Cranberry Bladder Control Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cranberry Bladder Control against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cranberry Bladder Control is a dietary supplement by Whitaker Nutrition with 3 active ingredients. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 1,098 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Cranberry concentrate, Soy extract, Pumpkin extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cranberry Bladder Control by Whitaker Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with Cranberry Bladder Control by Whitaker Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cranberry Bladder Control by Whitaker Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product has 3 active ingredients. Pumpkin extract is included for urinary and bladder support, though it's possibly effective only for benign prostatic hyperplasia (an enlarged prostate in men); evidence for its other uses, including bladder or urinary tract health, is insufficient.
Soy extract provides isoflavones and has possibly effective evidence for diabetes, cholesterol, bone health, and blood pressure support. Cranberry concentrate is included for urinary tract function and is possibly effective for urinary tract infections; its evidence for other uses is insufficient.
The product also contains inactive ingredients — gelatin, magnesium stearate, and silica — which serve as the capsule and binding materials.
Does it work?
Moderate evidence
The evidence for this product's effectiveness depends on which condition you're considering. Cranberry concentrate is possibly effective for urinary tract infections.
Soy extract shows possibly effective evidence for diabetes, high cholesterol, osteoporosis, high blood pressure, and diarrhea. Pumpkin extract is possibly effective for benign prostatic hyperplasia (enlarged prostate).
For other uses — such as general bladder control, interstitial cystitis, or parasitic infections — the evidence in our data is insufficient to establish effectiveness.
How safe is it?
Well-documented data
Pumpkin extract is generally well tolerated when taken orally; the most common side effects are abdominal discomfort, diarrhea, nausea, and vomiting. Very rarely, anaphylaxis (severe allergic reaction) has been reported.
Soy is well tolerated and the most common side effects are bloating, constipation, diarrhea, and nausea; allergic reactions including skin rash and itching can occur in sensitive people. Cranberry concentrate is well tolerated; the most common side effects are diarrhea and gastrointestinal discomfort.
At very high doses, it can cause more significant stomach upset. For pregnancy, soy extract is rated likely safe, though one rating suggests it's possibly unsafe — talk with your doctor about what this means for your situation.
Cranberry concentrate is likely safe in pregnancy. Pumpkin supplement safety in pregnancy and breastfeeding is not well studied, so check with your provider before using it.
Meds to double-check
Major interaction found
Before taking this product, check with your pharmacist if you take monoamine oxidase inhibitors (MAOIs) — this is a major concern with the soy extract. Also double-check if you take lithium, blood thinners (particularly warfarin), blood pressure medications, thyroid medication (levothyroxine), diabetes medications, statin cholesterol drugs (atorvastatin), the blood pressure drug nifedipine, or diuretics (water pills).
The tool below will help you verify your specific medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product may help with urinary tract infections (cranberry) and general bladder support, though evidence for some uses is limited. If you take MAOIs, lithium, blood thinners, thyroid medication, or blood pressure drugs, you'll need to check your exact medications with the tool below — soy and cranberry in particular interact with several common drugs.
Talk with your pharmacist before starting, especially if you're pregnant, breastfeeding, or taking any regular medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cranberry Bladder Control, straight from the product label.
| Brand | Whitaker Nutrition |
|---|---|
| Barcode (UPC) | 678829212975 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 22, 2023 |
| DSLD ID | 288245 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cranberry Bladder Control by Whitaker Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pumpkin extract | 0 NP | -- |
| Soy extract | 0 NP | -- |
| Go-Less Blend | 335 mg | -- |
| Cranberry concentrate | 250 mg | -- |
Other ingredients: Gelatin, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Unconditionally guaranteed for purity and labeled potency.
Due to the nature of these ingredients, color variation may occur.
For healthy bladder and urinary function
GF Gluten free
Storage
To preserve quality and freshness, store bottle with cap tightly closed in a cool, dry place.
Brand IP Statement(s)
Go-Less is a registered trademark of Frutarom, Ltd. Cran-Max and Bio-Shield are registered trademarks of Pharmachem Laboratories Inc.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
Includes clinically validated Go-Less and Cran-Max
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Doctor's suggested use: For the first two weeks, take 1 capsule three times daily. Afterward, take 2 capsules daily, 1 in the morning and 1 in the evening.
Precautions
Contains: Soy
Precautions: Consult a health care practitioner before use if you are pregnant or nursing, have a serious medical condition, or use any medications.
Keep out of reach of children.
General Statements
Almost out? Call 1-800-722-8008 or visit healthydirections.com Choose refill & save, and never run out!
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cranberry Bladder Control by Whitaker Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cranberry Bladder Control by Whitaker Nutrition
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Go-Less Blend
Cranberry concentrate
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry concentrate monograph & interactionsOther (inactive) ingredients: Gelatin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Cranberry Bladder Control by Whitaker Nutrition Drug Interactions
HelloPharmacist Interaction Report
Cranberry Bladder Control by Whitaker Nutrition contains three active ingredients, and two of them have documented interactions with medications.
Soy extract carries the most serious concern — it contains tyramine, which when taken with monoamine oxidase inhibitors (MAOIs, a class of older antidepressants) can cause a dangerous spike in blood pressure called hypertensive crisis.
Read the full breakdown — every affected drug type, severity by severity
Soy extract also interacts with several other medication types at moderate severity: blood pressure drugs (antihypertensive medications), hormone replacement therapy (estrogens), diabetes medications (antidiabetes drugs), water pills (diuretics), caffeine, blood thinners like warfarin, and thyroid medication (levothyroxine). Cranberry concentrate adds moderate-severity interactions with statin cholesterol drugs (specifically atorvastatin and the broader category of CYP3A4 substrates), the blood pressure drug nifedipine, warfarin, and minor interactions with other pain relievers and an anti-inflammatory called diclofenac.
Pumpkin extract carries a moderate interaction with lithium, a medication for bipolar disorder — pumpkin may reduce how your body clears lithium, raising its level.
Altogether, these interactions span 1,099 individual medications. We could not check Go-Less Blend for interactions since it is a proprietary blend of unlisted components.
If you take any of these medication types — especially MAOIs, lithium, blood thinners, or thyroid medication — use the medication checker on this page before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cranberry Bladder Control?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cranberry Bladder Control interact with 1,098 drugs. Click any drug to see the details.
3 of the 3 ingredients in Cranberry Bladder Control interact with drugs. Each result below shows which ingredient is responsible. Cranberry concentrate Soy extract Pumpkin extract
AlprazolamNiravam, Xanax
How Alprazolam interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Alprazolam interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Soy ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy Extract + Ambrisentan interactionCranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Soy ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Soy ExtractAntihypertensive Drugs, Diuretic Drugs Moderate
Interaction Summary
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy Extract + Amiloride, Hydrochlorothiazide interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Amiodarone interactionAmitriptylineElavil
How Amitriptyline interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Concentrate + Amitriptyline interactionSoy ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Soy might modestly induce CYP2C9 enzymes.
Read the full Soy Extract + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Concentrate + Amitriptyline, Chlordiazepoxide interactionSoy ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Soy might modestly induce CYP2C9 enzymes.
Read the full Soy Extract + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Concentrate + Amitriptyline, Perphenazine interactionSoy ExtractCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Soy might modestly induce CYP2C9 enzymes.
Read the full Soy Extract + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Amlodipine interactionSoy ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Soy ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy Extract + Amlodipine Benzoate interactionCranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Soy ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy Extract + Amlodipine Besilate interactionCranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Amlodipine Besylate interactionSoy ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Soy ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy Extract + Amlodipine Besylate, Benazepril interactionCranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Concentrate + Amlodipine, Celecoxib interactionSoy ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Soy might modestly induce CYP2C9 enzymes.
Read the full Soy Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Soy ExtractDiuretic Drugs, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, soy might have additive effects when used with diuretic drugs.
Read the full Soy Extract + Ammonium Chloride interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionSoy ExtractAntibiotic Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, antibiotics may decrease the activity of soy isoflavones.
Read the full Soy Extract + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmprenavirAgenerase
How Amprenavir interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Amprenavir interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Soy ExtractAntidiabetes Drugs Moderate
Interaction Summary
Soy can lower blood glucose and have additive effects with antidiabetes drugs.
Read the full Soy Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionApalutamideErleada
How Apalutamide interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Apixaban interactionApremilastOtezla
How Apremilast interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aprepitant interactionAprocitentanTryvio
How Aprocitentan interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Soy ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy Extract + Aprocitentan interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Cranberry Bladder Control — through 1 ingredient. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Armodafinil interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Soy ExtractCaffeine Moderate
Interaction Summary
Theoretically, soy might reduce the clearance of caffeine.
Read the full Soy Extract + Aspirin, Butalbital, Caffeine interactionCranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionSoy ExtractCaffeine Moderate
Interaction Summary
Theoretically, soy might reduce the clearance of caffeine.
Read the full Soy Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Soy ExtractCaffeine Moderate
Interaction Summary
Theoretically, soy might reduce the clearance of caffeine.
Read the full Soy Extract + Aspirin, Butalbital, Caffeine, Phenacetin interactionCranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Cranberry Bladder Control — through 2 ingredients. Tap an ingredient for the detail:
Cranberry ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry Concentrate + Aspirin, Caffeine interactionSoy ExtractCaffeine Moderate
Interaction Summary
Theoretically, soy might reduce the clearance of caffeine.
Read the full Soy Extract + Aspirin, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cranberry Bladder Control with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry concentrate
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Soy extract
Monoamine Oxidase Inhibitors (Maois)
Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.
Fermented soy products such as tofu and soy sauce contain tyramine, a naturally occurring chemical that affects blood pressure regulation. The metabolism of tyramine is decreased by MAOIs. Consuming more than 6 mg of tyramine while taking an MAOI can increase the risk of hypertensive crisis. The amount of tyramine in fermented soy products is usually less than 0.6 mg per serving; however, there can be significant variation depending on the specific product used, storage conditions, and length of storage. Storing one brand of tofu for a week can increase tyramine content from 0.23 mg to 4.8 mg per serving. Advise patients taking MAOIs to avoid fermented soy products that contain high amounts of tyramine.
Antidiabetes Drugs
Soy can lower blood glucose and have additive effects with antidiabetes drugs.
Clinical research shows that whole soy diets and soy-based meals reduce fasting glucose levels in diabetic and non-diabetic individuals. Also, individuals following a soy-based meal replacement plan seem to require lower doses of sulfonylureas and metformin to manage blood glucose levels when compared with individuals following a diet plan recommended by the American Diabetes Association.
Antihypertensive Drugs
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Although some contradictory research exists, most clinical evidence suggests that consuming soy protein modestly reduces systolic and diastolic blood pressure in individuals with prehypertension or hypertension.
Caffeine
Theoretically, soy might reduce the clearance of caffeine.
Soy contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. This effect has been attributed to inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if this effect occurs with the lower amounts of genistein found in soy.
Diuretic Drugs
Theoretically, soy might have additive effects when used with diuretic drugs.
Animal research suggests that genistein, a soy isoflavone, increases diuresis within 6 hours of subcutaneous administration in rats. The effects seem to be similar to those of furosemide. This effect has not been reported in humans.
Estrogens
Theoretically, soy might competitively inhibit the effects of estrogen replacement therapy.
Soy contains phytoestrogens and has been shown to have estrogenic activity in some patients. Although this has not been demonstrated in humans, theoretically, concomitant use of soy with estrogen replacement therapy might reduce the effects of the estrogen replacement therapy.
Levothyroxine (Synthroid, Others)
Soy products might reduce the absorption of levothyroxine in some patients.
Preliminary clinical research and a case report suggest that soy-based formulas inhibit the absorption of levothyroxine in infants with congenital hypothyroidism. A levothyroxine dosage increase may be needed for infants with congenital hypothyroidism while using soy-based formulas, and the dose may need to be reduced when soy-based formulas are no longer administered. However, in postmenopausal adults, clinical research shows that taking a single dose of soy extract containing isoflavones 60 mg along with levothyroxine does not affect the oral bioavailability of levothyroxine.
Progesterone
Theoretically, combining soy isoflavones with transdermal progesterone may worsen bone density.
Clinical research suggests that significant bone loss may occur in females with osteoporosis who receive a combination of transdermal progesterone with soy milk containing isoflavones when compared with placebo, soy milk alone, or progesterone alone.
Tamoxifen (Nolvadex)
Theoretically, estrogenic soy isoflavones might alter the effects of tamoxifen.
Laboratory research suggests that genistein and daidzen, isoflavones from soy, can antagonize the antitumor effects of tamoxifen under some circumstances; however, soy isoflavones might have different effects when used at different doses. A relatively low in vitro concentration of soy isoflavones such as 1 microM/L seems to interfere with tamoxifen, whereas high in vitro concentrations such as those >10 microM/L might actually enhance tamoxifen effects. People on a high-soy diet have soy isoflavones levels ranging from 0.1-6 microM/L. Until more is known, advise patients taking tamoxifen to avoid therapeutic use of soy products.
Warfarin (Coumadin)
Theoretically, soy might interfere with the effects of warfarin.
Soy milk has been reported to decrease the international normalized ratio (INR) in a patient taking warfarin. The mechanism of this interaction is not known. However, animal and in vitro research suggests that soy may also inhibit platelet aggregation. Dosing adjustments for warfarin may be necessary.
Antibiotic Drugs
Theoretically, antibiotics may decrease the activity of soy isoflavones.
Intestinal bacteria are responsible in part for converting soy isoflavones into their active forms. Antibiotics may decrease the amount of intestinal bacteria and decrease its ability to convert isoflavones.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Soy might modestly induce CYP2C9 enzymes. However, this effect does not seem to be clinically significant.
In vitro research suggests that an unhydrolyzed soy extract might induce CYP2C9. However, the significance of this interaction is likely minimal. In healthy females taking a specific extract of soy (Genistein Soy Complex, Source Naturals), blood levels of losartan, a CYP2C9 substrate, were not significantly affected.
Pumpkin extract
Lithium
Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Cranberry Bladder Control, from the product label.
Whitaker Nutrition
See all Whitaker Nutrition products- Name
- Healthy Directions
- City
- Bethesda
- State
- MD
- ZipCode
- 20817
- Phone Number
- 1-800-722-8008
- Web Address
- healthydirections.com
Cranberry Bladder Control by Whitaker Nutrition: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cranberry Bladder Control’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Pumpkin
Interacts with 1 drugPumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...
Read the full Pumpkin monograph → Herb & supplement monographSoy
Interacts with 611 drugsSoy is a nutritious bean that is a staple food and a popular source of plant protein and isoflavones. Eating soy foods as part of a balanced diet is generally considered safe for most people...
Read the full Soy monograph → Herb & supplement monographCranberry
Interacts with 712 drugsCranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...
Read the full Cranberry monograph →Sources & How We Checked
Cranberry Bladder Control's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 126 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pumpkin 5 references
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Soy 88 references
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Cranberry 33 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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