D3 125 mcg (5000 IU) Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D3 125 mcg (5000 IU) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D3 125 mcg (5000 IU) is a dietary supplement by Nature's Bounty with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against D3 125 mcg (5000 IU) by Nature's Bounty
Ask about any prescription or over-the-counter medication and we check it for interactions with D3 125 mcg (5000 IU) by Nature's Bounty — and tell you which ingredient is responsible.
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HelloPharmacist Scorecard of D3 125 mcg (5000 IU) by Nature's Bounty
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: vitamin D at 125 mcg (5000 IU) per softgel. Vitamin D is a fat-soluble nutrient that your body uses to absorb calcium, support bone health, and regulate immune function.
The softgel also contains inactive ingredients—soybean oil, gelatin, vegetable glycerin, and corn oil—which help deliver the vitamin D.
Does it work?
Strong evidence
Vitamin D is effective for treating rickets, osteomalacia (soft bones), familial hypophosphatemia (a genetic calcium disorder), renal osteodystrophy (bone disease from kidney failure), and hypoparathyroidism (low parathyroid hormone). These are conditions where vitamin D deficiency or metabolism is the root problem.
For other uses—like general bone health or immune support in people without deficiency—the evidence in our data doesn't establish effectiveness.
How safe is it?
Well-documented data
Vitamin D is generally well tolerated at recommended doses. However, very high doses taken over time can cause vitamin D toxicity, with symptoms like high blood calcium (hypercalcemia), bone loss in adults, weak growth in children, eye inflammation, and light sensitivity.
Vitamin D is likely safe during pregnancy at recommended amounts, though you should take it only under your doctor's guidance. It's also likely safe while breastfeeding.
Because this product is at the upper safe limit for daily intake (5000 IU), talk with your doctor or pharmacist before adding it to your routine, especially if you're pregnant, breastfeeding, or have kidney disease.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take thiazide diuretics (water pills), verapamil or diltiazem (heart medications), digoxin (a heart medication), atorvastatin (cholesterol), calcipotriene (psoriasis cream), or aluminum-containing products. Also mention any other medications metabolized by the CYP3A4 enzyme, as vitamin D may reduce their effectiveness.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This vitamin D product is effective for specific deficiency-related bone and mineral disorders. If you take medications for heart rhythm, blood pressure, cholesterol, or calcium regulation, check with your doctor or pharmacist before starting—vitamin D can interact with these at higher doses.
At the recommended dose, vitamin D is generally well tolerated, but toxicity is possible with long-term excessive intake. Use it as directed and run your full medication list through the checker on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D3 125 mcg (5000 IU), straight from the product label.
| Brand | Nature's Bounty |
|---|---|
| Barcode (UPC) | 074312193774 |
| Net contents | 150 Rapid Release Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Dec 26, 2020 |
| DSLD ID | 240696 |
| Product type | Vitamin |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D3 125 mcg (5000 IU) by Nature's Bounty, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin D | 125 mcg | 625% |
Other ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Corn Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Nearly 50 years of trusted quality At Nature’s Bounty, we are committed to your health. For nearly 50 years we have been making trusted products, backed by science, and made with only the purest ingredients...guaranteed. So you can get the most out of life every day.
Nutrition Questions or Comments? Call 1-800-433-2990 Mon. - Sat. 9 AM - 7 PM ET Join our Loyalty Program at NaturesBountyRewards.com
Formulation
Your Sunshine Vitamin Guaranteed Quality Laboratory Tested
Non-GMO, No Artificial Color, No Artificial Flavor, No Artificial Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
Supports Strong Bones & Immune Health Immune health
Made In The USA with select ingredients from around the world
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Vitamin Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, take one (1) softgel daily, preferably with a meal.
Precautions
Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Do not use if seal under cap is broken or missing.
Storage
Store at room temperature.
Brand IP Statement(s)
2017 Nature’s Bounty, Inc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D3 125 mcg (5000 IU) by Nature's Bounty label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D3 125 mcg (5000 IU) by Nature's Bounty
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.
Vitamin D
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D monograph & interactionsOther (inactive) ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Corn Oil. These complete the product’s ingredient list but are not active constituents.
D3 125 mcg (5000 IU) by Nature's Bounty Drug Interactions
HelloPharmacist Interaction Report
Nature's Bounty D3 125 mcg (5000 IU) contains vitamin D, which interacts with a range of medications—most seriously with thiazide diuretics, verapamil, atorvastatin, aluminum-containing products, digoxin, diltiazem, and calcipotriene.
The primary concern across these is that high-dose vitamin D can raise blood calcium levels (hypercalcemia), which reduces how well some heart medications work and increases the risk of dangerous heart rhythms with digoxin. Altogether, these interactions span 716 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Thiazide diuretics, verapamil, diltiazem, and calcipotriene all carry Moderate risk because of hypercalcemia. Digoxin also carries Moderate risk—high-dose vitamin D can trigger life-threatening irregular heartbeats.
Atorvastatin and aluminum have Moderate interactions as well: vitamin D may reduce how much atorvastatin your body absorbs, and it may increase aluminum absorption in people with kidney problems. CYP3A4 substrates (a broad enzyme category affecting many drugs) carry Minor risk if vitamin D induces the enzyme that metabolizes them.
At the dose in this product—5000 IU—you're at the tolerable upper intake limit for adults. The interactions above are most concerning at higher doses, but if you take any of these medications, it's worth checking your exact drugs with the tool below before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against D3 125 mcg (5000 IU)?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in D3 125 mcg (5000 IU) interact with 715 drugs. Click any drug to see the details.
1 of the 1 ingredient in D3 125 mcg (5000 IU) interact with drugs. Each result below shows which ingredient is responsible. Vitamin D
Alginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Alginic Acid, Aluminum Hydroxide interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum, Magnesium Hydroxide (otc Drug) interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Amiloride, Hydrochlorothiazide interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Atenolol, Chlorthalidone interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DCytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Vitamin D might reduce absorption of atorvastatin.
Read the full Vitamin D + Atorvastatin Calcium interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Azilsartan, Chlorthalidone interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Benzthiazide interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DCalcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D + Betamethasone Dipropionate, Calcipotriene interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bisoprolol, Hydrochlorothiazide interactionCalcipotrieneDovonex
How Calcipotriene interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DCalcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D + Calcipotriene interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Captopril, Hydrochlorothiazide interactionChlorothiazideDiuril
How Chlorothiazide interacts with D3 125 mcg (5000 IU) — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Chlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in D3 125 mcg (5000 IU) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Brand information
Manufacturer and brand details for D3 125 mcg (5000 IU), from the product label.
Nature's Bounty
See all Nature's Bounty products- Name
- Nature's Bounty, Inc.
- City
- Bohemia
- State
- NY
- ZipCode
- 11716
- Phone Number
- 1-800-433-2990
D3 125 mcg (5000 IU) by Nature's Bounty: Common Questions
Does D3 125 mcg (5000 IU) by Nature's Bounty interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this dose of vitamin D safe to take every day?
Can I take this while pregnant or breastfeeding?
What does vitamin D actually do in my body?
Will this interact with my cholesterol or blood pressure medication?
What are the signs of taking too much vitamin D?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D3 125 mcg (5000 IU) is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D3 125 mcg (5000 IU)’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D3 125 mcg (5000 IU)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
- Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
- Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
- Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
- Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
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