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Dietary supplement

Estro8PN Hop Extract 10 mg Ingredients & Drug Interactions

by Swanson Superior Herbs

Estro8PN Hop Extract 10 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Estro8PN Hop Extract 10 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Estro8PN Hop Extract 10 mg is a dietary supplement by Swanson Superior Herbs with 1 active ingredient. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and restlessness, menopausal symptoms.Based on those ingredients, 863 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Estro8PN Hop extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Estro8PN Hop Extract 10 mg by Swanson Superior Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Estro8PN Hop Extract 10 mg by Swanson Superior Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Estro8PN Hop Extract 10 mg by Swanson Superior Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Estro8PN Hop extract at 10 mg per capsule. Hops is a plant used traditionally to support relaxation and sleep.

The extract is delivered in a capsule made of hypromellose with brown rice flour as an inactive filler.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hops product and its label doesn't state a use — see Hops's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The data we hold does not establish that hops extract is effective for the conditions it's marketed for—age-related cognitive decline, sexual dysfunction, anxiety, ADHD, indigestion (dyspepsia), or insomnia. All of these carry an Insufficient Reliable Evidence To Rate rating, meaning the research is too limited or weak to draw a firm conclusion.

If you're considering this for any of these purposes, talk it over with your doctor to explore what evidence exists and what might work better for your situation.

The evidence, ingredient by ingredient Hops

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hops extract is generally well tolerated in the short term but may cause drowsiness, and long-term safety hasn't been well studied. The safety data advises against use during pregnancy due to insufficient information.

Breastfeeding safety is unknown, so the data advises against it as well. Occupational exposure to hops dust (usually mixed with other dust) has been linked to chronic cough, shortness of breath, and bronchitis—though that's an industrial-exposure concern, not a typical supplement use.

A small number of reports link supplements containing both hops and soy to postmenopausal bleeding, though it's unclear whether hops, soy, or the combination is responsible. Fresh hops plant contact and pollen can trigger allergic reactions and contact dermatitis in some people.

Side effects, ingredient by ingredient Hops

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hops.
  • The most serious interaction on file is rated Moderate.
  • For scale: 864 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist if you use sedative drugs (sleeping pills, anxiety medications, or pain relievers with sedating effects)—hops may add to their drowsy effects. If you take estrogen or hormone replacement therapy, confirm it's okay, since hops might interfere.

Additionally, if you take any drugs metabolized by your liver (a very large group), mention this supplement so your pharmacist can verify there's no unexpected interaction.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Hops extract is generally well tolerated in the short term for people without sedative use, hormone therapy, or sensitivity to its ingredients. If you take any sedatives or estrogen-based medications, or if you're pregnant or breastfeeding, check with your doctor or pharmacist before starting.

Long-term safety isn't well understood, so this is worth discussing with your own healthcare provider if you plan to use it regularly.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Estro8PN Hop Extract 10 mg, straight from the product label.

Brand Swanson Superior Herbs
Barcode (UPC) 087614142173
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 184701
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Estro8PN Hop Extract 10 mg by Swanson Superior Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
UPC/BARCODE
087614142173
IngredientAmount% DV
Estro8PN Hop extract10 mg--

Other ingredients: Brown Rice Flour, Hypromellose, May contain one or both of the following

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Herbal Supplement

Formulation

V Vegetarian formula

Seals/Symbols

V Vegetarian formula Guaranteed purity & potency

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule one to two times per day with water.

General

SWH217 Rev 1 02 26 18

General Statements

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

Brand IP Statement(s)

Estro8PN is a trademark of Berg Imports, LLC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Estro8PN Hop Extract 10 mg by Swanson Superior Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Estro8PN Hop Extract 10 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Estro8PN Hop Extract 10 mg by Swanson Superior Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Amounts shown are per serving.

Estro8PN Hop extract

Interacts with
863 drugs
10 mg per serving

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Estro8PN Hop extract monograph & interactions

Other (inactive) ingredients: Brown Rice Flour, Hypromellose, May contain one or both of the following. These complete the product’s ingredient list but are not active constituents.

Interaction report

Estro8PN Hop Extract 10 mg by Swanson Superior Herbs Drug Interactions

Want to check YOUR meds against Estro8PN Hop Extract 10 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
863Drugs
289 Moderate 574 Minor

Ingredients driving the most interactions

Estro8PN Hop extract 863

Individual Drug Interactions

The ingredients in Estro8PN Hop Extract 10 mg interact with 863 drugs. Click any drug to see the details.

1 of the 1 ingredient in Estro8PN Hop Extract 10 mg interact with drugs. Each result below shows which ingredient is responsible. Estro8PN Hop extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Estro8PN Hop Extract 10 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Estro8PN Hop extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Estro8PN Hop extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Estro8PN Hop Extract 10 mg, from the product label.

Swanson Superior Herbs

See all Swanson Superior Herbs products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

Estro8PN Hop Extract 10 mg by Swanson Superior Herbs: Common Questions

Does Estro8PN Hop Extract 10 mg by Swanson Superior Herbs interact with any medications?
Yes. Based on its ingredients, Estro8PN Hop Extract 10 mg has a known interaction with 863 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Estro8PN Hop Extract 10 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Hops extract may cause drowsiness, especially in the short term. If you're sensitive to sedating effects or combine it with sleep aids or anxiety medications, drowsiness is more likely. Start low and see how you respond before driving or operating machinery.
Can I take this if I'm on hormone replacement therapy?
The data raises a Moderate-severity concern: hops compounds may compete with estrogen receptors and theoretically interfere with hormone therapy. The amounts in most extracts are small, but you should check with your doctor or pharmacist before combining them.
Is it safe to take long-term?
The safety data only covers short-term use well. Long-term safety hasn't been well studied, so if you plan to take this regularly, talk it over with your doctor or pharmacist to make sure it's right for you.
Can I use this while pregnant or breastfeeding?
No. The data advises against use during pregnancy because there isn't enough safety information. Breastfeeding safety is also unknown, so it's best avoided then too. Talk with your doctor about what's safe if you're planning pregnancy or nursing.
Does this actually help with sleep or anxiety?
The evidence we have is insufficient to say it works for insomnia, anxiety, or any of the other conditions listed. If you're looking for help with sleep or anxiety, your doctor can discuss what options have stronger evidence behind them.
What's the difference between this extract and whole hops?
This is a concentrated extract (10 mg per capsule). The data we hold doesn't compare it directly to whole hops or other forms, so we can't say how potency or effects differ. A pharmacist can help you weigh different hops products if that matters to your choice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Estro8PN Hop Extract 10 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Estro8PN Hop Extract 10 mg label
Go deeper

The Full Monographs Behind Estro8PN Hop Extract 10 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph →
Sources

Sources & How We Checked

Estro8PN Hop Extract 10 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  4. Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. PubMed
  5. Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. DOI
  6. Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. PubMed
  7. Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. DOI
  8. Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  9. Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. PubMed
  10. van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  11. Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. PubMed
  12. Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. DOI
  13. Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  14. Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  15. van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220. PubMed

See these in context on the Hops monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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