Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Colon Cleanser Ingredients & Drug Interactions

by Nature's Measure

Colon Cleanser label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Colon Cleanser against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Colon Cleanser is a dietary supplement by Nature's Measure with 3 active ingredients. Its ingredients are commonly taken for diarrhea relief, constipation and digestive health, cholesterol support.Based on those ingredients, 23 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Apple Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Colon Cleanser by Nature's Measure

Ask about any prescription or over-the-counter medication and we check it for interactions with Colon Cleanser by Nature's Measure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Colon Cleanser by Nature's Measure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Nature's Measure Colon Cleanser contains three active ingredients. Apple pectin is a soluble fiber derived from apples; psyllium is a plant-based fiber that absorbs water in your digestive tract; and bentonite is a mineral clay sometimes used in cleanse products.

The product also contains several inactive ingredients — whey, silica, croscarmellose sodium, stearic acid, and magnesium stearate — which are fillers, binders, and processing aids.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Pectin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Gently supports healthy colon function.
  • We looked for evidence on: Diarrhea, Irritable bowel syndrome (IBS), Constipation, Bowel regularity.
  • The closest evidence on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Irritable bowel syndrome (IBS).

Apple pectin in this product is rated possibly effective for high cholesterol (hypercholesterolemia). For other uses like blood-sugar control (prediabetes) or radiation exposure, the evidence we have is insufficient to know whether it works.

The effectiveness data for bentonite and psyllium isn't on file here, so we can't speak to what the science shows for those ingredients in this product.

The evidence, ingredient by ingredient Pectin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Apple pectin is generally well tolerated at typical supplement doses. The most common side effects are digestive — diarrhea, gas, loose stools, and mild cramps.

Allergic reactions, including severe ones like anaphylaxis, are rare but have been reported in people sensitive to pectin. If you have a history of oral allergies or asthma, let your pharmacist know before starting.

For pregnancy, pectin at dietary amounts is likely safe, though concentrated supplements haven't been well studied — talk with your doctor. Breastfeeding safety hasn't been well studied either, so the same advice applies.

We don't have safety data on file for bentonite or psyllium.

Side effects, ingredient by ingredient Pectin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pectin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 23 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Nature's Measure Colon Cleanser, check your medications against these drug types: digoxin (a heart medication) — apple pectin may reduce its absorption, tetracycline antibiotics, and lovastatin or other cholesterol-lowering statins, all Moderate-severity concerns. Use the medication checker on this page to see if any of your prescriptions are affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take digoxin, a statin like lovastatin, or a tetracycline antibiotic, you'll want to check with your pharmacist before trying this product — apple pectin can interfere with how your body absorbs these drugs. For others, the main thing to watch for is digestive upset.

A quick medication check on this page before you start is your best move.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Colon Cleanser, straight from the product label.

Brand Nature's Measure
Barcode (UPC) 311845345882
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25882
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Colon Cleanser by Nature's Measure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
311845345882
IngredientAmount% DV
Bentonite25 mg--
Psyllium125 mg--
Apple Pectin60 mg--

Other ingredients: Whey, Silica, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

QUALITY GUARANTEED This product has been manufactured and packaged in strict conformance with industry and government standards.

Gently supports healthy colon function

N

MADE IN USA

Precautions

FOIL -TAMPER RESISTANT SEAL If printed heat induced seal appears to be tampered with, do not use product.

Warnings: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Keep Out of the Reach of Children.

ALLERGEN CERTIFICATION Contains milk (dairy), may contain soy, wheat, gluten, tree nuts and/or peanuts.

Discontinue use and consult your doctor if any adverse reactions occur.

Suggested/Recommended/Usage/Directions

Directions: Adults, take one tablet daily as a dietary supplement, preferably with a meal.

Storage

Store in a dry, controlled room environment.

FDA Statement of Identity

Dietary Supplement

Formulation

GUARANTEED NO ADDED: Yeast, egg, fragrance, artificial colors or flavors and preservatives.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

Product #11271

Formula

ALLERGEN CERTIFICATION Contains milk (dairy), may contain soy, wheat, gluten, tree nuts and/or peanuts.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Colon Cleanser by Nature's Measure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Colon Cleanser label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Colon Cleanser by Nature's Measure

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bentonite

25 mg per serving

Psyllium

125 mg per serving

Apple Pectin

Interacts with
23 drugs
60 mg per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Apple Pectin monograph & interactions

Other (inactive) ingredients: Whey, Silica, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Colon Cleanser by Nature's Measure Drug Interactions

Want to check YOUR meds against Colon Cleanser?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
23Drugs
23 Moderate

Ingredients driving the most interactions

Apple Pectin 23

Individual Drug Interactions

The ingredients in Colon Cleanser interact with 23 drugs. Click any drug to see the details.

1 of the 3 ingredients in Colon Cleanser interact with drugs. Each result below shows which ingredient is responsible. Apple Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in Colon Cleanser with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Apple Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Apple Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Colon Cleanser, from the product label.

Nature's Measure

See all Nature's Measure products
Name
GREENBRIER INTERNATIONAL, INC.
City
CHESAPEAKE
State
VA
ZipCode
23320
Pharmacist Counseling Corner

Colon Cleanser by Nature's Measure: Common Questions

Does Colon Cleanser by Nature's Measure interact with any medications?
Yes. Based on its ingredients, Colon Cleanser has a known interaction with 23 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Colon Cleanser contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interfere with my digoxin or heart medication?
Yes — if you take digoxin (Lanoxin), apple pectin in this product may reduce how much your body absorbs, which could make it less effective. This is a Moderate concern. Check your exact medications with the tool on this page, and talk to your pharmacist or doctor before starting.
Can I take this if I'm on an antibiotic?
If your antibiotic is a tetracycline type (like doxycycline or minocycline), apple pectin may interfere with how your body absorbs it, reducing its effectiveness. That's a Moderate interaction. Check with your pharmacist using the tool here before you start.
Is it safe to take while I'm pregnant or breastfeeding?
Apple pectin at typical dietary amounts is likely safe in pregnancy, but concentrated supplements haven't been well studied. The same goes for breastfeeding — the data is limited. Talk with your doctor or pharmacist about whether this product is right for you.
What side effects should I expect?
Most people tolerate apple pectin well. You might notice digestive effects like gas, loose stools, diarrhea, or mild cramps. Allergic reactions are rare but possible if you're sensitive to pectin. If you have a history of oral allergies, mention it to your pharmacist.
Does this actually work for high cholesterol?
Apple pectin in the product is rated possibly effective for high cholesterol, meaning there's some evidence it may help, but the research isn't conclusive yet. We don't have effectiveness data on file for the other two active ingredients.
What are bentonite and psyllium in this product?
Bentonite is a mineral clay, and psyllium is a plant-based fiber that absorbs water in your digestive tract — both are commonly used in cleanse products. We don't hold interaction or effectiveness data for them, so ask your pharmacist if you have questions specific to those ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Colon Cleanser is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Colon Cleanser label
Go deeper

The Full Monographs Behind Colon Cleanser’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph →
Sources

Sources & How We Checked

Colon Cleanser's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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