Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Collagen Peptides Unflavored Ingredients & Drug Interactions

by Physician's Choice

Collagen Peptides Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Collagen Peptides Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Collagen Peptides Unflavored is a dietary supplement by Physician's Choice with 8 active ingredients. Its ingredients are commonly taken for skin health and wrinkles, joint pain and osteoarthritis, bone health.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L. acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Collagen Peptides Unflavored by Physician's Choice

Ask about any prescription or over-the-counter medication and we check it for interactions with Collagen Peptides Unflavored by Physician's Choice — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Collagen Peptides Unflavored by Physician's Choice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “DigeSEB Digestive Enzyme Blend” is a proprietary blend — the label gives one combined amount (50 mg) without saying how much of each component you get.

This powder contains 7 active ingredients working together as digestive enzymes and a collagen supplement. Hydrolyzed collagen is the main structural ingredient — it's collagen that's been broken down into small peptides your body can absorb easily.

The enzyme blend includes lipase (breaks down fats), lactase (breaks down milk sugar), proteases (break down proteins), amylase, and cellulase, plus Lactobacillus acidophilus, a beneficial gut bacteria. There are no inactive fillers listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Collagen peptides with digestive enzyme support.
  • We looked for evidence on: Joint pain, Knee pain, Osteoarthritis, Exercise-induced muscle damage, Exercise-induced muscle soreness, Muscle strength — and 4 related terms.
  • The closest evidence on file: Collagen Peptides is rated "Possibly Ineffective" for Muscle strength (Natural Medicines).
  • Also on file: Collagen Peptides is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Osteoarthritis, Knee pain, Wound healing, and more.

Hydrolyzed collagen is possibly effective for aging skin and dry skin, though the evidence isn't complete. For muscle strength, the data suggests it's likely ineffective.

L. acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection — though again, evidence is incomplete for all of these. Lactase is effective for lactose intolerance.

For the other enzymes and most other uses, we either don't have effectiveness data or the evidence is too limited to rate.

The evidence, ingredient by ingredient Collagen Peptides Lipase Lactase Lactobacillus Acidophilus Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hydrolyzed collagen is generally well tolerated, with nausea, indigestion, diarrhea, and gas being rare. L. acidophilus is also generally well tolerated in healthy adults and children, though it may rarely cause mild gut discomfort like bloating or diarrhea when combined with other probiotics.

Lactase is generally well tolerated and likely safe during pregnancy. For proteases, there's limited safety data in pregnancy, so check with your doctor first.

Lipase has little safety data in pregnancy and while breastfeeding, so ask your healthcare provider. L. acidophilus is possibly safe during pregnancy but data during breastfeeding are limited.

Side effects, ingredient by ingredient Collagen Peptides Lipase Lactase Lactobacillus Acidophilus Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 5 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antibiotic drugs with us before you take this product — Lactobacillus acidophilus can reduce their effectiveness if taken at the same time. The other ingredients we hold data for have no documented interactions, but we couldn't check amylase or cellulase.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is a straightforward digestive enzyme and collagen powder suitable for most adults looking to support digestion and skin health. If you take antibiotics, you'll want to space them apart from the L. acidophilus.

If you're pregnant or breastfeeding, talk to your doctor about the ingredients — safety data are limited for several of them. Run your medications through the checker before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Collagen Peptides Unflavored, straight from the product label.

Brand Physician's Choice
Barcode (UPC) 854226008063
Net contents 246 Gram(s); 0.54 lbs
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 259011
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Collagen Peptides Unflavored by Physician's Choice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Gram(s)
Maximum serving Sizes:
7 Gram(s)
Servings per container
35
UPC/BARCODE
854226008063
IngredientAmount% DV
Calories25 Calorie(s)--
Protein6 Gram(s)--
Amylase0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
L. acidophilus0 NP--
Proteases0 NP--
Hydrolyzed Collagen7 Gram(s)--
DigeSEB Digestive Enzyme Blend50 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

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Formulation

Professional Grade

Manufactured in the USA From imported and domestic ingredients

Hormone Free

Formulated to Support Hair, Nails, Skin, Bones

We guarantee our supplements for potency and purity

Post Workout & Recovery

Grass Fed Pasture Raised

Seals/Symbols

GMP Good Manufacturing Practice Sourced from a certified facility

3rd Party Tested

Manufactured in the USA Imported and domestic ingredients

Formula

DigeSEB is a digestive enzyme blend that breaks down proteins for improved absorption.

Keto Approved

DigeSEB for Enhanced Absorption

Suggested/Recommended/Usage/Directions

Suggested Use: Take one scoop and mix in liquid water or beverage. Stir and enjoy. Repeat daily. Mixes well with coffee, smoothies, recipes

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

To report a serious adverse event, call 1-877-395-2707

Storage

Store in a cool, dry place

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

DigeSEB is a registered trademark of Specialty Enzymes and Biotechnologies.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Collagen Peptides Unflavored by Physician's Choice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Collagen Peptides Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Collagen Peptides Unflavored by Physician's Choice

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Gram(s) Dosage formPowder Servings per container35 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

6 Gram(s) per serving

Hydrolyzed Collagen

No known
interactions
7 Gram(s) per serving

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...

Hydrolyzed Collagen monograph & interactions

DigeSEB Digestive Enzyme Blend

50 mg per serving
Interaction report

Collagen Peptides Unflavored by Physician's Choice Drug Interactions

Want to check YOUR meds against Collagen Peptides Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

L. acidophilus 182

Individual Drug Interactions

The ingredients in Collagen Peptides Unflavored interact with 182 drugs. Click any drug to see the details.

1 of the 8 ingredients in Collagen Peptides Unflavored interact with drugs. Each result below shows which ingredient is responsible. L. acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Collagen Peptides Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L. acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Collagen Peptides Unflavored, from the product label.

Physician's Choice

See all Physician's Choice products
Name
Physician's Choice JB7, LLC
Street Address
12365 Huron St. #1800
City
Westminster
State
CO
ZipCode
80234
Phone Number
1-877-395-2707
Pharmacist Counseling Corner

Collagen Peptides Unflavored by Physician's Choice: Common Questions

Does Collagen Peptides Unflavored by Physician's Choice interact with any medications?
Yes. Based on its ingredients, Collagen Peptides Unflavored has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Collagen Peptides Unflavored contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this work for digestive issues?
It depends on the issue. L. acidophilus is possibly effective for antibiotic-associated diarrhea and irritable bowel syndrome. The enzymes — lipase, lactase, and proteases — are designed to break down food, but we don't have strong evidence they work for specific digestive conditions. Talk to your pharmacist about whether this fits your situation.
Will this help my skin?
Hydrolyzed collagen is possibly effective for aging skin and dry skin, so it may help with those concerns. However, the evidence isn't definitive, and results vary from person to person.
Is lactase in here because of dairy?
Yes. Lactase breaks down lactose, the sugar in milk and dairy products. If you're lactose intolerant, this ingredient can help you digest dairy without discomfort.
Can I take this while I'm on antibiotics?
You can, but not at the same time. The antibiotics will kill the live L. acidophilus bacteria in this product, making it ineffective. Ask your pharmacist how far apart to space them — usually a few hours is enough.
Is it safe during pregnancy?
Safety data are limited for most of the ingredients here. Lactase is likely safe, but lipase, proteases, and L. acidophilus don't have enough pregnancy data to be sure. Check with your doctor before using during pregnancy.
What are these enzymes supposed to do?
Lipase breaks down fats, lactase breaks down milk sugar, and proteases break down proteins — all to help your digestive system process food more easily. Amylase breaks down starches, and cellulase breaks down fiber.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Collagen Peptides Unflavored is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Collagen Peptides Unflavored label
Go deeper

The Full Monographs Behind Collagen Peptides Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Collagen Peptides

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is still developing and results vary. They...

Read the full Collagen Peptides monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Collagen Peptides Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Collagen Peptides 2 references
  1. Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8. PubMed
  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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