Interactions on record — worth a quick check against your medications. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Collagen Peptides 13 in 1 Collagen Advanced Complex Ingredients & Drug Interactions

by KAPPA NUTRITION

Collagen Peptides 13 in 1 Collagen Advanced Complex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Collagen Peptides 13 in 1 Collagen Advanced Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Collagen Peptides 13 in 1 Collagen Advanced Complex is a dietary supplement by KAPPA NUTRITION with 8 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 386 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin C, Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Collagen Peptides 13 in 1 Collagen Advanced Complex by KAPPA NUTRITION

Ask about any prescription or over-the-counter medication and we check it for interactions with Collagen Peptides 13 in 1 Collagen Advanced Complex by KAPPA NUTRITION — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Collagen Peptides 13 in 1 Collagen Advanced Complex by KAPPA NUTRITION

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 13 active ingredients.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (25 mg) without saying how much of each component you get.
  • “Collagen Advanced Complex” is a proprietary blend — the label gives one combined amount (2,050 mg) without saying how much of each component you get.

This product contains 13 active ingredients. Three are hydrolyzed collagen peptides — from chicken, fish, and beef — that break down into amino acids your body can absorb more easily.

You also get biotin (a B vitamin), vitamin C, hyaluronic acid, and a probiotic blend with five live bacterial strains: Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus casei, and Bacillus coagulans. The product also includes medium chain triglyceride oil as a carrier.

The only inactive ingredient on file is cellulose, a plant-based binder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Skin, hair, nail, and joint health.
  • We looked for evidence on: Aging skin, Atrophic acne scars, Brittle nails, Dry skin, Exercise-induced muscle damage, Exercise-induced muscle soreness — and 3 related terms.
  • The strongest evidence on file: Collagen Peptides is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Collagen Peptides is rated "Possibly Effective" for Dry skin.
  • Also on file: Biotin is rated "Insufficient Reliable Evidence To Rate" for Brittle nails.

The collagen peptides in this formula are possibly effective for aging skin and dry skin based on available evidence; they're not shown to help muscle strength. Biotin is effective for biotin deficiency, but evidence rates it possibly ineffective for multiple sclerosis and seborrheic dermatitis.

Vitamin C is effective for vitamin C deficiency and possibly effective for anemia, atrial fibrillation, cataracts, and exercise-induced respiratory infections. The probiotic strains have mixed ratings — they're possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis, but possibly ineffective for atopic disease.

Hyaluronic acid is possibly effective for dry eye and venous leg ulcers.

The evidence, ingredient by ingredient Biotin Vitamin C Lactobacillus Acidophilus Bacillus Coagulans Hyaluronic Acid Collagen Peptides

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Biotin is generally well tolerated at normal and even fairly high doses because your body excretes excess amounts in urine; high-dose biotin rarely causes mild diarrhea. Vitamin C is safe at normal dietary amounts, but very high doses (above 2 grams daily) can cause abdominal cramps, heartburn, diarrhea, nausea, and kidney stones in people prone to them.

Lactobacillus acidophilus and Bacillus coagulans are generally well tolerated in healthy adults, though rare gastrointestinal side effects like bloating and flatulence can occur. The collagen peptides are generally well tolerated as a dietary protein, with nausea, indigestion, diarrhea, and gas being rare.

Hyaluronic acid appears well tolerated, though long-term safety data for oral supplements is limited. Data on most of these ingredients during pregnancy and breastfeeding is either limited or not well studied — discuss use with your doctor or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Biotin Vitamin C Lactobacillus Acidophilus Bacillus Coagulans Hyaluronic Acid Collagen Peptides

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 6 matched ingredients can interact with medications — Lactobacillus Acidophilus, Vitamin C, Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments.
  • For scale: 386 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take warfarin or other blood thinners (vitamin C can reduce effectiveness at high doses); estrogens in birth control or hormone replacement therapy (vitamin C may raise levels); chemotherapy drugs, especially alkylating agents and antitumor antibiotics (vitamin C's antioxidant effects may lower drug activity); antipsychotics like fluphenazine; HIV medications like indinavir; levothyroxine (thyroid medication); or any antibiotics (the probiotics may lose effectiveness if taken at the same time). These are all Moderate-severity interactions documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient supplement targeting skin, joint, and gut health with collagen, probiotics, and supporting vitamins. If you take warfarin, estrogen-based birth control, hormone therapy, chemotherapy, thyroid medication, or antibiotics, check your specific medications with us first — vitamin C and the probiotics have documented interactions that matter.

Talk with your pharmacist before starting, especially if you're pregnant, nursing, or have kidney problems.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Collagen Peptides 13 in 1 Collagen Advanced Complex, straight from the product label.

Brand KAPPA NUTRITION
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 286855
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Collagen Peptides 13 in 1 Collagen Advanced Complex by KAPPA NUTRITION, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
IngredientAmount% DV
Biotin10000 mcg33333%
Vitamin C90 mg100%
Lactobacillus acidophilus0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus paracasei0 NP--
Medium Chain Triglyceride Oil45 mg--
Lactobacillus casei0 NP--
Bacillus coagulans0 NP--
Probiotic Blend25 mg--
Lactobacillus rhamnosus0 NP--
Hyaluronic Acid80 mg--
Collagen Advanced Complex2050 mg--
Collagen Peptides Type I, Hydrolyzed0 NP--
Chicken Collagen Peptides Type II, Hydrolyzed0 NP--
Fish Collagen Peptides Type III, Hydrolyzed0 NP--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Why Collagen Peptides 13 in 1 Collagen Advanced Complex Is Better And More Bioavailable? Our commitment to exceptional quality. Is to create the perfect balance and superior supplements through the latest technologies, and the purest nutrients nature has to offer to us. Our compromise is to improve the health of those that trust our superior quality supplements to enhance their lives. Integrity and quality steer everything we make, and our commitment to our customers is to produce the highest advanced quality nutritional supplements out there. Collagen is a protein responsible for healthy joints and skin elasticity or stretchiness. It's in your bones, muscles, and blood, comprising three-quarters of your skin and a third of the protein in your body. As you age, your existing collagen breaks down, and it gets harder for your body to produce more. That is why it exists collagen peptides 13 in 1 collagen advanced complex.

Halal Food Premium

Kosher

Hydrolyzed Type I Hydrolyzed Type II Hydrolyzed Type III Lactobacillus rhamnosus Lactobacillus plantarum Lactobacillus casei Lactobacillus acidophilus Lactobacillus paracasei Bacillus coagulans MCT Oil Biotin Hyaluronic Acid Vitamin C 6 Billion Probiotics

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Formulation

Made in USA using Globally Sourced ingredients.

Non GMO Verified Gluten Free

Seals/Symbols

GMP Good Manufacturing Practice Halal Food Premium Third Party Tested Kosher

General Statements

Premium Product 100% Best Quality Guaranteed For Professional Use

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults, as a dietary supplement, take (4) capsules a day with a meal or as directed by a healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Collagen Peptides 13 in 1 Collagen Advanced Complex by KAPPA NUTRITION label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Collagen Peptides 13 in 1 Collagen Advanced Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Collagen Peptides 13 in 1 Collagen Advanced Complex by KAPPA NUTRITION

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
10000 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Vitamin C

Interacts with
207 drugs
90 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Medium Chain Triglyceride Oil

45 mg per serving

Probiotic Blend

Interacts with
182 drugs
25 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions

Hyaluronic Acid

No known
interactions
80 mg per serving Form: Sodium Hyaluronate

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Collagen Peptides 13 in 1 Collagen Advanced Complex by KAPPA NUTRITION Drug Interactions

Want to check YOUR meds against Collagen Peptides 13 in 1 Collagen Advanced Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
386Drugs
280 Moderate 106 Minor

Ingredients driving the most interactions

Vitamin C 207
Probiotic Blend 182

Individual Drug Interactions

The ingredients in Collagen Peptides 13 in 1 Collagen Advanced Complex interact with 386 drugs. Click any drug to see the details.

2 of the 8 ingredients in Collagen Peptides 13 in 1 Collagen Advanced Complex interact with drugs. Each result below shows which ingredient is responsible. Vitamin C Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Collagen Peptides 13 in 1 Collagen Advanced Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Collagen Peptides 13 in 1 Collagen Advanced Complex, from the product label.

KAPPA NUTRITION

See all KAPPA NUTRITION products
Name
Kappa Nutrition
Street Address
122 Rose Ln, Ste H4
City
Frisco
State
Tx
ZipCode
75036
Web Address
www.kappanutrition.com
Pharmacist Counseling Corner

Collagen Peptides 13 in 1 Collagen Advanced Complex by KAPPA NUTRITION: Common Questions

Does Collagen Peptides 13 in 1 Collagen Advanced Complex by KAPPA NUTRITION interact with any medications?
Yes. Based on its ingredients, Collagen Peptides 13 in 1 Collagen Advanced Complex has a known interaction with 386 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Collagen Peptides 13 in 1 Collagen Advanced Complex contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my skin and hair?
The collagen peptides and biotin are possibly effective for aging skin and dry skin. Biotin has insufficient evidence for alopecia (hair loss), so we can't say whether it'll help your hair. The evidence is mixed — talk with your pharmacist about what you're hoping to improve.
What do the probiotics in here do?
The five live probiotic strains are possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. They're generally well tolerated, though bloating and gas can rarely occur. If you take antibiotics, separate the timing — antibiotics can kill off the live organisms.
Is it safe if I'm pregnant?
Data on most of these ingredients during pregnancy is limited or not well studied. Biotin from food and prenatal vitamins is fine, but discuss high-dose supplements with your doctor. The collagen peptides and hyaluronic acid aren't well studied in pregnancy either. Check with your doctor or pharmacist before starting.
Can I take this with my birth control?
The vitamin C in this product may raise estrogen levels from birth control, which could increase side effects or change how well it works. Talk with your pharmacist to make sure the dose here won't cause problems with your specific medication.
What about side effects?
Most ingredients are generally well tolerated. Rare side effects include mild diarrhea or gastrointestinal discomfort (nausea, gas, bloating). Very high doses of vitamin C can cause abdominal cramps and diarrhea. If you develop new symptoms, stop and talk with your pharmacist.
Will this work better with antibiotics?
No — if you take antibiotics at the same time as this product, they'll kill off the live probiotic organisms and reduce the benefit. Separate them by a few hours or ask your pharmacist about the best timing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Collagen Peptides 13 in 1 Collagen Advanced Complex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Collagen Peptides 13 in 1 Collagen Advanced Complex label
Go deeper

The Full Monographs Behind Collagen Peptides 13 in 1 Collagen Advanced Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph →
Sources

Sources & How We Checked

Collagen Peptides 13 in 1 Collagen Advanced Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 96 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Vitamin C 51 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516.
  3. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
  4. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  5. Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevent
  6. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. PubMed
  7. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  8. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  9. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
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Lactobacillus Acidophilus 15 references
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See these in context on the Lactobacillus Acidophilus monograph →

Bacillus Coagulans 20 references
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See these in context on the Bacillus Coagulans monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
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  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Collagen Peptides 2 references
  1. Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8. PubMed
  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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