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Dietary supplement

Eupatorium Pur. Gravel Root Ingredients & Drug Interactions

by Wise Woman Herbals

Eupatorium Pur. Gravel Root label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Eupatorium Pur. Gravel Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Eupatorium Pur. Gravel Root is a dietary supplement by Wise Woman Herbals with 1 active ingredient. Its ingredients are commonly taken for kidney stones, urinary tract complaints, fluid retention.Based on those ingredients, 88 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gravel Root. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Eupatorium Pur. Gravel Root by Wise Woman Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Eupatorium Pur. Gravel Root by Wise Woman Herbals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Eupatorium Pur. Gravel Root by Wise Woman Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (2.50 mL) without saying how much of each component you get.

This liquid contains one active ingredient: gravel root. It's prepared as a proprietary blend in a base of spring water and organic alcohol.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Gravel Root product and its label doesn't state a use — see Gravel Root's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't have effectiveness data on file for gravel root.

The evidence, ingredient by ingredient Gravel Root

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gravel root carries significant safety concerns. It contains pyrrolizidine alkaloids — compounds that can damage your liver and lungs with chronic use.

The risk includes veno-occlusive disease, a serious liver condition that can cause belly pain, vomiting, diarrhea, fluid buildup, and persistent liver enlargement within weeks. Because of these risks and limited safety data, it should be used only short-term and with caution.

Don't use this product during pregnancy — there isn't enough safety information. The same applies to breastfeeding; reliable safety data doesn't exist.

If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before using it.

Side effects, ingredient by ingredient Gravel Root

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gravel Root.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 89 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take lithium — gravel root may raise lithium levels. Also double-check if you're on any CYP3A4-inducing drugs such as carbamazepine, phenobarbital, phenytoin, rifampin, or rifabutin.

These interactions are Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gravel root has real liver and lung safety risks from its alkaloid content, especially with long-term use. If you take lithium or medications that induce CYP3A4 enzymes, this product isn't a good fit without medical guidance.

Talk with your pharmacist before starting, and don't use it during pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Eupatorium Pur. Gravel Root, straight from the product label.

Brand Wise Woman Herbals
Barcode (UPC) 748840009059
Net contents 2 Fluid oz.; 60 mL
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 284822
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Eupatorium Pur. Gravel Root by Wise Woman Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
50 Drop(s)
Servings per container
24
UPC/BARCODE
748840009059
IngredientAmount% DV
Proprietary Blend2.5 mL--
Gravel Root0 NP--

Other ingredients: spring Water, organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Shake well. Add 10-50 drops to water, 1-4 times per day.

Formulation

The presence of particulate matter in this product is normal.

Precautions

Caution: Not recommended while nursing.

Keep out of the reach of children.

General Statements

Botanical Formula

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry area away from direct sunlight with the lid tightly sealed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Eupatorium Pur. Gravel Root by Wise Woman Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Eupatorium Pur. Gravel Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Eupatorium Pur. Gravel Root by Wise Woman Herbals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Servings per container24 Amounts shown are per serving.

Proprietary Blend

2.5 mL per serving

Other (inactive) ingredients: Spring Water, Organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Eupatorium Pur. Gravel Root by Wise Woman Herbals Drug Interactions

Want to check YOUR meds against Eupatorium Pur. Gravel Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

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88Drugs
88 Moderate

Ingredients driving the most interactions

Gravel Root 88

Individual Drug Interactions

The ingredients in Eupatorium Pur. Gravel Root interact with 88 drugs. Click any drug to see the details.

1 of the 1 ingredient in Eupatorium Pur. Gravel Root interact with drugs. Each result below shows which ingredient is responsible. Gravel Root

Each ingredient & the kinds of drugs it affects

For each ingredient in Eupatorium Pur. Gravel Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gravel Root2 drug types · 88 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Lithium

Gravel root is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, gravel root might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Gravel Root full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Eupatorium Pur. Gravel Root, from the product label.

Wise Woman Herbals

See all Wise Woman Herbals products
Name
Wise Woman Herbals
City
Creswell
State
OR
ZipCode
97426
Phone Number
541.895.5152
Web Address
wisewomanherbals.com
Pharmacist Counseling Corner

Eupatorium Pur. Gravel Root by Wise Woman Herbals: Common Questions

Does Eupatorium Pur. Gravel Root by Wise Woman Herbals interact with any medications?
Yes. Based on its ingredients, Eupatorium Pur. Gravel Root has a known interaction with 88 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Eupatorium Pur. Gravel Root contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does gravel root do?
Gravel root is thought to have diuretic properties — it's believed to increase urine output — though we don't have established effectiveness data in our files for what conditions it may help.
Can I take this while pregnant?
No. The safety data isn't sufficient, and the product carries significant liver concerns. Talk with your doctor before using it if you're pregnant or planning pregnancy.
Can I take this while breastfeeding?
No. There's no reliable safety information for use while breastfeeding. Ask your doctor or pharmacist for guidance.
What's the main safety worry with gravel root?
Its pyrrolizidine alkaloid content can damage your liver and lungs, especially with ongoing use. This can cause veno-occlusive disease — a serious liver condition with symptoms like belly pain, vomiting, diarrhea, and liver enlargement. It should only be used short-term and with caution.
What's in the bottle besides the herb?
Spring water and organic alcohol — these are the inactive ingredients that carry the active gravel root.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Eupatorium Pur. Gravel Root is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Eupatorium Pur. Gravel Root label
Go deeper

The Full Monographs Behind Eupatorium Pur. Gravel Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gravel Root

Interacts with 88 drugs

Gravel Root is a traditional North American herb long used by herbalists for kidney stones and urinary problems, but there is very little modern scientific evidence to support these uses. Be...

Read the full Gravel Root monograph →
Sources

Sources & How We Checked

Eupatorium Pur. Gravel Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gravel Root 5 references
  1. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  2. Stickel F, Seitz HK. The efficacy and safety of comfrey. Public Health Nutr 2000;3:501-8. PubMed
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

See these in context on the Gravel Root monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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