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Dietary supplement

DMAE (Dimethylaminoethanol) 50 mg Ingredients & Drug Interactions

by Kirkman

DMAE (Dimethylaminoethanol) 50 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DMAE (Dimethylaminoethanol) 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

DMAE (Dimethylaminoethanol) 50 mg is a dietary supplement by Kirkman with 1 active ingredient. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are DMAE. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DMAE (Dimethylaminoethanol) 50 mg by Kirkman

Ask about any prescription or over-the-counter medication and we check it for interactions with DMAE (Dimethylaminoethanol) 50 mg by Kirkman — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DMAE (Dimethylaminoethanol) 50 mg by Kirkman

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: DMAE (dimethylaminoethanol) at 50 mg per capsule. DMAE is a compound that may influence acetylcholine, a brain chemical involved in memory and nerve function.

The inactive ingredients are microcrystalline cellulose, dimethylaminoethanol bitartrate, and a plant cellulose capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Deanol product and its label doesn't state a use — see Deanol's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for DMAE is limited. It is rated likely ineffective for Alzheimer disease and tardive dyskinesia (involuntary movement disorder).

For aging skin, ADHD, and athletic performance, there is insufficient reliable evidence to know whether it works. The data on file does not establish that this product is effective for any condition.

The evidence, ingredient by ingredient Deanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DMAE is generally well tolerated in some adults, but side effects do occur and safety data is limited. The most common adverse effects reported are abdominal cramps, abdominal pain, diarrhea, drowsiness, nausea, and vomiting.

Less commonly, it has been reported to cause constipation, urticaria (hives), headache, insomnia, overstimulation, lucid dreams, confusion, motor retardation, depression, hypomania, and increased schizophrenia symptoms. At higher doses (above 1000 mg daily), mood changes including depression and hypomania have been reported in people with psychiatric conditions; at 1500 mg daily, it has increased schizophrenic symptoms in people with chronic schizophrenia.

There is not enough safety data in pregnancy, and use while breastfeeding is not advised due to limited evidence and animal research concerns.

Side effects, ingredient by ingredient Deanol

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Deanol.
  • The most serious interaction on file is rated Minor.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you take anticholinergic drugs (used for bladder control, certain movement disorders, and allergies) or cholinergic drugs (used for myasthenia gravis, glaucoma, and memory problems). Both categories may have their effectiveness or side effects altered by DMAE.

These interactions are rated Minor, but they are worth confirming with your own healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

DMAE at this dose may be considered by adults curious about memory or cognition, but the evidence for real benefit is weak and side effects are common. If you take anticholinergic or cholinergic medications, check your specific prescriptions with your pharmacist or doctor before starting.

Pregnant people, those planning to become pregnant, and those breastfeeding should not use this product. Talk with your doctor or pharmacist to see if it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DMAE (Dimethylaminoethanol) 50 mg, straight from the product label.

Brand Kirkman
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 24062
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DMAE (Dimethylaminoethanol) 50 mg by Kirkman, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
DMAE50 mg--

Other ingredients: Microcrystalline Cellulose, Dimethylaminoethanol Bitartrate, Plant Cellulose Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

IMPORTANT: STORE IN A COOL DRY PLACE AND TIGHTLY CAPPED.

Precautions

KEEP OUT OF THE REACH OF CHILDREN.

Formulation

CASEIN & GLUTEN FREE

FREE OF: Sugar, starch, soy, wheat, casein, gluten, milk, corn, preservatives, yeast, gelatin, flavorings, colorings, fish, peanuts or tree nuts.

Formula

HYPOALLERGENIC

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

SUGGESTED USE: 1 capsule per day or as directed by a physician.

General

290/90

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DMAE (Dimethylaminoethanol) 50 mg by Kirkman label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DMAE (Dimethylaminoethanol) 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DMAE (Dimethylaminoethanol) 50 mg by Kirkman

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

DMAE

Interacts with
219 drugs
50 mg per serving Form: Dimethylaminoethanol Bitartrate

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

DMAE monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Dimethylaminoethanol Bitartrate, Plant Cellulose Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

DMAE (Dimethylaminoethanol) 50 mg by Kirkman Drug Interactions

Want to check YOUR meds against DMAE (Dimethylaminoethanol) 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Minor

Ingredients driving the most interactions

DMAE 219

Individual Drug Interactions

The ingredients in DMAE (Dimethylaminoethanol) 50 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in DMAE (Dimethylaminoethanol) 50 mg interact with drugs. Each result below shows which ingredient is responsible. DMAE

Each ingredient & the kinds of drugs it affects

For each ingredient in DMAE (Dimethylaminoethanol) 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DMAE2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
DMAE full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DMAE (Dimethylaminoethanol) 50 mg, from the product label.

Kirkman

See all Kirkman products
Name
Kirkman
City
Lake Oswego
State
OR
ZipCode
97035
Phone Number
(800) 245-8282
Web Address
www.kirkmangroup.com
Pharmacist Counseling Corner

DMAE (Dimethylaminoethanol) 50 mg by Kirkman: Common Questions

Does DMAE (Dimethylaminoethanol) 50 mg by Kirkman interact with any medications?
Yes. Based on its ingredients, DMAE (Dimethylaminoethanol) 50 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DMAE (Dimethylaminoethanol) 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is DMAE, and what is it supposed to do?
DMAE is a compound thought to increase acetylcholine, a brain chemical involved in memory and nerve function. The evidence for whether it actually helps with memory, focus, or skin aging is limited or lacking.
Can I take DMAE if I'm pregnant or breastfeeding?
No, not for breastfeeding — there isn't enough safety data, and animal research raises concerns, so it's advised to avoid it. For pregnancy, there is not enough data to know either way; talk with your doctor or pharmacist for personalized advice.
What side effects might I experience?
The most common are abdominal cramps, abdominal pain, diarrhea, drowsiness, nausea, and vomiting. Less often, it can cause headache, insomnia, hives, confusion, depression, or mood changes, especially at higher doses or in people with psychiatric conditions.
Does DMAE really work for Alzheimer disease or ADHD?
For Alzheimer disease, the evidence says it is likely ineffective. For ADHD and aging skin, there is not enough reliable evidence to know whether it works. The data on file does not support its use for these conditions.
Is DMAE safe to take long-term?
Safety data is limited. While some adults tolerate it, side effects do occur, and there isn't enough long-term evidence to know how safe it is with ongoing use. Talk with your pharmacist or doctor about whether this is right for you and for how long.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DMAE (Dimethylaminoethanol) 50 mg label
Go deeper

The Full Monographs Behind DMAE (Dimethylaminoethanol) 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Deanol

Interacts with 219 drugs

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...

Read the full Deanol monograph →
Sources

Sources & How We Checked

DMAE (Dimethylaminoethanol) 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  2. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  3. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
  4. George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
  5. Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
  6. de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
  7. Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
  8. Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
  9. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
  10. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
  11. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
  12. Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
  13. Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
  14. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
  15. Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.

See these in context on the Deanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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