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Dietary supplement

Citrulline Unflavored Powder Ingredients & Drug Interactions

by FINAFLEX

Citrulline Unflavored Powder label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Citrulline Unflavored Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Citrulline Unflavored Powder is a dietary supplement by FINAFLEX with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline Malate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Citrulline Unflavored Powder by FINAFLEX

Ask about any prescription or over-the-counter medication and we check it for interactions with Citrulline Unflavored Powder by FINAFLEX — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Citrulline Unflavored Powder by FINAFLEX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains a single active ingredient: L-citrulline malate, an amino acid compound your body converts to L-arginine. The only other ingredient is silica, an inactive additive.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Blood flow, performance, pump and lean mass.
  • We looked for evidence on: Athletic performance, Muscle strength, Erectile dysfunction (ED), Endurance, Muscle power.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: L-citrulline is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength.

L-citrulline is possibly effective for athletic performance — some evidence suggests it may help with exercise capacity or endurance. For sarcopenia (age-related muscle loss), the evidence rates as possibly ineffective.

For cardiovascular disease, heart failure, Reye syndrome, and diabetes, there isn't enough reliable evidence in our data to say whether it works.

The evidence, ingredient by ingredient L-citrulline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal — stomach discomfort, heartburn, and general GI upset.

A small number of people in trials reported cough. There isn't enough safety data to recommend this supplement during pregnancy, so it's best to avoid it.

Safety while breastfeeding is unknown, so avoid it then too. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient L-citrulline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take blood pressure–lowering medications (antihypertensives) or erectile dysfunction drugs (PDE-5 inhibitors like sildenafil). Both interactions are Moderate-severity and could lead to a significant drop in blood pressure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to boost athletic performance, L-citrulline has some evidence behind it. But if you take blood pressure medication or erectile dysfunction drugs, you need to check with your pharmacist first — the combination could lower your blood pressure too much.

Stomach upset is the main side effect to watch for.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Citrulline Unflavored Powder, straight from the product label.

Brand FINAFLEX
Barcode (UPC) 854397007490
Net contents 10.9 Ounce(s); 309 Gram(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 333639
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Citrulline Unflavored Powder by FINAFLEX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.1 Gram(s)
Maximum serving Sizes:
2.1 Gram(s)
Servings per container
150
UPC/BARCODE
854397007490
IngredientAmount% DV
L-Citrulline Malate2 Gram(s)--

Other ingredients: Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Take it to the next level Blood flow Performance Lean mass

Unflavored powder

Formula

Premium L-Citrulline Malate 2:1 Powder Finaflex Citrulline is a premium muscular performance product designed to promote pump, performance, blood flow, and lean mass! Built with L-Citrulline Malate 2:1, Finaflex Citrulline supports nitric oxide production in the body, helping you power through workouts and reach your health and fitness goals!

Redefine yourself with Citrulline Premium L-Citrulline Malate 2:1

Brand IP Statement(s)

Finaflex Redefine yourself

General Statements

Find us online: Instagram Facebook TikTok YouTube www.finaflex.com

Join the FinaFlex Family #Redefineyourself

FDA Statement of Identity

Dietary Supplement

Precautions

Allergen warning: Produced in a facility that processes milk, eggs, soybeans, wheat, shellfish, fish oil, tree nuts, sesame, and peanuts.

Warning: Keep out of reach of children. Intended for healthy adults over 18.

Do not use if pregnant or nursing. Consult a doctor or medical authority before use if you have a medical condition, a family history of health problems, or if you take other medicines or supplements.

Do not exceed serving size. Stop use if you have a bad reaction. Stop use after 8 weeks. Stop use 2 weeks before surgery. Consumer accepts all liability if used inconsistent with label.

Do not discard desiccant. California Prop 65 Warning: Lead and Cancer and Reproductive Harm www.P65Warnings.ca.gov

Seals/Symbols

GMP Certified Certified Good Manufacturing Practice U.S.A. Made Domestic & Imported Material FDA Registered Facility

Suggested/Recommended/Usage/Directions

Suggested use: 1 As a dietary supplement mix 1 serving (1 scoop) of Citrulline with 4-12 fl oz of water or other beverage. Use Citrulline 1-4 times daily to promote pump, performance, blood flow, and lean muscle!

Storage

Sold by weight, not volume. Store under cool, dry conditions, ideally 50-80 degrees F.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Citrulline Unflavored Powder by FINAFLEX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Citrulline Unflavored Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Citrulline Unflavored Powder by FINAFLEX

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2.1 Gram(s) Dosage formPowder Servings per container150 Amounts shown are per serving.

L-Citrulline Malate

Interacts with
178 drugs
2 Gram(s) per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline Malate monograph & interactions

Other (inactive) ingredients: Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Citrulline Unflavored Powder by FINAFLEX Drug Interactions

Want to check YOUR meds against Citrulline Unflavored Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
178Drugs
178 Moderate

Ingredients driving the most interactions

L-Citrulline Malate 178

Individual Drug Interactions

The ingredients in Citrulline Unflavored Powder interact with 178 drugs. Click any drug to see the details.

1 of the 1 ingredient in Citrulline Unflavored Powder interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline Malate

Each ingredient & the kinds of drugs it affects

For each ingredient in Citrulline Unflavored Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline Malate2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline Malate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Citrulline Unflavored Powder, from the product label.

FINAFLEX

See all FINAFLEX products
Name
FINAFLEX
Street Address
3615 Francis Cir Suite 100
City
Alpharetta
State
GA
ZipCode
30004
Phone Number
888.678.7629
Web Address
www.FINAFLEX.com
Pharmacist Counseling Corner

Citrulline Unflavored Powder by FINAFLEX: Common Questions

Does Citrulline Unflavored Powder by FINAFLEX interact with any medications?
Yes. Based on its ingredients, Citrulline Unflavored Powder has a known interaction with 178 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Citrulline Unflavored Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-citrulline malate and what does it do?
L-citrulline malate is an amino acid compound. Your body converts it to L-arginine, which increases nitric oxide and widens your blood vessels — that's why it's used for athletic performance and circulation. This product contains only that one active ingredient.
Does this powder have any fillers or other stuff mixed in?
Beyond the L-citrulline malate, there's silica as an inactive ingredient. That's it — no other fillers.
What are the most common side effects?
Most people tolerate it well. The main ones to watch for are stomach-related: gastrointestinal discomfort, heartburn, and general stomach upset. A few people in studies reported cough.
Is it safe to use while pregnant or breastfeeding?
There isn't enough safety data to recommend it during pregnancy, so it's best to avoid it then. Safety while breastfeeding is also unknown, so avoid it then too. Talk with your doctor or pharmacist for personalized advice.
Does this actually work for athletic performance?
The evidence rates L-citrulline as possibly effective for athletic performance — there's some support that it may help with exercise capacity. For other uses like muscle loss or heart health, the evidence is either weak or not established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Citrulline Unflavored Powder is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Citrulline Unflavored Powder label
Go deeper

The Full Monographs Behind Citrulline Unflavored Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph →
Sources

Sources & How We Checked

Citrulline Unflavored Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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