Deep Breath Ingredients & Drug Interactions
by Herb Stop
What is this page for?
First and foremost: checking Deep Breath against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Deep Breath is a dietary supplement by Herb Stop with 6 active ingredients. Its ingredients are commonly taken for cough and chest congestion, sore throat, bronchitis and respiratory irritation.Based on those ingredients, 2,044 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Plantain Leaf Extract, Mullein leaf extract, Pleurisy Root Extract, Wild. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Deep Breath by Herb Stop
Ask about any prescription or over-the-counter medication and we check it for interactions with Deep Breath by Herb Stop — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Deep Breath by Herb Stop
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Deep Breath contains 6 active ingredients in a proprietary extract blend: mullein leaf, wild osha root, red root, wild pleurisy root, plantain leaf, and wild mullein flower. Mullein and plantain are traditionally used to support respiratory function and soothe cough, while pleurisy root and osha root have historical use for chest complaints and digestion.
The product also contains grape alcohol and water as inactive ingredients.
Does it work?
Not established
The evidence for most of Deep Breath's ingredients isn't established in the data we hold. Mullein leaf and flower both show insufficient reliable evidence for cough, asthma, bronchitis, migraine, and diarrhea.
Osha root shows insufficient evidence for dyspepsia (indigestion) and HIV/AIDS. Plantain leaf is effective for constipation and likely effective for heart health, but we hold no effectiveness ratings for the other ingredients — red root extract and pleurisy root lack established evidence in our data.
How safe is it?
Well-documented data
Mullein leaf and flower are generally well tolerated for short-term use, though human safety data are limited; topical exposure has caused dermatitis in rare case reports. Both should be avoided in pregnancy and breastfeeding.
Osha root has limited safety data and wild plants can be confused with poisonous look-alikes; it's traditionally avoided in pregnancy and unsafe to use while breastfeeding. Red root has little modern safety data and should be used only under professional guidance; avoid it in pregnancy and breastfeeding.
Pleurisy root contains potentially toxic compounds with little safety data and should not be used in pregnancy; it's possibly unsafe while breastfeeding. It can cause gastrointestinal upset and nausea at normal doses, and large amounts may cause digitalis-like poisoning with serious heart symptoms.
Plantain leaf is generally well tolerated with adequate fluid intake but can rarely cause bowel or esophageal blockage if not taken with enough water; it's likely safe in pregnancy and breastfeeding.
Meds to double-check
Major interaction found
Check with your doctor or pharmacist if you take digoxin (Lanoxin) — this is a Major interaction with pleurisy root that risks heart toxicity. Also double-check before use if you take estrogens, water-pill diuretics, metformin, lithium, carbamazepine, olanzapine, birth control pills, other oral medications, or blood thinners — pleurisy root and plantain leaf have documented Moderate interactions with these, and mullein has Minor interactions with blood thinners.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
Deep Breath is a multi-herb blend with strongest evidence only for plantain's effect on constipation and heart health. If you take digoxin, estrogen, diuretics, metformin, lithium, carbamazepine, olanzapine, birth control, blood thinners, or antiplatelet drugs, you need to check this product with your doctor or pharmacist first — the interactions can be serious.
Even if you're on other medications, run them through the checker on this page before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Deep Breath, straight from the product label.
| Brand | Herb Stop |
|---|---|
| Net contents | 1 Ounce(s); 30 mL |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 297291 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Deep Breath by Herb Stop, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 0 NP | -- |
| Mullein leaf extract | 0 NP | -- |
| Osha Root Extract, Wild | 0 NP | -- |
| Red Root Root Extract | 0 NP | -- |
| Pleurisy Root Extract, Wild | 0 NP | -- |
| Plantain Leaf Extract | 0 NP | -- |
| Mullein Flower Extract, Wild | 0 NP | -- |
Other ingredients: Grape Alcohol, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Take 30 drops in a small amount of water, 3-4 times daily or as directed.
Precautions
Safety guideline: Not to be used during pregnancy or lactation. If you have a medical condition or take pharmaceutical drugs, please consult with your doctor before use.
Keep away from children.
Use only as directed on label.
Brand IP Statement(s)
Herb Stop Health in your own hands
Formulation
Liquid herbal extract
Supports healthy respiratory function
Vegan & cruelty-free
Vegan & cruelty-free Made in the USA.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Deep Breath by Herb Stop label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Deep Breath by Herb Stop
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size30 Drop(s) Dosage formLiquid Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
Other (inactive) ingredients: Grape Alcohol, Water. These complete the product’s ingredient list but are not active constituents.
Deep Breath by Herb Stop Drug Interactions
HelloPharmacist Interaction Report
Deep Breath by Herb Stop has documented interactions with medications, primarily through its pleurisy root and plantain leaf extracts.
The most serious concern is pleurisy root's interaction with digoxin (Lanoxin), a heart medication — pleurisy root contains digitalis-like compounds that can increase the risk of toxicity and serious heart rhythm problems.
Read the full breakdown — every affected drug type, severity by severity
Pleurisy root also interacts with hormone drugs like estrogens (Moderate severity) and with water-pill diuretics (Moderate severity), which can raise the risk of heart complications by depleting potassium. Plantain leaf extract affects several medication types: it may alter absorption of metformin (diabetes), lithium (mood), carbamazepine (seizures), olanzapine (psychiatric), and birth control containing ethinyl estradiol, all rated Moderate severity.
Additionally, plantain leaf may reduce digoxin absorption (Minor). Both mullein leaf and mullein flower extracts have Minor interactions with blood thinners (anticoagulants) and antiplatelet drugs, increasing bleeding time slightly.
Altogether, these interactions span 2,045 individual medications.
We could not check osha root extract or red root extract for interactions — we hold no data on them. Use the medication checker on this page to look up your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Deep Breath?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Deep Breath interact with 2,044 drugs. Click any drug to see the details.
3 of the 6 ingredients in Deep Breath interact with drugs. Each result below shows which ingredient is responsible. Plantain Leaf Extract Mullein leaf extract Pleurisy Root Extract, Wild
DigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDigoxin (lanoxin) Major
Interaction Summary
Pleurisy root contains digitalis-like cardenolide glycosides.
Read the full Pleurisy Root Extract, Wild + Digoxin interactionPlantain Leaf ExtractOral Drugs, Digoxin (lanoxin) Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Digoxin interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Acetaminophen, Caffeine, Pyrilamine interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Acetaminophen, Pamabrom, Pyrilamine interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Acetazolamide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Acetazolamide interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Deep Breath — through 1 ingredient. Tap an ingredient for the detail:
Plantain Leaf ExtractOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Alogliptin, Metformin interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Amiloride, Hydrochlorothiazide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Ammonium Chloride interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Ammonium Chloride interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Atenolol, Chlortalidone interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Atenolol, Chlorthalidone interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Atenolol, Chlorthalidone interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Azilsartan, Chlorthalidone interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Azilsartan, Chlorthalidone interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildEstrogens Moderate
Interaction Summary
Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.
Read the full Pleurisy Root Extract, Wild + Bazedoxifene Acetate, Conjugated Estrogens interactionPlantain Leaf ExtractOral Drugs, Ethinyl Estradiol Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Benazepril, Hydrochlorothiazide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Bendroflumethiazide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Bendroflumethiazide, Nadolol interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Bendroflumethiazide, Potassium interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Bendroflumethiazide, Rauwolfia Serpentina interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Benzthiazide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Benzthiazide interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Bisoprolol, Hydrochlorothiazide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Bisoprolol, Hydrochlorothiazide interactionBumetanideBurinex
How Bumetanide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Bumetanide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Bumetanide interactionBumetanide, PotassiumBurinex K
How Bumetanide, Potassium interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Bumetanide, Potassium interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Bumetanide, Potassium interactionCaffeine, Potassium Salicylate, SalicylamideTrim-Elim
How Caffeine, Potassium Salicylate, Salicylamide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Caffeine, Potassium Salicylate, Salicylamide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Caffeine, Potassium Salicylate, Salicylamide interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Deep Breath — through 1 ingredient. Tap an ingredient for the detail:
Plantain Leaf ExtractOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Deep Breath — through 1 ingredient. Tap an ingredient for the detail:
Plantain Leaf ExtractMetformin (glucophage), Oral Drugs Moderate
Interaction Summary
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Read the full Plantain Leaf Extract + Canagliflozin, Metformin Hydrochloride interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Candesartan Cilexetil, Hydrochlorothiazide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Captopril, Hydrochlorothiazide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Captopril, Hydrochlorothiazide interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Deep Breath — through 1 ingredient. Tap an ingredient for the detail:
Plantain Leaf ExtractOral Drugs, Carbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Carbamazepine interactionChlorothiazideDiuril
How Chlorothiazide interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Chlorothiazide interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Chlorothiazide interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Chlorothiazide, Methyldopa interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Chlorothiazide, Methyldopa interactionChlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Chlorothiazide, Reserpine interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Chlorothiazide, Reserpine interactionChlorthalidoneHygroton, Thalitone
How Chlorthalidone interacts with Deep Breath — through 2 ingredients. Tap an ingredient for the detail:
Pleurisy Root Extract, WildDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root Extract, Wild + Chlorthalidone interactionPlantain Leaf ExtractOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Plantain Leaf Extract + Chlorthalidone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Deep Breath with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Plantain Leaf Extract
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Mullein leaf extract
Anticoagulant/Antiplatelet Drugs
Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.
Pleurisy Root Extract, Wild
Digoxin (Lanoxin)
Pleurisy root contains digitalis-like cardenolide glycosides. Taking pleurisy root in combination with digoxin could increase the risk of adverse effects and toxicity.
Diuretic Drugs
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.
Estrogens
Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.
Brand information
Manufacturer and brand details for Deep Breath, from the product label.
Herb Stop
See all Herb Stop products- Name
- The Herb Stop
- Street Address
- PO Box 673
- City
- Pine
- State
- AZ
- ZipCode
- 85544
- Phone Number
- 877.345.4372
- Web Address
- www.herbstop.com
Deep Breath by Herb Stop: Common Questions
Does Deep Breath by Herb Stop interact with any medications?
How can one product interact with so many drugs?
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What's pleurisy root and why is it concerning?
Why does plantain leaf interact with so many drugs?
Can I take this with water pills or heart medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Deep Breath’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Mullein
Interacts with 122 drugsMullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...
Read the full Mullein monograph → Herb & supplement monographOsha
Osha is a root from a wild mountain plant native to the western United States and Mexico, traditionally used by Native American and Hispanic communities for coughs, colds, and sore throats....
Read the full Osha monograph → Herb & supplement monographNew Jersey Tea
New Jersey Tea is a North American shrub whose leaves were historically brewed as a caffeine-free tea and used in folk medicine for sore throats and other complaints. There is very little mo...
Read the full New Jersey Tea monograph → Herb & supplement monographPleurisy Root
Interacts with 117 drugsPleurisy root is the dried root of Asclepias tuberosa (butterfly weed), a plant used in traditional North American and herbal medicine mainly for respiratory complaints. There is very little...
Read the full Pleurisy Root monograph → Herb & supplement monographBlack Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph →Sources & How We Checked
Deep Breath's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Mullein 2 references
- Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
- Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.
Osha 2 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
New Jersey Tea 1 reference
- Herbs at a Glance — NIH NCCIH Source
Pleurisy Root 7 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
- De Smet PAGM, Keller K, Hansel R, Chandler RF, Eds. Adverse Effects of Herbal Drugs 1. Verlag, Berlin: Springer, 1992. DOI
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC