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Dietary supplement

Digestive Probiotic Intestinal & Immune Health Ingredients & Drug Interactions

by CVS Pharmacy

Digestive Probiotic Intestinal & Immune Health label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Probiotic Intestinal & Immune Health against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Probiotic Intestinal & Immune Health is a dietary supplement by CVS Pharmacy with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus Bifidobacterium lactis Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Probiotic Intestinal & Immune Health by CVS Pharmacy

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HelloPharmacist Scorecard of Digestive Probiotic Intestinal & Immune Health by CVS Pharmacy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Lactobacillus acidophilus Bifidobacterium lactis Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product has 2 active ingredients: Lactobacillus acidophilus and Bifidobacterium animalis lactis, both live-culture probiotics designed to support digestive and immune function. The inactive ingredients—cellulose, magnesium stearate, and silicon dioxide—are fillers and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune system health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Respiratory tract infections, Rotaviral diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Constipation, Lactose intolerance, Rotaviral diarrhea, and more.

The Lactobacillus acidophilus in this product is rated Possibly Effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It's rated Possibly Ineffective for atopic disease and there isn't enough reliable evidence to rate it for acute respiratory distress syndrome (ARDS).

We don't have effectiveness data on file for Bifidobacterium animalis lactis on its own.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects like bloating, gas, abdominal discomfort, and diarrhea can occur, but they're uncommon.

In rare cases, the live organisms have been associated with serious infections (bacteremia, sepsis, endocarditis) in vulnerable patients, though most of these cases involve bacteria that crossed from other parts of the body where they naturally live. Because data are limited and individual risk varies, check with your doctor before use.

For pregnancy, the data suggest it's Possibly Safe, but there's insufficient information about use during lactation—talk with your healthcare provider for personalized advice.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, let your healthcare provider or pharmacist know—they should be spaced several hours apart from this probiotic to avoid reducing its effectiveness. We could not check Bifidobacterium animalis lactis for interactions; use the medication search tool on this page to confirm your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, traveler's diarrhea after antibiotics, and certain infections, though the evidence is mixed. If you're on antibiotics, space them apart from this product to preserve its effectiveness.

Before starting, especially if you're pregnant, immunocompromised, or taking any medications, run it by your doctor or pharmacist to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Probiotic Intestinal & Immune Health, straight from the product label.

Brand CVS Pharmacy
Barcode (UPC) 050428129319
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 18258
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), No Allergies, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Probiotic Intestinal & Immune Health by CVS Pharmacy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
050428129319
IngredientAmount% DV
Bifidobacterium animalis lactis0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus acidophilus Bifidobacterium lactis Blend0 NP--

Other ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

LACTOBACILLUS CULTURES BIFIDOBACTERIUM CULTURES

General Statements

-Helps maintain a healthy intestinal tract* -Supports healthy immune function* -Helps support regularity & digestion*

1 MONTH SUPPLY

The human digestive tract is colonized by trillions of health promoting "good bacteria" that live in balance with human cells. Maintaining a balanced intestinal tract is important not only for digestive health, but also for immune health - in fact the intestines are considered the largest immune organ in the body. Sometimes, our lifestyles can disrupt this healthy intestinal balance creating digestive and other health problems.

One capsule a day helps promote a healthy intestinal tract and immune system.

LOT #: 22685933 Best Used By: 03/2014

FDA Statement of Identity

DIETARY SUPPLEMENT

Brand IP Statement(s)

CVS/pharmacy(R) Digestive Probiotic is a source of "good bacteria" that when taken daily, will help rest ore and maintain this delicate balance, supporting your digestive and immune system health.*

CVS/pharmacy(R) Probiotic Benefits* Helps the body's natural defenses {check} Helps maintain healthy intestinal flora ("good bacteria") {check} Made under controlled conditions to ensure highest quality and potency. {check}

(c)2011 CVS/pharmacy

CVS(R) Quality Money Back Guarantee

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) capsule daily to support your immune system and maintain digestive health.* Safe and Effective for Children 2 Years of Age and Older: Give one (1) capsule per day by opening capsule and stirring contents into cold drink or food. Do not add to warm or hot foods. Consult your pediatrician for more information.

Storage

Store: At room temperature. For best results, we recommend you store this product in the original blister card package.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

(recycle) PLEASE RECYCLE

Precautions

NON-ALLERGENIC This product contains only non-allergenic ingredients.

TAMPER EVIDENT Carton sealed for your protection. Do not use if capsule blister is open or torn.

Formulation

This product does not contain any lactose, soy or gluten.

General

# 460442 5902021.00

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Probiotic Intestinal & Immune Health by CVS Pharmacy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Probiotic Intestinal & Immune Health label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Probiotic Intestinal & Immune Health by CVS Pharmacy

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lactobacillus acidophilus Bifidobacterium lactis Blend

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus Bifidobacterium lactis Blend monograph & interactions

Other (inactive) ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Probiotic Intestinal & Immune Health by CVS Pharmacy Drug Interactions

Want to check YOUR meds against Digestive Probiotic Intestinal & Immune Health?

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182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus Bifidobacterium lactis Blend 182

Individual Drug Interactions

The ingredients in Digestive Probiotic Intestinal & Immune Health interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Digestive Probiotic Intestinal & Immune Health interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus Bifidobacterium lactis Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Probiotic Intestinal & Immune Health with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus Bifidobacterium lactis Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus Bifidobacterium lactis Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Probiotic Intestinal & Immune Health, from the product label.

CVS Pharmacy

See all CVS Pharmacy products
Name
CVS Pharmacy, Inc.
Street Address
One CVS Drive
City
Woonsocket
State
RI
ZipCode
02895
Phone Number
1-800-764-7287
Web Address
www.cvs.com
Pharmacist Counseling Corner

Digestive Probiotic Intestinal & Immune Health by CVS Pharmacy: Common Questions

Does Digestive Probiotic Intestinal & Immune Health by CVS Pharmacy interact with any medications?
Yes. Based on its ingredients, Digestive Probiotic Intestinal & Immune Health has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Probiotic Intestinal & Immune Health contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What do these bacteria do?
Lactobacillus acidophilus and Bifidobacterium animalis lactis are live-culture probiotics that are meant to support healthy digestion and immune function. L. acidophilus in particular has some evidence supporting its use for IBS, antibiotic-associated diarrhea, and certain infections.
Will antibiotics ruin this probiotic?
Yes—if you take them at the same time. Antibiotics kill bacteria, including the live organisms in this product. If you're on antibiotics, ask your pharmacist about spacing them several hours apart from this probiotic so the organisms have a better chance of surviving.
Can I take this while pregnant or breastfeeding?
The Lactobacillus acidophilus in this product is rated Possibly Safe during pregnancy, but we don't have enough data on breastfeeding safety. Talk with your doctor or pharmacist before starting, since it's an individual decision based on your health.
What side effects might I notice?
Most people tolerate this product well, but some experience mild gastrointestinal effects like bloating, gas, or loose stools—these are uncommon. In very rare cases, the live bacteria have been linked to serious infections in vulnerable people, which is why it's important to check with your doctor first.
Is this product 'safe' overall?
It's generally well tolerated in healthy adults and children, but we still recommend checking with your doctor before starting because data are limited and risk varies by individual.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Probiotic Intestinal & Immune Health is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Probiotic Intestinal & Immune Health label
Go deeper

The Full Monographs Behind Digestive Probiotic Intestinal & Immune Health’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Digestive Probiotic Intestinal & Immune Health's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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