Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Connectivar Ingredients & Drug Interactions

by D'Adamo Personalized Nutrition

Connectivar label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Connectivar against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Connectivar is a dietary supplement by D'Adamo Personalized Nutrition with 4 active ingredients. Its ingredients are commonly taken for wound healing, varicose veins and poor circulation, anxiety and stress.Based on those ingredients, 738 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gotu Kola leaf extract, Butchers Broom Root Extract, Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Connectivar by D'Adamo Personalized Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Connectivar by D'Adamo Personalized Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Connectivar by D'Adamo Personalized Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Connectivar has four active ingredients. Gotu kola leaf extract is a plant used traditionally for circulation and wound healing.

Manganese is a mineral involved in bone health and metabolism. Butcher's broom root extract comes from a shrub and is used to support venous circulation — the blood vessels that carry blood back to your heart.

The fourth ingredient, rutin-hesperidin complex, is a combination of plant compounds; we hold no interaction data for it. The capsule also contains inactive ingredients: cellulose, magnesium citrate, L-leucine, and silica — these are fillers, binders, and processing aids.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support healthy connective tissue strength.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Varicose veins, Venous insufficiency, Wound healing, Scarring, Hypertrophic scars — and 4 related terms.
  • The strongest evidence on file: Manganese is rated "Effective" for Manganese deficiency (Natural Medicines).
  • Also on file: Butcher's Broom is rated "Possibly Effective" for Chronic venous insufficiency (CVI).
  • Also on file: Gotu Kola is rated "Possibly Effective" for Venous insufficiency.

For gotu kola, the evidence supports possibly effective use for venous insufficiency (sluggish circulation in the legs) and burns; it's rated possibly ineffective for radiation dermatitis and cognitive function. The data isn't established for Alzheimer disease or generalized anxiety disorder.

Manganese is effective for manganese deficiency itself but is rated insufficient evidence for hay fever, osteoporosis, COPD, obesity, and osteoarthritis. Butcher's broom is possibly effective for chronic venous insufficiency but has insufficient evidence for diabetic retinopathy, hemorrhoids, low blood pressure on standing, and lymphedema.

We don't have effectiveness data for the rutin-hesperidin complex in our system.

The evidence, ingredient by ingredient Gotu Kola Manganese Butcher's Broom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gotu kola is generally well tolerated short-term, but quality evidence on long-term safety is limited and liver damage has been reported — four case reports exist, though whether gotu kola was the cause isn't certain. The most common side effects are stomach irritation and nausea when taken by mouth, and eczema when applied to skin.

Avoid gotu kola during pregnancy (not enough safety data) and breastfeeding. Manganese at normal dietary doses is safe, but high-dose supplements can be harmful — there's concern that high doses might cause nerve damage including Parkinson-like symptoms, and one severe case of irreversible Parkinson disease linked to 100 mg daily has been reported.

Prenatal vitamins and food amounts are fine; avoid extra high-dose supplements unless a clinician advises it. Butcher's broom is generally well tolerated short-term but has limited long-term safety data.

Common side effects include diarrhea, indigestion, nausea, and vomiting. Avoid during pregnancy and breastfeeding due to insufficient safety information.

Side effects, ingredient by ingredient Gotu Kola Manganese Butcher's Broom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Manganese, Butcher's Broom, Gotu Kola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 739 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Connectivar, double-check with us if you're on CNS depressants (sedating drugs), hepatotoxic drugs (medications that stress the liver), antipsychotic drugs, quinolone or tetracycline antibiotics, or alpha-adrenergic drugs (blood-pressure medications and certain decongestants). Manganese may reduce how well some antibiotics work, and gotu kola may add to the sedating effects of calming drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Connectivar is aimed at supporting circulation and may help with venous insufficiency, but it comes with documented interactions across many medication types — most notably sedating drugs, antibiotics, blood-pressure medications, and antipsychotics. If you take any prescription medication, check it against our tool before starting.

Pregnant and breastfeeding individuals should avoid this product. Talk to your pharmacist about whether it's right for you and your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Connectivar, straight from the product label.

Brand D'Adamo Personalized Nutrition
Net contents 60 Veggiecap(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 287131
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Connectivar by D'Adamo Personalized Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Gotu Kola leaf extract30 mg--
Manganese3 mg150%
Butchers Broom Root Extract100 mg--
Rutin-Hesperidin Complex50 mg--

Other ingredients: Cellulose, Magnesium Citrate, L-Leucine, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Genoma Nutritionals All Types

Helps support healthy connective tissue

Stearate free encapsulation

Connectivar was designed by Dr. Peter D'Adamo to help maintain blood vessel, capillary, and ligament strength.

This 100% vegetarian product contains no sugar, salt, gluten, wheat, yeast, corn, soy, eggs or dairy, no preservatives, color or flavors, and no artificial ingredients.

This 100% vegetarian product contains no sugar, salt, gluten, wheat, yeast, corn, soy, eggs or dairy, no preservatives, color or flavors, and no artificial ingredients.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: 1 (One) capsule 1-2 times daily or as directed by physician

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Connectivar by D'Adamo Personalized Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Connectivar label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Connectivar by D'Adamo Personalized Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gotu Kola leaf extract

Interacts with
579 drugs
30 mg per serving Form: Asiaticosides

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporti...

Gotu Kola leaf extract monograph & interactions

Manganese

Interacts with
83 drugs
3 mg per serving Form: Manganese Picolinate

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Butchers Broom Root Extract

Interacts with
158 drugs
100 mg per serving Form: Ruscus aculeatus Root Extract

Butcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some evidence sug...

Butchers Broom Root Extract monograph & interactions

Rutin-Hesperidin Complex

50 mg per serving

Other (inactive) ingredients: Cellulose, Magnesium Citrate, L-Leucine, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Connectivar by D'Adamo Personalized Nutrition Drug Interactions

Want to check YOUR meds against Connectivar?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
738Drugs
738 Moderate

Ingredients driving the most interactions

Gotu Kola leaf extract 579
Butchers Broom Root Extract 158
Manganese 83

Individual Drug Interactions

The ingredients in Connectivar interact with 738 drugs. Click any drug to see the details.

3 of the 4 ingredients in Connectivar interact with drugs. Each result below shows which ingredient is responsible. Gotu Kola leaf extract Butchers Broom Root Extract Manganese

Each ingredient & the kinds of drugs it affects

For each ingredient in Connectivar with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gotu Kola leaf extract2 drug types · 579 drugs

Cns Depressants

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.

Likelihood Possible Evidence D
Gotu Kola leaf extract full monograph & interactions

Butchers Broom Root Extract2 drug types · 158 drugs

Alpha-Adrenergic Agonists

Theoretically, butcher's broom might increase the effects and adverse effects of alpha-adrenergic agonists.
Animal and in vitro studies show that butcher's broom has alpha-adrenergic agonist effects.

Likelihood Possible Evidence D
Alpha-Adrenergic Antagonists

Theoretically, butcher's broom might reduce the effects of alpha-adrenergic antagonists.
Animal and in vitro studies show that butcher's broom has alpha-adrenergic agonist effects.

Likelihood Possible Evidence D
Butchers Broom Root Extract full monograph & interactions

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Connectivar, from the product label.

D'Adamo Personalized Nutrition

See all D'Adamo Personalized Nutrition products
Name
North American Pharmacal, Inc.
Street Address
213 Danbury Road
City
Wilton
State
CT
ZipCode
06897
Phone Number
1-877-226-8973
Web Address
www.4yourtype.com
Pharmacist Counseling Corner

Connectivar by D'Adamo Personalized Nutrition: Common Questions

Does Connectivar by D'Adamo Personalized Nutrition interact with any medications?
Yes. Based on its ingredients, Connectivar has a known interaction with 738 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Connectivar contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Connectivar if I'm pregnant or breastfeeding?
No. Gotu kola should be avoided during pregnancy (not enough safety data) and breastfeeding (safety is unknown). Butcher's broom also hasn't been studied enough in pregnancy and should be avoided while breastfeeding. Talk to your doctor or pharmacist for guidance during these times.
What are the most common side effects?
Gotu kola may cause stomach irritation and nausea when taken by mouth. Butcher's broom can cause diarrhea, indigestion, nausea, vomiting, and heartburn. Both are generally well tolerated short-term in most people.
Will this help with my varicose veins or poor circulation?
Gotu kola and butcher's broom are both rated possibly effective for chronic venous insufficiency (sluggish circulation in the legs). The evidence supports their use for this purpose, though results vary by person.
Is the manganese in this safe?
Yes, at the typical dietary amount in a supplement like this. The concern is with high-dose manganese supplements taken over long periods, which can cause nerve damage. Normal amounts in food and standard supplements are fine, but avoid extra-high-dose manganese unless your doctor says to take it.
What is gotu kola used for?
Gotu kola is a plant traditionally used to support circulation and wound healing. In this product, it's meant to support venous health — the blood vessels that carry blood back to your heart.
Does this product have any fillers?
Yes. The inactive ingredients are cellulose, magnesium citrate, L-leucine, and silica — these are standard binders and processing aids.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Connectivar is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Connectivar label
Go deeper

The Full Monographs Behind Connectivar’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gotu Kola

Interacts with 579 drugs

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...

Read the full Gotu Kola monograph → Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph → Herb & supplement monograph

Butcher's Broom

Interacts with 158 drugs

Butcher's broom is a plant extract most often used for circulation problems in the legs, such as chronic venous insufficiency, where some evidence suggests it may help reduce swelling and di...

Read the full Butcher's Broom monograph →
Sources

Sources & How We Checked

Connectivar's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 47 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gotu Kola 18 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  4. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
  5. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
  6. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  7. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI
  8. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed
  9. Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. PubMed
  10. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
  11. Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  12. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
  13. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
  14. Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. PubMed
  15. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.
  16. Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201.
  17. Bilbao, I., Aguirre, A., Zabala, R., Gonzalez, R., Raton, J., and Diaz Perez, J. L. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33(6):435-436.
  18. Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. PubMed

See these in context on the Gotu Kola monograph →

Manganese 21 references
  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  2. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
  3. Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  5. Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
  6. Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
  7. McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
  8. Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
  9. Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
  10. Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
  11. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
  12. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
  13. Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
  14. Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
  15. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
  16. Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. PubMed
  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
  21. Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed

See these in context on the Manganese monograph →

Butcher's Broom 8 references
  1. Beltramino R, Penenory A, Buceta AM. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Angiology 2000;51:535-44.. PubMed
  2. Redman DA. Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report. J Altern Complement Med 2000;6:539-49..
  3. Landa, N., Aguirre, A., Goday, J., Raton, J. A., and Diaz-Perez, J. L. Allergic contact dermatitis from a vasoconstrictor cream. Contact Dermatitis 1990;22(5):290-291. PubMed
  4. Cluzan, R. V., Alliot, F., Ghabboun, S., and Pascot, M. Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT. Lymphology 1996;29(1):29-35.
  5. Parrado F, Buzzi A. A study of the efficacy and tolerability of a preparation containing Ruscus aculeatus in the treatment of chronic venous insufficiency of the lower limbs. Clin Drug Invest 1999;18(4):255-61. DOI
  6. Sadarmin PP, Timperley J. An unusual case of Butcher's Broom precipitating diabetic ketoacidosis. J Emerg Med 2013;45(3):e63-e65. PubMed
  7. Ramirez-Hernandez M, Garcia-Selles J, Merida-Fernandez C, Martinez-Escribano JA. Allergic contact dermatitis to ruscogenins. Contact Dermatitis 2006;54(1):60. PubMed
  8. European Medicines Agency. Assessment report on Ruscus Aculeatus L rhizome. EMEA/HMPC/261939/2007. London, September 4, 2008. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_assessment_report/2009/12/WC500018288.pdf. Acces

See these in context on the Butcher's Broom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team