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Dietary supplement

Clear & Calm Ingredients & Drug Interactions

by True Botanica

Clear & Calm label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Clear & Calm against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Clear & Calm is a dietary supplement by True Botanica with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 350 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cyracos. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Clear & Calm by True Botanica

Ask about any prescription or over-the-counter medication and we check it for interactions with Clear & Calm by True Botanica — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Clear & Calm by True Botanica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Cyracos” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “Lemon Balm Pentas Mix” is listed as a grouped ingredient — the label gives one combined amount (25 mg) without saying how much of each component you get.

Clear & Calm contains 4 active ingredients: inulin, lemon balm, rosmarinic acid, and a blend labeled Cyracos. Inulin is a soluble fiber from plants that may support digestive health and blood sugar control.

Lemon balm is an herb traditionally used for stress and mood support. Rosmarinic acid is a plant compound, and Cyracos is a lemon balm extract blend.

The capsules also contain cellulose and magnesium stearate as inactive ingredients (excipients that hold the capsule together).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Promotes relaxed mental state, tranquility and restful sleep.
  • We looked for evidence on: Anxiety, Stress, Insomnia, Nervousness, Restlessness.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.

Inulin is possibly effective for constipation, obesity, and diabetes according to our data; evidence for iron deficiency anemia and nonalcoholic fatty liver disease is too limited to rate. Lemon balm is possibly effective for cold sores, stress, and depression.

We hold no effectiveness ratings for rosmarinic acid or the other ingredients in this product.

The evidence, ingredient by ingredient Lemon Balm Inulin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Inulin is likely safe in pregnancy and lactation when eaten in food amounts, but concentrated supplements haven't been well studied — talk to your doctor before using supplement doses. Most common side effects are gas, bloating, constipation, diarrhea, and stomach cramps, especially at doses above 30 grams; these effects are usually mild and well tolerated.

Lemon balm is generally well tolerated for short-term use in healthy adults, though high doses and long-term safety aren't well studied. The safety data advises against lemon balm in pregnancy unless your doctor says otherwise; during breastfeeding, there isn't enough reliable information, so discuss it with your doctor or pharmacist first.

A rare case of heart rhythm changes has been reported with a product containing lemon balm and other ingredients, but it's unclear if lemon balm alone was responsible.

Side effects, ingredient by ingredient Lemon Balm Inulin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lemon Balm, Inulin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 350 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications if you take CNS depressants (sleep aids, anti-anxiety drugs, sedating pain relievers) — lemon balm may add to their sedating effects (Moderate). Also check if you take thyroid hormone replacement — lemon balm may interfere with it (Moderate).

If you're on antidiabetes drugs, a Minor interaction with inulin is possible; verify your exact medication with the tool below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Clear & Calm may be worth considering if you're looking to support stress, mood, or digestive health and you don't take CNS depressants or thyroid medication. If you take sleep aids, anti-anxiety drugs, thyroid hormone replacement, or diabetes medications, talk to your pharmacist before starting — the interactions are documented and need a personal check.

Expect possible gas and bloating, especially early on.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Clear & Calm, straight from the product label.

Brand True Botanica
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336216
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Clear & Calm by True Botanica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Inulin0 NP--
Lemon Balm0 NP--
Rosmarinic Acid21 mg--
Cyracos300 mg--
Hydroxycinnamic Acids42 mg--
Lemon Balm Pentas Mix25 mg--

Other ingredients: Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

A uniquely potent extract of lemon balm (Melissa).

Formulation

Promotes creative mental processes, a relaxed state of mind, a sense of tranquility during the day and restful sleep at night. A lower stress perception supports the immune system.

Contains no milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame, or soybeans. Gluten free.

Vegetarian capsules.

Promotes a relaxed, creative mind

Precautions

Consult your health care provider before using this product if you are pregnant, lactating or have other medical concerns or compatibility issues.

Do not use this product if allergies to the listed ingredients are known to exist or if any adverse effects result after taking the first dose.

This product contains a desiccant package, which should not be eaten.

Keep out of the reach of children.

Storage

Keep desiccant in the bottle until all tablets have been taken.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested usage: One capsule twice daily, or as suggested by your health care provider.

Brand IP Statement(s)

Cyracos is a trademark of the "Actifs Innovants" division of Naturex

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Clear & Calm by True Botanica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Clear & Calm label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Clear & Calm by True Botanica

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Cyracos

Interacts with
264 drugs
300 mg per serving Form: Lemon Balm Leaf Extract

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Cyracos monograph & interactions
  • › Rosmarinic Acid
  • › Hydroxycinnamic Acids

Lemon Balm Pentas Mix

Interacts with
264 drugs
25 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm Pentas Mix monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Clear & Calm by True Botanica Drug Interactions

Want to check YOUR meds against Clear & Calm?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
350Drugs
264 Moderate 86 Minor

Ingredients driving the most interactions

Cyracos 264

Individual Drug Interactions

The ingredients in Clear & Calm interact with 350 drugs. Click any drug to see the details.

1 of the 2 ingredients in Clear & Calm interact with drugs. Each result below shows which ingredient is responsible. Cyracos

Each ingredient & the kinds of drugs it affects

For each ingredient in Clear & Calm with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cyracos2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Cyracos full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Clear & Calm, from the product label.

True Botanica

See all True Botanica products
Name
True Botanica, LLC
Street Address
1005 Richards Road, Suite D
City
Hartland
State
WI
ZipCode
53029
Phone Number
1-800-315-8783
Web Address
www.truebotanica.com
Pharmacist Counseling Corner

Clear & Calm by True Botanica: Common Questions

Does Clear & Calm by True Botanica interact with any medications?
Yes. Based on its ingredients, Clear & Calm has a known interaction with 350 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Clear & Calm contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product make me drowsy?
Lemon balm in this product has shown CNS depressant activity in studies, meaning it can slow brain activity; however, clinical trials haven't consistently shown it causes more dizziness or sleepiness than placebo. If you're already taking sleep aids or anti-anxiety medications, lemon balm's effects could add to theirs, so check with your pharmacist first.
Can I take this while pregnant or breastfeeding?
Inulin is likely safe in food amounts during pregnancy and lactation. Lemon balm, however, has limited pregnancy safety data, and the data advises against it unless your doctor approves. During breastfeeding, there isn't enough reliable information about lemon balm — talk to your doctor or pharmacist for personalized advice.
Is this safe if I have diabetes?
Inulin may theoretically increase the risk of low blood sugar when taken with antidiabetes drugs, though clinical research on inulin's blood-sugar effects is mixed. If you take diabetes medication, run your exact drug through the checker on this page and discuss it with your pharmacist or doctor first.
What side effects should I expect?
The most common side effects from inulin are gas, bloating, diarrhea, constipation, and stomach cramps — especially at higher doses — and these are usually mild and go away. Lemon balm is generally well tolerated, though high doses haven't been well studied.
What does inulin actually do?
Inulin is a soluble fiber that may help with constipation, support blood sugar control in diabetes, and possibly help with weight management. The evidence for these uses is rated as possibly effective.
Does this help with anxiety or stress?
Lemon balm in this product is possibly effective for stress and depression according to our data. It's been used traditionally for these purposes, though the clinical evidence is still developing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Clear & Calm label
Go deeper

The Full Monographs Behind Clear & Calm’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph →
Sources

Sources & How We Checked

Clear & Calm's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inulin 17 references
  1. Williams CM. Effects of inulin on lipid parameters in humans. J Nutr 1999 Jul;129(7 Suppl):1471S-3S. PubMed
  2. Pedersen A, Sandstrom B, Van Amelsvoort JM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 1997;78:215-22. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  5. Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int J Food Sci Nutr 2014;65(1):117-23. PubMed
  6. Guess ND, Dornhorst A, Oliver N, Frost GS. A randomised crossover trial: the effect of inulin on glucose homeostasis in subtypes of prediabetes. Ann Nutr Metab 2016;68(1):26-34. PubMed
  7. Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr 2011;62(2):164-70. PubMed
  8. Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL. Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics. Carbohydr Polym 2015;130:405-19. PubMed
  9. Slavin J, Feirtag J. Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects. Food Funct. 2011;2(1):72-7. PubMed
  10. Micka A, Siepelmeyer A, Holz A, Theis S, Schön C. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr. 2017;68(1):82-89. PubMed
  11. Smiljanec K, Mitchell CM, Privitera OF, Neilson AP, Davy KP, Davy BM. Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial. Nutr Health. 2017;23 PubMed
  12. Cai X, Yu H, Liu L, et al. Milk powder co-supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res PubMed
  13. Rao M, Gao C, Xu L, et al. Effect of inulin-type carbohydrates on insulin resistance in patients with type 2 diabetes and obesity: a systematic review and meta-analysis. J Diabetes Res. 2019;2019:5101423. PubMed
  14. Mitchell CM, Davy BM, Ponder MA, et al. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients 2021;13(9):3235. PubMed
  15. Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr 2021;9(8):4598-4616. PubMed
  16. Ziaei R, Shahshahan Z, Ghasemi-Tehrani H, Heidari Z, Ghiasvand R. Effects of inulin-type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized,
  17. Risso D, Kaczmarczyk M, Laurie I, et al. Moderate intakes of soluble corn fibre or inulin do not cause gastrointestinal discomfort and are well tolerated in healthy children. Int J Food Sci Nutr 2022;73(8):1104-1115. PubMed

See these in context on the Inulin monograph →

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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