Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Endo-Pan Ingredients & Drug Interactions

by Endo-met Laboratories

Endo-Pan label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Endo-Pan against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Endo-Pan is a dietary supplement by Endo-met Laboratories with 3 active ingredients. Its ingredients are commonly taken for general nutrition and energy, skin and hair health, acne (topical and oral).Based on those ingredients, 153 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Cysteine Hydrochloride, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Endo-Pan by Endo-met Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Endo-Pan by Endo-met Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Endo-Pan by Endo-met Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Endo-Pan contains 3 active ingredients. Pantothenic acid, also called vitamin B5, is a water-soluble vitamin involved in energy metabolism and skin health.

L-cysteine hydrochloride is an amino acid your body uses to make proteins and glutathione, a powerful antioxidant. Zinc is a mineral essential for immune function, wound healing, and protein synthesis.

The tablet also includes inactive ingredients—microcrystalline cellulose, stearic acid, hypromellose, silicon dioxide, magnesium stearate, glycerin, and hydroxypropyl cellulose—which serve as binders, flow agents, and coating materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Pantothenic acid and zinc supplement.
  • We looked for evidence on: Acne, Acrodermatitis enteropathica, Alopecia areata, Androgenic alopecia, Atopic dermatitis (eczema), Cheilitis — and 4 related terms.
  • The strongest evidence on file: Zinc is rated "Possibly Effective" for Acne (Natural Medicines).
  • Also on file: Zinc is rated "Possibly Effective" for Acrodermatitis enteropathica, Herpes labialis (cold sores).
  • Also on file: Zinc is rated "Possibly Ineffective" for Alopecia areata.

Pantothenic acid is effective for treating pantothenic acid deficiency. The evidence for the other uses listed—including support for hay fever, alcoholism, and alopecia areata—falls short of reliable evidence.

Zinc is effective for zinc deficiency and likely effective for Wilson disease (a copper metabolism disorder). For acne, macular degeneration, diabetes, and skin conditions like acrodermatitis enteropathica, zinc appears possibly effective, though the evidence isn't definitive.

L-cysteine's effectiveness is not established in our data; the listed uses (alopecia, leg ulcers, hangover, stroke, and gastritis) lack reliable evidence.

The evidence, ingredient by ingredient Pantothenic Acid L-cysteine Zinc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantothenic acid is generally well tolerated at typical supplement doses and rated likely safe in pregnancy and lactation. Normal dietary amounts and prenatal-vitamin amounts are fine; if you're considering high-dose supplements, check with your doctor first.

The most common side effect reported orally is diarrhea. L-cysteine is generally well tolerated in food amounts, but long-term safety at supplement doses isn't well studied; consult your doctor before taking it at supplement strength.

Zinc is well tolerated in doses at or below the recommended daily limit of 40 mg per day for adults. Common side effects at higher doses include nausea, vomiting, diarrhea, abdominal cramps, and a metallic taste.

High doses above 40 mg daily may carry a risk of copper deficiency over time. Zinc is rated likely safe in pregnancy and lactation, though one pregnancy rating flags "likely unsafe"—discuss high-dose zinc use in pregnancy with your doctor.

Side effects, ingredient by ingredient Pantothenic Acid L-cysteine Zinc

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Zinc, L-cysteine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 153 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Endo-Pan, double-check with your doctor or pharmacist if you use quinolone antibiotics (ciprofloxacin, levofloxacin), cephalexin, tetracycline antibiotics (doxycycline), penicillamine, HIV medications (ritonavir, integrase inhibitors, Biktarvy), antidiabetes drugs, cisplatin, or any other prescription medications. Zinc can reduce absorption of several of these, and spacing or timing adjustments may be needed—your pharmacist can help work that out for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Endo-Pan makes sense if you have a documented pantothenic acid deficiency or want to explore zinc's role in immune or wound health. If you take antibiotics, HIV medications, or antidiabetes drugs, check with your pharmacist first—timing and spacing can sometimes help, but your own medications may not be compatible.

Discuss this product with your doctor or pharmacist before starting, especially if you're pregnant, taking high doses, or juggling multiple prescriptions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Endo-Pan, straight from the product label.

Brand Endo-met Laboratories
Net contents 180 Tablet(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 255990
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Endo-Pan by Endo-met Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
180
IngredientAmount% DV
Pantothenic Acid200 mg2000%
L-Cysteine Hydrochloride50 mg--
Zinc22.5 mg150%

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Hypromellose, Silicon Dioxide, Magnesium Stearate, Glycerin, Hydroxypropyl Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Sustained release

FDA Statement of Identity

Pantothenic acid and zinc Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Endo-Pan by Endo-met Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Endo-Pan label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Endo-Pan by Endo-met Laboratories

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pantothenic Acid

No known
interactions
200 mg per serving Form: Calcium D-Pantothenate

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

L-Cysteine Hydrochloride

Interacts with
86 drugs
50 mg per serving

L-cysteine is a sulfur-containing amino acid your body uses to make proteins and the antioxidant glutathione. Most people get enough from food, and su...

L-Cysteine Hydrochloride monograph & interactions

Zinc

Interacts with
67 drugs
22.5 mg per serving Form: Zinc Hydrolyzed Rice Protein Chelate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Hypromellose, Silicon Dioxide, Magnesium Stearate, Glycerin, Hydroxypropyl Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Endo-Pan by Endo-met Laboratories Drug Interactions

Want to check YOUR meds against Endo-Pan?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
153Drugs
149 Moderate 4 Minor

Ingredients driving the most interactions

L-Cysteine Hydrochloride 86
Zinc 67

Individual Drug Interactions

The ingredients in Endo-Pan interact with 153 drugs. Click any drug to see the details.

2 of the 3 ingredients in Endo-Pan interact with drugs. Each result below shows which ingredient is responsible. L-Cysteine Hydrochloride Zinc

Each ingredient & the kinds of drugs it affects

For each ingredient in Endo-Pan with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Cysteine Hydrochloride1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that L-cysteine can have hypoglycemic effects.

Likelihood Possible Evidence D
L-Cysteine Hydrochloride full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Endo-Pan, from the product label.

Endo-met Laboratories

See all Endo-met Laboratories products
Name
Endo-met Laboratories, Inc.
Pharmacist Counseling Corner

Endo-Pan by Endo-met Laboratories: Common Questions

Does Endo-Pan by Endo-met Laboratories interact with any medications?
Yes. Based on its ingredients, Endo-Pan has a known interaction with 153 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Endo-Pan contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Endo-Pan safe to take while pregnant?
Pantothenic acid and L-cysteine are rated likely safe in pregnancy. Zinc is also rated likely safe, though one safety rating flags it as possibly unsafe in pregnancy at high doses—so if you're pregnant or planning to be, talk with your doctor before taking this product to confirm it's right for you.
What is L-cysteine used for in this product?
L-cysteine is an amino acid your body uses to build proteins and make glutathione, a key antioxidant. The evidence for its effectiveness for conditions like hair loss, leg ulcers, and stroke isn't yet reliable, so we can't claim it works for those uses.
Can this product cause side effects?
Pantothenic acid and zinc are generally well tolerated. The most common side effect from zinc, especially at higher doses, is nausea, vomiting, or diarrhea, along with a metallic taste. Pantothenic acid may cause diarrhea. L-cysteine has no reported adverse effects on file.
Will Endo-Pan help with acne or hair loss?
Zinc appears possibly effective for acne based on current evidence. For hair loss, the evidence is insufficient to say whether pantothenic acid or L-cysteine will help—there isn't enough reliable data in our records.
Is it safe to take Endo-Pan long-term?
Pantothenic acid and zinc are safe in normal dietary amounts long-term. L-cysteine at supplement doses hasn't been well studied over time, so consult your doctor before using it long-term at supplement strength. High-dose zinc over time may increase the risk of copper deficiency, so avoid exceeding 40 mg daily without medical guidance.
Can I breastfeed while taking Endo-Pan?
Pantothenic acid, L-cysteine, and zinc are all rated likely safe during lactation. If you have specific concerns about nursing and this product, your doctor or pharmacist can offer personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Endo-Pan label
Go deeper

The Full Monographs Behind Endo-Pan’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

L-cysteine

Interacts with 86 drugs

L-cysteine is a sulfur-containing amino acid your body uses to make proteins and the antioxidant glutathione. Most people get enough from food, and supplements are usually well tolerated, bu...

Read the full L-cysteine monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph →
Sources

Sources & How We Checked

Endo-Pan's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 101 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantothenic Acid 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  4. Schmuth, M., Wimmer, M. A., Hofer, S., Sztankay, A., Weinlich, G., Linder, D. M., Elias, P. M., Fritsch, P. O., and Fritsch, E. Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br.J.Dermatol. 2 PubMed
  5. Schreck, U., Paulsen, F., Bamberg, M., and Budach, W. Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? Strahlenther.Onkol. 2002;178(6):321-329. PubMed
  6. Herbst, R. A., Uter, W., Pirker, C., Geier, J., and Frosch, P. J. Allergic and non-allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5-year period. Contact Dermatitis 2004;51(1):13-1 PubMed
  7. Champault, G. and Patel, J. C. [Treatment of constipation with Bepanthene]. Med.Chir Dig. 1977;6(1):57-59.
  8. Scott LN, Fiume M, Bergfeld WF, et al. Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Int J Toxicol 2022;41(3_suppl):77-128. PubMed
  9. Han J, Warshaw EM. Allergic Contact Dermatitis to Panthenol in "Hypoallergenic" Products. Dermatitis 2023;34(1):62-63. PubMed
  10. Blanchard G, Kerre S, Walker A, et al. Allergic contact dermatitis from pantolactone and dexpanthenol in wound healing creams. Contact Dermatitis 2022;87(5):468-471. PubMed
  11. Peltier E, Trapp S, de Salvo R, et al. A new dexpanthenol-containing liquid cleanser for atopic-prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function. J Cosme PubMed

See these in context on the Pantothenic Acid monograph →

L-cysteine 2 references
  1. Dowlati Y, Maheux M, Meyer JH. The effect of oral L-cysteine on breast milk and plasma cysteine concentrations. Neuropsychiatr Dis Treat 2020;16:3163-3172.
  2. Lee S, Han KH, Nakamura Y, et al. Dietary L-cysteine improves the antioxidative potential and lipid metabolism in rats fed a normal diet. Biosci Biotechnol Biochem 2013;77(7):1430-4.

See these in context on the L-cysteine monograph →

Zinc 88 references
  1. Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
  2. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
  3. Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
  4. Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
  5. Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
  6. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
  7. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  8. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
  9. Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, et al. Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30. PubMed
  10. Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990;51:225-7.
  11. Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. PubMed
  12. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  13. Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr 1982;1:207-14. PubMed
  14. Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976;11:45-54.. PubMed
  15. Hirt M, Nobel S, Barron E. Zinc nasal gel for the treatment of common cold symptoms: A double-blind, placebo-controlled trial. Ear Nose Throat J 2000;79:778-82.. DOI
  16. Simkin PA. Oral zinc sulphate in rheumatoid arthritis. Lancet 1976;2:539-42. PubMed
  17. Wray D. A double-blind trial of systemic zinc sulfate in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1982;53:469-72. PubMed
  18. Douglas RM, Miles HB, Moore BW, et al. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother 1987;31:1263-5. PubMed
  19. Lagiou P, Wuu J, Trichopoulou A, et al. Diet and benign prostatic hyperplasia: a study in Greece. Urology 1999;54:284-90. PubMed
  20. Ewing CI, Gibbs AC, Ashcroft C, David TJ. Failure of oral zinc supplementation in atopic eczema. Eur J Clin Nutr 1991;45:507-10.
  21. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  22. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Oph
  23. Greenberg JE, Lynn M, Kirsner RS, et al. Mucocutaneous pigmented macule as a result of zinc deposition. J Cutan Pathol 2002;29:613-5. PubMed
  24. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.
  25. Turner RB. Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds. Clin Infect Dis 2001;33:1865-70. PubMed
  26. Belongia EA, Berg R, Liu K. A randomized trial of zinc nasal spray for the treatment of upper respiratory illness in adults. Am J Med 2001;111:103-8. PubMed
  27. Mossad SB. Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. QJM 2003;96:35-43. DOI
  28. Leitzmann MF, Stampfer MJ, Wu K, et al. Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst 2003;95:1004-7.. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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