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Dietary supplement

Dr. Cutler's Ultimate Digestion Formula Ingredients & Drug Interactions

by True Health

Dr. Cutler's Ultimate Digestion Formula label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Dr. Cutler's Ultimate Digestion Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Dr. Cutler's Ultimate Digestion Formula is a dietary supplement by True Health with 6 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 256 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gentian, L-Glutamine, Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Dr. Cutler's Ultimate Digestion Formula by True Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Dr. Cutler's Ultimate Digestion Formula by True Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Dr. Cutler's Ultimate Digestion Formula by True Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Dr. Cutler's Ultimate Digestion Formula contains 6 active ingredients designed to support digestion.

L-glutamine is an amino acid, betaine hydrochloride is a stomach-acid booster, and lactase is an enzyme that breaks down milk sugar. The formula also includes glutamic acid, gentian (a plant root traditionally used for digestive support), and a proprietary digestive enzyme blend.

The capsules also contain inactive ingredients—gelatin, microcrystalline cellulose, magnesium stearate, and silicon dioxide—which serve as fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: gas, bloating and occasional heartburn relief.
  • We looked for evidence on: Dyspepsia, Flatulence, Gastroesophageal reflux disease (GERD), Lactose intolerance, indigestion, stomach upset.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Gastroesophageal reflux disease (GERD), Flatulence.

The evidence on this formula's ingredients is mixed. Lactase is effective for lactose intolerance if that's a concern for you.

L-glutamine has solid evidence for sickle cell disease and possibly helps with recovery after surgery or illness-related muscle loss. For the other ingredients—betaine hydrochloride, gentian, and glutamic acid—the evidence we hold doesn't establish effectiveness for their claimed digestive roles.

The data on gentian for wound healing, obesity, sinus issues, and gastritis shows insufficient evidence, and the same is true for betaine hydrochloride's use in indigestion, thyroid function, diarrhea, arthritis, and allergies.

The evidence, ingredient by ingredient Glutamine Betaine Hydrochloride Lactase Gentian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults, though people with kidney or liver disease should take it only under a doctor's supervision. Betaine hydrochloride can irritate the stomach and isn't safe if you have ulcers, gastritis, or true acid reflux (the kind where acid backs up into your esophagus).

Lactase is generally well tolerated and acts only in your digestive tract. Gentian is okay in small amounts for healthy adults but can upset your stomach, and high doses aren't well studied.

A small number of trial participants taking gentian in combination with other herbs reported nausea, vomiting, diarrhea, and bloating. For pregnancy: L-glutamine is rated likely safe; betaine hydrochloride should be avoided (not enough safety data); lactase is likely safe but check with your doctor before regular use; and gentian should be avoided (traditional cautions and insufficient data).

For breastfeeding: L-glutamine and lactase have limited data—talk with your doctor or pharmacist before using. Betaine hydrochloride and gentian should be avoided.

We hold no pregnancy or breastfeeding data for glutamic acid and the digestive enzyme blend.

Side effects, ingredient by ingredient Glutamine Betaine Hydrochloride Lactase Gentian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Betaine Hydrochloride, Gentian, Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 256 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this formula, check with your doctor or pharmacist if you take any of these: anticonvulsants (seizure medications)—glutamine may work against them; antihypertensive drugs (blood pressure medications)—gentian may lower your pressure too much; or acid-blocking medications including H2-blockers, antacids, and proton pump inhibitors—betaine hydrochloride may make them less effective.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This formula may help if you're lactose intolerant or recovering from surgery or serious illness (glutamine's supported roles), but the digestive claims of other ingredients lack strong evidence. It's not a good fit if you take anticonvulsants, blood pressure medications, or acid-blocking drugs—check your medications first.

Talk with your doctor or pharmacist before starting, especially if you have stomach ulcers, reflux, or kidney or liver disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dr. Cutler's Ultimate Digestion Formula, straight from the product label.

Brand True Health
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2012
DSLD ID 16770
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dr. Cutler's Ultimate Digestion Formula by True Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
L-Glutamine50 mg--
Betaine Hydrochloride270 mg--
Lactase50 mg--
Glutamic Acid160 mg--
Gentian30 mg--
Digestive Enzyme Blend65 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nature's Best Solution for Gas, Bloating and Occasional Heartburn*

This product is manufactured in a NSF GMP registered facility.

Contains the World's Finest Ingredients.

Seals/Symbols

SCIENTIFICALLY FORMULATED DOCTOR APPROVED

MADE IN U.S.A.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take one capsule three times daily with meals or as directed by your healthcare professional.

Precautions

Caution: Consult with your healthcare professional if you have any medical condition before taking this or any other dietary supplement or before changing any medications.

KEEP OUT OF REACH OF CHILDREN.

Storage

STORE IN A COOL, DRY PLACE.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

300-TUDFC-A

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Dr. Cutler's Ultimate Digestion Formula by True Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Dr. Cutler's Ultimate Digestion Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Dr. Cutler's Ultimate Digestion Formula by True Health

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
50 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Betaine Hydrochloride

Interacts with
36 drugs
270 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Lactase

No known
interactions
50 mg per serving

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Glutamic Acid

160 mg per serving Form: L-Glutamic Acid Hydrochloride

Gentian

Interacts with
172 drugs
30 mg per serving

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian monograph & interactions

Digestive Enzyme Blend

65 mg per serving Form: Amylases, Lipases, Proteases

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dr. Cutler's Ultimate Digestion Formula by True Health Drug Interactions

Want to check YOUR meds against Dr. Cutler's Ultimate Digestion Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
256Drugs
221 Moderate 35 Minor

Ingredients driving the most interactions

Gentian 172
L-Glutamine 50
Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in Dr. Cutler's Ultimate Digestion Formula interact with 256 drugs. Click any drug to see the details.

3 of the 6 ingredients in Dr. Cutler's Ultimate Digestion Formula interact with drugs. Each result below shows which ingredient is responsible. Gentian L-Glutamine Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Dr. Cutler's Ultimate Digestion Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gentian1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Dr. Cutler's Ultimate Digestion Formula, from the product label.

True Health

See all True Health products
Name
True Health(TM)
Street Address
P.O. Box 3703
City
Hueytown
State
AL
ZipCode
35023
Phone Number
1-800-746-4513
Web Address
www.TrueHealth.com
Pharmacist Counseling Corner

Dr. Cutler's Ultimate Digestion Formula by True Health: Common Questions

Does Dr. Cutler's Ultimate Digestion Formula by True Health interact with any medications?
Yes. Based on its ingredients, Dr. Cutler's Ultimate Digestion Formula has a known interaction with 256 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dr. Cutler's Ultimate Digestion Formula contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this formula really help with digestion?
Lactase in the formula definitely helps if you can't digest milk sugar. L-glutamine is proven to help with sickle cell disease and may help after surgery or serious illness. For the other ingredients' digestive roles, we don't have strong evidence.
Is it safe to take if I'm pregnant?
Not fully—it depends on the ingredient. L-glutamine and lactase are likely safe, but betaine hydrochloride and gentian should be avoided during pregnancy because there isn't enough safety data. Talk with your doctor before using it while pregnant.
Can I take this if I have acid reflux?
No. Betaine hydrochloride raises stomach acid, which can irritate or damage ulcers and make true acid reflux worse. If you have reflux or an ulcer, skip this product.
What are the most common side effects?
L-glutamine may cause belching, bloating, constipation, flatulence, nausea, vomiting, diarrhea, and stomach pain, especially at higher doses. Gentian, when combined with other herbs, has caused nausea, vomiting, diarrhea, and bloating in some users.
What is glutamine used for in this formula?
Glutamine is an amino acid your body makes naturally. It's proven to help people with sickle cell disease, and research suggests it may help muscle recovery after surgery or serious illness. Here it's meant to support overall digestive and nutritional health.
Can I take this with my blood pressure medication?
Check with your doctor first. Gentian in this formula may lower blood pressure further, raising the risk of it dropping too much. Your doctor or pharmacist can tell you if it's safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Dr. Cutler's Ultimate Digestion Formula is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Dr. Cutler's Ultimate Digestion Formula label
Go deeper

The Full Monographs Behind Dr. Cutler's Ultimate Digestion Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph →
Sources

Sources & How We Checked

Dr. Cutler's Ultimate Digestion Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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