Interactions on record — worth a quick check against your medications. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Digestive Advantage Daily Probiotics + Gas Defense Ingredients & Drug Interactions

by Schiff

Digestive Advantage Daily Probiotics + Gas Defense label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Advantage Daily Probiotics + Gas Defense against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Advantage Daily Probiotics + Gas Defense is a dietary supplement by Schiff with 6 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BC30 Bacillus coagulans GBI-30, 6086. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Advantage Daily Probiotics + Gas Defense by Schiff

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Advantage Daily Probiotics + Gas Defense by Schiff — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Advantage Daily Probiotics + Gas Defense by Schiff

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has six active ingredients, most of them enzymes designed to help break down food in your digestive tract. Invertase, hemicellulase, alpha-galactosidase, and cellulase all work to digest different components of what you eat — carbohydrates, fiber, and complex sugars that can cause gas and bloating.

The other active ingredient is BC30 Bacillus coagulans, a live probiotic (beneficial bacterial strain) meant to support gut health and digestion. The inactive ingredients are fillers and capsule materials — maltodextrin, hydroxypropyl methylcellulose, titanium dioxide, carrageenan, potassium chloride, microcrystalline cellulose, dextrin, citric acid, silicon dioxide, and magnesium stearate — that help hold the capsule together and keep it stable.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and gas reduction.
  • We looked for evidence on: Constipation, Diarrhea, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), bloating — and 1 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Diarrhea, Dyspepsia, Flatulence, and more.

The evidence shows BC30 Bacillus coagulans is possibly effective for constipation and for irritable bowel syndrome (IBS). For other uses listed on this product — antibiotic-associated diarrhea, athletic performance, cancer, and fatty liver disease — the evidence isn't strong enough to rate it either way, according to the data we hold.

We have no effectiveness data on file for the four enzyme ingredients in this product, so we can't speak to how well they work for gas defense or digestion.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

BC30 Bacillus coagulans is generally well tolerated in healthy adults, but the evidence and quality of probiotic products vary quite a bit. There isn't enough reliable safety data on this ingredient to make broad claims; talk to your doctor before using if you have any health concerns.

One important caution: since this product contains live organisms, there is theoretical concern it could cause infection in people with weakened immune systems, central lines (catheters), or severe illness — including preterm infants. Reports of serious infection in these populations have been documented with other probiotics.

In relatively healthy people with intact immune systems and no catheters, such complications haven't been well established. Pregnancy and lactation safety data isn't on file for this ingredient — talk with your doctor or pharmacist about whether it's right for you during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you use antibiotics. Taking them at the same time as this probiotic may reduce how well the probiotic works.

We could not check interactions for the four enzyme ingredients because we hold no data for them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have constipation or IBS, this product's probiotic may be worth trying — the evidence is modest but shows promise. The enzyme ingredients might help with gas and bloating, though we don't have strength-of-evidence data for them.

If you take antibiotics, space them apart from this product so the probiotic organisms stay alive. If you're pregnant, breastfeeding, immunocompromised, or have a central line, talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Advantage Daily Probiotics + Gas Defense, straight from the product label.

Brand Schiff
Barcode (UPC) 020525970220
Net contents 32 Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 300900
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegetarian, Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Advantage Daily Probiotics + Gas Defense by Schiff, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
32
UPC/BARCODE
020525970220
IngredientAmount% DV
Invertase0.29 mg--
Hemicellulase10.32 mg--
Alpha-Galactosidase1.6 mg--
Cellulase4.05 mg--
BC30 Bacillus coagulans GBI-30, 608613.33 mg--
Cellulase6.27 mg--

Other ingredients: Maltodextrin, Hydroxypropyl Methylcellulose, Titanium Dioxide, Carrageenan, Potassium Chloride, Microcrystalline Cellulose, Dextrin, Citric Acid, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Schiff Since 1936

Copyright 2021 RB Health

RB Health + Hygiene + Home Patents: www.rb.com/patents Take the Inside Advantage

Formulation

Probiotics survive stomach acid 100X better

Helps break down hard-to-digest carbohydrates and helps to stop gas before it starts

Our daily probiotic Plus enzymes helps stop gas before it starts 100X Better BC30 Probiotic survives stomach acid 100X better vs. leading yogurts Our probiotic is protected with a natural protein shell to deliver more live good bacteria to your gut, and works to support overall digestive and immune health Helps support digestive balance Based on median survivability of Digestive Advantage probiotic BC30 vs. leading yogurts in a simulated gastric environment.

Sugar-free

Vegetarian

Purity Freshness Potency

Formula

A unique blend of probiotic plus 5 enzyme ingredients

General Statements

Survives better than 50 billion vs. products offering 50 billion live cultures

For information call: 1-800-526-6251 CFUs may be higher than 2 billion per capsule at time of manufacture.

Our Story We know digestive health is key to overall health and that digestive issues can put you at a disadvantage. That is why, for over 15 years, Digestive Advantage has been dedicated to your digestive health. Bringing you breakthrough and patented probiotic strains that help support your digestive and immune health.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Direction: Adults: Take one (1) capsule daily with water before problem foods. Some individuals may require taking two (2) or more capsules daily depending on intake of problem foods. Do not take more than three (3) capsules daily. Children 8 years and over: For children it is recommended that one capsule be opened, and contents be mixed into food or drink. Upon initial use, it may take 7 to 14 days for you to feel the product working. Consistent daily use is needed to maintain results.

Precautions

Contains milk, soy, and wheat.

If pregnant, breastfeeding, taking medications or have a known medical condition (including galactosemia, diabetes or are immunocompromised), consult a physician before using this product.

Keep out of reach of children.

Do not use if carton is damaged or if printed seal on blister is broken or missing.

Storage

Store in a cool, dry place and avoid excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Schiff Quality Guarantee

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Advantage Daily Probiotics + Gas Defense by Schiff label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Advantage Daily Probiotics + Gas Defense label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Advantage Daily Probiotics + Gas Defense by Schiff

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container32 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Invertase

0.29 mg per serving Form: Saccharomyces cerevisiae

Hemicellulase

10.32 mg per serving Form: Aspergillus niger

Alpha-Galactosidase

1.6 mg per serving Form: Aspergillus niger

Cellulase

4.05 mg per serving Form: Trichoderma reesei

BC30 Bacillus coagulans GBI-30, 6086

Interacts with
182 drugs
13.33 mg per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

BC30 Bacillus coagulans GBI-30, 6086 monograph & interactions

Cellulase

6.27 mg per serving Form: Aspergillus niger

Other (inactive) ingredients: Maltodextrin, Hydroxypropyl Methylcellulose, Titanium Dioxide, Carrageenan, Potassium Chloride, Microcrystalline Cellulose, Dextrin, Citric Acid, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Advantage Daily Probiotics + Gas Defense by Schiff Drug Interactions

Want to check YOUR meds against Digestive Advantage Daily Probiotics + Gas Defense?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

BC30 Bacillus coagulans GBI-30, 6086 182

Individual Drug Interactions

The ingredients in Digestive Advantage Daily Probiotics + Gas Defense interact with 182 drugs. Click any drug to see the details.

1 of the 6 ingredients in Digestive Advantage Daily Probiotics + Gas Defense interact with drugs. Each result below shows which ingredient is responsible. BC30 Bacillus coagulans GBI-30, 6086

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Advantage Daily Probiotics + Gas Defense with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

BC30 Bacillus coagulans GBI-30, 60861 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
BC30 Bacillus coagulans GBI-30, 6086 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Advantage Daily Probiotics + Gas Defense, from the product label.

Schiff

See all Schiff products
Name
RB Health (US) LLC
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.digestiveadvantage.com
Pharmacist Counseling Corner

Digestive Advantage Daily Probiotics + Gas Defense by Schiff: Common Questions

Does Digestive Advantage Daily Probiotics + Gas Defense by Schiff interact with any medications?
Yes. Based on its ingredients, Digestive Advantage Daily Probiotics + Gas Defense has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Advantage Daily Probiotics + Gas Defense contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm on antibiotics?
Probably not as well as intended. Antibiotics can kill the live bacteria in this product, especially if you take them together. Space them out — ask your pharmacist how far apart to take them — so the probiotic has a chance to work.
Is this safe to take while pregnant?
We don't have pregnancy safety data on file for BC30 Bacillus coagulans. Talk with your doctor or pharmacist — they can help you weigh the potential benefits and risks for your situation.
Can it help with IBS?
The evidence suggests it may help — it's rated possibly effective for irritable bowel syndrome. That's not a guarantee, but it's worth discussing with your doctor if you're looking for a probiotic option.
What does the probiotic actually do?
BC30 Bacillus coagulans is a live bacterial strain meant to support digestion and gut health. It may reduce constipation and help with IBS symptoms.
Is this product well tolerated?
In healthy adults, yes — BC30 is generally well tolerated. However, it's not recommended for people with weakened immune systems, central lines, or severe illness due to rare but serious infection risk. Talk with your doctor if you fall into those groups.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Advantage Daily Probiotics + Gas Defense is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Advantage Daily Probiotics + Gas Defense label
Go deeper

The Full Monographs Behind Digestive Advantage Daily Probiotics + Gas Defense’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Digestive Advantage Daily Probiotics + Gas Defense's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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