CerebralCharge By NutriPharm Overview & Drug Interactions

Vitamin B12, also known as cobalamin, is a water-soluble vitamin crucial for several bodily functions. It plays a pivotal role in the formation of red blood cells, aiding in the prevention of anemia. Vitamin B12 is essential for maintaining a healthy nervous system and proper brain function, as it is involved in the synthesis of myelin, the protective sheath around nerve fibers. This vitamin is primarily found in animal-based foods such as meat, fish, dairy products, and eggs, making it important for vegetarians and vegans to consider supplementation. A deficiency in vitamin B12 can lead to neurological issues, fatigue, and cognitive impairment.

Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that is involved in a variety of functions, including regulating brain activity and behavior, relaxation, and sleep. GABA is endogenously produced in the brain from the amino acid glutamate and is responsible for inhibiting the activity of nerve cells in the brain and central nervous system. GABA is a popular dietary supplement and is used to help reduce anxiety and improve sleep, but more research is needed to determine its safety and effectiveness.

L-tyrosine is a non-essential amino acid produced within the body through the conversion of the essential amino acid, phenylalanine. It is often used as a dietary supplement to support cognitive function, enhance focus, and mitigate stress by serving as a precursor for neurotransmitters like dopamine and norepinephrine.

Phenethylamine (PEA) is a monoamine alkaloid present in various sources, including plants, bacteria, fungi, and animals, including humans. It is also found in certain foods like chocolate and eggs. This compound is synthesized in the body through the decarboxylation of the amino acid L-phenylalanine. Within the central nervous system, PEA serves as both a neuromodulator and neurotransmitter, playing a crucial role in neuronal signaling. Phenethylamine is available as a dietary supplement and is used for potential cognitive and mood-enhancing effects, although further research is needed to fully understand its effects in these regards.

Alpha-GPC (alpha-glycerylphosphorylcholine) is a natural compound found in small amounts in foods such as soy lecithin, and is also available as a dietary supplement. It is a source of choline, a nutrient that is important for brain health and function. Alpha-GPC is particularly known for its potential to improve cognitive function, particularly in the areas of memory and learning. It is also being studied for its potential to improve symptoms of Alzheimer's disease and other forms of dementia. Alpha-GPC is likely better absorbed and utilized in the body than other sources of choline as it is known to cross the blood-brain barrier. The choline provided from Alpha-GPC is also a precursor to acetylcholine, an important neurotransmitter for cognitive functions such as attention, memory, and learning.

Theanine, often referred to as L-theanine as that is the predominant isomer of theanine, is an amino acid commonly found in tea leaves, particularly in green tea. It is purported to increase levels of GABA, serotonin, and dopamine in the brain, which can help to reduce stress and anxiety. L-theanine may also promote a sense of calm and improve overall well-being. Some studies have also suggested that it may improve cognitive function, although more research is needed. Most reported drug interactions with theanine are due to its sedative effects.

Vinpocetine is a synthetic compound that is derived from the alkaloid vincamine, which is found in the periwinkle plant (Vinca minor). It is used as a dietary supplement and is claimed to have a number of potential health benefits, including improving memory and cognitive function, increasing blood flow to the brain, and reducing inflammation. The Food and Drug Administration (FDA), in 2019, issued a warning that those who are pregnant or who could become pregnant should avoid vinpocetine due to safety concerns.