Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Elderol Ingredients & Drug Interactions

by North American Herb & Spice

Elderol label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Elderol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Elderol is a dietary supplement by North American Herb & Spice with 3 active ingredients. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oregano, Elderberry Extract, Raw, Wild. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Elderol by North American Herb & Spice

Ask about any prescription or over-the-counter medication and we check it for interactions with Elderol by North American Herb & Spice — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Elderol by North American Herb & Spice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Elderol contains 3 active ingredients: elderberry extract (raw, wild), oregano, and a Multiple Spice Formula. The product is delivered as a liquid.

Elderberry and oregano are traditional culinary herbs now used as supplements. We hold no information on what the Multiple Spice Formula contains or why it's included in this formulation.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: immune support.
  • We looked for evidence on: Cough, Lower respiratory tract infections, Respiratory tract infections, Upper respiratory tract infection (URTI), Bronchitis, Rhinosinusitis — and 4 related terms.
  • The closest evidence on file: Elderberry is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).
  • Also on file: Elderberry is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis, Upper respiratory tract infection (URTI), Lower respiratory tract infections.
  • Also on file: Oregano is rated "Insufficient Reliable Evidence To Rate" for Bronchitis, Upper respiratory tract infection (URTI), Cough.

The evidence for elderberry isn't established for the conditions listed in our data — hay fever, heart disease, chronic fatigue, COPD, memory, and respiratory infections all carry a rating of Insufficient Reliable Evidence To Rate. The same goes for oregano: acne, bronchitis, asthma, headache, and upper respiratory infections also lack established evidence in our data.

If you're considering this product for a specific reason, talk with your pharmacist about what the evidence actually shows for that use.

The evidence, ingredient by ingredient Elderberry Oregano

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Properly prepared elderberry extracts are generally well tolerated, but this product is a raw, wild extract — a key distinction. Raw or unripe elderberries, seeds, leaves, and bark contain compounds that can cause nausea, vomiting, severe diarrhea, weakness, dizziness, and numbness.

Cooking eliminates this risk, but raw extracts do not. One rare case reported autoimmune hepatitis (liver inflammation) after years of elderberry use in someone with existing autoimmune disease.

Oregano is safe in food amounts but less studied at supplement doses; some people develop gastrointestinal upset, skin reactions, or rarely severe allergic reactions. During pregnancy, avoid elderberry supplements and medicinal oregano amounts (food seasonings are fine); breastfeeding safety for oregano supplements isn't established.

There's insufficient data on oregano during lactation to know either way.

Side effects, ingredient by ingredient Elderberry Oregano

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Elderberry, Oregano.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Elderol, double-check with your pharmacist if you're on immunosuppressant medications (like those after transplant), blood thinners or antiplatelet drugs, diabetes medications, or pazopanib (Votrient). Moderate interactions are documented for all of these drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for people interested in traditional herbal supplements, but the raw elderberry and oregano here come with meaningful drug interactions — especially with immune-suppressing drugs, blood thinners, cancer medications, and diabetes drugs. If you're on any prescription medication, check it against this product first.

Pregnant or nursing? Talk with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Elderol, straight from the product label.

Brand North American Herb & Spice
Barcode (UPC) 635824005506
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269231
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Elderol by North American Herb & Spice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
20 Drop(s)
Maximum serving Sizes:
20 Drop(s)
Servings per container
88
UPC/BARCODE
635824005506
IngredientAmount% DV
Proprietary Blend0 NP--
Elderberry Extract, Raw, Wild0 NP--
Oregano0 NP--
Multiple Spice Formula0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 20 or more drops of this potent extract under the tongue as often as needed.

General Statements

As a natural, wild product, color, taste, and consistency may vary.

Formula

Elderol is the only raw, wild, purple elderberry extract available. Elderol is a top source of powerful antioxidants. The berries are handpicked from the most remote regions of northern Canada and immediately cold-pressed. Elderol is a source of hemagglutinin protein, which provides healthy support for cell walls, making them difficult to penetrate.

Whole Food Elderberry Complex

Handpicked, wild elderberry extract

3,850 ORAC units per bottle

Formulation

Take Elderol daily with Oreganol P73 when you need powerful immune support.

Raw

Supports a healthy immune response

Non-GMO, Chemical-free, not standardized

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Elderol by North American Herb & Spice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Elderol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Elderol by North American Herb & Spice

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size20 Drop(s) Dosage formLiquid Servings per container88 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving
Interaction report

Elderol by North American Herb & Spice Drug Interactions

Want to check YOUR meds against Elderol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Oregano 208
Elderberry Extract, Raw, Wild 121

Individual Drug Interactions

The ingredients in Elderol interact with 327 drugs. Click any drug to see the details.

2 of the 3 ingredients in Elderol interact with drugs. Each result below shows which ingredient is responsible. Oregano Elderberry Extract, Raw, Wild

Each ingredient & the kinds of drugs it affects

For each ingredient in Elderol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Oregano2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.

Likelihood Possible Evidence D
Oregano full monograph & interactions

Elderberry Extract, Raw, Wild2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
Elderberry Extract, Raw, Wild full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Elderol, from the product label.

North American Herb & Spice

See all North American Herb & Spice products
Name
North American Herb & Spice
Street Address
13900 W. Polo Trail Drive
City
Lake Forest
State
IL
ZipCode
60045
Phone Number
1-847-473-4700
Web Address
www.oreganol.com
Pharmacist Counseling Corner

Elderol by North American Herb & Spice: Common Questions

Does Elderol by North American Herb & Spice interact with any medications?
Yes. Based on its ingredients, Elderol has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Elderol contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant?
No — there isn't enough reliable safety data on elderberry supplements during pregnancy, so it's best to avoid them. Oregano in food amounts is probably fine, but supplement amounts should be skipped. Talk with your doctor or pharmacist about whether this product is right for you right now.
Can I use this while breastfeeding?
Elderberry data isn't strong enough in pregnancy or lactation to recommend it. For oregano, there isn't enough information about supplement safety while nursing — food seasonings are a different story. Check with your pharmacist or doctor before starting.
Does elderberry really work for colds or flu?
The evidence for elderberry on respiratory infections isn't established in our data — we rate it Insufficient Reliable Evidence To Rate. If that's why you're thinking about this product, chat with your pharmacist about what research actually backs up.
What's in the 'Multiple Spice Formula' part?
We don't have information on file about what that ingredient contains, so we can't check it for interactions or side effects. You might contact the brand directly to find out what spices are in that blend.
Why does the label say 'raw, wild' elderberry?
Raw or unripe elderberries and other parts of the elderberry plant contain compounds that can cause nausea, vomiting, and severe diarrhea — cooking gets rid of this risk. Since this is a raw extract, those compounds may still be present. Properly prepared extracts are generally well tolerated, but raw ones carry more caution.
Can this cause allergic reactions?
Oregano can cause allergic reactions in sensitive people, ranging from mild rashes to severe reactions like swelling of the lips and tongue, breathing trouble, and drop in blood pressure — though these are rare. If you have known oregano, thyme, or mint family allergies, stay away from this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Elderol label
Go deeper

The Full Monographs Behind Elderol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph → Herb & supplement monograph

Oregano

Interacts with 208 drugs

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may hav...

Read the full Oregano monograph →
Sources

Sources & How We Checked

Elderol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Oregano 12 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Benito M, Jorro G, Morales C, et al. Labiatae allergy: systemic reactions due to ingestion of oregano and thyme. Ann Allergy Asthma Immunol 1996;76:416-8. PubMed
  3. Chevallier A. Encyclopedia of Herbal Medicine. 2nd ed. New York, NY: DK Publ, Inc., 2000.
  4. Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
  5. Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
  6. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  7. Goun, E., Cunningham, G., Solodnikov, S., Krasnykch, O., and Miles, H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002;73(7-8):692-694. PubMed
  8. Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H., and Eddouks, M. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol. 2004;92(2-3):251-256. PubMed
  9. McCue, P., Vattem, D., and Shetty, K. Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pac.J Clin.Nutr. 2004;13(4):401-408.
  10. Ragi, J., Pappert, A., Rao, B., Havkin-Frenkel, D., and Milgraum, S. Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating efficacy. J.Drugs Dermatol. 2011;10(10):1168-1172.
  11. Singletary K. Oregano: overview of the literature on health benefits. Nutrition Today 2010;45(3):129-38.
  12. Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.

See these in context on the Oregano monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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