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Dietary supplement

Sleep, Stress & Sleep Support Ingredients & Drug Interactions

by Ancient Nutrition

Sleep, Stress & Sleep Support label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sleep, Stress & Sleep Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sleep, Stress & Sleep Support is a dietary supplement by Ancient Nutrition with 5 active ingredients. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and restlessness, menopausal symptoms.Based on those ingredients, 1,440 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Ashwagandha root and leaf extract, Hops, Passion Flower. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sleep, Stress & Sleep Support by Ancient Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep, Stress & Sleep Support by Ancient Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Sleep, Stress & Sleep Support by Ancient Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Herbal and Mushroom Sleep Blend” is a proprietary blend — the label gives one combined amount (1.30 Gram(s)) without saying how much of each component you get.

This product contains five active ingredients: hops, passion flower, ashwagandha root and leaf extract, reishi mushroom, and lavender, plus one proprietary blend labeled as Herbal and Mushroom Sleep Blend (we cannot detail its contents without the ingredient list). Each is included to support sleep, stress resilience, or both.

The only inactive ingredient listed is hypromellose, a plant-derived capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Sleep and stress support.
  • We looked for evidence on: Anxiety, Insomnia, Adjustment disorders, Generalized anxiety disorder (GAD), Benzodiazepine withdrawal, Restlessness — and 1 related terms.
  • The strongest evidence on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Insomnia.
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD), Insomnia.

The evidence picture varies by ingredient and claimed use. Ashwagandha and passion flower are both rated Possibly Effective for insomnia, and ashwagandha is also Possibly Effective for anxiety and stress.

Passion flower is Possibly Effective for anxiety before a medical procedure. Lavender is Possibly Effective for menstrual cramps (dysmenorrhea), though that's not a primary claim here.

For all other uses listed—hops for cognitive decline, sexual function, anxiety, ADHD, or digestive upset; reishi for high cholesterol or altitude sickness; and several others—the evidence we hold is Insufficient to establish whether they work. We have no effectiveness rating for the proprietary blend component.

The evidence, ingredient by ingredient Hops Passion Flower Ashwagandha Reishi Mushroom Lavender

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hops, passion flower, ashwagandha, and reishi are all generally well tolerated short-term in healthy adults, though long-term safety data are limited for most. The most common side effects across these ingredients are drowsiness, dizziness, nausea, and gastrointestinal upset—most mild and uncommon at typical doses.

Ashwagandha carries rare but serious concerns: case reports link it to acute liver failure, hepatitis, and even death, as well as one case of reversible cerebral vasoconstriction (a condition affecting brain blood vessels). Lavender is generally well tolerated orally and topically but can cause headache and digestive upset; the essential oil is toxic if swallowed.

Occupational exposure to hops dust is linked to chronic respiratory symptoms, though that applies mainly to farm or factory workers. For pregnancy: passion flower is rated Possibly Unsafe and ashwagandha is rated Likely Unsafe; hops, reishi, and lavender have insufficient safety data, so avoid medicinal amounts unless your doctor approves.

For breastfeeding: passion flower, ashwagandha, and reishi all lack sufficient safety data and should be avoided. Lavender has not been formally rated for lactation.

Side effects, ingredient by ingredient Hops Passion Flower Ashwagandha Reishi Mushroom Lavender

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Lavender, Hops, Passion Flower, Reishi Mushroom, Ashwagandha.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,441 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any CNS depressants (sedatives, sleep aids, pain relievers like tramadol, or benzodiazepines like lorazepam), blood pressure medications, blood thinners or antiplatelet drugs, diabetes medications, thyroid hormones, or drugs that might strain your liver. Ashwagandha poses a Major risk with the last category; all five ingredients affect sedative drugs.

Minor interactions are possible with drugs metabolized through CYP3A4 or CYP1A2 liver pathways—a long list that includes many antibiotics, antifungals, statins, and heart medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you struggle with sleep or stress and are not on blood pressure, diabetes, thyroid, or blood-thinning medications, and you don't have liver disease, this product may be worth trying—ashwagandha and passion flower do have some evidence for insomnia. But if you take any prescription medication, especially sedatives, blood thinners, diabetes drugs, blood pressure meds, or immune-suppressing drugs, you'll need to check each one against the interaction tool below before you start.

Pregnant or breastfeeding? Talk to your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep, Stress & Sleep Support, straight from the product label.

Brand Ancient Nutrition
Barcode (UPC) 816401025586
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 258855
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep, Stress & Sleep Support by Ancient Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
816401025586
IngredientAmount% DV
Hops0 NP--
Passion Flower0 NP--
organic Ashwagandha root and leaf extract0 NP--
Reishi0 NP--
Lavender0 NP--
Herbal and Mushroom Sleep Blend1.3 Gram(s)--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Formulated for maximum absorption

Color and odor may vary from lot to lot.

General Statements

Dr. Axe formula

FDA Statement of Identity

Whole Food Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 2 capsules, once per day.

Precautions

Warning: As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, or under medical supervision.

If you are currently undergoing HIV treatment, chemotherapy, or allograft therapy, do not use before consulting your physician. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Notice: Use this product as a food supplement only. Do not use for weight reduction.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sleep, Stress & Sleep Support by Ancient Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sleep, Stress & Sleep Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sleep, Stress & Sleep Support by Ancient Nutrition

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Herbal and Mushroom Sleep Blend

1.3 Gram(s) per serving

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep, Stress & Sleep Support by Ancient Nutrition Drug Interactions

Want to check YOUR meds against Sleep, Stress & Sleep Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,440Drugs
1,024 Moderate 416 Minor

Ingredients driving the most interactions

organic Ashwagandha root and leaf extract 1,372
Hops 863
Passion Flower 836
Reishi 375
Lavender 248

Individual Drug Interactions

The ingredients in Sleep, Stress & Sleep Support interact with 1,440 drugs. Click any drug to see the details.

5 of the 5 ingredients in Sleep, Stress & Sleep Support interact with drugs. Each result below shows which ingredient is responsible. organic Ashwagandha root and leaf extract Hops Passion Flower Reishi Lavender

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep, Stress & Sleep Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Ashwagandha root and leaf extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
organic Ashwagandha root and leaf extract full monograph & interactions

Hops4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Hops full monograph & interactions

Passion Flower3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passion Flower full monograph & interactions

Reishi3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi full monograph & interactions

Lavender1 drug type · 248 drugs

Cns Depressants

Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.

Likelihood Unlikely Evidence D
Lavender full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sleep, Stress & Sleep Support, from the product label.

Ancient Nutrition

See all Ancient Nutrition products
Name
Ancient Nutrition, LLC
Street Address
2000 Mallory Lane Suite 130-307
City
Franklin
State
TN
ZipCode
37067
Web Address
www.AncientNutrition.com
Pharmacist Counseling Corner

Sleep, Stress & Sleep Support by Ancient Nutrition: Common Questions

Does Sleep, Stress & Sleep Support by Ancient Nutrition interact with any medications?
Yes. Based on its ingredients, Sleep, Stress & Sleep Support has a known interaction with 1,440 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep, Stress & Sleep Support contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Yes, drowsiness is common. All five active ingredients—hops, passion flower, ashwagandha, reishi, and lavender—have sedative properties, so you may feel sleepy, especially if taken before bed. If you're sensitive to sedation, start with a lower dose or take it only at night.
Is this safe to take long-term?
Short-term use (weeks to a few months) is generally well tolerated, but long-term safety data are limited for most of these ingredients. If you plan to take it for more than a few months, talk to your pharmacist or doctor about whether that's right for you.
Can I take this if I'm pregnant or nursing?
No, not without your doctor's approval. Passion flower is rated Possibly Unsafe in pregnancy, and ashwagandha is rated Likely Unsafe. Reishi, hops, and lavender lack sufficient safety data. If you're breastfeeding, passion flower, ashwagandha, and reishi should be avoided.
Does ashwagandha in this product have any serious side effects?
Most people tolerate it well, but rare cases have been reported of acute liver damage, hepatitis, and even liver failure. If you have liver disease or take other drugs that stress your liver, this ingredient poses a real concern—check with your doctor first.
What's the Herbal and Mushroom Sleep Blend in here?
The product label lists it as a proprietary blend, which means the individual ingredients and their amounts are not detailed separately. We can't evaluate its interactions or effectiveness without that information.
Can I use this with my blood pressure medication?
Ashwagandha and reishi may lower blood pressure, so taking them with blood pressure drugs could cause your pressure to drop too far. Check with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep, Stress & Sleep Support label
Go deeper

The Full Monographs Behind Sleep, Stress & Sleep Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Lavender

Interacts with 248 drugs

Lavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standardized oral lavender oil product for anxie...

Read the full Lavender monograph →
Sources

Sources & How We Checked

Sleep, Stress & Sleep Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 103 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  4. Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. PubMed
  5. Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. DOI
  6. Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. PubMed
  7. Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. DOI
  8. Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  9. Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. PubMed
  10. van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  11. Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. PubMed
  12. Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. DOI
  13. Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  14. Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  15. van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220. PubMed

See these in context on the Hops monograph →

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
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Ashwagandha 32 references
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Reishi Mushroom 17 references
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Lavender 20 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
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  17. Barbaud A, Kurihara F, Raison-Peyron N, et al. Allergic contact dermatitis from essential oil in consumer products: Mode of uses and value of patch-tests with an essential oil series. Results of a French study of the DAG (dermato-allergy group of the Fren
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  20. Simaei SR, Askari VR, Rostami M, et al. Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial. Fitoterapia 2023;172:105720. PubMed

See these in context on the Lavender monograph →

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