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Dietary supplement

Carnosine-500 Ingredients & Drug Interactions

by AOR Advanced Orthomolecular Research Premium

Carnosine-500 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Carnosine-500 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Carnosine-500 is a dietary supplement by AOR Advanced Orthomolecular Research Premium with 1 active ingredient. Its ingredients are commonly taken for anti-aging and general wellness, exercise performance and muscle support, brain and cognitive health.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Carnosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Carnosine-500 by AOR Advanced Orthomolecular Research Premium

Ask about any prescription or over-the-counter medication and we check it for interactions with Carnosine-500 by AOR Advanced Orthomolecular Research Premium — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Carnosine-500 by AOR Advanced Orthomolecular Research Premium

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-carnosine, a naturally occurring compound made from two amino acids in your body. The capsule itself is the only inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Carnosine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: brain health and muscle protein maintenance.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive impairment, neurodegeneration, neuroprotection.
  • The closest evidence on file: Carnosine is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Carnosine is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Cognitive impairment.

The evidence for carnosine is mixed and limited. For autism spectrum disorder, the research suggests it's probably not effective.

For other uses—age-related cognitive decline, Alzheimer disease, athletic performance, cataracts, and cognitive impairment generally—we don't have enough reliable evidence yet to rate whether it works. If you're considering this product for a specific condition, talk with your doctor about what the current science shows for your situation.

The evidence, ingredient by ingredient Carnosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Carnosine is generally well tolerated in short-term studies, though long-term safety data are limited. Some people have reported decreased appetite, dry mouth, small weight changes, foot and joint pain, and in rare cases, pneumonia.

Because there isn't enough safety information, the data advises against use during pregnancy and while breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Carnosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Carnosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs or medications that lower your blood sugar, check with your doctor or pharmacist before starting this product. Carnosine may lower blood glucose levels further, raising your risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Carnosine-500 may be worth considering if you're interested in the compound and don't take diabetes medications—but the evidence for most uses is still developing. Anyone on antidiabetes drugs, pregnant, or breastfeeding should check with their doctor or pharmacist first.

Long-term safety isn't well established, so discuss it with your healthcare provider to make sure it fits your needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Carnosine-500, straight from the product label.

Brand AOR Advanced Orthomolecular Research Premium
Barcode (UPC) 624917082630
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214552
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Carnosine-500 by AOR Advanced Orthomolecular Research Premium, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
624917082630
IngredientAmount% DV
L-Carnosine500 mg--

Other ingredients: Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GMP Manufacturing Quality assured Independent testing

Vegan

Non-GMO Gluten free

A powerful antioxidant to support cellular function

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, corn, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Precautions

Do not use if safety seal is broken

Warning: Consult your physician before use if you are pregnant, lactating, have a medical condition, if you're taking any medication or for use beyond 8 weeks.

Keep out of reach of children.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Storage

Store tightly sealed in a cool, dry place

Formula

Discussion: Carnosine is a dipeptide found in high concentrations in the brain and a source of amino acids which promotes the maintenance of muscle protein synthesis.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule a day without food, or as directed by a qualified health care practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Product of Canada

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Carnosine-500 by AOR Advanced Orthomolecular Research Premium label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Carnosine-500 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Carnosine-500 by AOR Advanced Orthomolecular Research Premium

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

L-Carnosine

Interacts with
86 drugs
500 mg per serving Form: Beta-Alanyl-L-Histidine

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is so...

L-Carnosine monograph & interactions

Other (inactive) ingredients: Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Carnosine-500 by AOR Advanced Orthomolecular Research Premium Drug Interactions

Want to check YOUR meds against Carnosine-500?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

L-Carnosine 86

Individual Drug Interactions

The ingredients in Carnosine-500 interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Carnosine-500 interact with drugs. Each result below shows which ingredient is responsible. L-Carnosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Carnosine-500 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Carnosine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Some, but not all, preliminary clinical research shows that carnosine might reduce fasting blood glucose levels.

Likelihood Possible Evidence D
L-Carnosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Carnosine-500, from the product label.

AOR Advanced Orthomolecular Research Premium

See all AOR Advanced Orthomolecular Research Premium products
Name
AOR Inc.
Street Address
30 Industrial West
City
Clifton
State
NJ
ZipCode
07012
Phone Number
1-866-215-0450
Pharmacist Counseling Corner

Carnosine-500 by AOR Advanced Orthomolecular Research Premium: Common Questions

Does Carnosine-500 by AOR Advanced Orthomolecular Research Premium interact with any medications?
Yes. Based on its ingredients, Carnosine-500 has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Carnosine-500 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes?
If you take diabetes medication, you'll want to talk with your doctor or pharmacist first. Carnosine might lower blood sugar on its own, and combining it with antidiabetes drugs could increase your risk of low blood sugar. They can assess your situation and help you decide.
Is carnosine safe to take long-term?
Short-term studies show it's generally well tolerated, but we don't have enough long-term safety data to say how it holds up over months or years. If you're thinking about taking it regularly, discuss that timeline with your doctor or pharmacist.
Can I take this while pregnant or breastfeeding?
No—there isn't enough safety information. The data advises against use during pregnancy and while breastfeeding. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.
What side effects might I experience?
Some people report decreased appetite, dry mouth, or small weight changes. Foot and joint pain have also been reported, and pneumonia is rare. Most users tolerate it well in the short term, but let your doctor know if you notice anything unusual.
Does carnosine actually work for Alzheimer disease or cognitive decline?
We don't have enough reliable evidence yet to say whether it helps with those conditions. For autism spectrum disorder, research suggests it's probably not effective. If you're considering carnosine for a specific condition, ask your doctor what the current evidence shows for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Carnosine-500 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Carnosine-500 label
Go deeper

The Full Monographs Behind Carnosine-500’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Carnosine

Interacts with 86 drugs

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is sold as an anti-aging and performance supp...

Read the full Carnosine monograph →
Sources

Sources & How We Checked

Carnosine-500's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Carnosine 5 references
  1. Chengappa KN, Turkin SR, DeSanti S, et al. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophr Res 2012;142(1-3):145-52. PubMed
  2. Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203.
  3. Peng W, Mao P, Liu L, et al. Effect of carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and insulin resistance: a systematic review and meta-analysis of long-term randomized controlled trials. Complement Ther Med 2020;48:102241. PubMed
  4. Siriwattanasit N, Satirapoj B, Supasyndh O. Effect of oral carnosine supplementation on urinary TGF-ß in diabetic nephropathy: a randomized controlled trial. BMC Nephrol 2021;22(1):236. PubMed
  5. Sureshkumar K, Durairaj M, Srinivasan K, et al. Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis. Front Biosci (Landmark Ed) 2023;28(1):18. PubMed

See these in context on the Carnosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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