Interactions on record — worth a quick check against your medications. Based on 8 of 15 ingredients. Check your meds →
Dietary supplement

D-Mannose 1000 mg Ingredients & Drug Interactions

by Biophix

D-Mannose 1000 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Mannose 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Mannose 1000 mg is a dietary supplement by Biophix with 15 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 909 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry, Bifidobacterium bifidum, Bifidobacterium breve. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against D-Mannose 1000 mg by Biophix

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Mannose 1000 mg by Biophix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Mannose 1000 mg by Biophix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 15 active ingredients.
  • “Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 15 ingredients, including the active component D-mannose and multiple live probiotic strains (species of Lactobacillus and Bifidobacterium, plus Saccharomyces boulardii yeast), along with cranberry extract. D-mannose is a simple sugar.

The probiotics are live microorganisms intended to support digestive and urinary health. Cranberry is included for its compounds that may affect urinary tract health.

The remaining ingredients are inactives: cellulose, acacia gum, inulin, silicon dioxide, and magnesium stearate — standard capsule materials and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain healthy urinary tract.
  • We looked for evidence on: Clostridioides difficile infection, urinary tract infection, bladder health, cystitis.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Clostridioides difficile infection (Natural Medicines).
  • Also on file: Cranberry is rated "Possibly Effective" for Urinary tract infections (UTIs).
  • Also on file: D-mannose is rated "Possibly Ineffective" for Urinary tract infections (UTIs).

D-mannose is rated possibly ineffective for urinary tract infections in our data, though it is likely effective for a rare genetic condition (carbohydrate-deficient glycoprotein syndrome type 1b). Among the probiotics, Saccharomyces boulardii is possibly effective for several types of diarrhea and H. pylori infection; Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, H. pylori, antibiotic-associated diarrhea, and bacterial vaginosis; and Bifidobacterium bifidum is possibly effective for irritable bowel syndrome and respiratory infections.

Most of the other probiotic strains lack established evidence for the conditions listed. Cranberry is possibly effective for urinary tract infections.

For many conditions listed on the label, the evidence is insufficient to rate effectiveness.

The evidence, ingredient by ingredient Bifidobacterium Bifidum Bifidobacterium Breve Lactobacillus Acidophilus Bifidobacterium Longum Lactobacillus Delbrueckii Saccharomyces Boulardii Cranberry D-mannose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotics here are generally well tolerated in healthy adults and children, though people who are critically ill or have weakened immune systems should be cautious — rare cases of serious bloodstream infections from these organisms have been reported in that population. D-mannose is generally well tolerated short-term but long-term safety data are limited.

Cranberry is likely safe in pregnancy and is generally well tolerated as a food or supplement. Common side effects across these ingredients include bloating, flatulence, diarrhea, nausea, and abdominal discomfort.

Saccharomyces boulardii rarely causes gastrointestinal complaints like cramps and nausea. D-mannose may cause loose stools, diarrhea, bloating, and nausea, especially at higher doses.

Side effects, ingredient by ingredient Bifidobacterium Bifidum Bifidobacterium Breve Lactobacillus Acidophilus Bifidobacterium Longum Lactobacillus Delbrueckii Saccharomyces Boulardii Cranberry D-mannose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 8 matched ingredients can interact with medications — Saccharomyces Boulardii, Lactobacillus Acidophilus, Cranberry, Bifidobacterium Breve, Bifidobacterium Bifidum, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 910 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before combining this product with blood thinners (like warfarin), blood pressure medications (like nifedipine), cholesterol drugs (like atorvastatin), antifungals, or antibiotics. These are the drug types most likely to be affected by cranberry and the live probiotic organisms in here.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient product aimed at urinary and digestive health. If you take blood pressure or cholesterol medications, blood thinners, or antifungals, you'll need to check your specific drugs with your pharmacist or doctor before starting — cranberry and the probiotics can interfere with how these work.

If you're on antibiotics, separate them from the probiotics by a few hours. Talk with your doctor or pharmacist about whether this product makes sense for you and your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Mannose 1000 mg, straight from the product label.

Brand Biophix
Barcode (UPC) X001EIY8DD
Net contents 120 Veg Cap(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276055
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Mannose 1000 mg by Biophix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X001EIY8DD
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrate1 Gram(s)1%
Lactobacillus salivarius0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus paracasei0 NP--
Bifidobacterium breve0 NP--
Lactobacillus acidophilus0 NP--
Blend0 NP--
Bifidobacterium longum0 NP--
Lactobacillus rhamnosus0 NP--
Lactobacillus casei0 NP--
Lactobacillus brevis0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus bulgaricus0 NP--
Sugars1 Gram(s)--
Saccharomyces boulardii0 NP--
Cranberry100 mg--
D-Mannose1000 mg--
Bifidobacterium animalis lactis0 NP--

Other ingredients: Cellulose, Acacia Gum, Inulin, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 1-2 capsules twice daily.

Formula

D-mannose is a simple sugar occurs naturally in some plants, including cranberries.

Biophix D-mannose features a blend of whole cranberry fruit juice with a unique probiotic profile that supports the maintenance of a healthy urinary tract when used regularly.

D-mannose + cranberry & probiotics 1000 mg serving

10 billion CFU probiotics per serving

General Statements

Although small amounts of D-mannose are metabolized by the human body, much of it is rapidly excreted in the urine.

Please recycle.

Precautions

Caution: For adults only.

Consult physician if pregnant/ nursing, taking medication (especially immune-suppressing drugs), or have a medical condition (especially if immune system is compromised).

Keep out of reach of children.

Do not eat freshness packet enclosed.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut ingredients. Manufactured in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Triple action, maximum strength formula Supports a healthy urinary tract

Vegan

GMP tested

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut ingredients.

Storage

Store in a cool, dry place after opening.

Keep in bottle.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Manufactured in a GMP Inspected Facility

Made in USA

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Mannose 1000 mg by Biophix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Mannose 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Mannose 1000 mg by Biophix

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Blend

0 NP per serving

Cranberry

Interacts with
712 drugs
100 mg per serving

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...

Cranberry monograph & interactions

D-Mannose

No known
interactions
1000 mg per serving

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...

D-Mannose monograph & interactions

Other (inactive) ingredients: Cellulose, Acacia Gum, Inulin, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Mannose 1000 mg by Biophix Drug Interactions

Want to check YOUR meds against D-Mannose 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
909Drugs
807 Moderate 102 Minor

Ingredients driving the most interactions

Cranberry 712
Bifidobacterium bifidum 182
Bifidobacterium breve 182
Lactobacillus acidophilus 182
Bifidobacterium longum 182

Individual Drug Interactions

The ingredients in D-Mannose 1000 mg interact with 909 drugs. Click any drug to see the details.

7 of the 15 ingredients in D-Mannose 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Cranberry Bifidobacterium bifidum Bifidobacterium breve Lactobacillus acidophilus Bifidobacterium longum Lactobacillus bulgaricus Saccharomyces boulardii

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Mannose 1000 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cranberry6 drug types · 712 drugs

Atorvastatin (Lipitor)

Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.

Likelihood Unlikely Evidence B
Diclofenac (Voltaren, Others)

Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.

Likelihood Unlikely Evidence B
Cranberry full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Bifidobacterium breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Lactobacillus bulgaricus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus bulgaricus full monograph & interactions

Saccharomyces boulardii1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Mannose 1000 mg, from the product label.

Biophix

See all Biophix products
Name
Biophix Health & Nutrition
Street Address
4131 SW 47th Ave. Unit 1404
City
Davie
State
FL
ZipCode
33314
Phone Number
305-861-0898
Web Address
www.biophix.com
Pharmacist Counseling Corner

D-Mannose 1000 mg by Biophix: Common Questions

Does D-Mannose 1000 mg by Biophix interact with any medications?
Yes. Based on its ingredients, D-Mannose 1000 mg has a known interaction with 909 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Mannose 1000 mg contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does D-mannose actually help with urinary tract infections?
According to the evidence we hold, D-mannose is rated possibly ineffective for urinary tract infections. Cranberry in this product is rated possibly effective for UTIs, so that's the ingredient with the stronger support for this use.
Can I take this while pregnant?
The data on this product during pregnancy are limited. Cranberry is rated likely safe in pregnancy. Bifidobacterium bifidum and Lactobacillus acidophilus are rated possibly safe, but D-mannose and several other ingredients have no established pregnancy rating in our data. Talk with your doctor or pharmacist for personalized advice — they know your full health picture.
What are the live probiotics in here for?
The probiotics — strains like Lactobacillus acidophilus and Bifidobacterium species — are intended to support digestive health and potentially help with conditions like irritable bowel syndrome, diarrhea, and urinary health. They work as living microorganisms in your gut.
Will I get bloating or gas from this?
Yes, bloating and flatulence are commonly reported with probiotic products, and D-mannose may also cause bloating and diarrhea. These side effects tend to be mild and temporary, but if they're severe or don't improve, talk with your pharmacist.
I'm on an antibiotic right now — should I skip this?
Not necessarily skip it, but you do need to separate the timing. Since antibiotics can kill the live probiotics in this product, take them at least a few hours apart — your doctor or pharmacist can advise on the best schedule for you.
Is there anything in this besides the probiotics and D-mannose?
Yes — cranberry extract is an active ingredient for urinary health, and the capsule also contains cellulose, acacia gum, inulin, silicon dioxide, and magnesium stearate as inactive binders and fillers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Mannose 1000 mg label
Go deeper

The Full Monographs Behind D-Mannose 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Lactobacillus Delbrueckii

Interacts with 182 drugs

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...

Read the full Lactobacillus Delbrueckii monograph → Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph → Herb & supplement monograph

Cranberry

Interacts with 712 drugs

Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...

Read the full Cranberry monograph → Herb & supplement monograph

D-mannose

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is sti...

Read the full D-mannose monograph →
Sources

Sources & How We Checked

D-Mannose 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 126 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
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Lactobacillus Acidophilus 15 references
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  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
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Bifidobacterium Longum 21 references
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  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
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See these in context on the Bifidobacterium Longum monograph →

Lactobacillus Delbrueckii 9 references
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See these in context on the Lactobacillus Delbrueckii monograph →

Saccharomyces Boulardii 26 references
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Cranberry 33 references
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D-mannose 6 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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