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Dietary supplement

D-Ribose Powder 5000 mg Ingredients & Drug Interactions

by NOW Sports

D-Ribose Powder 5000 mg label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Ribose Powder 5000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Ribose Powder 5000 mg is a dietary supplement by NOW Sports with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioenergy Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against D-Ribose Powder 5000 mg by NOW Sports

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Ribose Powder 5000 mg by NOW Sports — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Ribose Powder 5000 mg by NOW Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

D-Ribose Powder 5000 mg contains one active ingredient: Bioenergy Ribose, a naturally occurring five-carbon sugar (pentose) that your body uses to produce energy in cells. Each serving provides 5 grams of ribose in powder form.

There are no other active ingredients listed.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: energy production and muscle fuel for athletic performance.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Muscle soreness, Congestive heart failure (CHF), Coronary heart disease (CHD) — and 2 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for ribose's effectiveness is mixed and limited. For athletic performance and McArdle disease (a rare metabolic disorder), the data suggests it's possibly ineffective.

For restless legs syndrome, muscle soreness, congestive heart failure, and recovery after bypass surgery, we don't have enough reliable evidence to say whether it works or doesn't. If any of these uses is on your mind, that's worth discussing with your doctor — the research just isn't there yet to make a solid call.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ribose is generally well tolerated when taken by mouth for up to a month. The most common side effects are diarrhea, gastrointestinal upset, headache, nausea, and low blood sugar (hypoglycemia).

Some people have reported anxiety, lightheadedness, or increased appetite; lowering the dose has resolved these in some cases. There isn't enough safety data to know whether ribose is okay during pregnancy or while breastfeeding — the facts advise against it during both.

Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or nursing. Long-term safety beyond one month hasn't been well studied.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting D-Ribose Powder 5000 mg, check with your doctor or pharmacist if you take insulin or any antidiabetes medications (including metformin, sulfonylureas, GLP-1 agonists, or others). Ribose can strengthen their blood-sugar-lowering effect, raising the risk of dangerously low blood sugar (hypoglycemia).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose may be worth considering if you're interested in supporting cellular energy, but the evidence for most common uses is either lacking or points toward it not being effective. The biggest caution is if you take insulin or blood-sugar medications — you'll need to clear this with your doctor first because of the risk of low blood sugar.

Talk with your doctor or pharmacist about whether this product fits your situation and any medications you're on.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Ribose Powder 5000 mg, straight from the product label.

Brand NOW Sports
Net contents 8 Ounce(s); 227 Gram(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 245434
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Ribose Powder 5000 mg by NOW Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 Level Teaspoon(s), 5 Gram(s)
Maximum serving Sizes:
1.5 Level Teaspoon(s), 5 Gram(s)
Servings per container
45
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
Bioenergy Ribose5 Gram(s)--
Total Sugars5 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Energy production Muscle fuel ATP production

Steroid free Non GMO

Vegan

Natural color variation may occur in this product.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Formula

Bioenergy RIBOSE

Triangle K (Kosher)

Ribose is a simple sugar that occurs naturally in all living cells. Ribose is the structural backbone of ATP, the primary form of energy used for all cellular processes. Demand for ATP availability is especially critical in the heart and skeletal muscle and Ribose supplementation can help to maintain optimal energy levels in these tissues.

Seals/Symbols

Informed-Sport.com Trusted by sport Informed-Choice.org Trusted by sport Triangle K (Kosher) Non GMO Project Verified nongmoproject.org

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested usage: Take 1 1/2 level teaspoons daily, prior to exercise.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not eat freshness packet enclosed.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool, dry place after opening.

Brand IP Statement(s)

Bioenergy RIBOSE is a registered trademark of Bioenergy Life Science, Inc. Use of ribose is licensed by Bioenergy Life Science, Inc. under U.S. Patents and other U.S. and foreign patents issued and pending.

General Statements

This product is sold by weight not volume.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Ribose Powder 5000 mg by NOW Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Ribose Powder 5000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Ribose Powder 5000 mg by NOW Sports

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.5 Level Teaspoon(s) Dosage formPowder Servings per container45 Amounts shown are per serving.

Bioenergy Ribose

Interacts with
86 drugs
5 Gram(s) per serving Form: D-Ribose, Powder

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

Bioenergy Ribose monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Ribose Powder 5000 mg by NOW Sports Drug Interactions

Want to check YOUR meds against D-Ribose Powder 5000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Bioenergy Ribose 86

Individual Drug Interactions

The ingredients in D-Ribose Powder 5000 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Ribose Powder 5000 mg interact with drugs. Each result below shows which ingredient is responsible. Bioenergy Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Ribose Powder 5000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioenergy Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
Bioenergy Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Ribose Powder 5000 mg, from the product label.

NOW Sports

See all NOW Sports products
Name
NOW FOODS
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowsportsproducts.com
Pharmacist Counseling Corner

D-Ribose Powder 5000 mg by NOW Sports: Common Questions

Does D-Ribose Powder 5000 mg by NOW Sports interact with any medications?
Yes. Based on its ingredients, D-Ribose Powder 5000 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Ribose Powder 5000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take D-Ribose if I have diabetes or prediabetes?
Not without checking with your doctor first. Ribose lowers blood sugar on its own, and if you're already taking insulin or diabetes medications, combining them could push your blood sugar too low. Your doctor can help you figure out whether it's safe for you and whether any dose adjustments are needed.
What are the most common side effects?
Diarrhea, stomach upset, nausea, and headache are the most frequently reported. Some people have also experienced low blood sugar, anxiety, lightheadedness, or increased appetite. Lowering the dose has helped resolve nausea and anxiety in some cases.
Is D-Ribose safe to take long-term?
It's been studied safely for up to one month, but long-term safety hasn't been well established. If you're thinking about taking it regularly beyond that, talk with your doctor about what we know and don't know.
Can I take this while pregnant or breastfeeding?
There isn't enough safety information to know either way, so it's best to avoid it during pregnancy and while nursing. Talk with your doctor or pharmacist for personalized advice if you're in either situation.
Does D-Ribose actually boost athletic performance?
The research suggests it's possibly ineffective for that purpose. If improving athletic performance is your goal, there may be better-studied options — worth discussing with your doctor or a sports nutritionist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Ribose Powder 5000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Ribose Powder 5000 mg label
Go deeper

The Full Monographs Behind D-Ribose Powder 5000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

D-Ribose Powder 5000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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