CranRx 500 mg Ingredients & Drug Interactions
by Nature's Way
What is this page for?
First and foremost: checking CranRx 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
CranRx 500 mg is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 714 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are CranRx. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against CranRx 500 mg by Nature's Way
Ask about any prescription or over-the-counter medication and we check it for interactions with CranRx 500 mg by Nature's Way — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of CranRx 500 mg by Nature's Way
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
CranRx 500 mg is a single-ingredient capsule. Its one active ingredient is cranberry, and the product's listed effectiveness and safety data come from the cranberry monograph.
The inactive ingredients are hypromellose, cellulose, magnesium stearate, and silica, which are non-active materials used in the capsule and its manufacturing.
Does it work?
Moderate evidence
Cranberry is rated Possibly Effective for urinary tract infections (UTIs). For age-related cognitive decline, benign prostatic hyperplasia (BPH), cancer, nonalcoholic fatty liver disease (NAFLD), and chronic fatigue syndrome (CFS), the rating is Insufficient Reliable Evidence To Rate, which means the evidence isn't established in the data we hold.
How safe is it?
Well-documented data
Cranberry is generally well tolerated as a food or supplement, but it is not a substitute for medical treatment of infections. Our safety notes say that food amounts are likely fine, while concentrated supplement doses have not been well studied, so talk with your provider before using them.
The most common side effects are diarrhea and stomach discomfort. Very large amounts, such as 3-4 liters of juice per day, can cause stomach upset and diarrhea, especially in young children.
Skin redness and itching have been reported in a single patient. For pregnancy and breastfeeding, the data rates cranberry as Likely Safe.
That is a rating, not a personal answer, so talk with your own doctor or pharmacist about your situation.
Meds to double-check
Moderate interaction found
Double-check these medication types before you take CranRx, starting with the Moderate-rated group: CYP3A4 substrates, atorvastatin, nifedipine, and warfarin. The Minor-rated group includes CYP2C9 substrates and diclofenac.
Your doctor or pharmacist can confirm whether any of these apply to you.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
CranRx may be worth a conversation if you're looking into cranberry for urinary tract infections, which is the only use rated Possibly Effective in our data. If you take warfarin, a statin, nifedipine, or any other medication on the list below, be especially careful and get personal advice first.
Talk the decision over with your own doctor or pharmacist before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about CranRx 500 mg, straight from the product label.
| Brand | Nature's Way |
|---|---|
| Barcode (UPC) | 033674152898 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 327941 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for CranRx 500 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| CranRx | 500 mg | -- |
Other ingredients: Hypromellose, Cellulose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Recommendations: Adults take 1 capsule one to two times daily.
Precautions
If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.
Keep out of reach of children.
This product has a tamper-evident foil pouch. Do not use if foil or plastic is punctured.
Formulation
Gluten free. No wheat, corn, soy, dairy, gelatin, or artificial colors or flavors.
Vegan Gelatin Free
Vegan Gelatin Free
Supports urinary tract health Antioxidant support Plant powered
Non GMO Project Verified nongmoproject.org
Packed and tested in the USA
Healthy urinary tract support Supports antioxidant pathways
Storage
Store at room temperature. Avoid excessive heat and direct sunlight.
Brand IP Statement(s)
Copyright 2023 Nature's Way Brands, LLC
General Statements
Questions? 1-800-962-8873 / naturesway.com Explore more products at naturesway.com
Formula
Researched Cranberry Fruit Concentrate Made with 100% whole cranberry fruit Derived from 25,000 mg of fresh cranberries per serving
Bioactive Cranberry
CranRx 500 mg potency
Standardized to PACs (proanthocyanidins), the key bioactives in cranberries
Seals/Symbols
Non GMO Project Verified nongmoproject.org
Vegan Gelatin free
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
CranRx 500 mg by Nature's Way label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in CranRx 500 mg by Nature's Way
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
CranRx
Interacts with714 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
CranRx monograph & interactionsOther (inactive) ingredients: Hypromellose, Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
CranRx 500 mg by Nature's Way Drug Interactions
HelloPharmacist Interaction Report
CranRx 500 mg from Nature's Way has one active ingredient, cranberry, and cranberry has documented interactions with several types of medication.
The most serious rating we hold is Moderate, and the clearest example is warfarin (Coumadin), a blood thinner (anticoagulant), where case reports link cranberry juice to rises in INR, a blood-clotting measure. Altogether, these interactions span 715 individual medications.
Read the full breakdown — every affected drug type, severity by severity
The Moderate-rated drug types are CYP3A4 substrates, which are drugs your liver breaks down through the CYP3A4 enzyme. Cranberry may raise their levels and side effects.
One case report describes upper back pain, muscle breakdown (rhabdomyolysis), and abnormal liver function in a patient taking atorvastatin, a cholesterol-lowering statin, who drank 16 ounces of cranberry juice daily for two weeks. Nifedipine, a blood pressure medication, is also Moderate, based on animal research suggesting higher drug exposure.
The evidence for warfarin is conflicting, but it is still rated Moderate.
The Minor-rated drug types are CYP2C9 substrates and diclofenac (Voltaren). Lab evidence suggests cranberry can slow CYP2C9 enzymes, but the clinical findings are conflicting.
For diclofenac, lab findings did not carry over to humans who drank cranberry juice. Check your exact medications with the search tool on this page, and confirm any concerns with your own doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against CranRx 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in CranRx 500 mg interact with 714 drugs. Click any drug to see the details.
1 of the 1 ingredient in CranRx 500 mg interact with drugs. Each result below shows which ingredient is responsible. CranRx
ZaleplonSonata, Starnoc
How Zaleplon interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Zaleplon interactionZanubrutinibBrukinsa
How Zanubrutinib interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Zanubrutinib interactionZileutonZyflo, Zyflo CR
How Zileuton interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Zileuton interactionZiprasidoneGeodon
How Ziprasidone interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Ziprasidone interactionZolpidemAmbien CR, Intermezzo, Sublinox
How Zolpidem interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Zolpidem interactionZolpidem TartrateAmbien
How Zolpidem Tartrate interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Zolpidem Tartrate interactionZonisamideZonegran, Zonisade
How Zonisamide interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Zonisamide interactionZopicloneApo-Zopiclone, Co Zopiclone, Dom-Zopiclone, Imovane, Mylan-Zopiclone, Rhovane +1 more
How Zopiclone interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Zopiclone interactionZuranoloneZurzuvae
How Zuranolone interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Zuranolone interactionDrospirenone, Ethinyl Estradiol, LevomefolateBeyaz
How Drospirenone, Ethinyl Estradiol, Levomefolate interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Drospirenone, Ethinyl Estradiol, Levomefolate interactionNefazodoneSerzone
How Nefazodone interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Nefazodone interactionNilotinibTasigna
How Nilotinib interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Nilotinib interactionPioglitazone, MetforminActoPlus Met
How Pioglitazone, Metformin interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Pioglitazone, Metformin interactionSimvastatin/ezetimibeVytorin
How Simvastatin/ezetimibe interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Simvastatin/ezetimibe interactionTipranavirAptivus
How Tipranavir interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranrx + Tipranavir interactionAbrocitinibCibinqo
How Abrocitinib interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Abrocitinib interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Acetaminophen, Ibuprofen interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAgomelatineValdoxan
How Agomelatine interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Agomelatine interactionAzilsartanEdarbi
How Azilsartan interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Azilsartan, Chlorthalidone interactionBudesonide, FormoterolSymbicort
How Budesonide, Formoterol interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Budesonide, Formoterol interactionBupivacaine, MeloxicamZynrelef Kit
How Bupivacaine, Meloxicam interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Bupivacaine, Meloxicam interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Carvedilol interactionCelecoxibCelebrex, Elyxyb
How Celecoxib interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Celecoxib interactionDiclofenacZorvolex
How Diclofenac interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates, Diclofenac (voltaren, Others) Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Diclofenac interactionDiclofenac PotassiumCambia, Cataflam, Cataflam IR, Voltaren Rapide, Voltarol Rapid
How Diclofenac Potassium interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates, Diclofenac (voltaren, Others) Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Diclofenac Potassium interactionDiclofenac SodiumAcoflam, Acoflam 75 SR, Acoflam Retard, Defenac, Defenac Retard, Defenac SR +40 more
How Diclofenac Sodium interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxDiclofenac (voltaren, Others), Cytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
Read the full Cranrx + Diclofenac Sodium interactionDiclofenac Sodium, MisoprostolArthrotec 50, Arthrotec 75
How Diclofenac Sodium, Misoprostol interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxCytochrome P450 2c9 (cyp2c9) Substrates, Diclofenac (voltaren, Others) Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranrx + Diclofenac Sodium, Misoprostol interactionDiclofenac EpolamineFlector, Licart
How Diclofenac Epolamine interacts with CranRx 500 mg — through 1 ingredient. Tap an ingredient for the detail:
CranrxDiclofenac (voltaren, Others), Cytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
Read the full Cranrx + Diclofenac Epolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in CranRx 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
CranRx
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for CranRx 500 mg, from the product label.
Nature's Way
See all Nature's Way products- Name
- Nature's Way Brands, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 1-800-962-8873
- Web Address
- naturesway.com
CranRx 500 mg by Nature's Way: Common Questions
Does CranRx 500 mg by Nature's Way interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does CranRx help with urinary tract infections?
Is CranRx okay to take during pregnancy or while breastfeeding?
What side effects can cranberry cause?
Does cranberry help with memory or cognitive decline?
What are the inactive ingredients in CranRx?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if CranRx 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind CranRx 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
CranRx 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
- Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
- Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
- Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
- Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
- Garcia-Calatayud, S., Larreina Cordoba, J. J., and Lozano De La Torre MJ. [Severe cranberry juice poisoning]. An.Esp.Pediatr. 2002;56(1):72-73.
- Patel, D. A., Gillespie, B., Sobel, J. D., Leaman, D., Nyirjesy, P., Weitz, M. V., and Foxman, B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet.Gy PubMed
- Isele, H. [Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?]. MMW.Fortschr.Med 3-11-2004;146(11):13.
- Linsenmeyer, T. A., Harrison, B., Oakley, A., Kirshblum, S., Stock, J. A., and Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospecti
- McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., and Crombie, I. K. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34(3):256- PubMed
- Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000.
- Niklasson, A. and Andren, L. [Interaction between Waran and cranberry juice]. Lakartidningen 3-15-2006;103(11):853-854.
- Rindone, J. P. and Murphy, T. W. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2006;13(3):283-284. PubMed
- Uesawa, Y. and Mohri, K. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 2006;58(8):1067-1072. PubMed
- Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried
- Royer, D. J., George, J. N., and Terrell, D. R. Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages. Eur J Haematol 2010;84(5):421-429. PubMed
- Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. PubMed
- Doad GJ, Kabange W. Cranberry juice, atorvastatin and back pain. J Med Assoc Ga 2014;103(1):14.
- Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 2008;128(6):324-6. PubMed
- Mellen CK, Ford M, Rindone JP. Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients. Br J Clin Pharmacol 2010;70(1):139-42. PubMed
- Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmaco PubMed
- Ngo N, Brantley SJ, Carrizosa DR, et al. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010;2010(2):83-91.
- Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2023;11(11):CD001321. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC