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Dietary supplement

D-Ribose 700 mg Ingredients & Drug Interactions

by Best Naturals

D-Ribose 700 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Ribose 700 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Ribose 700 mg is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D-Ribose 700 mg by Best Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Ribose 700 mg by Best Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Ribose 700 mg by Best Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: D-Ribose Powder at 700 mg per capsule. D-Ribose is a naturally occurring sugar that your body uses to make and repair muscle cells.

The capsule also contains inactive ingredients — cellulose, silicon dioxide, microcrystalline cellulose, and magnesium stearate — which help form and stabilize the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: energy production and cellular function.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Congestive heart failure (CHF), Coronary heart disease (CHD), Coronary artery bypass graft (CABG) surgery — and 4 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Possibly Ineffective" for McArdle disease.
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for D-Ribose is mixed and often limited. For athletic performance and McArdle disease (a rare muscle disorder), it's rated possibly ineffective — meaning the research doesn't support its use.

For restless legs syndrome, muscle soreness, heart failure, and recovery after bypass surgery, there simply isn't enough reliable evidence yet to say whether it works or doesn't. If you're considering it for any of these reasons, talk it over with your doctor about whether the science supports a trial.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-Ribose is generally well tolerated for short-term use (up to about a month in studies), but long-term safety isn't well studied, so caution is warranted with extended use. The most common side effects are diarrhea, stomach discomfort, headache, nausea, and low blood sugar — and in one study, lowering the dose resolved nausea and anxiety.

The safety data advises against D-Ribose during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe in those situations. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take insulin or any antidiabetes drug (oral medications that lower blood sugar), check your exact medications on this page before starting D-Ribose, and confirm with your doctor or pharmacist — both carry Moderate-severity interactions that raise the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose is a single-ingredient supplement generally well tolerated short-term, but the evidence for what it actually does is weak or absent for most conditions. The main concern is its blood-sugar-lowering effect: if you take insulin or diabetes medications, you need to clear this with your doctor or pharmacist first.

Because long-term safety isn't established and it's not recommended in pregnancy or breastfeeding, this is worth a conversation with your healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Ribose 700 mg, straight from the product label.

Brand Best Naturals
Barcode (UPC) 817716013817
Net contents 180 Vcap(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269612
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Ribose 700 mg by Best Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vcap(s)
Maximum serving Sizes:
12 Vcap(s)
Servings per container
90
UPC/BARCODE
817716013817
IngredientAmount% DV
Calories6 Calorie(s)--
Total Carbohydrates1.4 Gram(s)1%
Total Sugars1.4 Gram(s)--
D-Ribose Powder1.4 Gram(s)--

Other ingredients: Cellulose, Silicon Dioxide, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ribose is a naturally occurring pentose (5-carbon) sugar found in all living cells. It is an essential component, utilized by the body to synthesize DNA, RNA and produce energy. Ribose is a fundamental building block of adenosine triphosphate (ATP-the substance in which the body stores intracellular energy), the preferential source of energy for skeletal muscle and heart tissue. Certain research publications indicate that D-Ribose may help support the following: Supports healthy energy level in heart & muscle tissue Supports normal heart function

Precautions

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Storage

Keep in cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

GMP Good Manufacturing Practice Product

Formulation

Premium formula

3rd party lab tested

No artificial color, flavor or sweetener, preservatives, no starch, no milk, no corn, no soy, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take two (2) to six (6) Vcaps daily, prior to exercise. Serious athletes may want to double the dosage during training. Consisder taking this product in combination with Best Naturals CoQ10, Magnesium, L-Carnitine and Creatine.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Ribose 700 mg by Best Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Ribose 700 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Ribose 700 mg by Best Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vcap(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

D-Ribose Powder

Interacts with
86 drugs
1.4 Gram(s) per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose Powder monograph & interactions

Other (inactive) ingredients: Cellulose, Silicon Dioxide, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Ribose 700 mg by Best Naturals Drug Interactions

Want to check YOUR meds against D-Ribose 700 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose Powder 86

Individual Drug Interactions

The ingredients in D-Ribose 700 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Ribose 700 mg interact with drugs. Each result below shows which ingredient is responsible. D-Ribose Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Ribose 700 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose Powder2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Ribose 700 mg, from the product label.

Best Naturals

See all Best Naturals products
Name
Best Naturals
Street Address
PO Box 394
City
Kenilworth
State
NJ
ZipCode
07033
Phone Number
1-877-659-6004
Web Address
www.shopbestnaturals.com
Pharmacist Counseling Corner

D-Ribose 700 mg by Best Naturals: Common Questions

Does D-Ribose 700 mg by Best Naturals interact with any medications?
Yes. Based on its ingredients, D-Ribose 700 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Ribose 700 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does D-Ribose really boost athletic performance?
The research says it's possibly ineffective for that purpose. While it's a sugar your muscles use, clinical studies haven't shown it improves athletic performance, so it's not a reliable choice if that's what you're after.
What side effects might I get?
The most common ones are diarrhea, nausea, headache, stomach discomfort, and low blood sugar. Some people have also reported lightheadedness, increased appetite, and anxiety — but in one study, lowering the dose resolved the anxiety and nausea.
Is it safe to take long-term?
Short-term (up to about a month), D-Ribose is generally well tolerated. Long-term safety hasn't been studied, so caution is warranted if you're thinking of taking it regularly.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety information, so the data advises against it in both pregnancy and breastfeeding. Talk with your doctor or pharmacist about your options.
What is D-Ribose and what does it do?
D-Ribose is a naturally occurring sugar your body uses to make and repair muscle cells. It's promoted for heart health, muscle recovery, and energy, but the evidence for most of those uses is weak or not yet established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Ribose 700 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Ribose 700 mg label
Go deeper

The Full Monographs Behind D-Ribose 700 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

D-Ribose 700 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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