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Dietary supplement

Culver's Root Ingredients & Drug Interactions

by Herb Pharm

Culver's Root label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Culver's Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Culver's Root is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for constipation, liver and gallbladder complaints, digestive upset.Based on those ingredients, 78 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Culver's root rhizome w/ rootlet (Veronicastrum virginicum) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Culver's Root by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Culver's Root by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Culver's Root by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Culver's root rhizome with rootlet (Veronicastrum virginicum) extract. It also includes certified organic cane alcohol and distilled water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: cleanse and detoxify.
  • We looked for evidence on: liver support, digestive detoxification, bile stimulation.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We hold no effectiveness ratings for Culver's root in our data. The evidence isn't established in the information available to us.

The evidence, ingredient by ingredient Black Root

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Culver's root is a potent laxative and modern safety data are limited; the fresh root in particular can cause significant digestive upset. You may experience abdominal pain or cramps, nausea, vomiting, headache, drowsiness, and changes in stool color or odor.

In rare cases, large amounts have caused liver toxicity (hepatotoxicity). The safety data advise against Culver's root during pregnancy because of its strong laxative effect and lack of safety information.

There isn't enough data to know if it's safe while breastfeeding — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Black Root

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Black Root.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 78 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Culver's root, double-check with your pharmacist if you're on warfarin (Coumadin) or other blood thinners — diarrhea from this product can increase your bleeding risk. Also check if you take water pills (diuretics) — the combination can worsen potassium loss.

If you're on digoxin (Lanoxin) for your heart, mention that too, since overuse may reduce the drug's effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Culver's root is a strong herbal laxative best suited to short-term use under professional guidance. If you take warfarin, diuretics, or digoxin, check with us first.

Pregnant and breastfeeding people should avoid it or discuss it with their pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Culver's Root, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700000035
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 220584
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Culver's Root by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
42
UPC/BARCODE
090700000035
IngredientAmount% DV
Culver's root rhizome w/ rootlet (Veronicastrum virginicum) extract629 mg--

Other ingredients: certified organic Cane Alcohol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use Shake well before using Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 4 times per day. Best taken between meals.

Precautions

Keep out of the reach of children.

Storage

Store away from heat & light

Formula

Veronicastrum virginicum

Culver's Root Liquid Extract

Formulation

Cleanse & Detoxify

Gluten-free

Dry herb / menstruum ratio: 1 :3

Certified organic by Organic Certifiers

Seals/Symbols

USDA Organic

FDA Statement of Identity

Herbal Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Culver's Root by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Culver's Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Culver's Root by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container42 Amounts shown are per serving.

Culver's root rhizome w/ rootlet (Veronicastrum virginicum) extract

Interacts with
78 drugs
629 mg per serving

Black Root is a traditional North American herb that was historically used as a strong laxative and to support digestion and liver function. There is...

Culver's root rhizome w/ rootlet (Veronicastrum virginicum) extract monograph & interactions

Other (inactive) ingredients: Certified organic Cane Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Culver's Root by Herb Pharm Drug Interactions

Want to check YOUR meds against Culver's Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
78Drugs
78 Moderate

Ingredients driving the most interactions

Culver's root rhizome w/ rootlet (Veronicastrum virginicum) extract 78

Individual Drug Interactions

The ingredients in Culver's Root interact with 78 drugs. Click any drug to see the details.

1 of the 1 ingredient in Culver's Root interact with drugs. Each result below shows which ingredient is responsible. Culver's root rhizome w/ rootlet (Veronicastrum virginicum) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Culver's Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Culver's root rhizome w/ rootlet (Veronicastrum virginicum) extract3 drug types · 78 drugs

Digoxin (Lanoxin)

Theoretically, the overuse or abuse of black root can increase the risk of adverse effects of cardiac glycoside drugs. Black root chemically binds with the glycosides while in the gastrointestinal (GI) tract, which may reduce their effectiveness if used concomitantly.

Likelihood Probable Evidence D
Diuretic Drugs

Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia. Initiation of potassium supplementation or an increase in potassium supplement dose may be necessary for some patients. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Black root has stimulant laxative effects. In some people black root can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of black root.

Likelihood Possible Evidence D
Culver's root rhizome w/ rootlet (Veronicastrum virginicum) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Culver's Root, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Culver's Root by Herb Pharm: Common Questions

Does Culver's Root by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Culver's Root has a known interaction with 78 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Culver's Root contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is Culver's root and what does it do?
Culver's root is a potent herbal laxative made from the rhizome and rootlet of Veronicastrum virginicum. It's meant to stimulate bowel movements, but it's a strong one — modern safety data are limited and the fresh root can cause serious digestive upset.
What side effects might I get?
The most common ones are abdominal pain or cramps, nausea, vomiting, headache, drowsiness, and changes in stool color or smell. Large amounts have rarely caused liver damage, so don't overuse it.
Can I take this while pregnant or breastfeeding?
No, not during pregnancy — the safety data advise against it because of its strong laxative effect and lack of safety information. If you're breastfeeding, there isn't enough data to know either way, so talk with your pharmacist for personalized advice.
Does this product have any fillers or other inactive ingredients?
Yes — it contains certified organic cane alcohol and distilled water as inactive ingredients. The active ingredient is the Culver's root extract itself.
What should I do if I take a blood thinner like warfarin?
Tell us first. Culver's root can cause diarrhea, which increases how much warfarin your body absorbs and raises your bleeding risk. If you do take both, avoid large amounts of this product and keep your doctor in the loop.
I'm on a water pill for my blood pressure — is this safe?
Check with your pharmacist before starting. Water pills already cause potassium loss, and Culver's root can make that worse. You may need a potassium supplement adjustment or closer monitoring.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Culver's Root label
Go deeper

The Full Monographs Behind Culver's Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Root

Interacts with 78 drugs

Black Root is a traditional North American herb that was historically used as a strong laxative and to support digestion and liver function. There is very little modern scientific evidence t...

Read the full Black Root monograph →
Sources

Sources & How We Checked

Culver's Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Root 2 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

See these in context on the Black Root monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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