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Dietary supplement

DMAE Ingredients & Drug Interactions

by Higher Nature

DMAE label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DMAE against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

DMAE is a dietary supplement by Higher Nature with 1 active ingredient. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are DMAE. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DMAE by Higher Nature

Ask about any prescription or over-the-counter medication and we check it for interactions with DMAE by Higher Nature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DMAE by Higher Nature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This is a single-ingredient supplement: DMAE (dimethylaminoethanol), also known as deanol. The product contains one active ingredient in tablet form, along with microcrystalline cellulose (a binder), lithothamnion calcarea (a mineral source), silicon dioxide, magnesium stearate, and a coating.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Deanol's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: mind health and choline production.
  • We looked for evidence on: Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Alzheimer disease, Memory, Mental clarity, Brain health.
  • The closest evidence on file: Deanol is rated "Likely Ineffective" for Alzheimer disease (Natural Medicines).
  • Also on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

The evidence for DMAE is limited. For Alzheimer disease, the data shows it's likely ineffective.

For aging skin, ADHD, and athletic performance, there isn't enough reliable evidence yet to say whether it works. The science here just isn't settled.

The evidence, ingredient by ingredient Deanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Deanol seems to be tolerated by some adults, but the safety data is thin and side effects do happen. The most common ones are stomach discomfort (cramps, pain, diarrhea, nausea, vomiting) and drowsiness.

Less commonly, people have reported headache, insomnia, overstimulation, vivid dreams, confusion, and mood changes. At higher doses (above 1,000 mg daily), mood problems including depression and hypomania have been reported, especially in people with psychiatric conditions; at 1,500 mg daily, it's been linked to worsening schizophrenia symptoms.

Safety during pregnancy isn't established — the data isn't there. For breastfeeding, the concern is significant enough that it's best to avoid it.

Talk to your doctor or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Deanol

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Deanol.
  • The most serious interaction on file is rated Minor.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take cholinergic drugs (Minor interaction — deanol may boost their effects and side effects) or anticholinergic drugs (Minor interaction — deanol may reduce their effectiveness). Use the search tool on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

DMAE is a single-ingredient supplement with limited evidence for its intended uses and a modest interaction risk with certain medication types. If you have a psychiatric condition, take brain or digestion medications, or are pregnant or breastfeeding, check with your pharmacist first.

For everyone else on prescription medication, verify your exact drugs before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DMAE, straight from the product label.

Brand Higher Nature
Barcode (UPC) 5031013105173
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228404
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DMAE by Higher Nature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s), 0.5 Tablet(s)
Maximum serving Sizes:
2 Tablet(s), 1 Tablet(s)
UPC/BARCODE
5031013105173
IngredientAmount% DV
DMAE175 mg--

Other ingredients: DMAE, Microcrystalline Cellulose, natural Lithothamnion calcarea, Silicon Dioxide, Magnesium Stearate, Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free From: Artificial colours, flavourings or preservatives, dairy products, gluten, lactose, salt, soya, sugar, wheat, yeast.

Mind health Advanced formula Optimal benefit Naturally occurs in oily fish

Vegetarian and vegan

DMAE is found naturally in oily fish For choline production

General Statements

This product has not been tested on animals.

FDA Statement of Identity

Food Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults take 1-2 tablets (children 8 and over 1/2- 1 tablet) each morning. Do not exceed recommended daily intake.

Precautions

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle. Warning: Not advisable in cases of bipolar disorder, schizophrenia or epilepsy.

Storage: Store in a cool, dry place out of reach of children.

Storage

Storage: Store in a cool, dry place out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DMAE by Higher Nature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DMAE label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DMAE by Higher Nature

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

DMAE

Interacts with
219 drugs
175 mg per serving

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

DMAE monograph & interactions

Other (inactive) ingredients: DMAE, Microcrystalline Cellulose, Natural Lithothamnion calcarea, Silicon Dioxide, Magnesium Stearate, Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

DMAE by Higher Nature Drug Interactions

Want to check YOUR meds against DMAE?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Minor

Ingredients driving the most interactions

DMAE 219

Individual Drug Interactions

The ingredients in DMAE interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in DMAE interact with drugs. Each result below shows which ingredient is responsible. DMAE

Each ingredient & the kinds of drugs it affects

For each ingredient in DMAE with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DMAE2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
DMAE full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DMAE, from the product label.

Higher Nature

See all Higher Nature products
Name
Higher Nature Ltd
Street Address
10 Discovery Way
City
Horam TN21 0GE
State
East Sussex
Web Address
highernature.com
Pharmacist Counseling Corner

DMAE by Higher Nature: Common Questions

Does DMAE by Higher Nature interact with any medications?
Yes. Based on its ingredients, DMAE has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DMAE contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take DMAE if I'm pregnant?
The safety data during pregnancy isn't on file — there isn't enough information to know either way. Talk with your doctor or pharmacist about what's right for you.
Can I take DMAE while breastfeeding?
No. The safety data for breastfeeding raises enough concern that it's best to avoid it. Check with your pharmacist or doctor if you have questions.
Does DMAE actually work for Alzheimer disease?
No, the evidence shows it's likely ineffective for Alzheimer disease.
What's the most common side effect I might notice?
Stomach trouble — cramps, pain, diarrhea, nausea, or vomiting — is the most commonly reported side effect. Drowsiness also shows up fairly often.
Is DMAE safe for people with depression or schizophrenia?
No. At doses above 1,000 mg daily, deanol has caused mood changes including depression and hypomania in people with psychiatric conditions. At 1,500 mg daily, it's been reported to worsen schizophrenia symptoms. If you have a psychiatric condition, talk to your doctor before taking this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DMAE label
Go deeper

The Full Monographs Behind DMAE’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph →
Sources

Sources & How We Checked

DMAE's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  2. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  3. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
  4. George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
  5. Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
  6. de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
  7. Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
  8. Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
  9. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
  10. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
  11. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
  12. Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
  13. Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
  14. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
  15. Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.

See these in context on the Deanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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