Interactions on record — worth a quick check against your medications. Based on 8 of 14 ingredients. Check your meds →
Dietary supplement

Cranberry Mannose + Probiotics Ingredients & Drug Interactions

by NOW

Cranberry Mannose + Probiotics label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cranberry Mannose + Probiotics against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cranberry Mannose + Probiotics is a dietary supplement by NOW with 14 active ingredients. Its ingredients are commonly taken for tooth decay prevention, dry mouth, sugar substitute.Based on those ingredients, 1,004 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are uva ursi Extract, Cranberry juice powder, Bifidobacterium breve (Bb-03). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cranberry Mannose + Probiotics by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Cranberry Mannose + Probiotics by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cranberry Mannose + Probiotics by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 14 active ingredients.
  • “Blend of 10 Strains of Probiotic Bacteria” is a proprietary blend — the label gives one combined amount (16 mg) without saying how much of each component you get.

This powder contains 14 ingredients: a blend of 10 live probiotic bacterial strains (Lactobacillus acidophilus, Lactobacillus paracasei, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus salivarius, Lactobacillus plantarum, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, and Streptococcus thermophilus), plus xylitol (a sweetener), D-mannose (a simple sugar), cranberry juice powder, and uva ursi extract. The remaining ingredients are inactive: natural and organic flavoring, stevia leaf extract, silicon dioxide, citric acid, tartaric acid, malic acid, and FOS (a prebiotic fiber).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy urinary tract and microbial balance.
  • We looked for evidence on: Bacterial vaginosis, Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Bladder health — and 3 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis.
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Radiation-induced diarrhea, Rotaviral diarrhea, Travelers' diarrhea, and more.

Cranberry juice powder is possibly effective for urinary tract infections. D-mannose is possibly ineffective for UTIs but is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b.

Most of the probiotic strains show insufficient evidence for the conditions tested—their effectiveness ratings don't establish clear benefit for common uses. Lactobacillus acidophilus has possibly effective evidence for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis, but the other strains lack established evidence.

Xylitol is likely effective for preventing dental cavities and possibly effective for ear infections.

The evidence, ingredient by ingredient Xylitol D-mannose Cranberry Uva Ursi Bifidobacterium Breve Streptococcus Thermophilus Lactobacillus Acidophilus Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Xylitol is generally well tolerated at food amounts but can cause diarrhea, bloating, and gas at high doses (30-40 grams or more)—and it is highly toxic to dogs. D-mannose commonly causes bloating, diarrhea, and nausea; long-term safety data are limited.

Cranberry is generally well tolerated but may cause diarrhea and stomach upset, especially in large doses. Uva ursi may be used short-term but is not safe for long-term use and is likely unsafe in pregnancy; it should be avoided while breastfeeding.

At high doses (20 grams or more), uva ursi can cause serious effects like shortness of breath, delirium, and convulsions. The probiotic strains are generally well tolerated in healthy people but should be used cautiously in those who are severely ill or immunocompromised—rare cases of serious infection (bacteremia) have been reported in critically ill patients.

Streptococcus thermophilus is possibly safe in pregnancy according to available data.

Side effects, ingredient by ingredient Xylitol D-mannose Cranberry Uva Ursi Bifidobacterium Breve Streptococcus Thermophilus Lactobacillus Acidophilus Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 8 matched ingredients can interact with medications — Uva Ursi, Lactobacillus Acidophilus, Cranberry, Bifidobacterium Breve, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 1,005 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting, double-check with your own doctor or pharmacist if you take cholesterol medications like atorvastatin or nifedipine (Moderate risk), warfarin or other blood thinners (Moderate risk), lithium (Moderate risk), or antibiotics (Moderate risk—separate timing by a few hours). If you take other medications metabolized by your liver or kidney, those should be reviewed as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines cranberry and D-mannose with multiple probiotic strains for urinary and digestive support, though cranberry's effectiveness for UTIs is modest and D-mannose appears ineffective for them. The biggest concern is interaction risk with cholesterol drugs, blood thinners, and antibiotics—if you take any of these, check with your doctor or pharmacist before starting.

Uva ursi limits how long you should use this product, and if you're pregnant or breastfeeding, talk it over with your own healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cranberry Mannose + Probiotics, straight from the product label.

Brand NOW
Net contents 24 Packet(s); 144 Gram(s); 5.08 Oz(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 245947
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cranberry Mannose + Probiotics by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Gram(s)
Maximum serving Sizes:
6 Gram(s)
Servings per container
24
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates4.5 Gram(s)2%
Xylitol2.5 Gram(s)--
Total Sugars2 Gram(s)--
Lactobacillus paracasei Lpc-370 NP--
D-Mannose2 Gram(s)--
Lactobacillus casei (Lc-11)0 NP--
Lactobacillus rhamnosus (Lr-32)0 NP--
Lactobacillus salivarius (Ls-33)0 NP--
Bifidobacterium breve (Bb-03)0 NP--
Streptococcus thermophilus (St-21)0 NP--
Cranberry juice powder500 mg--
uva ursi Extract5 mg--
Blend of 10 Strains of Probiotic Bacteria16 mg--
Lactobacillus acidophilus (La-14)0 NP--
Bifidobacterium lactis (Bl-04)0 NP--
Lactobacillus plantarum Lp-1150 NP--
Bifidobacterium longum (Bl-05)0 NP--

Other ingredients: natural Cranberry flavor, other Natural flavors, organic Stevia leaf extract, Silicon Dioxide, Citric Acid, Tartaric Acid, Malic Acid, FOS

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports a Healthy Urinary Tract Helps support healthy microbial balance

No artificial colors or flavors

Vegetarian-Vegan product

With 10 probiotic strains to support healthy microbial balance Cleanses the bladder

Vegetarian/Vegan

Packaged in the USA.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.

The probiotic strains in this product have been identity-verified using DNA- fingerprinting technology.

Supports a healthy urinary tract

Formula

Beneficial for both Women and Men

Triangle K (Kosher)

NOW Cranberry Mannose Packets is a women’s probiotic formula with Cranberry and D-Mannose, which are two well-researched ingredients for urinary tract care. Our immune-supporting blend of 10 probiotic bacterial strains assists in the maintenance of a woman’s delicate microbial balance. Cranberries naturally possess flavonoids and other bioactive components that can also promote normal urinary tract ecology by helping to maintain a healthy mucosal surface within the bladder.

D-Mannose is a naturally occurring simple sugar that is metabolized only in small amounts by the body, with the remainder being rapidly excreted with the urine. Because insubstantial amounts of D-mannose are used by the body, it does not interfere with healthy blood sugar regulation. In the urinary tract, D-mannose complements the body's natural elimination process by maintaining a healthy environment in the bladder. Clinical studies have demonstrated that when taken regularly, D-mannose can help to maintain the health of the urinary tract.

Contains Xylitol, which is harmful to pets.

For Women on the go

Seals/Symbols

Strain Verified Triangle K (Kosher)

FDA Statement of Identity

A Dietary Supplement

General Statements

General Health

*** At the time of manufacture.

This carton is made from 100% recycle material.

Suggested/Recommended/Usage/Directions

Suggested Usage: Empty 1 packet into 4 to 6 oz. of water. Use 1 packet 1 to 3 times daily.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Caution: For adults only.

Consult physician of pregnant/nursing, taking medications (especially immune-suppressing drugs), or have a medical condition (especially if immune system is compromised).

Keep out of reach of children.

Contains Xylitol, which is harmful to pets.

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cranberry Mannose + Probiotics by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cranberry Mannose + Probiotics label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cranberry Mannose + Probiotics by NOW

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Gram(s) Dosage formPowder Servings per container24 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Xylitol

No known
interactions
2.5 Gram(s) per serving

Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or loz...

Xylitol monograph & interactions

D-Mannose

No known
interactions
2 Gram(s) per serving

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...

D-Mannose monograph & interactions

Cranberry juice powder

Interacts with
712 drugs
500 mg per serving

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...

Cranberry juice powder monograph & interactions

Uva ursi Extract

Interacts with
803 drugs
5 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva ursi Extract monograph & interactions

Blend of 10 Strains of Probiotic Bacteria

16 mg per serving

Other (inactive) ingredients: Natural Cranberry flavor, Other Natural flavors, Organic Stevia leaf extract, Silicon Dioxide, Citric Acid, Tartaric Acid, Malic Acid, FOS. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cranberry Mannose + Probiotics by NOW Drug Interactions

Want to check YOUR meds against Cranberry Mannose + Probiotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,004Drugs
903 Moderate 101 Minor

Ingredients driving the most interactions

uva ursi Extract 803
Cranberry juice powder 712
Bifidobacterium breve (Bb-03) 182
Lactobacillus acidophilus (La-14) 182
Bifidobacterium longum (Bl-05) 182

Individual Drug Interactions

The ingredients in Cranberry Mannose + Probiotics interact with 1,004 drugs. Click any drug to see the details.

5 of the 14 ingredients in Cranberry Mannose + Probiotics interact with drugs. Each result below shows which ingredient is responsible. uva ursi Extract Cranberry juice powder Bifidobacterium breve (Bb-03) Lactobacillus acidophilus (La-14) Bifidobacterium longum (Bl-05)

Each ingredient & the kinds of drugs it affects

For each ingredient in Cranberry Mannose + Probiotics with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

uva ursi Extract6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
uva ursi Extract full monograph & interactions

Cranberry juice powder6 drug types · 712 drugs

Atorvastatin (Lipitor)

Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.

Likelihood Unlikely Evidence B
Diclofenac (Voltaren, Others)

Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.

Likelihood Unlikely Evidence B
Cranberry juice powder full monograph & interactions

Bifidobacterium breve (Bb-03)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve (Bb-03) full monograph & interactions

Lactobacillus acidophilus (La-14)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus (La-14) full monograph & interactions

Bifidobacterium longum (Bl-05)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum (Bl-05) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cranberry Mannose + Probiotics, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Cranberry Mannose + Probiotics by NOW: Common Questions

Does Cranberry Mannose + Probiotics by NOW interact with any medications?
Yes. Based on its ingredients, Cranberry Mannose + Probiotics has a known interaction with 1,004 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cranberry Mannose + Probiotics contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interact with my birth control?
We have no documented interactions between this product and hormonal birth control. That said, interaction data are incomplete for several of the probiotic strains here, so if you're concerned, check with your pharmacist with your specific birth-control prescription.
Can I take this if I'm pregnant?
Pregnancy safety data are limited or not available for most ingredients. Uva ursi is likely unsafe in pregnancy. Streptococcus thermophilus is possibly safe, but you'll need to talk with your doctor or midwife about whether this product is right for you during pregnancy.
What are the probiotics in this supposed to do?
Probiotics are live beneficial bacteria. Lactobacillus acidophilus has evidence supporting it for irritable bowel syndrome, some infections, and diarrhea related to antibiotics. The other strains don't have established evidence for specific uses in our data.
Will this give me diarrhea?
Possibly. D-mannose and cranberry can cause diarrhea, especially at higher doses. Some people also experience bloating, gas, or stomach upset when starting probiotics. Start with a smaller amount and see how you feel.
Can I take this with antibiotics?
The three probiotic strains Bifidobacterium breve, Lactobacillus acidophilus, and Bifidobacterium longum may lose effectiveness if you take antibiotics at the same time, because antibiotics kill the live bacteria. Separate doses by a few hours if possible, and ask your doctor or pharmacist for the best timing.
Is xylitol safe in this product?
Xylitol is generally well tolerated at the amounts used in food and supplements, though it can cause digestive upset (diarrhea, gas, bloating) at very high doses. The main caution: xylitol is extremely poisonous to dogs, so keep this product away from pets.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cranberry Mannose + Probiotics label
Go deeper

The Full Monographs Behind Cranberry Mannose + Probiotics’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Xylitol

Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or lozenges. It is generally safe for people i...

Read the full Xylitol monograph → Herb & supplement monograph

D-mannose

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is sti...

Read the full D-mannose monograph → Herb & supplement monograph

Cranberry

Interacts with 712 drugs

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...

Read the full Cranberry monograph → Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Streptococcus Thermophilus

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may...

Read the full Streptococcus Thermophilus monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Cranberry Mannose + Probiotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 120 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Xylitol 7 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Weissman JD, Fernandez F, Hwang PH. Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. Laryngoscope 2011;121:2468-72. PubMed
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D-mannose 6 references
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Bifidobacterium Breve 9 references
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  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
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Streptococcus Thermophilus 21 references
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Cranberry 33 references
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See these in context on the Cranberry monograph →

Uva Ursi 8 references
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  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
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Lactobacillus Acidophilus 15 references
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  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
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See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
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  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
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  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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