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Dietary supplement

Chewable D-Ribose 1500 mg Natural Orange Juice Flavor Ingredients & Drug Interactions

by NOW Sports

Chewable D-Ribose 1500 mg Natural Orange Juice Flavor label
See full label image
Tablet Or Pill Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chewable D-Ribose 1500 mg Natural Orange Juice Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chewable D-Ribose 1500 mg Natural Orange Juice Flavor is a dietary supplement by NOW Sports with 3 active ingredients. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioenergy Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Chewable D-Ribose 1500 mg Natural Orange Juice Flavor by NOW Sports

Ask about any prescription or over-the-counter medication and we check it for interactions with Chewable D-Ribose 1500 mg Natural Orange Juice Flavor by NOW Sports — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Chewable D-Ribose 1500 mg Natural Orange Juice Flavor by NOW Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients: Bioenergy Ribose (the main one) and dextrose. Ribose is a five-carbon sugar your cells use for energy — it's the 'R' in RNA, and it plays a role in how your body makes and uses fuel.

The product also contains inactive ingredients like natural orange and vanilla flavors, citric acid, magnesium stearate, silica, stearic acid, and beta-carotene for color and texture.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Fuels ATP energy production.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Congestive heart failure (CHF), Coronary artery bypass graft (CABG) surgery, Coronary heart disease (CHD) — and 4 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Possibly Ineffective" for McArdle disease.
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for ribose is mixed. For athletic performance and McArdle disease (a rare muscle disorder), it's rated possibly ineffective — meaning the research doesn't support benefit.

For restless legs syndrome, muscle soreness, congestive heart failure, and recovery after heart bypass surgery, we don't have enough reliable evidence to say whether it works or not.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ribose is generally well tolerated in the short term — up to about a month in the studies we have. The main concern is that it lowers blood sugar, and long-term safety hasn't been well studied.

Common side effects include diarrhea, stomach discomfort, headache, nausea, and anxiety. A small number of people reported lightheadedness, increased appetite, or a hyperanxious feeling; lowering the dose resolved these in some cases.

The safety data advises against ribose during pregnancy and while breastfeeding because there isn't enough information to know it's safe.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your own doctor or pharmacist if you take insulin or any antidiabetes medication — both can have a Moderate interaction with ribose involving low blood sugar. The search tool on this page can help you verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose may appeal to athletes or people with heart or muscle conditions, but the evidence for most uses is either lacking or shows it doesn't work as claimed. The bigger concern is its effect on blood sugar — if you take insulin or diabetes medication, talk with your doctor or pharmacist before adding this.

And if you're pregnant or breastfeeding, the data recommends avoiding it until you've discussed it with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chewable D-Ribose 1500 mg Natural Orange Juice Flavor, straight from the product label.

Brand NOW Sports
Barcode (UPC) 733739021489
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62466
Product type Fiber And Other Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chewable D-Ribose 1500 mg Natural Orange Juice Flavor by NOW Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
3 Chewable Tablet(s)
Servings per container
30
UPC/BARCODE
733739021489
IngredientAmount% DV
Calories25 Calorie(s)--
Total Carbohydrates6 Gram(s)2%
Sugar6 Gram(s)--
Dextrose1 Gram(s)--
Bioenergy Ribose4.5 Gram(s)--

Other ingredients: natural Orange flavors, natural Orange juice powder, Magnesium Stearate, Stearic Acid, Silica, Citric Acid, natural Vanilla flavor, Beta-Carotene

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Do Not Eat Freshness Packet. Keep in Bottle.

Not manufactured with wheat, gluten, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Contains soy.

Brand IP Statement(s)

Bioenergy RIBOSE is a registered trademark of Bioenergy Life Science, Inc. Use of ribose is licensed by Bioenergy Life Science, Inc. under U.S. Patents 6,159,942; 6,534,480; 6,218,366; 6,339,716, and other U.S. and foreign patents issued and pending.

General Statements

Natural color variation may occur in this product.

Fuels ATP Energy Production

Please Recycle.

Ribose is a simple sugar that occurs naturally in all living cells. Ribose is the structural backbone of ATP, the primary form of energy used for all cellular processes. Demand for ATP availability is especially critical in the heart and skeletal muscle and Ribose supplementation can help to maintain optimal energy levels in these tissues.

General

CODE 2148 V7

Formula

BIOENERGY RIBOSE OU

BIOENERGY RIBOSE OU

Contains soy.

FDA Statement of Identity

A Dietary Supplement

Formulation

Vegetarian/Vegan

Not manufactured with wheat, gluten, milk, egg, fish, shellfish or tree nut ingredients.

Seals/Symbols

GMP QUALITY ASSURED

Storage

Store in a cool, dry, dark place after opening.

Suggested/Recommended/Usage/Directions

SUGGESTED USAGE: Chew 1-3 tablets daily, prior to exercise.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chewable D-Ribose 1500 mg Natural Orange Juice Flavor by NOW Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chewable D-Ribose 1500 mg Natural Orange Juice Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chewable D-Ribose 1500 mg Natural Orange Juice Flavor by NOW Sports

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

6 Gram(s) per serving

Dextrose

1 Gram(s) per serving

Bioenergy Ribose

Interacts with
86 drugs
4.5 Gram(s) per serving Form: D-Ribose, Powder

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

Bioenergy Ribose monograph & interactions

Other (inactive) ingredients: Natural Orange flavors, Natural Orange juice powder, Magnesium Stearate, Stearic Acid, Silica, Citric Acid, Natural Vanilla flavor, Beta-Carotene. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chewable D-Ribose 1500 mg Natural Orange Juice Flavor by NOW Sports Drug Interactions

Want to check YOUR meds against Chewable D-Ribose 1500 mg Natural Orange Juice Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Bioenergy Ribose 86

Individual Drug Interactions

The ingredients in Chewable D-Ribose 1500 mg Natural Orange Juice Flavor interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in Chewable D-Ribose 1500 mg Natural Orange Juice Flavor interact with drugs. Each result below shows which ingredient is responsible. Bioenergy Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in Chewable D-Ribose 1500 mg Natural Orange Juice Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioenergy Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
Bioenergy Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chewable D-Ribose 1500 mg Natural Orange Juice Flavor, from the product label.

NOW Sports

See all NOW Sports products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowsportsproducts.com
Pharmacist Counseling Corner

Chewable D-Ribose 1500 mg Natural Orange Juice Flavor by NOW Sports: Common Questions

Does Chewable D-Ribose 1500 mg Natural Orange Juice Flavor by NOW Sports interact with any medications?
Yes. Based on its ingredients, Chewable D-Ribose 1500 mg Natural Orange Juice Flavor has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chewable D-Ribose 1500 mg Natural Orange Juice Flavor contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this give me a burst of energy?
Ribose is a sugar your cells use for energy, but for athletic performance specifically, the evidence shows it's likely ineffective. The research doesn't support that it boosts your workouts or recovery.
Can I take this if I have diabetes?
Ribose can lower blood sugar on its own, so combining it with diabetes or insulin medication could drop your level too low. You'll need to talk with your doctor or pharmacist before starting — they can weigh the risk for your specific situation and medications.
What are the side effects?
The most common ones are diarrhea, stomach discomfort, headache, and nausea. Some people also reported anxiety, lightheadedness, or increased appetite, though lowering the dose helped in those cases. These tend to happen in the short term; long-term safety isn't well studied.
Is it safe to take while pregnant or breastfeeding?
There isn't enough safety information, so the data advises against it during pregnancy and while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in those situations.
Does this help with muscle soreness or heart problems?
For muscle soreness, we don't have enough reliable evidence to say either way. For congestive heart failure and bypass surgery recovery, the same applies — the evidence is too limited to know if it works.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chewable D-Ribose 1500 mg Natural Orange Juice Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chewable D-Ribose 1500 mg Natural Orange Juice Flavor label
Go deeper

The Full Monographs Behind Chewable D-Ribose 1500 mg Natural Orange Juice Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

Chewable D-Ribose 1500 mg Natural Orange Juice Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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