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Dietary supplement

Digestive Advantage Daily Probiotics + Lactose Support Ingredients & Drug Interactions

by Schiff

Digestive Advantage Daily Probiotics + Lactose Support label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Advantage Daily Probiotics + Lactose Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Advantage Daily Probiotics + Lactose Support is a dietary supplement by Schiff with 2 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BC30 Bacillus coagulans GBI-30, 6086. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Advantage Daily Probiotics + Lactose Support by Schiff

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Advantage Daily Probiotics + Lactose Support by Schiff — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Advantage Daily Probiotics + Lactose Support by Schiff

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.

This product contains two active ingredients. BC30 Bacillus coagulans GBI-30, 6086 is a probiotic — a beneficial live organism meant to support digestive health.

Lactase is an enzyme that breaks down lactose, the sugar found in dairy products, to help people who have trouble digesting it. The capsule also contains several inactive ingredients (fillers and binders): maltodextrin, hypromellose, microcrystalline cellulose, dicalcium phosphate, stearic acid, titanium dioxide, and silicon dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: break down lactose and relieve abdominal discomfort.
  • We looked for evidence on: Lactose intolerance, Diarrhea, Flatulence, Constipation, Irritable bowel syndrome (IBS), Dyspepsia — and 2 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Dyspepsia, Flatulence, Rotaviral diarrhea.

The Bacillus coagulans in this product is possibly effective for constipation and irritable bowel syndrome (IBS). For antibiotic-associated diarrhea, athletic performance, cancer prevention, and fatty liver disease, the evidence isn't established well enough to rate it.

Lactase is effective for lactose intolerance. For colic and prematurity, the evidence isn't strong enough to rate.

If you're taking this product mainly for lactose support, the lactase ingredient is backed by solid evidence.

The evidence, ingredient by ingredient Bacillus Coagulans Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, but the evidence and product quality can vary. The main caution is that live probiotic organisms could theoretically cause infection in people with central lines (indwelling catheters), severe illness, weakened immunity, or prematurity — but healthy people with intact immune systems are at low risk.

Talk to your doctor before starting if you have any of these concerns. Lactase is generally well tolerated and considered likely safe during pregnancy and breastfeeding.

A rare allergic reaction to lactase (contact dermatitis and allergic rhinitis) has been reported in a worker exposed to powdered lactase — this is very uncommon in people taking it by mouth. Talk with your doctor or pharmacist if you have a known allergy to any ingredient.

Side effects, ingredient by ingredient Bacillus Coagulans Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotics are the medication type to watch — they can reduce how well the Bacillus coagulans in this product works. Ask your doctor or pharmacist how to time your doses if you're taking both.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product works best if you need help with lactose digestion — that ingredient is well supported by evidence. The probiotic may help with constipation and IBS, though evidence is less clear-cut.

The main thing to watch is antibiotics: they can kill the live organisms in the probiotic, so you'll want to time your doses carefully. Check with your own doctor or pharmacist before starting, especially if you have a weakened immune system or central catheter, or if you take antibiotics regularly.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Advantage Daily Probiotics + Lactose Support, straight from the product label.

Brand Schiff
Barcode (UPC) 815066001010
Net contents 32 Capsule(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 240964
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Advantage Daily Probiotics + Lactose Support by Schiff, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
815066001010
IngredientAmount% DV
BC30 Bacillus coagulans GBI-30, 608633 mg--
Lactase0 NP--

Other ingredients: Maltodextrin, Hypromellose, Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Titanium Dioxide, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Take the inside advantage

Our Story We know digestive health is the key to overall health and that digestive issues can put you at a disadvantage. That is why, for over 15 years, Digestive Advantage has been dedicated to your digestive health. Bringing you breakthrough and patented probiotic strains that help support your digestive and immune health.

Schiff since 1936

Formulation

Our daily probiotic Plus Lactase Enzyme helps break down lactose and relieves minor abdominal discomfort.

100X better probiotic survives stomach acid 100X better vs. leading probiotic & yogurts Our probiotic is protected with a natural protein shell to deliver more live good bacteria to your gut, and works to support overall digestive and immune health. Helps support digestive balance Based on median survivability of Digestive Advantage probiotic vs. leading probiotics and yogurts in a simulated gastric environment.

GMO-free Dairy-free

Vegetarian

Schiff Quality Guarantee Purity Freshness Potency Labeled potency of live cultures

Probiotic survives stomach acid 100X better

Helps break down lactose & relieves minor abdominal discomfort

Survives better than 50 billion

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Do not use if carton is damaged or if printed seal on blister is broken or missing.

Contains wheat and soy.

If pregnant, breastfeeding, or on medication, consult your physician before using this product.

Keep out of reach of children. Always consult your pediatrician before giving your child dietary supplements.

Storage

Store in a cool, dry place and avoid excessive heat.

Formula

A unique blend of probiotic plus lactase enzyme

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: Take one (1) capsule with meals containing dairy. Some individuals may require two (2) or more capsules daily, depending on frequency of dairy intake. Do not take more than three (3) capsules daily. Children 8 years and older: For children it is recommended that one (1) capsule be opened, and contents mixed into food or drink.

Brand IP Statement(s)

2019 RB Health rb Health Hygiene Home Patents: www. rb.com/patents

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Advantage Daily Probiotics + Lactose Support by Schiff label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Advantage Daily Probiotics + Lactose Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Advantage Daily Probiotics + Lactose Support by Schiff

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

BC30 Bacillus coagulans GBI-30, 6086

Interacts with
182 drugs
33 mg per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

BC30 Bacillus coagulans GBI-30, 6086 monograph & interactions

Lactase

No known
interactions
0 NP per serving Form: Aspergillus niger

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hypromellose, Microcrystalline Cellulose, Dicalcium Phosphate, Stearic Acid, Titanium Dioxide, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Advantage Daily Probiotics + Lactose Support by Schiff Drug Interactions

Want to check YOUR meds against Digestive Advantage Daily Probiotics + Lactose Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

BC30 Bacillus coagulans GBI-30, 6086 182

Individual Drug Interactions

The ingredients in Digestive Advantage Daily Probiotics + Lactose Support interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Digestive Advantage Daily Probiotics + Lactose Support interact with drugs. Each result below shows which ingredient is responsible. BC30 Bacillus coagulans GBI-30, 6086

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Advantage Daily Probiotics + Lactose Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

BC30 Bacillus coagulans GBI-30, 60861 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
BC30 Bacillus coagulans GBI-30, 6086 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Advantage Daily Probiotics + Lactose Support, from the product label.

Schiff

See all Schiff products
Name
RB Health (US) LLC
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.digestiveadvantage.com
Pharmacist Counseling Corner

Digestive Advantage Daily Probiotics + Lactose Support by Schiff: Common Questions

Does Digestive Advantage Daily Probiotics + Lactose Support by Schiff interact with any medications?
Yes. Based on its ingredients, Digestive Advantage Daily Probiotics + Lactose Support has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Advantage Daily Probiotics + Lactose Support contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help if I'm lactose intolerant?
Yes — lactase, one of the two active ingredients, is effective for lactose intolerance. It breaks down the lactose in dairy so your body can digest it more easily.
Can I take this if I'm on antibiotics?
You can, but timing matters. Antibiotics can kill the live organisms in the probiotic, making it less effective. Separate your doses and talk with your doctor or pharmacist about the best spacing — usually a few hours apart works.
Is this safe during pregnancy?
Lactase is likely safe during pregnancy. The Bacillus coagulans doesn't have enough safety data during pregnancy — talk with your doctor or pharmacist for personalized advice.
What does the Bacillus coagulans do?
It's a probiotic — a beneficial live organism meant to support digestive health. It's possibly effective for constipation and irritable bowel syndrome (IBS), but the evidence for other uses like athletic performance or cancer isn't established yet.
Are there any fillers or other ingredients?
Yes — the capsule contains maltodextrin, hypromellose, microcrystalline cellulose, dicalcium phosphate, stearic acid, titanium dioxide, and silicon dioxide as inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Advantage Daily Probiotics + Lactose Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Advantage Daily Probiotics + Lactose Support label
Go deeper

The Full Monographs Behind Digestive Advantage Daily Probiotics + Lactose Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Digestive Advantage Daily Probiotics + Lactose Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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