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Dietary supplement

DMAE 250 mg Ingredients & Drug Interactions

by Best Naturals

DMAE 250 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DMAE 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

DMAE 250 mg is a dietary supplement by Best Naturals with 1 active ingredient. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Dimethylaminoethanol Bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DMAE 250 mg by Best Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with DMAE 250 mg by Best Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DMAE 250 mg by Best Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: dimethylaminoethanol bitartrate, also called deanol — a compound thought to increase acetylcholine, a chemical messenger in your brain. Each capsule delivers 250 mg.

The remaining ingredients are inert fillers and the gelatin capsule itself: rice flour, bovine gelatin, silicon dioxide, and magnesium stearate.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Deanol product and its label doesn't state a use — see Deanol's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for deanol is quite limited. For Alzheimer disease, it's rated as likely ineffective based on available research.

For tardive dyskinesia (involuntary movements sometimes caused by antipsychotic medications), the data also shows it's likely ineffective. For other uses — aging skin, athletic performance, and ADHD — there simply isn't enough reliable evidence yet to know whether it works.

The evidence, ingredient by ingredient Deanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Deanol is generally well tolerated when taken by mouth, though side effects do occur in some people. The most common ones are stomach upset (abdominal cramps, pain, diarrhea, nausea, vomiting) and nervous system effects (drowsiness, insomnia, headache, overstimulation).

Less often, it's been reported to cause skin reactions, confusion, or mood changes. At doses above 1000 mg daily, mood changes including depression and elevated mood have been reported in people with psychiatric conditions, and at 1500 mg daily it may worsen schizophrenic symptoms.

There isn't enough safety data during pregnancy to know whether it's safe, so it's best to avoid it if you're pregnant. The same applies to breastfeeding — safety is unknown, so talk with your doctor or pharmacist before using it.

Side effects, ingredient by ingredient Deanol

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Deanol.
  • The most serious interaction on file is rated Minor.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use anticholinergic drugs (for overactive bladder, certain poisonings, and other conditions) or cholinergic drugs (for myasthenia gravis, Alzheimer disease, glaucoma, and similar conditions). Deanol may theoretically affect how these medications work.

These are Minor interactions, but your exact medications and doses matter — your own healthcare provider is the right person to clear it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

DMAE might appeal to someone curious about brain-supporting supplements, but the evidence doesn't support it for Alzheimer disease or tardive dyskinesia, and data is missing for other claimed uses. Before you start, check with your doctor or pharmacist if you take anticholinergic or cholinergic medications — deanol may interfere with how they work.

If you're pregnant, breastfeeding, or have a history of psychiatric conditions, discuss this with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DMAE 250 mg, straight from the product label.

Brand Best Naturals
Barcode (UPC) 817716018812
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 305997
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DMAE 250 mg by Best Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
817716018812
IngredientAmount% DV
Dimethylaminoethanol Bitartrate250 mg--

Other ingredients: Rice Flour, Bovine Gelatin, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution: Consult your physician prior to using this product if you are pregnant, may become pregnant, breast-feeding, or if you are taking prescription medication(s) for conditions such as heart disease or erectile dysfunction.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one (1) capsule twice daily or as directed by a health care professional.

Storage

Keep in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

GMP Good Manufacturing Practice Product

Formulation

Premium formula 3rd party lab tested

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish. Sodium free.

FDA Statement of Identity

Dietary Supplement

General Statements

For additional information call: 1-877-659-5004

Formula

DMAE (dimethylaminoethanol)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DMAE 250 mg by Best Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DMAE 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DMAE 250 mg by Best Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Dimethylaminoethanol Bitartrate

Interacts with
219 drugs
250 mg per serving

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

Dimethylaminoethanol Bitartrate monograph & interactions

Other (inactive) ingredients: Rice Flour, Bovine Gelatin, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

DMAE 250 mg by Best Naturals Drug Interactions

Want to check YOUR meds against DMAE 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Minor

Ingredients driving the most interactions

Dimethylaminoethanol Bitartrate 219

Individual Drug Interactions

The ingredients in DMAE 250 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in DMAE 250 mg interact with drugs. Each result below shows which ingredient is responsible. Dimethylaminoethanol Bitartrate

Each ingredient & the kinds of drugs it affects

For each ingredient in DMAE 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Dimethylaminoethanol Bitartrate2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Dimethylaminoethanol Bitartrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DMAE 250 mg, from the product label.

Best Naturals

See all Best Naturals products
Name
Best Naturals
Street Address
PO Box 394
City
Kenilworth
State
NJ
ZipCode
07033
Phone Number
1-877-659-6004
Web Address
www.shopbestnaturals.com
Pharmacist Counseling Corner

DMAE 250 mg by Best Naturals: Common Questions

Does DMAE 250 mg by Best Naturals interact with any medications?
Yes. Based on its ingredients, DMAE 250 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DMAE 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is DMAE, and what is it supposed to do?
DMAE (dimethylaminoethanol) is a compound that's thought to raise acetylcholine, a chemical messenger in your brain. It's been studied for brain and skin health, but research support is limited.
Does this actually work for Alzheimer disease or ADHD?
For Alzheimer disease, research shows it's likely ineffective. For ADHD, there isn't enough reliable evidence yet to say whether it works. The evidence base is quite thin.
What side effects should I watch for?
The most common ones are stomach upset — cramps, pain, diarrhea, nausea, or vomiting — and nervous system effects like drowsiness, insomnia, or headache. At higher doses (above 1000 mg daily), mood changes have been reported, especially in people with psychiatric conditions.
Is it safe to take during pregnancy or while breastfeeding?
There isn't enough safety data during pregnancy or breastfeeding to know either way. Talk with your doctor or pharmacist before using this supplement if you're pregnant or nursing.
Can I take this with my anticholinergic or cholinergic medications?
Deanol may theoretically interfere with both types. Before you start, check with your own doctor or pharmacist — they'll know your specific medications and can tell you whether it's okay for you.
Does this product have any fillers or artificial additives?
The capsule contains inactive ingredients: rice flour, silicon dioxide, magnesium stearate, and bovine gelatin. There are no other active ingredients — just the deanol itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DMAE 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DMAE 250 mg label
Go deeper

The Full Monographs Behind DMAE 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph →
Sources

Sources & How We Checked

DMAE 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  2. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  3. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
  4. George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
  5. Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
  6. de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
  7. Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
  8. Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
  9. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
  10. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
  11. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
  12. Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
  13. Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
  14. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
  15. Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.

See these in context on the Deanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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