Interactions on record — worth a quick check against your medications. Based on 4 of 10 ingredients. Check your meds →
Dietary supplement

Digestzymes Ingredients & Drug Interactions

by Designs for Health

Digestzymes label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Digestzymes is a dietary supplement by Designs for Health with 10 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestzymes by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestzymes by Designs for Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestzymes by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 10 active ingredients.
  • “GastroENZ Proprietary Blend” is a proprietary blend — the label gives one combined amount (180 mg) without saying how much of each component you get.

Digestzymes contains 10 active ingredients—digestive enzymes and supporting compounds. Lactase breaks down lactose (milk sugar); lipase and protease break down fats and proteins, respectively.

Pepsin is another protease. Amylase and glucoamylase break down starches and complex carbohydrates.

Invertase handles sucrose. Peptidase breaks down peptides (small protein fragments).

Betaine HCl is a stomach-acid booster intended to support digestion. The blend also includes ox bile extract, which aids fat digestion.

The capsule itself and microcrystalline cellulose (a binder) are inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive enzyme support for improved digestion.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Pancreatic enzyme insufficiency, Bloating and gas.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for most ingredients in this product isn't established in the data we hold. Lactase is effective for lactose intolerance—if you have trouble digesting milk products, this ingredient has solid support.

For the other enzymes and betaine HCl, we have insufficient evidence to rate whether they work for dyspepsia (indigestion), inflammatory bowel disease, or other digestive complaints. That doesn't mean they don't work; it means the research backing isn't in our current data.

The evidence, ingredient by ingredient Betaine Hydrochloride Lactase Lipase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these enzymes are generally well tolerated when used as directed. Lactase is likely safe in pregnancy and lactation.

However, betaine HCl stands out: it's not safe if you have ulcers, gastritis, or acid reflux, because it raises stomach acid and could irritate those conditions. Avoid betaine HCl in pregnancy and breastfeeding—safety data is insufficient.

Protease and pepsin also should be avoided in pregnancy unless prescribed, and safety data during breastfeeding is limited. For lipase, safety data in pregnancy and breastfeeding is sparse; ask your doctor before use.

Occupational exposure to protease enzymes (like pepsin in powdered form) has rarely caused allergic reactions; oral use in supplements is different, but if you have a known enzyme allergy, be cautious.

Side effects, ingredient by ingredient Betaine Hydrochloride Lactase Lipase Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you use proton pump inhibitors (PPIs), H2-blockers, or antacids. Betaine HCl in this product increases stomach acid and may reduce how well these medications work.

No interactions are documented for the enzyme ingredients we could fully check (lactase, lipase, protease, and pepsin), but confirm your exact medications with the search tool below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product is built around digestive enzymes, and lactase has solid evidence for lactose intolerance. If you manage stomach acid with medications—PPIs, H2-blockers, or antacids—this product isn't the right fit because betaine HCl may interfere.

Pregnant or breastfeeding people should talk to their doctor or pharmacist before starting, especially because of betaine HCl and the proteases. If you have ulcers or active acid reflux, skip it entirely.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestzymes, straight from the product label.

Brand Designs for Health
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 276118
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestzymes by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Lactase0 NP--
Lipase0 NP--
Protease0 NP--
Amylase0 NP--
Glucoamylase0 NP--
Invertase0 NP--
Peptidase0 NP--
Pepsin0 NP--
Betaine HCl200 mg--
GastroENZ Proprietary Blend180 mg--
Ox bile extract0 NP--

Other ingredients: Capsule, Microcrystalline Cellulose, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Pancreatic Enzymes + Betaine HCI

Dietary Supplement

Precautions

For Professional Use Only

Formulation

Gluten free formula Non GMO ingredients

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one capsule per day with a meal, or as directed by your health care practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestzymes by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestzymes by Designs for Health

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine HCl

Interacts with
36 drugs
200 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

GastroENZ Proprietary Blend

180 mg per serving

Other (inactive) ingredients: Capsule, Microcrystalline Cellulose, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestzymes by Designs for Health Drug Interactions

Want to check YOUR meds against Digestzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine HCl 36

Individual Drug Interactions

The ingredients in Digestzymes interact with 36 drugs. Click any drug to see the details.

1 of the 10 ingredients in Digestzymes interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestzymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestzymes, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health
Pharmacist Counseling Corner

Digestzymes by Designs for Health: Common Questions

Does Digestzymes by Designs for Health interact with any medications?
Yes. Based on its ingredients, Digestzymes has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestzymes contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me digest lactose better?
Lactase, one of the active ingredients here, is effective for lactose intolerance. If you have trouble digesting milk products, this enzyme is evidence-backed and may help.
Can I take this if I have acid reflux or heartburn?
No. Betaine HCl in this product increases stomach acid, and safety data says it's not safe if you have acid reflux, ulcers, or gastritis. It could make those conditions worse. Skip this product and talk to your doctor about alternatives.
Is it safe to take during pregnancy?
Not without talking to your doctor first. Betaine HCl should be avoided in pregnancy. Lactase is likely safe, but for the other enzymes—lipase, protease, and pepsin—safety data is limited or absent. You need personalized advice from your doctor or pharmacist.
What do all these enzymes do?
They help break down different foods in your digestive tract. Lactase breaks down milk sugar; lipase handles fats; proteases (protease and pepsin) break down proteins; amylase and glucoamylase break down starches; invertase breaks down table sugar; peptidase breaks down small protein fragments. Ox bile extract helps digest fats too.
Will this interact with my stomach acid medication?
Yes, if you take a proton pump inhibitor (PPI), H2-blocker, or antacid. Betaine HCl boosts stomach acid and could make those medications less effective. Check your specific drugs using the search tool on this page and confirm with your pharmacist before starting.
Are there any fillers or other ingredients I should know about?
The capsule itself is an inactive ingredient, along with microcrystalline cellulose (a binder) and medium-chain triglycerides. No other fillers are listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestzymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestzymes label
Go deeper

The Full Monographs Behind Digestzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Digestzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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