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Dietary supplement

Digestive Advantage Advanced Probiotics Ingredients & Drug Interactions

by Schiff

Digestive Advantage Advanced Probiotics label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Advantage Advanced Probiotics against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Advantage Advanced Probiotics is a dietary supplement by Schiff with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Restore Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Advantage Advanced Probiotics by Schiff

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Advantage Advanced Probiotics by Schiff — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Advantage Advanced Probiotics by Schiff

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Probiotic Restore Blend” is a proprietary blend — the label gives one combined amount (120 mg) without saying how much of each component you get.

This product contains four active probiotic strains: Bifidobacterium lactis Bl-04, Lactobacillus paracasei Lpc-37, Lactobacillus acidophilus NCFM, and Bifidobacterium lactis Bi-07. These are live microorganisms intended to support digestive health.

The capsule also contains several inactive ingredients—hypromellose, microcrystalline cellulose, titanium dioxide, magnesium stearate, and silicon dioxide—which help form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: helps relieve digestive discomfort and occasional diarrhea.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Lactose intolerance, and more.

Lactobacillus acidophilus, one of the strains here, is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The same strain is possibly ineffective for atopic disease (allergic conditions), and evidence is insufficient to rate it for acute respiratory distress syndrome.

We don't have effectiveness data on file for the other three strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects including stomach discomfort, abdominal pain, indigestion, gas, bloating, diarrhea, vomiting, and burping are possible when taking probiotics in combination, but these events are uncommon.

Since L. acidophilus preparations contain live organisms, there's a theoretical concern they could cause infection in certain patients—though most documented cases appear linked to bacteria that moved from their normal location in the body. For pregnancy, the data suggest it's possibly safe, though we don't have lactation safety data on file.

Check with your doctor or pharmacist before starting, especially if you're pregnant, nursing, or have a weakened immune system.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main concern—they can reduce how well the live bacteria in this product work. If you're on antibiotics, ask your doctor or pharmacist how many hours apart to take them.

We couldn't check the other three probiotic strains for interactions, so mention this product to your pharmacist when you pick up any new prescription.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, antibiotic-associated diarrhea, and a few other digestive or bacterial conditions—though evidence is modest. If you take antibiotics, you'll need to separate the timing from this product.

Talk with your doctor or pharmacist about whether it's right for you and how to time it with any medications you're on.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Advantage Advanced Probiotics, straight from the product label.

Brand Schiff
Barcode (UPC) 020525939258
Net contents 32 Capsule(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 240960
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Advantage Advanced Probiotics by Schiff, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
16
UPC/BARCODE
020525939258
IngredientAmount% DV
Bifidobacterium lactis Bl-040 NP--
Lactobacillus paracasei Lpc-370 NP--
Lactobacillus acidophilus NCFM0 NP--
Probiotic Restore Blend120 mg--
Bifidobacterium lactis Bi-070 NP--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Titanium Dioxide, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Take the inside advantage

Our Story We know digestive health is the key to overall health and that digestive issues can put you at a disadvantage. That is why, for over 15 years, Digestive Advantage has been dedicated to your digestive health. Bringing you breakthrough and patented probiotic strains that help support your digestive and immune health.

Schiff since 1936 New!

Formulation

Clinically proven probiotic blend that helps restore digestive balance Clinically proven

Helps relieve minor abdominal discomfort and occasional bloating Helps relieve occasional diarrhea Supports digestive balance

Non-GMO Dairy free

Vegetarian

Schiff Quality Guarantee Purity Freshness Potency

Multi-strain support Clinically proven blend that helps restore digestive balance Reduces occasional diarrhea, minor abdominal discomfort & bloating

Formula

A unique 4-strain blend of probiotics

10 billion CFUs per capsule

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults 18 years and older, take one (1) or two (2) capsules daily with water.

Brand IP Statement(s)

rb Health Hygiene Home Patents: www. rb.com/patents

NCFM, Bi-07, Lpc-37 and BI-04 are trademarks of DuPont or its affiliates.

Precautions

Caution: If pregnant, breastfeeding, or on medication, consult your physician before using this product.

Keep out of reach of children.

Sealed for your protection. Do not use if protective wrap is damaged or missing.

Storage

Store in a cool, dry place and avoid excessive heat.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Advantage Advanced Probiotics by Schiff label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Advantage Advanced Probiotics label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Advantage Advanced Probiotics by Schiff

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container16 Amounts shown are per serving.

Probiotic Restore Blend

Interacts with
182 drugs
120 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Restore Blend monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Titanium Dioxide, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Advantage Advanced Probiotics by Schiff Drug Interactions

Want to check YOUR meds against Digestive Advantage Advanced Probiotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Restore Blend 182

Individual Drug Interactions

The ingredients in Digestive Advantage Advanced Probiotics interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Digestive Advantage Advanced Probiotics interact with drugs. Each result below shows which ingredient is responsible. Probiotic Restore Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Advantage Advanced Probiotics with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Restore Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Restore Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Advantage Advanced Probiotics, from the product label.

Schiff

See all Schiff products
Name
RB Health (US) LLC
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.digestiveadvantage.com
Pharmacist Counseling Corner

Digestive Advantage Advanced Probiotics by Schiff: Common Questions

Does Digestive Advantage Advanced Probiotics by Schiff interact with any medications?
Yes. Based on its ingredients, Digestive Advantage Advanced Probiotics has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Advantage Advanced Probiotics contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
Antibiotics can kill the live organisms in probiotics, making the supplement less effective. You'll need to space them out—typically a few hours apart—so ask your doctor or pharmacist for the timing that works best with your specific antibiotic.
Will this help my IBS?
Lactobacillus acidophilus, one strain in here, is possibly effective for IBS based on available evidence. That means some people may see benefit, but it's not guaranteed. Talk with your doctor about whether to try it for your symptoms.
Is it safe if I'm pregnant?
The data suggest Lactobacillus acidophilus is possibly safe during pregnancy, but we don't have enough information to be certain. Check with your doctor or midwife before starting, especially if you're pregnant or planning to be.
What side effects might I notice?
Gas, bloating, stomach discomfort, and diarrhea are possible when taking probiotics, but these are uncommon. Most people tolerate them well.
Does this product have fillers?
Yes—it contains hypromellose, microcrystalline cellulose, titanium dioxide, magnesium stearate, and silicon dioxide as inactive ingredients to form the capsule.
What do these probiotic strains do?
They're live beneficial bacteria meant to support digestive health. We have effectiveness data for Lactobacillus acidophilus, but not for the other three strains in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Advantage Advanced Probiotics is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Advantage Advanced Probiotics label
Go deeper

The Full Monographs Behind Digestive Advantage Advanced Probiotics’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Digestive Advantage Advanced Probiotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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