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Dietary supplement

DMAE 351 mg Ingredients & Drug Interactions

by Source Naturals

DMAE 351 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DMAE 351 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

DMAE 351 mg is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are DMAE. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DMAE 351 mg by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with DMAE 351 mg by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DMAE 351 mg by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “DMAE” is listed as a grouped ingredient — the label gives one combined amount (130 mg) without saying how much of each component you get.

Source Naturals DMAE 351 mg contains one active ingredient: DMAE bitartrate, a form of DMAE (dimethylaminoethanol), which is a compound that may influence neurotransmitter levels in the brain. The capsule also contains inactive ingredients — gelatin, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate, and silica — which serve as the capsule shell and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Deanol's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: mental concentration and focus.
  • We looked for evidence on: Cognitive function, Attention deficit-hyperactivity disorder (ADHD), memory, mental clarity.
  • The closest evidence on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD) (Natural Medicines).
  • Also on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Cognitive function.

The evidence for DMAE is limited. It's considered likely ineffective for Alzheimer's disease and tardive dyskinesia (a movement disorder).

For aging skin, ADHD, and athletic performance, there isn't enough reliable evidence to rate whether it works. If you're considering this supplement for one of those uses, the data we hold doesn't support that it will help.

The evidence, ingredient by ingredient Deanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DMAE is generally well tolerated by some adults, but side effects can occur and safety data are limited. The most common reported side effects are abdominal cramps, abdominal pain, diarrhea, drowsiness, nausea, and vomiting.

At higher doses (over 1000 mg daily), deanol has been linked to mood changes including depression and hypomania; at 1500 mg daily, it may worsen schizophrenic symptoms in people with chronic schizophrenia. There isn't enough safety data for use during pregnancy.

Because some animal research raises concern, the data on file advises against use while breastfeeding. Talk with your doctor or pharmacist about whether this product is right for your situation.

Side effects, ingredient by ingredient Deanol

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Deanol.
  • The most serious interaction on file is rated Minor.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take anticholinergic drugs (such as antihistamines or certain bladder or antidepressant medications) or cholinergic drugs (such as those for myasthenia gravis). DMAE may theoretically reduce how well anticholinergic drugs work and may increase the effects of cholinergic drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

DMAE has limited evidence for the conditions it's typically marketed for and isn't proven effective for Alzheimer's disease or tardive dyskinesia. It may interact with anticholinergic and cholinergic medications, so if you take either type, check with your doctor or pharmacist before starting.

Side effects like nausea, diarrhea, and drowsiness can occur, and safety in pregnancy and breastfeeding isn't established.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DMAE 351 mg, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078015819
Net contents 50 Capsule(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 214268
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DMAE 351 mg by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
021078015819
IngredientAmount% DV
DMAE130 mg--
DMAE Bitartrate351 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Dimethylaminoethanol Bitartrate supports mental concentration

Formulation

DMAE is naturally found in some foods. It is structurally similar to choline, and has been found to support mental concentration in clinical research.

Contains no yeast, gluten, corn, sugar, starch, preservatives, or artificial color, flavor or fragrance.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule 1 to 2 times daily.

Precautions

Caution: If you are pregnant, may become pregnant, breastfeeding, or have epilepsy, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DMAE 351 mg by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DMAE 351 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DMAE 351 mg by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

DMAE

Interacts with
219 drugs
130 mg per serving

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

DMAE monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

DMAE 351 mg by Source Naturals Drug Interactions

Want to check YOUR meds against DMAE 351 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Minor

Ingredients driving the most interactions

DMAE 219

Individual Drug Interactions

The ingredients in DMAE 351 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in DMAE 351 mg interact with drugs. Each result below shows which ingredient is responsible. DMAE

Each ingredient & the kinds of drugs it affects

For each ingredient in DMAE 351 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DMAE2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
DMAE full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DMAE 351 mg, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

DMAE 351 mg by Source Naturals: Common Questions

Does DMAE 351 mg by Source Naturals interact with any medications?
Yes. Based on its ingredients, DMAE 351 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DMAE 351 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is DMAE, and what is it supposed to do?
DMAE (dimethylaminoethanol) is a compound that may influence levels of acetylcholine, a neurotransmitter in the brain. It's been studied for brain and skin health, though evidence is sparse.
Does DMAE actually work for Alzheimer's disease or ADHD?
For Alzheimer's disease, it's considered likely ineffective. For ADHD, athletic performance, and aging skin, there isn't enough reliable evidence to know either way.
What are the most common side effects?
The most common reported side effects are abdominal cramps, abdominal pain, diarrhea, drowsiness, nausea, and vomiting. Other effects like headache, insomnia, or constipation have also been reported.
Is DMAE safe to take while pregnant or breastfeeding?
There isn't enough safety data for pregnancy. Because animal research raises concerns, the data advises against use while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
Can I take DMAE if I have depression or schizophrenia?
At higher doses, DMAE has been reported to worsen mood and psychiatric symptoms in some people. If you have a psychiatric condition, discuss this supplement with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DMAE 351 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DMAE 351 mg label
Go deeper

The Full Monographs Behind DMAE 351 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph →
Sources

Sources & How We Checked

DMAE 351 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  2. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  3. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
  4. George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
  5. Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
  6. de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
  7. Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
  8. Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
  9. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
  10. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
  11. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
  12. Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
  13. Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
  14. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
  15. Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.

See these in context on the Deanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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