Cran-Diazyme Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cran-Diazyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cran-Diazyme is a dietary supplement by Dr. Wong's Essentials with 3 active ingredients. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cran-Diazyme by Dr. Wong's Essentials
Ask about any prescription or over-the-counter medication and we check it for interactions with Cran-Diazyme by Dr. Wong's Essentials — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cran-Diazyme by Dr. Wong's Essentials
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Cran-Diazyme has three active ingredients. Cranberry extract is included for urinary tract health.
The other two — serratiopeptidase and diastase — are enzymes. The product also contains inactive ingredients (gelatin capsule material, silicon dioxide, microcrystalline cellulose, carbomer, and magnesium stearate) that help hold it together and keep it stable.
Does it work?
Moderate evidence
Cranberry extract in this product is rated possibly effective for urinary tract infections (UTIs). That means there's decent evidence it may help, though it's not a proven cure — and it's not a substitute for antibiotics if you have a diagnosed infection.
For age-related cognitive decline, benign prostatic hyperplasia, cancer, nonalcoholic fatty liver disease, and chronic fatigue syndrome, the evidence isn't established well enough to rate. We don't hold effectiveness data on serratiopeptidase or diastase.
How safe is it?
Well-documented data
Cranberry is generally well tolerated when taken as a food or supplement. The most common side effects are diarrhea and stomach upset.
Very large doses — several liters of juice a day or high-dose supplements taken for weeks — raise the risk of nausea, vomiting, and gastrointestinal discomfort; one person reported skin redness and itching. Concentrated supplement doses haven't been studied as thoroughly as whole cranberry, so ask your doctor or pharmacist before starting if you have any concerns.
Cranberry is rated likely safe in pregnancy and lactation.
Meds to double-check
Moderate interaction found
Before taking Cran-Diazyme, check with your doctor or pharmacist if you take any drug that relies on the liver enzyme CYP3A4 (a very long list including many cholesterol and blood pressure medications), blood thinners like warfarin, or pain relievers like diclofenac. Cranberry extract may slow how your liver clears these drugs and raise their levels.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Cran-Diazyme might be worth considering if you're dealing with recurrent UTIs and want a possibly effective herbal option. If you take any prescription medication — especially cholesterol drugs, blood thinners, or blood pressure medicine — check with your doctor or pharmacist first, because cranberry can raise levels of several drugs.
A little stomach upset is normal, but if diarrhea or nausea becomes bothersome, dial it back or stop and talk it over with your provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cran-Diazyme, straight from the product label.
| Brand | Dr. Wong's Essentials |
|---|---|
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2019 |
| DSLD ID | 203931 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cran-Diazyme by Dr. Wong's Essentials, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 470 mg | -- |
| Serratiopeptidase | 0 NP | -- |
| Diastase | 0 NP | -- |
| Cranberry extract | 0 NP | -- |
Other ingredients: Gelatin, Silicon Dioxide, Microcrystalline Cellulose, Carbomer Homopolymer Type A, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, 1 capsule one to three times daily as needed or as directed by your health care provider.
Precautions
Keep out of the reach of children.
Tamper resistant package. Do not use if outer seal is missing.
Formulation
This product contains no gluten, milk, eggs, wheat, soybeans, peanuts, tree nuts, fish or shellfish.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
WAM Essentials, Inc. Fanning the winds of change
FDA Statement of Identity
A Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cran-Diazyme by Dr. Wong's Essentials label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cran-Diazyme by Dr. Wong's Essentials
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Serratiopeptidase
- › Diastase
- › Cranberry extract
Other (inactive) ingredients: Gelatin, Silicon Dioxide, Microcrystalline Cellulose, Carbomer Homopolymer Type A, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Cran-Diazyme by Dr. Wong's Essentials Drug Interactions
HelloPharmacist Interaction Report
Cran-Diazyme by Dr.
Wong's Essentials contains cranberry extract, which has documented interactions with several medication types. The most serious concern is with drugs that rely on a liver enzyme called CYP3A4 to break down — cranberry may slow that process and raise drug levels to potentially harmful amounts.
Atorvastatin (a cholesterol drug) is the best-studied example: one case reported severe muscle breakdown, upper back pain, and liver problems when a patient combined atorvastatin with large amounts of cranberry juice daily for two weeks.
Read the full breakdown — every affected drug type, severity by severity
Cranberry also interacts with blood thinners (warfarin), certain blood pressure medications (nifedipine), and a pain reliever (diclofenac). These are rated Moderate or Minor severity, meaning cranberry could theoretically boost their effects or side effects — though for some, the research is mixed.
We could not check two other ingredients in this product: serratiopeptidase and diastase. We hold no interaction data for them.
Altogether, these interactions span 713 individual medications. Before you start Cran-Diazyme, use the search tool on this page to check your exact medications, or talk it over with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cran-Diazyme?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cran-Diazyme interact with 712 drugs. Click any drug to see the details.
1 of the 3 ingredients in Cran-Diazyme interact with drugs. Each result below shows which ingredient is responsible. Cranberry extract
ApremilastOtezla
How Apremilast interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aprepitant interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Armodafinil interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Aspirin, Hydrocodone interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Extract + Aspirin, Omeprazole interactionAtazanavirReyataz
How Atazanavir interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Atazanavir interactionAtazanavir, CobicistatEvotaz
How Atazanavir, Cobicistat interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Atazanavir, Cobicistat interactionAtogepantQulipta
How Atogepant interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Atogepant interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Extract + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry Extract + Atorvastatin Calcium interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAvacopanTavneos
How Avacopan interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Avacopan interactionAvanafilStendra
How Avanafil interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Avanafil interactionAvapritinibAyvakit
How Avapritinib interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Avapritinib interactionAxitinibInlyta
How Axitinib interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Axitinib interactionAzelastine Hydrochloride, Fluticasone PropionateDymista
How Azelastine Hydrochloride, Fluticasone Propionate interacts with Cran-Diazyme — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Extract + Azelastine Hydrochloride, Fluticasone Propionate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cran-Diazyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry extract
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Cran-Diazyme, from the product label.
Dr. Wong's Essentials
See all Dr. Wong's Essentials products- Name
- WAM Essentials, Inc.
- Street Address
- 320 Grant Ave.
- City
- Strawn
- State
- TX
- ZipCode
- 76475
- Phone Number
- 1-866-268-3216
Cran-Diazyme by Dr. Wong's Essentials: Common Questions
Does Cran-Diazyme by Dr. Wong's Essentials interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does cranberry actually prevent or treat urinary tract infections?
What are the most common side effects of cranberry?
Is Cran-Diazyme safe during pregnancy or while breastfeeding?
What are serratiopeptidase and diastase supposed to do?
Can I take this if I'm on a cholesterol medication or blood thinner?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cran-Diazyme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cran-Diazyme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cran-Diazyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
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- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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