708
Web Address
healthydirections.com
Pharmacist Counseling Corner

CardioSense Probiotic by Dr. Sinatra: Common Questions

Does CardioSense Probiotic by Dr. Sinatra interact with any medications?
Yes. Based on its ingredients, CardioSense Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CardioSense Probiotic contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
You can, but timing matters. The live bacteria in this product may be killed by antibiotics if you take them together, which defeats the purpose of the probiotic. Ask your pharmacist to help you space the doses a few hours apart — that way each can do its job.
Is this safe if I have a weakened immune system?
That's a conversation to have with your doctor first. While these probiotics are generally well tolerated in healthy people, caution is advised if your immune system is compromised. Rare but serious infections have been reported in critically ill patients on probiotics.
Can I take this while breastfeeding?
The data on breastfeeding safety for most of these probiotic strains are limited or not on file. B. longum is rated possibly safe, but B. bifidum has no lactation data. Check with your doctor or pharmacist for personalized advice before starting.
What side effects should I watch for?
Most people tolerate this well, but rare gastrointestinal effects like bloating, flatulence, abdominal discomfort, and constipation have been reported with these probiotic species. If you're seriously ill or have a central line or recent heart surgery, rare infections are a concern — talk to your doctor.
Does this really work for heart health?
We don't have effectiveness evidence on file for cardiovascular benefits from any of these strains in our database. The brand positions it for cardiac support, but talk with your pharmacist about whether the science backs that claim for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CardioSense Probiotic is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CardioSense Probiotic label
Sources

Sources & How We Checked

CardioSense Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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