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Dietary supplement

Corvalene Ribose Ingredients & Drug Interactions

by Douglas Laboratories

Corvalene Ribose label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Corvalene Ribose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Corvalene Ribose is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Corvalene Ribose by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Corvalene Ribose by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Corvalene Ribose by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Corvalene Ribose is a single-ingredient powder: D-ribose, a naturally occurring sugar your cells use to make energy. That's it — no fillers or other active ingredients.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Ribose product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“Energy and stamina support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for D-ribose is limited. For athletic performance and McArdle disease (a rare muscle disorder), it's rated possibly ineffective.

For restless legs syndrome, muscle soreness, congestive heart failure, and recovery after bypass surgery, we don't have enough reliable evidence to say whether it works or doesn't. If you're considering ribose for one of these reasons, talk with your doctor about whether the evidence supports a trial.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ribose is generally well tolerated for up to a month. The most common side effects from taking it by mouth are diarrhea, stomach discomfort, headache, nausea, and — importantly — low blood sugar.

A few people have reported anxiety, lightheadedness, or increased appetite; lowering the dose resolved these in some cases. Long-term safety hasn't been well studied.

During pregnancy and breastfeeding, there isn't enough safety information. Talk with your doctor or pharmacist before using ribose if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your insulin and any blood-sugar-lowering medications (antidiabetes drugs) before taking this product. Both can be affected with Moderate severity — ribose may increase the risk of dangerously low blood sugar when combined with them.

Use the medication checker below to review your prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ribose is a supplement some people take hoping to boost energy or athletic performance, but evidence for those uses is weak or absent. The main caution is low blood sugar — especially if you take insulin or diabetes medication.

If that's you, check your exact drugs before starting. Otherwise, chat with your pharmacist about whether ribose makes sense for what you're after.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Corvalene Ribose, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539036976
Net contents 10.18 Ounce(s); 288.6 Gram(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 317990
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Corvalene Ribose by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5.1 Gram(s)
Maximum serving Sizes:
5.1 Gram(s)
Servings per container
56
UPC/BARCODE
310539036976
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
D-Ribose5 Gram(s)--
Total Sugars5 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Normal dosage is 5 grams D-Ribose taken two times a day with the morning and evening meals. A third dose may be added at midday as needed, or as directed by your healthcare professional. Continued use is required to maintain the benefits of Corvalen.

Precautions

Warning: If you are pregnant, or nursing, or if you are taking prescription medication, consult your health professional before using this product.

Not for parenteral use, store at room temperature, avoid excess heat and moisture

Keep out of the reach of children.

Use only if safety seal is intact.

Brand IP Statement(s)

Protected by U.S. patents 6,159,942; 6,534,480; 6,218,366; 6,339,716; 6,703,370 and other U.S. and foreign patents issued and pending Copyright 2008 Bioenergy, Inc.

Storage

Not for parenteral use, store at room temperature, avoid excess heat and moisture

Store in a cool, dry place.

Packaged by weight, not volume. Settling may occur.

Formulation

Gluten-free, Non-GMO

Cellular energy

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Scan to learn about our manufacturing excellence

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Corvalene Ribose by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Corvalene Ribose label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Corvalene Ribose by Douglas Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5.1 Gram(s) Dosage formPowder Servings per container56 Amounts shown are per serving.

D-Ribose

Interacts with
86 drugs
5 Gram(s) per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions
Interaction report

Corvalene Ribose by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Corvalene Ribose?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in Corvalene Ribose interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Corvalene Ribose interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in Corvalene Ribose with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Corvalene Ribose, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
City
Sudbury
State
MA
ZipCode
01776
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Corvalene Ribose by Douglas Laboratories: Common Questions

Does Corvalene Ribose by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Corvalene Ribose has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Corvalene Ribose contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes or take insulin?
Not without talking to your doctor or pharmacist first. Ribose can lower blood sugar, and mixing it with insulin or diabetes medication raises the risk of your blood sugar dropping too low. Use the medication checker on this page for your exact drugs, then discuss the result with your pharmacist.
Will ribose help my muscle soreness or boost my athletic performance?
The evidence doesn't support it. Athletic performance is rated possibly ineffective, and for muscle soreness we simply don't have enough reliable evidence to say whether it works.
What are the most common side effects?
Diarrhea, stomach discomfort, headache, nausea, and low blood sugar are the main ones reported when taken by mouth. Some people also report anxiety or lightheadedness, but these resolved when the dose was lowered. Ribose is generally well tolerated for up to a month.
Is it safe to take ribose while I'm pregnant or breastfeeding?
No — there isn't enough safety information. It's best avoided during pregnancy and breastfeeding. Talk with your doctor or pharmacist about whether ribose is right for you in these situations.
What exactly is D-ribose?
It's a naturally occurring sugar your cells use to make energy. This product contains only that one ingredient — no fillers or added actives.
How long can I safely take ribose?
Ribose is generally well tolerated for up to one month in studies. Long-term safety hasn't been well studied, so talk with your pharmacist about how long it makes sense for you to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Corvalene Ribose is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Corvalene Ribose label
Go deeper

The Full Monographs Behind Corvalene Ribose’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

Corvalene Ribose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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