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Dietary supplement

D400 Infant Vitamin D Daily Oral Spray Ingredients & Drug Interactions

by BetterYou

Liquid Category: Vitamin
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

D400 Infant Vitamin D Daily Oral Spray is a dietary supplement by BetterYou with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 717 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of D400 Infant Vitamin D Daily Oral Spray by BetterYou

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This spray contains a single active ingredient: vitamin D. The product also includes coconut oil as an inactive ingredient to deliver the vitamin in liquid form.

Vitamin D is a fat-soluble vitamin your body uses to absorb calcium, support bone health, and regulate immune function. In infants, it's essential for proper bone development and calcium balance.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: vitamin D supplementation for infants.
  • We looked for evidence on: Infant development, Child growth, Familial hypophosphatemia, Osteomalacia, Hypoparathyroidism, Renal osteodystrophy — and 3 related terms.
  • The strongest evidence on file: Vitamin D is rated "Effective" for Familial hypophosphatemia (Natural Medicines).
  • Also on file: Vitamin D is rated "Effective" for Osteomalacia, Renal osteodystrophy, Rickets, Hypoparathyroidism, and more.
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Infant development.

Vitamin D in this form is effective for treating vitamin D deficiency diseases — rickets, osteomalacia (soft bones in adults), renal bone disease, hypoparathyroidism, and familial hypophosphatemia. The data we hold doesn't establish how well the spray formulation works for general wellness or immune support in healthy infants, so talk with your pediatrician about whether this product is right for your child's specific needs.

The evidence, ingredient by ingredient Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, but very high doses over time can cause toxicity with symptoms like elevated blood calcium, bone loss, and in children, slowed growth. The product's adverse effects are rare when used as directed — serious vitamin D toxicity happens with excessive doses taken over extended periods.

For pregnancy and breastfeeding: the safety data shows vitamin D is likely safe in pregnancy at recommended amounts, though one rating notes possibly unsafe — this mixed picture means you should use it only under your doctor's guidance if you're pregnant. It's considered likely safe while breastfeeding at recommended doses, but again, check with your doctor before taking higher amounts.

Side effects, ingredient by ingredient Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 718 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before giving this product, tell your child's doctor or pharmacist if they take digoxin (Lanoxin) for heart rhythm, verapamil or diltiazem for arrhythmia, thiazide diuretics (water pills), atorvastatin (Lipitor), calcipotriene (Dovonex) for psoriasis, or any medications that rely on the liver enzyme CYP3A4. High-dose vitamin D can raise blood calcium and interfere with how these drugs work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This spray is designed for infants who need vitamin D to prevent or treat deficiency-related bone disease. If your child takes any heart medications, water pills, cholesterol drugs, or uses a vitamin D-like psoriasis cream, talk with your pediatrician or pharmacist before starting this product.

For any questions about the right dose for your infant or about combining it with other medications or supplements, check with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D400 Infant Vitamin D Daily Oral Spray, straight from the product label.

Brand BetterYou
Barcode (UPC) 96170816
Net contents 0.51 Fluid Ounce(s); 15 mL
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 313020
Product type Vitamin
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Infants/Baby (0 - 1 Year), Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D400 Infant Vitamin D Daily Oral Spray by BetterYou, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Children less than 4 years of age
Minimum serving Sizes:
0.13 mL
Maximum serving Sizes:
0.13 mL
Servings per container
100
UPC/BARCODE
96170816
IngredientAmount% DV
Vitamin D75 mcg50%

Other ingredients: Coconut Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

How to use Initial use: press the pump 3 times to get the liquid flowing. Shake well before every use. Carefully spray into your child's mouth. Replace cap after use. Directions Use 1 spray daily.

Storage

Once opened, use within 6 months. Store at room temperature and out of direct sunlight.

Precautions

Warnings Keep out of reach and sight of children.

Formulation

Suitable for vegetarians.

Palm oil free

Vitamin D3 helps: Support a normal immune system Aid normal muscle function Maintain normal bones and teeth Formulated in Great Britain

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

No more pills The UK's original vitamin oral spray range Recycling instructions Carton This carton is made of material from well-managed, FSC - certified forests and other controlled sources. Please recycle it with other paper and card products. Bottle & pump The bottle is made from 70% Ocean Waste Plastic - recovered from the Indian Ocean, the Caribbean Sea and the Philippine Sea - and 30% post-consumer recycling (PCR). Separate components and recycle. Cap Our bottle cap is made from Post-Consumer Recycling (PCR) - this means it has been manufactured from recycled household plastics and can be recycled with them again. This packaging uses ocean plastic. www.betterplanetproject.co.uk Recyclable board

100 daily servings

Seals/Symbols

Palm oil free Vegetarian Society Approved

Formula

Under 3 years For babies and children under 3 years

D400 Infant Vitamin D Daily Oral Spray 10 mcg (400 IU) per daily serving A simple and pure formulation designed to maintain your infant's Vitamin D levels

FDA Statement of Identity

Dietary Supplement

See for yourself

D400 Infant Vitamin D Daily Oral Spray by BetterYou label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in D400 Infant Vitamin D Daily Oral Spray by BetterYou

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.13 mL Dosage formLiquid Servings per container100 Amounts shown are per serving.

Vitamin D

Interacts with
717 drugs
75 mcg per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Other (inactive) ingredients: Coconut Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

D400 Infant Vitamin D Daily Oral Spray by BetterYou Drug Interactions

Want to check YOUR meds against D400 Infant Vitamin D Daily Oral Spray?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
717Drugs
80 Moderate 637 Minor

Ingredients driving the most interactions

Vitamin D 717

Each ingredient & the kinds of drugs it affects

For each ingredient in D400 Infant Vitamin D Daily Oral Spray with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 717 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for D400 Infant Vitamin D Daily Oral Spray, from the product label.

BetterYou

See all BetterYou products
Name
BetterYou Ltd
City
Barnsley S74 9LH.
Phone Number
+1(512)782-9726
Web Address
www.betteryou.com
Pharmacist Counseling Corner

D400 Infant Vitamin D Daily Oral Spray by BetterYou: Common Questions

Does D400 Infant Vitamin D Daily Oral Spray by BetterYou interact with any medications?
Yes. Based on its ingredients, D400 Infant Vitamin D Daily Oral Spray has a known interaction with 717 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D400 Infant Vitamin D Daily Oral Spray contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe for my infant?
Vitamin D is generally well tolerated at recommended doses, and this spray is formulated for infants. Very high doses over time can cause toxicity, so stick to the dosing instructions on the label and talk with your pediatrician if you have any concerns about the right amount for your child.
Can I use this if my child takes other medications?
Vitamin D can interact with several types of medications, especially heart drugs, water pills, and cholesterol medicines. Before starting this spray, tell your child's doctor or pharmacist about any other medications or supplements your child takes.
What is vitamin D for, exactly?
Vitamin D helps your child's body absorb calcium and build strong bones. This product is effective for treating vitamin D deficiency diseases like rickets and is often used to prevent bone disease in infants who don't get enough sun exposure or dietary vitamin D.
What does the D400 dose mean?
D400 means the spray contains 400 international units (IU) of vitamin D per dose — a common amount for infant vitamin D products. Your pediatrician can tell you whether this is the right dose for your child.
Are there any side effects?
At recommended doses, vitamin D is well tolerated and serious side effects are rare. Very high doses taken over time can cause vitamin D toxicity with symptoms like elevated blood calcium and, in children, slowed growth — which is why it's important to follow the dosing instructions and not exceed recommended amounts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D400 Infant Vitamin D Daily Oral Spray label
Go deeper

The Full Monographs Behind D400 Infant Vitamin D Daily Oral Spray’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

D400 Infant Vitamin D Daily Oral Spray's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 25 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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