Major interaction on record — check this product against your medications before combining. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

DDR Prime Ingredients & Drug Interactions

by doTERRA

DDR Prime label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DDR Prime against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

DDR Prime is a dietary supplement by doTERRA with 8 active ingredients. Its ingredients are commonly taken for joint pain and osteoarthritis, inflammation, digestive complaints.Based on those ingredients, 1,218 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Clove (Eugenia caryophyllus) bud Oil, wild Orange (Citrus aurantium dulcis) peel Oil, Lemongrass (Cymbopogon flexuosus) leaf Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against DDR Prime by doTERRA

Ask about any prescription or over-the-counter medication and we check it for interactions with DDR Prime by doTERRA — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of DDR Prime by doTERRA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “DDR Prime Proprietary Blend” is a proprietary blend — the label gives one combined amount (480 mg) without saying how much of each component you get.

DDR Prime contains eight active ingredients, most of them essential oils: frankincense, wild orange, litsea, thyme, summer savory, niaouli, lemongrass, and clove. These are blended into a base of extra virgin olive oil and packaged in softgel capsules with food starch, glycerin, carrageenan, maltitol, and purified water as inactive ingredients.

Each oil brings its own aromatic and traditional properties to the formula.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support healthy cellular response and regeneration.
  • We looked for evidence on: Cancer, Cancer-related fatigue, Fatigue, Cellular oxidative stress, Cellular senescence, Antioxidant support.
  • The closest evidence on file: Frankincense is rated "Insufficient Reliable Evidence To Rate" for Cancer-related fatigue (Natural Medicines).
  • Also on file: Lemongrass is rated "Insufficient Reliable Evidence To Rate" for Fatigue.
  • Also on file: Bitter Orange is rated "Insufficient Reliable Evidence To Rate" for Cancer, Fatigue.

The evidence supporting DDR Prime's ingredients is limited. Frankincense, wild orange, thyme, lemongrass, and clove all show insufficient reliable evidence for the health claims commonly made about them—whether for skin, colds, bronchitis, headaches, or other uses listed on supplement labels.

Clove alone has one use rated as possibly effective: ventilator-associated pneumonia (VAP), which is a hospital-acquired lung infection in intubated patients. For the other uses these ingredients are promoted for, the data we hold doesn't establish that they work.

The evidence, ingredient by ingredient Frankincense Bitter Orange Thyme Summer Savory Lemongrass Clove

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Frankincense is generally well tolerated short-term when used topically or inhaled, but safety data is limited for oral use in supplements—it's not enough to know either way during pregnancy or breastfeeding, so talk with your doctor or pharmacist first. Wild orange can raise heart rate and blood pressure, especially when taken with caffeine or other stimulants; it's not recommended during pregnancy because of these stimulant effects.

Thyme is likely safe in food amounts and likely safe during pregnancy, but the concentrated essential oil in this supplement is less studied. Clove is safe as a spice but toxic in large amounts (clove oil at 5–10 mL has poisoned children), so stick to the manufacturer's dose.

Lemongrass has limited safety data for medicinal doses, particularly during pregnancy. One small clinical study of bitter orange juice showed it can raise blood pressure and heart rate, and rare serious events—including heart attack, stroke, and irregular heartbeats—have been reported.

Side effects, ingredient by ingredient Frankincense Bitter Orange Thyme Summer Savory Lemongrass Clove

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Clove, Summer Savory, Lemongrass, Thyme, Bitter Orange.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take MAOIs (older antidepressants), midazolam (Versed) or other sedatives, blood thinners or antiplatelet drugs like warfarin or aspirin, heart medications that control rhythm, diabetes drugs, stimulants, or caffeine regularly. Wild orange is the main culprit for Major-severity issues, but several ingredients can slow how your liver breaks down medications, potentially raising their levels and side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

DDR Prime is an essential oil blend with limited evidence that it works for any specific condition. If you take heart, blood pressure, diabetes, blood thinner, or psychiatric medications, or if you use caffeine regularly, talk to your pharmacist before starting this product—the interactions could be serious.

Pregnant or breastfeeding? Check with your doctor or pharmacist first, since safety data is thin for most of these oils at supplement doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DDR Prime, straight from the product label.

Brand doTERRA
Net contents 60 Vegetarian Softgel(s)
Market status On market
Date entered into DSLD May 28, 2019
DSLD ID 203085
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DDR Prime by doTERRA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
IngredientAmount% DV
Frankincense (Boswellia carterii) resin Oil0 NP--
wild Orange (Citrus aurantium dulcis) peel Oil0 NP--
Litsea (Litsea cubeba) fruit Oil0 NP--
Thyme (Thymus vulgaris) leaf Oil0 NP--
Summer Savory (Satureja hortensis) plant Oil0 NP--
Niaouli (Melaleuca quinquenervia) leaf Oil0 NP--
Lemongrass (Cymbopogon flexuosus) leaf Oil0 NP--
DDR Prime Proprietary Blend480 mg--
Clove (Eugenia caryophyllus) bud Oil0 NP--

Other ingredients: extra virgin Olive Oil, Food Starch, Glycerin, Carrageenan, Maltitol, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

doTERRA DDR Prime is a proprietary blend of CPTG Certified Pure Therapeutic Grade essential oils formulated to support healthy cellular response and regeneration. As we age, cellular renewal can slow or be compromised by oxidative damage to cellular DNA. The essential oils in DDR Prime provide antioxidant protection and support a healthy response to cellular stressors.

Essential oil cellular complex

30-day supply

Suggested/Recommended/Usage/Directions

Directions for use: Take 2 softgels daily with meal (may take once morning and evening)

Precautions

Note: Keep out of reach of children.

Pregnant or nursing women and people with known medical conditions should consult a physician before using.

Do not use if safety seal is broken or missing.

Formulation

Does not contain milk or wheat products.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

CPTG

General

v5 34410001

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DDR Prime by doTERRA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DDR Prime label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DDR Prime by doTERRA

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

DDR Prime Proprietary Blend

480 mg per serving

Other (inactive) ingredients: Extra virgin Olive Oil, Food Starch, Glycerin, Carrageenan, Maltitol, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

DDR Prime by doTERRA Drug Interactions

Want to check YOUR meds against DDR Prime?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,218Drugs
10 Major 1,208 Moderate

Ingredients driving the most interactions

Clove (Eugenia caryophyllus) bud Oil 977
wild Orange (Citrus aurantium dulcis) peel Oil 957
Lemongrass (Cymbopogon flexuosus) leaf Oil 708
Thyme (Thymus vulgaris) leaf Oil 379
Summer Savory (Satureja hortensis) plant Oil 122

Individual Drug Interactions

The ingredients in DDR Prime interact with 1,218 drugs. Click any drug to see the details.

5 of the 8 ingredients in DDR Prime interact with drugs. Each result below shows which ingredient is responsible. Clove (Eugenia caryophyllus) bud Oil wild Orange (Citrus aurantium dulcis) peel Oil Lemongrass (Cymbopogon flexuosus) leaf Oil Thyme (Thymus vulgaris) leaf Oil Summer Savory (Satureja hortensis) plant Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in DDR Prime with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Clove (Eugenia caryophyllus) bud Oil7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove (Eugenia caryophyllus) bud Oil full monograph & interactions

wild Orange (Citrus aurantium dulcis) peel Oil13 drug types · 957 drugs

Midazolam (Versed)

Bitter orange might increase blood levels of midazolam.
One small clinical study shows that bitter orange juice can increase midazolam levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4). Theoretically, bitter orange might increase the risk of midazolam-related adverse effects.

Likelihood Probable Evidence B
Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to hypertensive crisis.
Bitter orange contains tyramine, octopamine, and synephrine, which are MAO substrates.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that drinking a tea containing bitter orange and Indian snakeroot reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are using antidiabetes drugs. However, it is unclear if these effects are due to bitter orange, Indian snakeroot, or the combination. An animal study also shows that p-synephrine in combination with gliclazide , a sulfonylurea, causes an additional 20% to 44% decrease in glucose levels when compared with gliclazide alone.

Likelihood Possible Evidence B
Caffeine

Bitter orange might increase blood pressure and heart rate when taken with caffeine.
Small clinical studies show that taking bitter orange in combination with caffeine can increase blood pressure and heart rate in otherwise healthy normotensive adults. Theoretically, this might increase the risk of serious cardiovascular adverse effects.

Likelihood Possible Evidence B
Colchicine

Bitter orange might affect colchicine levels.
Colchicine is a substrate of P-glycoprotein and cytochrome P450 3A4 (CYP3A4). Bitter orange has been reported to inhibit CYP3A4 and increase levels of CYP3A4 substrates. However, one small clinical study in healthy adults shows that drinking bitter orange juice 240 mL twice daily for 4 days and taking a single dose of colchicine 0.6 mg on the 4th day decreases colchicine peak serum levels by 24%, time to peak serum level by 1 hour, and overall exposure to colchicine by 20%. The clinical significance of this finding is unclear.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Bitter orange might increase levels of drugs metabolized by CYP3A4.
Small clinical studies suggest that single or multiple doses of freshly squeezed bitter orange juice 200-240 mL can inhibit CYP3A4 metabolism of drugs, causing increased drug levels and potentially increasing the risk of adverse effects. However, the extent of the effect of bitter orange on CYP3A4-mediated drug interactions is unknown. Some evidence suggests that bitter orange selectively inhibits intestinal CYP3A4, but not hepatic CYP3A4. Its effect on P-glycoprotein, which strongly overlaps with CYP3A4 interactions, is unclear. One small clinical study shows that drinking 8 ounces of freshly squeezed bitter orange juice has no effect on cyclosporine, which seems to be more dependent on hepatic CYP3A4 and P-glycoprotein than intestinal CYP3A4.

Likelihood Possible Evidence B
Dextromethorphan (Robitussin Dm, Others)

Bitter orange might increase blood levels of dextromethorphan.
One small clinical study shows that bitter orange juice increases dextromethorphan levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for dextromethorphan-related adverse effects.

Likelihood Possible Evidence B
Felodipine (Plendil)

Bitter orange might increase blood levels of felodipine.
One small clinical study shows that bitter orange juice increases felodipine levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for felodipine-related adverse effects.

Likelihood Probable Evidence B
Indinavir (Crixivan)

Bitter orange might increase blood levels of indinavir.
One small clinical study shows that bitter orange juice slightly increases indinavir levels, but this effect is likely to be clinically insignificant. Bitter orange selectively inhibits intestinal cytochrome P450 3A4 (CYP3A4); however, the metabolism of indinavir seems to be more dependent on hepatic CYP3A4. The effect of bitter orange on other protease inhibitors has not been studied.

Likelihood Possible Evidence B
Qt Interval-Prolonging Drugs

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
One case report suggests that taking bitter orange in combination with other stimulants such as caffeine might prolong the QT interval in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Bitter orange juice might increase blood levels of sildenafil.
A small clinical study in healthy adult males shows that drinking freshly squeezed bitter orange juice 250 mL daily for 3 days and taking a single dose of sildenafil 50 mg on the 3rd day increases the peak plasma concentration of sildenafil by 18% and the overall exposure to sildenafil by 44%. Theoretically, this may be due to inhibition of cytochrome P450 3A4 by bitter orange.

Likelihood Probable Evidence B
Stimulant Drugs

Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.
Bitter orange appears to have stimulant effects.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
In vitro research shows that octopamine, a constituent of bitter orange, weakly inhibits CYP2D6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
wild Orange (Citrus aurantium dulcis) peel Oil full monograph & interactions

Lemongrass (Cymbopogon flexuosus) leaf Oil3 drug types · 708 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Animal research shows that lemongrass and its constituent citral inhibit CYP3A4.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Animal research shows that lemongrass and its constituent citral induce uridine diphosphoglucuronosyl transferase (UGT), the major phase 2 enzyme that is responsible for glucuronidation.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, lemongrass might increase the effects and adverse effects of pentobarbital.
Animal research shows that high doses of lemongrass essential oil increases sleep time and decreases time to fall asleep in animals administered pentobarbital.

Likelihood Possible Evidence D
Lemongrass (Cymbopogon flexuosus) leaf Oil full monograph & interactions

Thyme (Thymus vulgaris) leaf Oil4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Thyme (Thymus vulgaris) leaf Oil full monograph & interactions

Summer Savory (Satureja hortensis) plant Oil1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

In vitro research suggests that summer savory extract inhibits platelet aggregation and adhesion. Theoretically, summer savory might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Summer Savory (Satureja hortensis) plant Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DDR Prime, from the product label.

doTERRA

See all doTERRA products
Name
doTERRA Intl, LLC
Street Address
389 S 1300 W
City
Pleasant Grove
State
UT
ZipCode
84062
Phone Number
1-800-411-8151
Web Address
www.doterra.com
Pharmacist Counseling Corner

DDR Prime by doTERRA: Common Questions

Does DDR Prime by doTERRA interact with any medications?
Yes. Based on its ingredients, DDR Prime has a known interaction with 1,218 medications, including 10 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DDR Prime contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take DDR Prime if I'm on blood thinners?
No, not without checking first. Thyme, summer savory, and clove can theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs like warfarin or aspirin. Talk to your pharmacist or doctor before taking this product.
Is this safe during pregnancy?
There isn't enough safety data to say yes. Frankincense and lemongrass should be avoided during pregnancy, and medicinal amounts of thyme and summer savory haven't been studied well enough either. Wild orange has stimulant effects that make it a poor choice when pregnant. Talk to your doctor before use.
What is wild orange doing in here?
Wild orange (bitter orange) is added for its aromatic properties, but it contains stimulant compounds—synephrine and octopamine—that can raise blood pressure and heart rate. That's why it's risky if you take heart, blood pressure, or certain psychiatric medications, or if you use caffeine.
Does DDR Prime actually do anything?
The evidence is thin. Most of the ingredients don't have reliable proof they work for the uses they're promoted for—acne, aging skin, colds, bronchitis, and so on. The one exception is clove, which is possibly effective for a hospital-acquired lung infection (VAP).
Can I take this with caffeine?
Not safely. Wild orange in this product can raise blood pressure and heart rate on its own, and studies show combining it with caffeine increases those effects further. If you drink coffee or tea regularly, skip this product or talk to your pharmacist first.
What if I'm diabetic and taking insulin or diabetes pills?
Check with your pharmacist. Clove and wild orange may lower blood sugar levels, and if you're already on a diabetes drug, that could push your blood sugar too low. You might need a dose adjustment—don't start without professional guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DDR Prime label
Go deeper

The Full Monographs Behind DDR Prime’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Frankincense

Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. Early research is promising for condition...

Read the full Frankincense monograph → Herb & supplement monograph

Bitter Orange

Interacts with 957 drugs

Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements. Evidence that it works for weight loss or performance i...

Read the full Bitter Orange monograph → Herb & supplement monograph

Thyme

Interacts with 379 drugs

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...

Read the full Thyme monograph → Herb & supplement monograph

Summer Savory

Interacts with 122 drugs

Summer savory is a common kitchen herb that has long been used as a tea or remedy for digestive complaints and minor infections. Food amounts are generally considered safe, but human studies...

Read the full Summer Savory monograph → Herb & supplement monograph

Lemongrass

Interacts with 708 drugs

Lemongrass is a fragrant tropical grass widely used as a cooking herb, a tea, and an aromatherapy oil. It is generally considered safe in the small amounts used in food, but most of its clai...

Read the full Lemongrass monograph → Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph →
Sources

Sources & How We Checked

DDR Prime's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 96 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Frankincense 2 references
  1. Acebo, E., Raton, J. A., Sautua, S., Eizaguirre, X., Trebol, I., and Perez, J. L. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream. Contact Dermatitis 2004;51(2):91-92.
  2. Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil. Contact Dermatitis 2021;85(4):465-467.

See these in context on the Frankincense monograph →

Bitter Orange 47 references
  1. Penzak SR, Jann MW, Cold JA, et al. Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. J Clin Pharmacol 2001;41:1059-63. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Calapai G, Firenzuoli F, Saitta A, et al. Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: A preliminary report. Fitoterapia 1999;70:586-92. DOI
  4. Keogh AM, Baron DW. Sympathomimetic abuse and coronary artery spasm. Br Med J 1985;291:940.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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