Cinnamon Bark 500 mg Ingredients & Drug Interactions
by Thompson
What is this page for?
First and foremost: checking Cinnamon Bark 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cinnamon Bark 500 mg is a dietary supplement by Thompson with 2 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,058 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Cinnamon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cinnamon Bark 500 mg by Thompson
Ask about any prescription or over-the-counter medication and we check it for interactions with Cinnamon Bark 500 mg by Thompson — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cinnamon Bark 500 mg by Thompson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Ceylon cinnamon at 500 mg per capsule. Cinnamon is a spice that's been studied for possible effects on blood sugar and weight, though the evidence for those uses is mixed.
The capsule itself is made from vegetable cellulose, which is just the container.
Does it work?
Not established
The evidence for cinnamon's uses is limited. For obesity and diabetes, the data suggests it's possibly ineffective — meaning the research hasn't shown a real benefit.
For hay fever, COPD, and the common cold, there isn't enough reliable evidence to say whether it works or doesn't. If you're considering cinnamon for any of these, talk with your doctor about whether it makes sense for you.
How safe is it?
Well-documented data
Ceylon cinnamon is generally well tolerated when eaten as a food spice. At supplement doses like this one, however, it's less well studied.
The most common side effects from oral cinnamon are bloating, indigestion, and nausea — a small number of users reported these in trials. Rare cases of allergic rashes or itching have been reported.
There's also a single case report of unusual bleeding after someone took cinnamon daily for months, though this is very uncommon. During pregnancy, Ceylon cinnamon is rated likely safe in food amounts, though one source flags it as possibly unsafe at supplement doses — check with your doctor or pharmacist for personalized guidance.
During breastfeeding, food amounts are considered safe, but the safety of supplement doses isn't known.
Meds to double-check
Moderate interaction found
Check this product against any blood pressure medications you take — cinnamon may lower your pressure further. Also check diabetes medications, as cinnamon may intensify their blood-sugar-lowering effect.
Use the medication checker on this page with your exact drug names.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
If you take blood pressure or diabetes medications, you need to check with your pharmacist before adding this product — cinnamon can add to their effects. If you're pregnant or breastfeeding, talk it over first.
For the conditions it's marketed for, the evidence doesn't support strong benefits.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cinnamon Bark 500 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cinnamon Bark 500 mg by Thompson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| Dietary Fiber | 1 Gram(s) | 1% |
| Cinnamon | 1000 mg | -- |
Other ingredients: Vegetable Cellulose Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
(C)2008
Our own laboratory analysis guarantees purity and freshness of all Thompson(R) products.
Suggested/Recommended/Usage/Directions
Directions: Use only as directed. Take two vegetarian capsules daily with a meal or glass of water.
Storage
Store in a cool, dry place.
General Statements
Keep your licensed health care practitioner informed when using this product.
Discussion: Cinnamon is one of the oldest and most treasured spices in culinary use. Modern research has since discovered that its antioxidant properties may help provide nutritive support for normal, healthy blood glucose levels. It may also help provide nutritive support for healthy digestion.
SINCE 1932
CINNAMOMUM VERUM
General
3123637 0408
FDA Statement of Identity
DIETARY SUPPLEMENT
Seals/Symbols
FRESH HEALTHY
Precautions
Keep out of reach of children
WARNING: Do not use if safety seal is broken or missing.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cinnamon Bark 500 mg by Thompson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cinnamon Bark 500 mg by Thompson
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsCinnamon
Interacts with258 drugs
Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evid...
Cinnamon monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose Capsule. These complete the product’s ingredient list but are not active constituents.
Cinnamon Bark 500 mg by Thompson Drug Interactions
HelloPharmacist Interaction Report
Thompson's Cinnamon Bark 500 mg contains Ceylon cinnamon, which interacts with two major medication categories.
The most serious concern is with blood pressure medications (antihypertensives): cinnamon may add to their effects and push your blood pressure too low (hypotension). Animal studies show cinnamon relaxes blood vessels and lowers pressure, so combining it with blood pressure drugs needs caution.
Read the full breakdown — every affected drug type, severity by severity
Cinnamon also has Moderate interactions with diabetes medications. It may lower blood glucose on its own, so taking it alongside diabetes drugs could drop your blood sugar further than intended.
Your doses might need adjusting.
Altogether, these interactions span 258 individual medications. Use the medication checker below to look up your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cinnamon Bark 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cinnamon Bark 500 mg interact with 2,058 drugs. Click any drug to see the details.
2 of the 2 ingredients in Cinnamon Bark 500 mg interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Cinnamon
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon + Acarbose interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Acebutolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Acetazolamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon + Acetohexamide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Cinnamon Bark 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CinnamonAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Aliskiren interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon + Alogliptin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
Dietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Alogliptin, Metformin interactionCinnamonAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon + Alogliptin, Pioglitazone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Alogliptin, Pioglitazone interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Ambrisentan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Amiloride interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Amiloride, Hydrochlorothiazide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Amlodipine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Amlodipine Benzoate interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Amlodipine Besilate interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Amlodipine Besylate interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Amlodipine Besylate, Benazepril interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Amlodipine, Celecoxib interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Ammonium Chloride interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ammonium Chloride interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Read the full Cinnamon + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAprocitentanTryvio
How Aprocitentan interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Aprocitentan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Atenolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Atenolol, Chlortalidone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Atenolol, Chlorthalidone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Atenolol, Chlorthalidone interactionAzilsartanEdarbi
How Azilsartan interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Azilsartan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Azilsartan, Chlorthalidone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Benazepril interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Benazepril, Hydrochlorothiazide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Bendroflumethiazide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Cinnamon Bark 500 mg — through 2 ingredients. Tap an ingredient for the detail:
CinnamonAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Cinnamon + Bendroflumethiazide, Nadolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bendroflumethiazide, Nadolol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cinnamon Bark 500 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Cinnamon
Antidiabetes Drugs
Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Ceylon cinnamon may lower blood glucose levels. Dose adjustments might be necessary.
Antihypertensive Drugs
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Animal research shows that Ceylon cinnamon extract has vasorelaxant properties and reduces blood pressure in rat models of hypertension, possibly via inhibition of calcium influx through L-type voltage-sensitive channels.
Brand information
Manufacturer and brand details for Cinnamon Bark 500 mg, from the product label.
Cinnamon Bark 500 mg by Thompson: Common Questions
Does Cinnamon Bark 500 mg by Thompson interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will cinnamon help me lose weight?
Can I take this if I have diabetes?
What are the most common side effects?
Is cinnamon safe to take while breastfeeding?
What exactly is Ceylon cinnamon?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cinnamon Bark 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cinnamon Bark 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographCeylon Cinnamon
Interacts with 258 drugsCeylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evidence for most health benefits is limited...
Read the full Ceylon Cinnamon monograph →Sources & How We Checked
Cinnamon Bark 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 40 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Ceylon Cinnamon 22 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity. J Agric Food Chem 2004;52:65-70. PubMed
- Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-36. PubMed
- Onderoglu S, Sozer S, Erbil KM, et al. The evaluation of long-term effcts of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J Pharm Pharmacol 1999;51:1305-12.
- Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
- Ranasinghe P, Jayawardena R, Galappaththy P, et al. Response to Akilen et al. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 2013 Apr;30(4):506-7.
- Oliveira JdA, da Silva IC, Trindade LA, et al. Safety and tolerability of essential oil from Cinnamomum zeylanicum blume leaves with action on oral candidosis and its effect on the physical properties of the acylic resin. Evid Based Complement Alternat Me
- Ranasinghe P, Pigera S, Premakumara GA, et al. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med 2013;13:275. PubMed
- Ranasinghe P, Galappaththy P. Health benefits of Ceylon cinnamon (Cinnamomum zeylanicum): a summary of the current evidence. Ceylon Med J 2016;61(1):1-5. PubMed
- Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extracts. J Complement Integr Med 2011;8.
- Wansi SL, Nyadjeu P, Ngamga D, et al. Blood pressure lowering effect of the ethanol extract from the stembark of Cinnamomum zeylanicum (lauraceae) in rats. Pharmacol online 2007;3:166-76.
- Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
- Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
- Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
- Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
- Ranasinghe P, Jayawardena R, Pigera S, et al. Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med 2017;17(1):550. PubMed
- Zareie A, Sahebkar A, Khorvash F, Bagherniya M, Hasanzadeh A, Askari G. Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double-blind placebo-controlled trial. Phytother Res 2020;34(11):2945-52. PubMed
- Zobeiri M, Parvizi F, Shahpiri Z, et al. Evaluation of the effectiveness of cinnamon oil soft capsule in patients with functional dyspepsia: A randomized double-blind placebo-controlled clinical trial. Evid Based Complement Alternat Med 2021;2021:6634115. PubMed
- Chase C, Doyle A, John SS, Laurent T, Griffith S. Post-operative haemorrhage secondary to cinnamon use. A case report. Int J Surg Case Rep 2022;95:107179. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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