Eleuthero 500 mg Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking Eleuthero 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Eleuthero 500 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for fatigue and low energy, physical and athletic performance, stress resistance (adaptogen).Based on those ingredients, 1,140 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Eleuthero. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Eleuthero 500 mg by NOW
Ask about any prescription or over-the-counter medication and we check it for interactions with Eleuthero 500 mg by NOW — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Eleuthero 500 mg by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: organic eleuthero root extract at 500 mg per capsule. Eleuthero, also called Siberian ginseng, is a plant traditionally used for stress and energy.
The capsule itself is made with inactive ingredients including hypromellose (a plant-based capsule material) and magnesium stearate (a binding agent).
Does it work?
Not established
The evidence for eleuthero is mixed and incomplete. It's possibly effective for genital herpes, based on available data.
For chronic fatigue syndrome, familial Mediterranean fever, bipolar disorder, and osteoporosis, we don't have enough reliable evidence to say whether it works. If you're considering it for one of those conditions, that's worth discussing with your doctor.
How safe is it?
Well-documented data
Eleuthero is generally well tolerated when used short-term. The most common side effects are stomach upset — diarrhea, nausea, indigestion — plus headache and rash.
About 7% of people report nervousness, and some experience anxiety, irritability, or low mood, especially at higher doses. Less commonly, it may raise blood pressure or cause a faster heart rate, though it's unclear whether eleuthero itself or product contamination is responsible.
The safety data for long-term use is limited, so extended use isn't well studied. Eleuthero is not recommended during pregnancy or while breastfeeding because there isn't enough safety information.
Meds to double-check
Moderate interaction found
Before taking Eleuthero 500 mg, check with your pharmacist if you take digoxin (Lanoxin) for your heart, blood thinners or antiplatelet drugs like warfarin or aspirin, diabetes medications, drugs that suppress your immune system, or any drugs your liver breaks down — especially those metabolized by CYP1A2, CYP2C9, or CYP2D6 enzymes. These are Moderate-severity interactions based on lab and animal research, not yet confirmed in humans, but worth verifying against your specific medicines.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Eleuthero may help with genital herpes, though the evidence is preliminary. If you take digoxin, blood thinners, diabetes drugs, immune-suppressing medications, or drugs metabolized by your liver, you'll want to check with your pharmacist before starting this — the interactions are theoretical but documented in lab work and case reports.
Keep your doctor in the loop, especially if you have high blood pressure, heart disease, or anxiety.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Eleuthero 500 mg, straight from the product label.
| Brand | NOW |
|---|---|
| Barcode (UPC) | 733739040336 |
| Net contents | 250 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2024 |
| DSLD ID | 314301 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Eleuthero 500 mg by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| organic Eleuthero | 500 mg | -- |
Other ingredients: Hypromellose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 capsule daily as needed.
Formula
Eleuthero Root (Eleutherococcus senticosus) has been used traditionally as an adaptogen, which is a compound that supports the body's natural ability to adapt to stress of everyday life. Eleuthero Root is known to possess numerous bioactive constituents, including its characteristic profile of Eleutheroside compounds.
Adaptogenic herb Traditional Siberian herb
Triangle K (Kosher)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: For adults only. Keep out of reach of children.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation
Natural color variation may occur in this product.
Enhances vitality
Non GMO Project Verified nongmoproject.org
Vegetarian/Vegan
Made in Canada with globally sourced ingredients.
Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.
Seals/Symbols
Non GMO Project Verified nongmoproject.org
Triangle K (Kosher)
GMP Quality Assured
FDA Statement of Identity
A Dietary Supplement
General Statements
Botanicals/herbs Family owned since 1968.
Storage
Store in a cool, dry place after opening.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Eleuthero 500 mg by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Eleuthero 500 mg by NOW
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container250 Amounts shown are per serving.
Organic Eleuthero
Interacts with1,140 drugs
Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence beh...
Organic Eleuthero monograph & interactionsOther (inactive) ingredients: Hypromellose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Eleuthero 500 mg by NOW Drug Interactions
HelloPharmacist Interaction Report
Eleuthero 500 mg by NOW contains one active ingredient — organic eleuthero — that has documented interactions with a number of medication types.
The most serious concern is with digoxin (Lanoxin), a heart drug: a case report describes a patient whose digoxin level rose after starting eleuthero, returning to normal once the supplement stopped. This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Other Moderate-severity interactions affect several drug categories. Eleuthero may increase levels of drugs broken down by liver enzymes called CYP1A2, CYP2C9, and CYP2D6 — though human data on CYP2D6 is reassuring.
It may also increase levels of P-glycoprotein substrates (a transport protein in your body). The supplement has theoretically antiplatelet activity and may raise bleeding risk if you're on blood thinners (anticoagulants) or antiplatelet drugs like aspirin.
It may interfere with immune-suppressing drugs because eleuthero itself stimulates immune activity, and it may add to the blood-sugar-lowering effect of diabetes medications.
Although these interactions are theoretical — based on lab and animal data rather than human reports — they warrant caution. Altogether, these interactions span 1,123 individual medications.
Use the medication checker on this page to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Eleuthero 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Eleuthero 500 mg interact with 1,140 drugs. Click any drug to see the details.
1 of the 1 ingredient in Eleuthero 500 mg interact with drugs. Each result below shows which ingredient is responsible. organic Eleuthero
Azilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
Read the full Organic Eleuthero + Azilsartan, Chlorthalidone interactionBasiliximabSimulect
How Basiliximab interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Organic Eleuthero + Basiliximab interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Eleuthero + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroP-glycoprotein Substrates, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Organic Eleuthero + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Eleuthero + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroImmunosuppressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Organic Eleuthero + Beclomethasone Dipropionate interactionBelinostatBeleodaq
How Belinostat interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Organic Eleuthero + Belinostat interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Eleuthero + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Eleuthero + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionBendamustineBelrapzo, Treanda, Vivimusta
How Bendamustine interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Organic Eleuthero + Bendamustine interactionBendamustine HydrochlorideBendeka
How Bendamustine Hydrochloride interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Organic Eleuthero + Bendamustine Hydrochloride interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Organic Eleuthero + Benzhydrocodone, Acetaminophen interactionBerotralstat HydrochlorideOrladeyo
How Berotralstat Hydrochloride interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Organic Eleuthero + Berotralstat Hydrochloride interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroP-glycoprotein Substrates, Immunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Organic Eleuthero + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroImmunosuppressants, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Organic Eleuthero + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroP-glycoprotein Substrates, Immunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Organic Eleuthero + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroImmunosuppressants, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Organic Eleuthero + Betamethasone Valerate interactionBetrixabanBevyxxa
How Betrixaban interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroP-glycoprotein Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Organic Eleuthero + Betrixaban interactionBictegravir, Emtricitabine, Tenofovir AlafenamideBiktarvy
How Bictegravir, Emtricitabine, Tenofovir Alafenamide interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Organic Eleuthero + Bictegravir, Emtricitabine, Tenofovir Alafenamide interactionBimekizumab-bkzxBimzelx
How Bimekizumab-bkzx interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Organic Eleuthero + Bimekizumab-bkzx interactionBivalirudinAngiomax, Angiomax Rtu, Angiox
How Bivalirudin interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Organic Eleuthero + Bivalirudin interactionBoceprevirVictrelis
How Boceprevir interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Organic Eleuthero + Boceprevir interactionBosentanTracleer
How Bosentan interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Eleuthero + Bosentan interactionBromfenac SodiumBromsite, Prolensa
How Bromfenac Sodium interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Organic Eleuthero + Bromfenac Sodium interactionBudesonide, FormoterolSymbicort
How Budesonide, Formoterol interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
Read the full Organic Eleuthero + Budesonide, Formoterol interactionBupivacaine, MeloxicamZynrelef Kit
How Bupivacaine, Meloxicam interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
Read the full Organic Eleuthero + Bupivacaine, Meloxicam interactionCabliviCablivi
How Cablivi interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Organic Eleuthero + Cablivi interactionCaffeine (otc Drug)Molie, Overtime, Vivarin
How Caffeine (otc Drug) interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Organic Eleuthero + Caffeine (otc Drug) interactionCaffeine (prescription Drug)Caffeine, Dextrophin
How Caffeine (prescription Drug) interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Eleuthero + Caffeine (prescription Drug) interactionCaffeine , Sodium BenzoateCaffeine and Sodium Benzoate
How Caffeine , Sodium Benzoate interacts with Eleuthero 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic EleutheroCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Organic Eleuthero + Caffeine , Sodium Benzoate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Eleuthero 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Eleuthero
Anticoagulant/Antiplatelet Drugs
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.
Antidiabetes Drugs
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.
Digoxin (Lanoxin)
Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.
Immunosuppressants
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.
P-Glycoprotein Substrates
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.
Brand information
Manufacturer and brand details for Eleuthero 500 mg, from the product label.
NOW
See all NOW products- Name
- NOW FOODS
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- nowfoods.com
Eleuthero 500 mg by NOW: Common Questions
Does Eleuthero 500 mg by NOW interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is eleuthero safe to take while I'm pregnant or breastfeeding?
What side effects might I notice?
Does eleuthero actually work?
How long can I safely take this supplement?
Can eleuthero affect my blood pressure or heart?
What's actually in this capsule besides eleuthero?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Eleuthero 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Eleuthero 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Eleuthero 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Eleuthero 24 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ 1996;155:293-5.
- Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
- Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
- Harkey MR, Henderson GL, Zhou L, et al. Effects of Siberian ginseng (Eleutherococcus senticosus) on c-DNA-expressed P450 drug metabolizing enzymes. Alt Ther 2001;7:S14.
- Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986;49:293-7. PubMed
- Yun-Choi HS, Kim JH, Lee JR. Potential inhibitors of platelet aggregation from plant sources, III. J Nat Prod 1987;50:1059-64. PubMed
- Donovan JL, DeVane CL, Chavin KD, et al. Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers. Drug Metab Dispos 2003;31:519-22.. PubMed
- Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed
- Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr 2004;23:248-58. PubMed
- Dasgupta A, Wu S, Actor J, et al. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol 2003;119:298-303. DOI
- Takahashi T, Kaku T, Sato T, et al. Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2. J Nat Med. 2010;64(1):55-62. PubMed
- Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2006;34:577-82. PubMed
- Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
- Molokovskii, D. S., Davydov, V. V., and Tiulenev, V. V. [The action of adaptogenic plant preparations in experimental alloxan diabetes]. Probl.Endokrinol.(Mosk) 1989;35(6):82-87.
- Schmolz, M. W., Sacher, F., and Aicher, B. The synthesis of Rantes, G-CSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots. Phytother.Res 2001;15(3):268-270.
- Huang, D. B., Ran, R. Z., and Yu, Z. F. [Effect of Acanthopanax senticosus injection on the activities of human tumor necrosis factor and natural killer cell in blood in the patients with lung cancer]. Zhongguo Zhong.Yao Za Zhi. 2005;30(8):621-624.
- Niu, H. S., Hsu, F. L., Liu, I. M., and Cheng, J. T. Increase of beta-endorphin secretion by syringin, an active principle of Eleutherococcus senticosus, to produce antihyperglycemic action in type 1-like diabetic rats. Horm.Metab Res 2007;39(12):894-898
- Watanabe, K., Kamata, K., Sato, J., and Takahashi, T. Fundamental studies on the inhibitory action of Acanthopanax senticosus Harms on glucose absorption. J Ethnopharmacol. 10-28-2010;132(1):193-199. PubMed
- Bazaz'ian, G. G., Liapina, L. A., Pastorova, V. E., and Zvereva, E. G. [Effect of Eleutherococcus on the functional status of the anticoagulation system in older animals]. Fiziol.Zh.SSSR Im I.M.Sechenova 1987;73(10):1390-1395.
- Kaloeva, Z. D. [Effect of the glycosides of Eleutherococcus senticosus on the hemodynamic indices of children with hypotensive states]. Farmakol.Toksikol. 1986;49(5):73.
- Martinez, B. and Staba, E. J. The physiological effects of Aralia, Panax and Eleutherococcus on exercised rats. Jpn J Pharmacol 1984;35(2):79-85. DOI
- Medon, P. J., Thompson, E. B., and Farnsworth, N. R. Hypoglycemic effect and toxicity of Eleutherococcus senticosus following acute and chronic administration in mice. Zhongguo Yao Li Xue.Bao. 1981;2(4):281-285.
- Freye E, GLeske J. Siberian ginseng results in beneficial effects on glucose metabolism in diabetes type 2 patients: a double blind placebo-controlled study in comparison to panax ginseng. Int J Clin Nutr. 2013;1(1):11-17.
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