Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Collagen Natural Clean Flavor Ingredients & Drug Interactions

by NaturesPlus Keto Living

Collagen Natural Clean Flavor label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Collagen Natural Clean Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Collagen Natural Clean Flavor is a dietary supplement by NaturesPlus Keto Living with 4 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 322 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Collagen Natural Clean Flavor by NaturesPlus Keto Living

Ask about any prescription or over-the-counter medication and we check it for interactions with Collagen Natural Clean Flavor by NaturesPlus Keto Living — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Collagen Natural Clean Flavor by NaturesPlus Keto Living

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Collagen Enzyme” is listed as a grouped ingredient — the label gives one combined amount (30 mg) without saying how much of each component you get.
  • “Collagen Boosting Enzyme Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Collagenase” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This powder contains four active ingredients: sodium, proteases, serrapeptase, and hydrolyzed collagen (also called collagen peptides). Hydrolyzed collagen is the main collagen source — it's broken-down collagen protein designed to be easier for your body to absorb.

Serrapeptase is a proteolytic enzyme (a protein-digesting enzyme) that some products use to support protein breakdown. Proteases are additional enzymes that break down protein.

Sodium is an electrolyte (a mineral that helps your body balance fluids and nerve function). The product contains no inactive fillers or other ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Hair, skin, nails, and joint health.
  • We looked for evidence on: Aging skin, Androgenic alopecia, Atopic dermatitis (eczema), Back pain, Brittle nails, Cellulite — and 4 related terms.
  • The strongest evidence on file: Collagen Peptides is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Collagen Peptides is rated "Possibly Effective" for Dry skin.
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Back pain.

The evidence on these ingredients is mixed and mostly thin. For hydrolyzed collagen, there's possibly effective evidence for aging skin and dry skin, but it's possibly ineffective for muscle strength — and the data on acne and athletic performance isn't established.

Serrapeptase shows insufficient evidence for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis. Sodium has possibly effective evidence for amphotericin B nephrotoxicity (kidney damage from a specific drug) and is likely effective for cystic fibrosis, but the data on congestive heart failure and bipolar disorder is insufficient.

We hold no effectiveness data for proteases.

The evidence, ingredient by ingredient Sodium Collagen Peptides

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated when you stay within normal dietary amounts, but the safety cautions are important: too much sodium is linked to high blood pressure and heart strain, and you should avoid sodium supplements or very high intake without medical guidance. Serrapeptase is generally tolerated short-term, though long-term safety isn't well studied; reported side effects include stomach pain, nausea, and digestive upset, though these occur at roughly the same rate as placebo.

Hydrolyzed collagen is generally well tolerated as a dietary protein, with rare side effects like nausea, indigestion, diarrhea, and bloating. Proteases are generally well tolerated but may rarely cause digestive upset or allergic reactions.

Side effects, ingredient by ingredient Sodium Collagen Peptides

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Serrapeptase, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 322 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take blood pressure drugs (antihypertensives), because sodium may reduce how well they work. Also double-check if you're on lithium, corticosteroids, blood thinners or antiplatelet drugs, didanosine, sodium phosphates, tolvaptan, or any other sodium-containing medications — the sodium content here could raise your blood sodium levels dangerously or interfere with your drug.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product works best if you're interested in collagen for skin aging or dryness and don't take blood pressure medications, lithium, blood thinners, corticosteroids, or other sodium-heavy drugs. If you take any of those medications or have kidney disease or heart disease, talk to your pharmacist or doctor before starting — sodium load matters for you.

Pregnant or breastfeeding? The safety data is thin; check with your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Collagen Natural Clean Flavor, straight from the product label.

Brand NaturesPlus Keto Living
Barcode (UPC) 097467820203
Net contents 1.36 Pound(s); 616 Gram(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 249653
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Collagen Natural Clean Flavor by NaturesPlus Keto Living, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
11 Gram(s), 22 Gram(s)
Maximum serving Sizes:
11 Gram(s), 22 Gram(s)
Servings per container
28
UPC/BARCODE
097467820203
IngredientAmount% DV
Calories80 Calorie(s), 40 Calorie(s)--
Sodium40 mg, 20 mg2%, 1%
Protein20 Gram(s), 10 Gram(s)--
Proteases0 NP, 0 NP--
Serrapeptase0 NP, 0 NP--
Hydrolyzed Collagen20 Gram(s), 10 Gram(s)--
Collagen Enzyme30 mg, 15 mg--
Collagen Boosting Enzyme Blend0 NP, 0 NP--
Collagenase0 NP, 0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Look and feel your best while maintaining your keto lifestyle. KetoLiving Natural Collagen is a great source of protein and with zero carbs! Enjoy the power of KetoLiving Natural Collagen to boost the health of your hair, skin, nails, joints, immune system and much more. NautresPlus KetoLiving Natural Collagen provides the highest quality Collagen available: Sourced from Grass-Fed Beef, Wild-Caught Cod, Cage-Free chicken and Eggshell Membrane. These 6 major Collagen Types (I, II, III, IV, V & X) provide a powerful profile delivering exceptional whole body benefits. Maximized Absorption Superior Source Hydrolyzed Collagen is blended with Collagen Digesting Enzymes to maximize digestion and absorption. Full Spectrum Collagen provides whole body results: Type I - Skin elasticity Type II - Joints and immune system Type III - Skin, blood vessels, vital organs Type IV - Cell, health and growth Type V - Skin, tendons and immune system Type X - Joints, bones, muscles and hair

Formulation

Full Spectrum Collagen provides whole body results: Type I - Skin elasticity Type II - Joints and immune system Type III - Skin, blood vessels, vital organs Type IV - Cell, health and growth Type V - Skin, tendons and immune system Type X - Joints, bones, muscles and hair

LCHF

Gluten Free NON-GMO

Natural collagen Excellent source of protein Preferred peptide form Easy to digest

Zero carbs

Product independently tested for purity, quality and potency Manufactured in independently certified GMP facilities

Free from carbohydrates of all sources

Notice: This product is sold by weight, not volume, therefore settling of contents may occur during shipping and handling.

Free from artificial colors and preservatives. Does not contain milk, crustacean shellfish, tree nut, peanut, wheat or soybean allergens.

High-quality collagen protein is naturally free from the essential amino acid tryptophan and therefore has no % daily value.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Add 1 heaping scoop (11g) or 2 heaping scoops (22g) of KetoLiving Natural Collagen powder to 8 fl. oz. of any liquid or recipe of your choice.

Precautions

Contains egg and fish.

Not to be used as the sole source of dietary calories or protein.

Keep out of reach of children.

Storage

Keep tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Collagen Natural Clean Flavor by NaturesPlus Keto Living label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Collagen Natural Clean Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Collagen Natural Clean Flavor by NaturesPlus Keto Living

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size11 Gram(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
40 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Protein

20 Gram(s) per serving

Hydrolyzed Collagen

No known
interactions
20 Gram(s) per serving Form: cage-free Chicken, Eggshell Membrane, grass-fed Beef, wild-caught Fish

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...

Hydrolyzed Collagen monograph & interactions

Collagen Enzyme

30 mg per serving
  • › Collagen Boosting Enzyme Blend
Interaction report

Collagen Natural Clean Flavor by NaturesPlus Keto Living Drug Interactions

Want to check YOUR meds against Collagen Natural Clean Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
322Drugs
322 Moderate

Ingredients driving the most interactions

Sodium 205

Individual Drug Interactions

The ingredients in Collagen Natural Clean Flavor interact with 322 drugs. Click any drug to see the details.

1 of the 4 ingredients in Collagen Natural Clean Flavor interact with drugs. Each result below shows which ingredient is responsible. Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Collagen Natural Clean Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Collagen Natural Clean Flavor, from the product label.

NaturesPlus Keto Living

See all NaturesPlus Keto Living products
Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Collagen Natural Clean Flavor by NaturesPlus Keto Living: Common Questions

Does Collagen Natural Clean Flavor by NaturesPlus Keto Living interact with any medications?
Yes. Based on its ingredients, Collagen Natural Clean Flavor has a known interaction with 322 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Collagen Natural Clean Flavor contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my joint pain or arthritis?
The evidence we hold doesn't cover joint or arthritis use. The data shows hydrolyzed collagen is possibly effective for aging skin and dry skin, but we can't speak to joints. That's a conversation for your doctor.
Is it safe to take while I'm pregnant?
The safety data is mixed and incomplete. Serrapeptase is best avoided in pregnancy — there isn't enough safety data. For hydrolyzed collagen and proteases, the data during pregnancy isn't well studied, so talk with your doctor before using. Sodium safety in pregnancy shows conflicting ratings, so that also needs a chat with your provider.
Can I take this while breastfeeding?
There's little safety data for any of these ingredients during breastfeeding. Serrapeptase has no reliable safety information while nursing, so it's best avoided. For the others, caution is advised — talk with your doctor or pharmacist before starting.
What does serrapeptase actually do in this product?
Serrapeptase is an enzyme that breaks down protein. We don't have strong evidence that it works for the conditions it's used for — chronic bronchitis, asthma, back pain, and others all show insufficient evidence. It's in here, but the proof it works is thin.
Is there a lot of sodium in this powder?
The product facts don't tell us how much sodium per serving, so I can't say whether it's a big dose or a small one. If you're watching your sodium intake — because of blood pressure, heart disease, or kidney issues — ask your pharmacist to check the label with you.
What are the side effects I might notice?
Most people tolerate this well. The most likely mild effects are from serrapeptase and collagen: stomach pain, nausea, digestive upset, indigestion, diarrhea, or bloating. Proteases rarely cause allergic reactions. These are uncommon, but if you notice them, stop and reach out to us.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Collagen Natural Clean Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Collagen Natural Clean Flavor label
Go deeper

The Full Monographs Behind Collagen Natural Clean Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph →
Sources

Sources & How We Checked

Collagen Natural Clean Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 45 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Collagen Peptides 2 references
  1. Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8. PubMed
  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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