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Dietary supplement

Culver's Root Ingredients & Drug Interactions

by Herbalist & Alchemist

Liquid Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Culver's Root is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for constipation, liver and gallbladder complaints, digestive upset.Based on those ingredients, 78 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are dried Culver's root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Culver's Root by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: dried Culver's root extract, which is also known as black root. It's a plant-based supplement traditionally used for its strong laxative properties.

The supplement also includes ethyl alcohol and distilled water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports healthy bowel function.
  • We looked for evidence on: constipation, digestive health, bowel regularity.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't hold effectiveness ratings for Culver's Root in our data, so the evidence for what this supplement actually accomplishes isn't established here. If you're curious about what it's meant to do, your pharmacist can point you toward the research.

The evidence, ingredient by ingredient Black Root

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Modern safety data for Culver's Root are limited, and the fresh root can cause serious digestive trouble. The supplement may cause abdominal pain or cramps, nausea, vomiting, headache, or drowsiness.

Liver toxicity has been reported after large doses. Stay away from Culver's Root during pregnancy because of its strong laxative effect and lack of safety data — it's rated possibly unsafe.

Avoid it while breastfeeding too, since there isn't enough information to know whether it's safe for your baby.

Side effects, ingredient by ingredient Black Root

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Black Root.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications.
  • For scale: 78 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Culver's Root, make sure to check with us if you're on warfarin (Coumadin) or other blood thinners, diuretics (water pills), or digoxin (Lanoxin) for your heart. These are the medication types documented to interact with black root.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Culver's Root is best avoided if you take blood thinners, diuretics, or heart medications like digoxin. The limited safety data and potential for digestive upset — plus the pregnancy and breastfeeding cautions — mean it's worth a conversation with your pharmacist before you start.

If you're on any prescription medication at all, check it against your meds first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Culver's Root, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056110284
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 173990
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Culver's Root by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1.5 mL
Servings per container
40
UPC/BARCODE
667056110284
IngredientAmount% DV
dried Culver's root extract1.5 mL--

Other ingredients: Ethyl Alcohol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Veronicastrum virginicum

OK

General Statements

Supports healthy bowel function

Botanical preparation ratio 1:4

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 20-30 drops (1-1.5 mL) in juice or water. Take 3 times per day. Shake well before using.

Precautions

Contraindications: Do not use during pregnancy or lactation.

Do not use if you have acute gallbladder inflammation or biliary or intestinal obstruction.

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

NO. CUV-2 1723MO

Seals/Symbols

OK

See for yourself

Culver's Root by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Culver's Root by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container40 Amounts shown are per serving.

Dried Culver's root extract

Interacts with
78 drugs
1.5 mL per serving

Black Root is a traditional North American herb that was historically used as a strong laxative and to support digestion and liver function. There is...

Dried Culver's root extract monograph & interactions

Other (inactive) ingredients: Ethyl Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Culver's Root by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against Culver's Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
78Drugs
78 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Culver's Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

dried Culver's root extract3 drug types · 78 drugs

Digoxin (Lanoxin)

Theoretically, the overuse or abuse of black root can increase the risk of adverse effects of cardiac glycoside drugs. Black root chemically binds with the glycosides while in the gastrointestinal (GI) tract, which may reduce their effectiveness if used concomitantly.

Likelihood Probable Evidence D
Diuretic Drugs

Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia. Initiation of potassium supplementation or an increase in potassium supplement dose may be necessary for some patients. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Black root has stimulant laxative effects. In some people black root can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of black root.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Culver's Root, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Culver's Root by Herbalist & Alchemist: Common Questions

Does Culver's Root by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, Culver's Root has a known interaction with 78 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Culver's Root contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Culver's Root while I'm pregnant?
No — it's rated possibly unsafe during pregnancy because of its strong laxative effect and the lack of safety data. Talk with your doctor or pharmacist about what's safe for you instead.
Is it safe to take while breastfeeding?
The safety data aren't there, so we can't say yes or no. There isn't enough information to know whether it's safe for your baby. Please check with your doctor or pharmacist before using it.
What side effects might I experience?
Black root can cause abdominal pain or cramps, nausea, vomiting, headache, and drowsiness. Large amounts have been linked to liver toxicity, so this isn't something to overuse.
Why do I need to be careful if I take warfarin?
Culver's Root has strong laxative effects, and diarrhea can increase how much warfarin your body absorbs, raising your bleeding risk. Avoid excessive amounts if you take a blood thinner.
What's Culver's Root actually used for?
It's traditionally used as a laxative because of its strong stimulant properties. We don't have effectiveness data on file for what it accomplishes, so ask us if you want to know more.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Culver's Root label
Sources

Sources & How We Checked

Culver's Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Root 2 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

See these in context on the Black Root monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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